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partial obstruction
相关语句
  不全梗阻
    Effect of reversible partial obstruction of common bile duct on function of sphincter of Oddi in dogs
    犬可复性胆总管不全梗阻对Oddi括约肌功能的影响
短句来源
    Objective To establish and evaluate acute cholangitis rat model,so as to provide the foundation for the study of therapeutic effects of herbs Methods Healthy Wistar rats were selected and the bile duct near the hepatic porta was intubated retrogradely,then the bile duct was ligated properly near porta hepatis to cause partial obstruction of the duct,followed by intracholedochal injection of 1×10~9 cFu/ml E.
    目的:建立并评价可供直接观察药物治疗作用的大鼠急性不全梗阻性胆管炎的实验模型。 方法:选用健康Wistar大鼠行胆管插管,并于近肝门处借由硅胶管的支撑作用适度结扎,造成胆管的不全梗阻,然后经导管逆行注入浓度为1×10 9cFu/mL的大肠杆菌。
短句来源
    Objective To establish a reversible partial obstruction model of the common bile duct(CBD) in dogs and explore the influence of partial obstruction of CBD on the motility of sphincter of Oddi(SO).
    目的建立可复性胆总管不全梗阻的动物模型,研究胆总管不全梗阻对Odd i括约肌(sph incter of Odd i,SO)运动的影响。
短句来源
  不全梗阻
    Effect of reversible partial obstruction of common bile duct on function of sphincter of Oddi in dogs
    犬可复性胆总管不全梗阻对Oddi括约肌功能的影响
短句来源
    Objective To establish and evaluate acute cholangitis rat model,so as to provide the foundation for the study of therapeutic effects of herbs Methods Healthy Wistar rats were selected and the bile duct near the hepatic porta was intubated retrogradely,then the bile duct was ligated properly near porta hepatis to cause partial obstruction of the duct,followed by intracholedochal injection of 1×10~9 cFu/ml E.
    目的:建立并评价可供直接观察药物治疗作用的大鼠急性不全梗阻性胆管炎的实验模型。 方法:选用健康Wistar大鼠行胆管插管,并于近肝门处借由硅胶管的支撑作用适度结扎,造成胆管的不全梗阻,然后经导管逆行注入浓度为1×10 9cFu/mL的大肠杆菌。
短句来源
    Objective To establish a reversible partial obstruction model of the common bile duct(CBD) in dogs and explore the influence of partial obstruction of CBD on the motility of sphincter of Oddi(SO).
    目的建立可复性胆总管不全梗阻的动物模型,研究胆总管不全梗阻对Odd i括约肌(sph incter of Odd i,SO)运动的影响。
短句来源
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  partial obstruction
Electron microscopy of cells infected with a gE mutant revealed accumulations of particles within cytoplasmic vesicles, consistent with a partial obstruction of maturation.
      
Partial obstruction of the rabbit bladder outlet induces a rapid hypertrophy characterized by increased bladder mass, increased smooth muscle content, and increased collagen deposition.
      
Partial obstruction of the small intestine results in dysmotility and morphometric changes proximal to the site of obstruction.
      
Partial obstruction was created surgically in 2 groups of animals living for 2 and 4 weeks.
      
We sought to determine the effect of partial obstruction on mechanical and morphologic properties of the guinea pig small intestine.
      
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The effect of urine flow rate on the dynamics and electromyograms of ureters were studied in experimental dogs.Synchronous-video-pressure-flow-pelvioureterographyfor the direct observation of the morphologic and urodynamic changes was adopted.The results suggested that urine transport by the pelvic and ureteral contractionsincreased with urine flow increment.The urine transport, however,might be decreased or even absent when there was an excessive increase of urine flow (Ureter: 5ml/min) and then the urine transport...

The effect of urine flow rate on the dynamics and electromyograms of ureters were studied in experimental dogs.Synchronous-video-pressure-flow-pelvioureterographyfor the direct observation of the morphologic and urodynamic changes was adopted.The results suggested that urine transport by the pelvic and ureteral contractionsincreased with urine flow increment.The urine transport, however,might be decreased or even absent when there was an excessive increase of urine flow (Ureter: 5ml/min) and then the urine transport was wholly dependent on the hydrostatic pressure difference between the pelvis and the bladder.In partial obstruction,urine transport by the pelvic and ureteral contractions would be lessened even with slight increase of the urine flow.

