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   egf treatment 的翻译结果: 查询用时:0.192秒
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egf treatment
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  egf处理
     Meanwhile, pretreatment with 2.5mol/L U73122 before EGF treatment decreased nuclear positive rate of cells from 40.83%±4.36% to 18.21%±1.34%.
     同时,EGF刺激前若以2.5μmol/LU73122预处理,胞核阳性的细胞与只用EGF处理组相比也显著减少,从40.83%±4.36%降至18.21%±1.34%。
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     EGF could induce the phosphorylation of EGFR and AKT,which peaked at 5 minutes after EGF treatment,and lasted for 1 hour.
     EGF可诱导EG-FR和AKT磷酸化,EGF处理后5min,EGFR和AKT的磷酸化达到峰值,作用可持续1h,EGFR抑制剂可阻断EGF诱导的AKT磷酸化;
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     Results When the mouse epidermal KC were incubated with EGF for 12, 24, 48, 72 h, the expression of tPA mRNA/protein was significantly increased compared with the control( P < 0.01) , and that of mRNA reached the peak in 24 h and of tPA protein in 48 h after EGF treatment.
     结果 小鼠表皮KC经EGF处理 12、2 4、48、72h后 ,tPAmRNA/蛋白质的量均增加 (P <0 .0 1) ,tPAmRNA表达的高峰出现于EGF作用 2 4h时 ,tPA蛋白质表达的高峰则出现于EGF作用 48h时。
短句来源
     Results Compared with the control group, the positivity rate of ER and its expression level were significantly increased in the mouse prostate after EGF treatment (P<0.01), and the ER expression level was significantly higher in mouse with 2 μg/day EGF treatment than in those treated with 2 μg/day EGF (P<0.01).
     结果经EGF处理后,前列腺细胞雌激素受体阳性标记率和表达强度均明显升高(P<0.01),2μg/dEGF组雌激素受体表达强度明显高于1μg/dEGF处理组(P<0.01);
短句来源
     Result The effects of proliferation were found in the culture cells treated with 20ng/ml EGF and 1μmol/L RA, but the proliferative activity after EGF treatment was markedly higher than after present of RA, and nestin- and BrdU-positive cells were obtained in the suspension.
     结果  2 0ng/mlEGF和 1μmol/LRA处理的培养细胞均显示增殖效应 ,但EGF处理组增殖速度明显高于RA组 ,悬浮细胞中有大量nestin和BrdU阳性细胞。
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  “egf treatment”译为未确定词的双语例句
     After the 48h EGF treatment, the transferring distance of human lens epithelial cells increased with treatment concentration increasing, with the peak at the concentration of 20μg/L.
     人晶状体上皮细胞在不同浓度EGF作用48h后,其迁移距离随着EGF浓度的增加而增加,在20μg/L时达到高峰;
短句来源
     After the 2h EGF treatment, the expression of β-catenin protein of human lens epithelial cells increased with the treatment concentration increasing, with the peak at the concentration of 10μg/L.
     人晶状体上皮细胞在不同浓度EGF作用2h,β-catenin蛋白表达水平随着EGF浓度的增加而升高,在10μg/LEGF作用下达到最大值。
短句来源
     Further more, at the concentration of 10μg/L EGF treatment, the expression of β-catenin protein of human lens epithelial cells increased with the treatment time lasting, with the peak after 2h treatment.
     人晶状体上皮细胞在10μg/LEGF作用下,β-catenin蛋白表达水平随着作用时间的延长而升高,在2h达到高峰;
短句来源
     RESULTS: At the concentration of 20μg/L EGF treatment, the transferring distance of human lens epithelial cells increased with the treating time lasting, reached the peak after 48h treatment.
     结果:人晶状体上皮细胞在20μg/LEGF作用下,其迁移距离随着作用时间的延长而增加,在48h达到高峰;
短句来源
     3 The effect on the intracellular signal molecules: The intracellular cAMP level was decreased by TNFa(10-8 mol/L) or retinoic acid(10-5/mol/L),while tyrosine protein kinase activity was increased by EGF or PTH (10-9mol/L),The intracellular IP3 level was also increased by EGF treatment.
     3对细胞内信息分子的影响:TNFa或维甲酸可降低细胞内cAMP水平,EGF或PTH(10-9mol/L)则能增加酪氨酸蛋白激酶活性。 EGF还能增高细胞内IP3水平。
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  相似匹配句对
     L. P. treatment.
     L. P.
短句来源
     Research on treatment of diabetic foot by EGF
     EGF在糖尿病足坏疽治疗中的应用研究
短句来源
     EGF treatment augmented these trends.
     E组EGF mRNA和EGFRmRNA的表达较R组增加。
短句来源
     Cough and Its Treatment
     咳嗽与咳嗽治疗
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     (3) EGF;
     (3)TCM-199+EGF;
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  egf treatment
Overexpression of EGFR vIII in U87 cells or EGF treatment of U87-EGFR stable cells led to marked increase in JNK activation compared to parental U87 cells.
      
