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the rats
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  大鼠
    Research on the Mechanism of Colon Dysmotility after MODS in the Rats and the Effect of KangYanLing and Emodin
    MODS大鼠结肠动力障碍机制和抗炎灵及大黄素治疗作用的研究
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    Effects of Youguiwan on the Expression of GluT-4 in Skeletal Muscle and Cardiac Muscle Tissue and bcl-2/bax of Follicular Cells in the Rats with Experimental Hypothyroidism
    右归丸对实验性甲减大鼠骨骼肌及心肌GluT-4和甲状腺滤泡细胞bcl-2/bax表达的影响
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    The Role of Heme Oxygenase-1 in the Pathogenesis of Asthma, Hypoxic Pulmonary Hypertension, and the Effect of Chinese Herbs 814 in the Rats
    血红素氧合酶-1在大鼠哮喘和肺动脉高压发病中的作用及中药814干预的探讨
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    INFLUENCE OF FLUORINE ON THE ~3H-LEUCINE UPTAKE IN NONSKELETAL TISSUES IN THE RATS
    氟对大鼠非骨性组织~3H—亮氨酸掺入值的影响
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    EFFECT OF GOSSYPOL ACETATE ON THE TESTICULAR HCG REACTIVITY AND IT'S RECEPTOR IN THE RATS
    醋酸棉酚对大鼠睾丸HCG反应性及其受体功能的影响
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    Results Compared with the blank group,all the nine berbs were downtrend to the contents of MTL in the gastric mucosa and PGE2 in gastric mucosa and blood of the rats;
    结果与空白组比较,9味苦寒药对胃黏膜MTL、血与胃黏膜PGE2均有降低趋势;
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    Results:The findings showed that TNF-α,D-D,water content in cerebral tissue of the rats given therapy returned to normal value in 7 days(P>0.05)while bleeding coagulation index showed no change.
    结果:给药7d后汤药各组的TNF-α与D-D均恢复至正常值上下(P>0.05),且以9时组更接近正常值(P<0.05);
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    Then the rats in group C,D,E and Fwere treated with low-,middle-,and high-dose PCAL (0.06,0.12,0.24 g/kg,repectively),and Dongbao Gantai (DBGT,0.7 g/kg),respectively.
    华夏小葱制剂低、中、高剂量组及东宝肝泰片组分别给予相应剂量的华夏小葱制剂0.06,0.12,0.24g/kg或东宝肝泰片混悬液0.7g/kg.
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    The rats in Xuebijing injection group were injected with Xuebijing injection(4 ml/kg) intraperitoneally 0.5 hour after scald injury,twice per day for 3 days.
    血必净治疗组于烫伤后0.5 h腹腔注射血必净注射液4 ml/kg,每日2次,连用3 d。
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    The rats of the treatment group were treated with oxymatrineafter operation(100mg/Kg/d,intraperitoneal injection).
    治疗组在UUO的基础上每天以苦参素100mg/Kg腹腔注射。
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  the rats
Serum samples from the rats with the two kinds of doses of light rare earths were obtained after 48 h and analyzed by a 600 MHz 1H-NMR spectrometer.
      
An intestinal I/R injury model of rats was made; the rats were grouped according to the time of after 60 min ischemia.
      
The rats in group A was subjected to retrograde injection of 5% sodium taurocholate via the pancreatic duct, and those in group B received chondroitin-sulfate therapy after ANP induction.
      
The levels of angiopoietin-2 (Ang-2), its receptor (Tie-2) and CD34 of the rats' endometria in each group were examined by using the S-P method of the immunohistochemistry 30 and 180 days after insertion, respectively.
      
The ratio of left ventricle weight to body weight (LV/BW) of the rats in pAT1a-shRNA1, pAT1a-shRNA2, and valsartan groups decreased significantly than in the control group (P >amp;lt; 0.01), similar to those of the normal SD rats (P >amp;gt; 0.05).
      
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Intraperitoneal injection of Sabianine,A an alkaloid isolated from the stem of Sabia japonica (Qingfengdung),at A dose of 50 mg/kg in mice raised the pain threshold significantly.The po- tency ratio of Sabianine A and morphine hydrochloride was about 1:2.5. In addition,Sabianine a administered intraperitoneally at a dosage of 60 mg/kg not only lessened the severity of the swelling of the ankle joint of the rats hind leg caused by the injection of formalin or egg-white,but also rendered the swelling of...