以狗为实验对象,观察尿量对狗输尿管的动力学和肌电活动的影响,同时动态观察了部分狗的上尿路形态变化与压力变化的关系。结果表明:肾盂输尿管的排尿能力随尿量增加而增加,但过量的增加(每侧≥5ml/min)时,收缩的排尿能力下降,甚至消失。此时尿液靠肾盂膀胱静压差排出。部分性梗阻后少量的尿量增加即可使收缩的排尿作用下降。

Objective To establish and evaluate acute cholangitis rat model,so as to provide the foundation for the study of therapeutic effects of herbs Methods Healthy Wistar rats were selected and the bile duct near the hepatic porta was intubated retrogradely,then the bile duct was ligated properly near porta hepatis to cause partial obstruction of the duct,followed by intracholedochal injection of 1×10~9 cFu/ml E.coli.After 72 hours,liver tissue was examined by microscopy.Liver function tests and the levels...

Objective To establish and evaluate acute cholangitis rat model,so as to provide the foundation for the study of therapeutic effects of herbs Methods Healthy Wistar rats were selected and the bile duct near the hepatic porta was intubated retrogradely,then the bile duct was ligated properly near porta hepatis to cause partial obstruction of the duct,followed by intracholedochal injection of 1×10~9 cFu/ml E.coli.After 72 hours,liver tissue was examined by microscopy.Liver function tests and the levels of cytokines and endotoxin were also measured. Results The liver function parameters and the levels of cytokines and endotoxin were aggravated remarkably.The pathologic changes of the liver were also obvious. Conclusion The method of making acute cholangitis rat model by partly ligating the bile duct and intraledochal injection of E.coli is reliable,convenient and economic,thus providing the fundation for the study of therapeutic effects of herbs.

目的:建立并评价可供直接观察药物治疗作用的大鼠急性不全梗阻性胆管炎的实验模型。方法:选用健康Wistar大鼠行胆管插管,并于近肝门处借由硅胶管的支撑作用适度结扎,造成胆管的不全梗阻,然后经导管逆行注入浓度为1×10 9cFu/mL的大肠杆菌。术后72h取肝脏行病理学检查,并测定肝功能、血清细胞因子及血浆内毒素水平。结果:与假手术组大鼠相比,模型组大鼠血中ALT、AST、TBIL水平显著升高,血清TNF、IL - 1、IL - 6和血浆ET水平显著增加,病理学检查亦证实肝胆结构病理改变明显。结论:建立的急性不全梗阻性胆管炎实验模型,方法可靠,术后可直接予利胆治疗而无须再次手术解梗,简便经济

Objective To establish a reversible partial obstruction model of the common bile duct(CBD) in dogs and explore the influence of partial obstruction of CBD on the motility of sphincter of Oddi(SO).Methods Adult mongrel dogs were anesthetized.In the partial obstruction(PO) group,a double ligature was performed around both a cannula(1 mm in diameter) and the common bile duct near to its bifurcation,then the cannula was withdrawn,while in the control group,only sham operation was done.The serum...

Objective To establish a reversible partial obstruction model of the common bile duct(CBD) in dogs and explore the influence of partial obstruction of CBD on the motility of sphincter of Oddi(SO).Methods Adult mongrel dogs were anesthetized.In the partial obstruction(PO) group,a double ligature was performed around both a cannula(1 mm in diameter) and the common bile duct near to its bifurcation,then the cannula was withdrawn,while in the control group,only sham operation was done.The serum of venous blood was obtained before and on day 1,3,5,7,14,28 after operation.Liver specimens were obtained by biopsy on postoperative day 3,7,14.SO motility was recorded on postoperative day 28.Results All the obsrtuction of CBDs were removed in PO group,the structure of hepatocytes and liver function recovered to normal on day 28 after operation.SO basal pressure(SOBP),SO amplitude(SOAP) and frequency of SO phasic contraction(SOF) significantly decreased,whereas the duration of SO contraction did not change.Conclusion Partial obstruction of CBD inhibited the motility of SO.The clinical manifestation of this model is similar to that of patients with temporary obstructive jaundice that influenced the motility of SO.This model was relatively simple,easy and reliable.

目的建立可复性胆总管不全梗阻的动物模型,研究胆总管不全梗阻对Odd i括约肌(sph incter of Odd i,SO)运动的影响。方法将成年杂种犬麻醉后,暴露并游离胆总管中段,不全梗阻(PO)组以丝线将胆总管和一直径1 mm的导管一同结扎后拔除导管,正常对照(NC)组不结扎胆总管。术后不同时间点获取血液和肝脏的标本分别检测肝功及肝脏的病理变化;术后第28天进行SO测压。结果术后28 d实验组胆总管梗阻完全解除,肝细胞形态结构恢复,肝功能正常;实验组SO基础压和峰压降低,收缩频率减慢,但收缩间期无明显变化。结论胆总管不全梗阻对SO运动具有抑制作用,该动物模型能够模拟短期的梗阻性黄疸对胆道动力学的影响,方法简便、易行,可重复性好。

 
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