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osteosarcoma
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  骨肉瘤
    Forskolin augments the effect of glucocorticoids on proliferation and differentiation of a human osteosarcoma cell line by up-regulation of glucocorticoid receptor
    Forskolin加强糖皮质激素对人骨肉瘤细胞系增殖分化的调节作用
短句来源
    Expression of Human IL-2 cDNA in the Human Osteosarcoma Cell Line
    人白细胞介素-2基因在人骨肉瘤细胞系内表达
短句来源
    Study on the pharmacodynamics of the adriamycin liposome conjugated MDP on UMR 106 osteosarcoma tumor model
    MDP-阿霉素脂质体交联物治疗大鼠成骨肉瘤的药效学研究
短句来源
    OBJECTIVE:To prepare adriamycin liposome conjugated with MDP (Methylenediphonate,MDP LADM) and observe its therapeutic effect on UMR106 osteosarcoma tumor model in rat, as well as comparing it with adriamycin liposome (LADM) and free adriamycin(ADM) .
    目的 :制备出 MDP-阿霉素脂质体交联物 (MDP-L ADM) ,观察 MDP-LADM治疗大鼠成骨肉瘤 UMR10 6模型的疗效 ,并与游离阿霉素 (ADM)及阿霉素脂质体 (L ADM)作比较。
短句来源
    Expression of cbfa1 gene in rat osteosarcoma UMR106 cell was detected by RTPCR after the 72? h's treatment of FSK88 liquid with different mol concentration(25,50,100?μmol/L),Retinoic Acid(RA,10?μmol/L) and mixed liquid of FSK88 and RA(1∶1).
    以大鼠成骨肉瘤细胞———UMR106为模型,应用RT-PCR方法,检测用不同浓度的FSK88药液(25,50,100μmol/L)、维甲酸(RA,10μmol/L,阳性对照)以及FSK88+RA(等体积)混合药液处理细胞72 h后,细胞内cbfa1基因表达量的变化.
短句来源
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  成骨肉瘤
    Study on the pharmacodynamics of the adriamycin liposome conjugated MDP on UMR 106 osteosarcoma tumor model
    MDP-阿霉素脂质体交联物治疗大鼠成骨肉瘤的药效学研究
短句来源
    OBJECTIVE:To prepare adriamycin liposome conjugated with MDP (Methylenediphonate,MDP LADM) and observe its therapeutic effect on UMR106 osteosarcoma tumor model in rat, as well as comparing it with adriamycin liposome (LADM) and free adriamycin(ADM) .
    目的 :制备出 MDP-阿霉素脂质体交联物 (MDP-L ADM) ,观察 MDP-LADM治疗大鼠成骨肉瘤 UMR10 6模型的疗效 ,并与游离阿霉素 (ADM)及阿霉素脂质体 (L ADM)作比较。
短句来源
    Expression of cbfa1 gene in rat osteosarcoma UMR106 cell was detected by RTPCR after the 72? h's treatment of FSK88 liquid with different mol concentration(25,50,100?μmol/L),Retinoic Acid(RA,10?μmol/L) and mixed liquid of FSK88 and RA(1∶1).
    以大鼠成骨肉瘤细胞———UMR106为模型,应用RT-PCR方法,检测用不同浓度的FSK88药液(25,50,100μmol/L)、维甲酸(RA,10μmol/L,阳性对照)以及FSK88+RA(等体积)混合药液处理细胞72 h后,细胞内cbfa1基因表达量的变化.
短句来源
    METHOD:The MDP was conjugated to the membrane of adriamycin liposome with tolylendiisocyanate(TDI). The model of UMR106 osteosarcoma tumor model in SD rat has been established.
    方法 :建立 SD大鼠 U MR10 6成骨肉瘤模型 ,将磷脂修饰后用1,4-二异氰基甲苯酯 (TDI)与 MDP交联 ,用改良的逆向蒸发法将其制备成阿霉素脂质体 -MDP交联物。
短句来源
  “osteosarcoma”译为未确定词的双语例句
    Effcts of 17β-estradiol on cell proliferation, cAMP and cGMP content,and iNOS activity in human osteoblast like osteosarcoma cell line TE85
    17β-雌二醇对人成骨细胞株HOS TE85细胞增殖及胞内cAMP,cGMP,iNOS影响
短句来源
    Effect of FSK88 on cbfa1 Gene Expression in Rat Osteosarcoma UMR106 Cell
    FSK88对UMR106细胞中cbfa1基因表达的影响
短句来源
    The mean dose delivered to bone which couldinduced osteosarcoma was 14.17Gy.
    骨的平均剂量估算为14.17Gy。
短句来源
    The retention of ~(239)Pu in local wounded skin was fullyfitted to a exponential equation y=0.7145e~(-0.0076)x,while the contentof ~(239)Pu in skeleton was fitted to y′=0.0086x~(0.5041). The undesirablelate effect of complex wound by ~(239)Pu(NO_3)_4 is osteosarcoma.
    结果表明:局部钚残留量的变化在450天内符合 y=0.7145e~(-0·0076x)的指数方程,而骨钚含量的动态变化在450天内则符合 y′=0.0086X~(0·5041)的方程。
短句来源
    AIM to study the effects of 17β-estradiol on cell proliferation, cAMP and cGMP content, and iNOS activity in human osteoblast like osteosarcoma cell line TE85. METHOD Utilizing the method of thymidine incorporation for cell proliferation, radioimmunoassay for cAMP and cGMP measurement, and transferring L [ 3H] arginine to L citruline for iNOS assay.
    目的观察17β-雌二醇(E2)对HOSTE85细胞增殖及胞内cAMP,cGMP,iNOS影响。 方法[3H]-TdR参入,放射免疫及L-3H-精氨酸转化法。
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  osteosarcoma
Measurement of bone alkaline phosphatase and relative study with osteosarcoma
      