Intraperitoneal injection of Sabianine,A an alkaloid isolated from the stem of Sabia japonica (Qingfengdung),at A dose of 50 mg/kg in mice raised the pain threshold significantly.The po- tency ratio of Sabianine A and morphine hydrochloride was about 1:2.5. In addition,Sabianine a administered intraperitoneally at a dosage of 60 mg/kg not only lessened the severity of the swelling of the ankle joint of the rats hind leg caused by the injection of formalin or egg-white,but also rendered the swelling of the ankle joint disappear more rapidly. The LD_(50) of Sabianine for mice A administered intraperitoneally was 285±29 mg/kg.

一、清风藤硷甲50及100毫克/公斤给小白鼠腹腔注射能显著提高动物对热刺激的痛阈,其作用强度与吗啡比较约为1:2.5.二、清风藤硷甲60毫克/公斤腹腔注射对大白鼠甲醛性及蛋清性“关节炎”,无论预先给药或与产生”关节炎”同时给药,不但可使关节肿胀程度较对照组显著为少,且消退亦速.三、清风藤硷甲腹腔注射对小白鼠之半数致死量为285±29毫克/公斤.

The LD_(50) in mice was found to be 19.4 g/kg and 0.98±0.075 g/kg respectively for the infusion and crude extract of Chou-wu-tung, given by intravenous injections. The subacute toxicity is negligible when the infusion was crally administered to rats (0.25—2.5 g/kg/day) for 60 days, except that some animals showed quietness, slight fall of systolic pressure and soft stool. No apparent toxic effects were observed. A crude extract and infusion of Chou-wu-tung, when injected intravenously at respective dosages...

The LD_(50) in mice was found to be 19.4 g/kg and 0.98±0.075 g/kg respectively for the infusion and crude extract of Chou-wu-tung, given by intravenous injections. The subacute toxicity is negligible when the infusion was crally administered to rats (0.25—2.5 g/kg/day) for 60 days, except that some animals showed quietness, slight fall of systolic pressure and soft stool. No apparent toxic effects were observed. A crude extract and infusion of Chou-wu-tung, when injected intravenously at respective dosages of 50—100 mg/kg and 150 mg/kg, produced primary and secondary falls of blood pressure on anaesthetized rats and dogs, but with intramuscular injection or oral administration, only the secondary fall of blood pressure was apparent. This hypotensive effect might last for 2—3 hours. Intravenous injection of the decoction to anaesthetized animals produced only primary fall of blood pressure, the infusions of alcohol, ether and ,chloroform, given by the same route, did not lower the blood pressure. Twenty-eight renal hypertensive rats were divided into three groups, the first (11 rats) and the second (7 rats) groups were treated with the infusion at respective dosages of 0.5 g/kg/day and 5 g/kg/day, and the third (10 rats) with the crude extract at 50 mg/kg/day. The drug was given to all the rats for 2 weeks by oral administration. Hypotensive effect was observed in 3—10 days after medication, and became more remarkable in the second week of the therapeutic period or the first week after cessation of medication; the blood pressure dropped 57.4%. The blood pressure in most rats returned in 2 weeks, and in some rats in 2—4 days or 4 weeks after the stopping of medication.

1.本文就臭梧桐的一般性质作了实验性研究,结果证明其降血压成分易溶于水,难溶或不溶于乙醚、乙醇和氯仿,对热稳定,在碱性溶液中可被氯化钙沉淀出来。臭梧桐降血压效果可因产地而不同。开花前的和新鲜的臭梧桐降血压作用分别较开花后的和经长时间保存的要强。 2.臭梧桐毒性甚小,其热浸剂和提出物给小鼠静脉注射时半数致死量分别为19.4克/公斤和0.98±0.075克/公斤。给大鼠每天用热浸剂(0.25—2.5克/公斤)灌胃经60天,除少数动物出现安静、轻度收缩压下降和大便变稀外,未发现其他毒性反应。 3.臭梧桐提出物(50—100毫克/公斤)和热浸剂(150毫克/公斤)给麻醉大鼠和狗静脉注射时,可引起两度血压下降,但肌肉注射或经口给药,仅引起第二度降血压作用,其作用可维持2—3小时。静脉注射煎剂(麻醉大鼠和狗实验)仅出现第一度降血压作用,经口给药时无效。乙醚、乙醇和氯仿的浸出液不论静脉注射或经口给药,均不引起麻醉动物的血压下降。给肾型高血压大鼠每天经口投予臭梧桐热浸剂(0.5—5克/公斤)和提出物(50毫克/公斤)时,给药的第3—10天卽口出现血压下降,在给药的第二周和停药后的第一周,血压下降最明显,最大降血压作用可达原值...