In conclusion, this study demonstrates that systemic EGF treatment caused remodeling of the morphology of the zero-stress state in the large intestine in a time-dependent manner.
      
In the controls and during the first week of EGF treatment, the opening angle was approximately 100 degrees.
      
The increase was most prominent in the proximal colon after 7 days of EGF treatment.
      
EGF-treated rats and control rats were allocated into group with EGF treatment for 2, 4, 7, and 14 days (N = 6 for each EGF treatment group except N = 4 for the 14-day group).
      
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proliferation is the fundamental Physiological activity of cells.It is regulated either positively or negatively by many growth factors and hormones and effected profoundly by its environment.The followings are the results found in the study of osteoblast-like cells.1 The effect on cell proliferation:IGF-1(10-8mol/L)or EGF(10ng/ml) could increase cell growth,3HTdR incorporation and the Percentage of S stage cells. TNFa(10-8 mol/ L)down regulated the & stage cells and also the c-myc ,c-ki-ras expression.2...

proliferation is the fundamental Physiological activity of cells.It is regulated either positively or negatively by many growth factors and hormones and effected profoundly by its environment.The followings are the results found in the study of osteoblast-like cells.1 The effect on cell proliferation:IGF-1(10-8mol/L)or EGF(10ng/ml) could increase cell growth,3HTdR incorporation and the Percentage of S stage cells. TNFa(10-8 mol/ L)down regulated the & stage cells and also the c-myc ,c-ki-ras expression.2 The effect on the number of receptors and k+ channels:PTH(10-8mol/L)up regulated while retinoic acid(10-5mol/L)down regulated the EGF receptors and its gene expression. EGF or IGF-1 influence the conductivity and open probability of k+ channel. T3/T4 (10-7mol/L) up regulated while TNFa(3×10-10mol/L)or retinoic acid(10-5mol/L) down regulated the PTHreceptors.3 The effect on the intracellular signal molecules: The intracellular cAMP level was decreased by TNFa(10-8 mol/L) or retinoic acid(10-5/mol/L),while tyrosine protein kinase activity was increased by EGF or PTH (10-9mol/L),The intracellular IP3 level was also increased by EGF treatment.4 The expression of characteristic proteins of osteoblasts:Alkaline phosphatase activity was increased by T3/T4(10-7mol/L) and decreased by retinoic acid.β-tubulin and its gene expression was increased by EGF or IGF-1,and decreased by TNFa.In conclusion, cross talk among growth factors and hormones was essential in the regulation of cell proliferation.

细胞的增殖分化受多种激素和生长因子的正负调控,内环境对其也有深刻的影响。在成骨样细胞的研究中获得下列结果:1对细胞增殖的影响:IGF-1(10-8mol/L)或EGF(10ng/ml)可促进细胞生长,3HTdR参入及S期细胞的百分率,TNFa(10-8mol/L)则可下调S期细胞以及C-myc,C-ki-ras的基因表达。2对受体数量及K+通道的影响:PTH(10-8mol/L)可上调EGF受体及其基因表达,而维甲酸(10-5mol/L)则有相反作用。EGF或IGF-1可影响K+通道的电导及开放概率,抑制K+通道也就抑制了EGF或IGF-1的促细胞增殖作用。T3/T4(10-7mol/L)可上调PTH受体,而TNFα(3×10-10mol/L)或维甲酸(10-5mol/L)则相反地下调PTH受体。3对细胞内信息分子的影响:TNFa或维甲酸可降低细胞内cAMP水平,EGF或PTH(10-9mol/L)则能增加酪氨酸蛋白激酶活性。EGF还能增高细胞内IP3水平。4成骨样细胞特征性蛋白的表达:碱性磷酸酶活性可受T3/T4的诱导而增加,而维甲酸则有相反作用。β-微管蛋白及其基因的表达可受EGFα或ICF-1的诱导而?