The objective of this paper is to explore the value of bone alkaline phosphatase (BALP) for diagnosing osteosarcoma, evaluating the effect of the chemotherapy, judging the prognosis and supervising the relapse and metastasis.
      
The immunoassay was used to check the BALP of the blood serum that was from 42 primary osteosarcoma patients.
      
BALP was more sensitive than ALP in diagnosing osteosarcoma (P = 0.015).
      
It has applied value in the diagnosis of osteosarcoma, reflection of the effect of chemotherapy and forecast the prognosis.
      
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The distribution of plutonium-239 in bone,liver,kidneyand local contaminated skin in rats was observed at different timeinterval after its uptake through wounded skin(0.5N~(239)Pu(NO_3)_4,3.07×10~4Bq).The retention of ~(239)Pu in local wounded skin was fullyfitted to a exponential equation y=0.7145e~(-0.0076)x,while the contentof ~(239)Pu in skeleton was fitted to y′=0.0086x~(0.5041).The undesirablelate effect of complex wound by ~(239)Pu(NO_3)_4 is osteosarcoma.Fiveout of nine contaminated rats have developed...

The distribution of plutonium-239 in bone,liver,kidneyand local contaminated skin in rats was observed at different timeinterval after its uptake through wounded skin(0.5N~(239)Pu(NO_3)_4,3.07×10~4Bq).The retention of ~(239)Pu in local wounded skin was fullyfitted to a exponential equation y=0.7145e~(-0.0076)x,while the contentof ~(239)Pu in skeleton was fitted to y′=0.0086x~(0.5041).The undesirablelate effect of complex wound by ~(239)Pu(NO_3)_4 is osteosarcoma.Fiveout of nine contaminated rats have developed osteosarcoma 367—478days after contamination.The mean dose delivered to bone which couldinduced osteosarcoma was 14.17Gy.In another experiment,use of tou-rniguet was shown to be ineffective to prevent transfer of soluable pl-utonium from wounded skin into body.For treatment of wounds,thesurgical operation was found to be the most effective among all meanstested.The local ~(239)Pu content could be decreased to 2.28% of originalvalue after a single operation.The local administration of chelating ag-ents in wound might decrease the level of ~(239)pu in viscera and contami-nated wound.

以0.5N 的~(239)Pu(NO_3)_4 (3.07×10~4Bq)沾染大鼠皮肤伤口,观察沾染后不同时间钚自伤口吸收入体内的动态分布。结果表明:局部钚残留量的变化在450天内符合 y=0.7145e~(-0·0076x)的指数方程,而骨钚含量的动态变化在450天内则符合 y′=0.0086X~(0·5041)的方程。钚沾染伤口后的远期效应为:9只动物在伤口沾染钚后的第367—478d,有5只发生了6个骨肉瘤。骨的平均剂量估算为14.17Gy。实验结果还说明:可溶性钚沾染皮肤伤口后,上止血带并不能有效地阻止钚自伤口向体内转移。在局部治疗的方案中,以手术去污效果最佳。络合剂局部注射,不仅能使伤口钚含量显著减少,而且也可减少骨钚的沉积量。钚在生产和使用过程中,发生伤口沾染的事故较为常见。伤口沾染钚的事故,国内外均有报道~([1-2])。为了进一步观察硝酸钚沾染皮肤伤口后污染物在局部的残留、体内分布、远期效应及实验治疗等,做了如下实验研究。

In order to investigate the myocardial changes in patients with malignant tumors in the late stage before and after adriamycin(ADR)administration, the electron microscopic observation and comparison of 5 cases (osteosarcoma 2, fibrosarcoma 1, liver carcinoma 1, malignant lymphoma 1) were conduced. The changes of myocardial cells before ADR administration are: (1) distension of sarcoplasmic reticulum and some T-tubules: vacuolar dilatation of some intercalated discs; the local area of the sarcolemma defects,...