Objective:To analyse the state of chromatin structure and c-fos gene local chromatin insenescent fibroblasts. Methods: DNase Ⅰ sensitivity assay, Southern blot.Results: The chromatin inyoung cells were more sensitive to DNase Ⅰ than that in aging cells, the chrornatin in EGF-treated cellswere more sensitive to DNase Ⅰ than that in control groups. The c-fos gene local chromatin structure inaging cell after EGF-treatment was resistent to DNase Ⅰ as compared to that in young cells.Conclusion:...

Objective:To analyse the state of chromatin structure and c-fos gene local chromatin insenescent fibroblasts. Methods: DNase Ⅰ sensitivity assay, Southern blot.Results: The chromatin inyoung cells were more sensitive to DNase Ⅰ than that in aging cells, the chrornatin in EGF-treated cellswere more sensitive to DNase Ⅰ than that in control groups. The c-fos gene local chromatin structure inaging cell after EGF-treatment was resistent to DNase Ⅰ as compared to that in young cells.Conclusion: The c-fos gene of human senescent fibroblasts maybe located in heterochromatin.

目的:研究人衰老成纤维细胞c-fos基因染色质结构状态。方法:DNaseⅠ敏感性分析法。结果:衰老细胞c-fos基因在表皮生长因子(EGF)诱导后对DNaseⅠ的敏感性无明显变化,而年轻细胞对DNaseⅠ的敏感性显著升高。结论:衰老细胞的c-fos基因可能在异染色质上,处于关闭状态,因而不易为EGF所诱导。

Objective: To investigate the effects of infused exogenous EGF on the EGF receptors (EGFR) expression in the intestinal crypts of total parental nutrition (TPN) rats and determine whether the change in EGFR expression was related to variations in proliferative activity. Methods: Twenty four male Sprague Dowley rats (200~250 g) were randomized into three groups, 8 in each: group Ⅰ (chow) were fed on rat chow and water adlibitum, group Ⅱ (TPN) received a standard formula of TPN, and group Ⅲ (TPN ...

Objective: To investigate the effects of infused exogenous EGF on the EGF receptors (EGFR) expression in the intestinal crypts of total parental nutrition (TPN) rats and determine whether the change in EGFR expression was related to variations in proliferative activity. Methods: Twenty four male Sprague Dowley rats (200~250 g) were randomized into three groups, 8 in each: group Ⅰ (chow) were fed on rat chow and water adlibitum, group Ⅱ (TPN) received a standard formula of TPN, and group Ⅲ (TPN EGF) received the same TPN as group Ⅱ and injections of EGF (0.1 μg/mg body weight) subcutaneously twice daily. The sections of small intestine were stained with haematoxylin and eosin for measuring crypt cell population and mitotic index. EGF and EGFR were studied immunohistochemically and quantitated using image processing and analysis system. Results: TPN induced a marked reduction of intestinal crypt EGF content and EGFR expression ( P <0.01 vs controls). When EGF was administered along with TPN, crypt EGF content and EGFR expression did not fall. Morphometric analysis of the small intestinal mucosa showed that the crypt cell population and mitotic index were significantly reduced ( P <0.05 vs controls) in TPN rats and restored by EGF treatment. Conclusion: EGF supplemented TPN can increase the intestinal crypt EGFR expression and EGF content, thus promoting the rate of cell renewal.

目的:研究给予外源性表皮生长因子(EGF)对完全胃肠外营养(TPN)大鼠小肠隐窝EGF受体表达的影响以及与小肠粘膜细胞增殖的关系.方法:采用大鼠TPN模型,小肠组织切片HE染色,测定隐窝细胞数及有丝分裂指数;采用免疫组织化学结合计算机图像分析的方法,测定隐窝细胞EGF含量及EGF受体的表达.实验共使用200~250g体重SD大鼠24只,随机分组:对照组(n=8),仅行虚拟手术,即行右颈静脉结扎,每日饲以普通饲料及水;TPN组(n=8),禁食水,输注常规TPN;TPN-EGF组(n=8),输注常规TPN溶液,并每日按0.1μg/(次·g)皮下注射EGF2次.各组均观察14d.结果:TPN大鼠小肠隐窝EGF含量及EGF受体表达显著减少(P<0.01),隐窝细胞数和有丝分裂指数也明显降低(P<0.05);当给予外源性EGF后,隐窝EGF含量、EGF受体表达以及隐窝细胞数、有丝分裂指数均未降低.结论:EGF能预防TPN大鼠小肠隐窝EGF受体表达及EGF含量下降,维持细胞生成率.

 
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