In order to investigate the myocardial changes in patients with malignant tumors in the late stage before and after adriamycin(ADR)administration, the electron microscopic observation and comparison of 5 cases (osteosarcoma 2, fibrosarcoma 1, liver carcinoma 1, malignant lymphoma 1) were conduced. The changes of myocardial cells before ADR administration are: (1) distension of sarcoplasmic reticulum and some T-tubules: vacuolar dilatation of some intercalated discs; the local area of the sarcolemma defects, (2) hyperplastic mitochondria witn swelling, (3) focal myofibrillar loss and numerous lipofuscin granules in the cytoplasm. The changes after ADR administration were the same as those before administration, but more prominent. In addition, some mitochondria botn of their external and internal membranes were all lysed and disappeared. Only a group of cristae were remained. According to our observation, the myocardial cells before ADR administration have some submicroscopic changes. These changes may be produced by some toxic metabolites in the patients. Our sstudies suggest that the cnanges are a latent crisis for the patient, although they are only a ubclinical phenomenon.

阿霉素(ADR)可致卉叶量依赖性心肌病,故临床化疗往往受到限制。为了解其对心肌的毒性作用,我们对5例晚期恶性肿瘤患者(骨肉瘤2例;纤维肉瘤、肝癌、恶性淋巴瘤各1例),分别在阿霉素化疗前后,各取心内膜心肌活检进行电镜观察,并对比其亚细胞结构之改变。结果发现:化疗前少数细胞质膜局部缺损,肌质网、横管呈囊泡状扩张,闰盘间隙扩大;线粒体增生,部分肿胀退变,心肌原纤维局灶性溶解脱失。胞质内脂褐素颗粒增多。化疗后以上病变继续存在且加重,并见部分线粒体内外膜溶解消失,仅呈嵴群堆集残留者。胞质内出现小脂滴,脂褐素颗粒更为增多。

The pharmacokinetics of MTX in 52 patients with neoplastic diseases received 1 g to 5 g/m~2 MTX /CF rescue (102 courses) werestudied by modified bioassay. The serum levels of MTX at 0 and 6 hoursafter iv infusion were dose-r elated. However, except the lower level inthe 1 g regimen, the serum levels of MTX at 18, 42 and 66 hours werepractically the same in the 3 to 5 g/m~2 regimens. A formula for the prediction of MTX serum level was suggested. Itwas also shown that the serum levels of MTX which were less than...

The pharmacokinetics of MTX in 52 patients with neoplastic diseases received 1 g to 5 g/m~2 MTX /CF rescue (102 courses) werestudied by modified bioassay. The serum levels of MTX at 0 and 6 hoursafter iv infusion were dose-r elated. However, except the lower level inthe 1 g regimen, the serum levels of MTX at 18, 42 and 66 hours werepractically the same in the 3 to 5 g/m~2 regimens. A formula for the prediction of MTX serum level was suggested. Itwas also shown that the serum levels of MTX which were less than 1. 3×10~(-6) M at 24h after the beginning of iy infusion, less than 2.4×10~(-7) M at48h and less than 9×10~(-8) M at 72h, were safe. And then, the pharmacokinetics of MTX in 5 osteosarcoma patientswere studied by both HPLC and modified bioassay. The Serum level ofMTX was shown to be a biphasic clearance pattern and no statisticallysignificant difference was found between these two methods. The serum levels of 7-hydroxymethotrexate (7-OH-MTX) could bemeasured by HPLC method. The peak time of as 6 hoursafter iv infusion and the peak level was 78.75±25.33μM, the apparentelimination half-life was 14.83±5.88 hours.

在应用1g/次—5g/m~2MTX加CF解救的52例肿瘤病人的102疗程中,用改良微生物法测定其血药浓度及药代动力学参数,表明在停止滴注后0及6小时的血清中MTX水平与所给剂量大小成正比,但在18、42、66小时期间则除用1gMTX治疗方案者水平较低外,3g/次—5g/m~2各治疗方案组的血药浓度均相接近。提出了根据获得的参数推算血清MTX浓度预测公式,并提出用药后MTX血清浓度在24小时≤1.3×10~(-6)M,在48小时≤2.4×10~(-7)M,在72小时≤9×10~(-8)M为安全阈值。其中5例用5g/m~2MTX患者同时用HPLC法及改良微生物法检测进行对比,二法所得的体内动力学均符合二室模型,各参数值间统计学上无明显差异,说明改良微生物法测定MTX原型是可靠的。HPLC法还能测出血清7-OH MTX浓度,其达峰时间为停止滴注后6小时,峰浓度为78.75±25.33μM,表观半衰期为14.83±5.88小时。

 
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