1.本文就臭梧桐的一般性质作了实验性研究,结果证明其降血压成分易溶于水,难溶或不溶于乙醚、乙醇和氯仿,对热稳定,在碱性溶液中可被氯化钙沉淀出来。臭梧桐降血压效果可因产地而不同。开花前的和新鲜的臭梧桐降血压作用分别较开花后的和经长时间保存的要强。 2.臭梧桐毒性甚小,其热浸剂和提出物给小鼠静脉注射时半数致死量分别为19.4克/公斤和0.98±0.075克/公斤。给大鼠每天用热浸剂(0.25—2.5克/公斤)灌胃经60天,除少数动物出现安静、轻度收缩压下降和大便变稀外,未发现其他毒性反应。 3.臭梧桐提出物(50—100毫克/公斤)和热浸剂(150毫克/公斤)给麻醉大鼠和狗静脉注射时,可引起两度血压下降,但肌肉注射或经口给药,仅引起第二度降血压作用,其作用可维持2—3小时。静脉注射煎剂(麻醉大鼠和狗实验)仅出现第一度降血压作用,经口给药时无效。乙醚、乙醇和氯仿的浸出液不论静脉注射或经口给药,均不引起麻醉动物的血压下降。给肾型高血压大鼠每天经口投予臭梧桐热浸剂(0.5—5克/公斤)和提出物(50毫克/公斤)时,给药的第3—10天卽口出现血压下降,在给药的第二周和停药后的第一周,血压下降最明显,最大降血压作用可达原值的57.4%。多数高血压大鼠的血压在停药后的第二周恢复,少数在停药的2—4天或4周后恢复。

Hydrocortisone acetate was administered daily by intramuscular injection (2.5mg/ 100gm body weight) to 14 adulat rats.Another 6 rats were used as controls.The ex- perimental animals were divided into 3 groups of which the first group were sacrificed 24 hours after 3 injections,the second group 24 hours after 6 injections and the third group 9 days after 6 injections.The liver of both the experimental and control animals were studied with routine histological and histochemical methods. After the hydrocortisone...

Hydrocortisone acetate was administered daily by intramuscular injection (2.5mg/ 100gm body weight) to 14 adulat rats.Another 6 rats were used as controls.The ex- perimental animals were divided into 3 groups of which the first group were sacrificed 24 hours after 3 injections,the second group 24 hours after 6 injections and the third group 9 days after 6 injections.The liver of both the experimental and control animals were studied with routine histological and histochemical methods. After the hydrocortisone treatment,the rats decreased in body weight,but the liver weight/body weight percentage increased.The parenchymal cells showed a marked de- pletion of eosinophil granules,protein and ribonucleic acid,but the content of glycogen and the activity of phosphorylase increased.There was a drop in the activity of non- specific esterase. The change of alkaline phosphatase was not consistent.The content of desoxyribo- nucleic acid and lipids and the activity of acid phosphatase and succinic dehydrogenase did not show any distinct changes.

1.本实验用成年雄雌性大白鼠20只,体重为100—200克。其中六只动物作为对照。其余动物经臀部肌肉注射氢化可的松2.5毫克/100克体重,每日一次,分为注射三次、六次和注射六次后生活9日三组。大部分动物(16只雄性动物)经绝食24小时后杀死取材,分别进行组织学及组织化学观察。2.注射氢化可的松后动物体重下降,肝重略有增加,肝重/体重百分比也随之升高。3.实验动物肝细胞中,嗜伊红性颗粒、核糖核酸以及蛋白质均显著的减少。与此相反,肝糖原合量急剧增加。与其相伴,磷酸化酶的活性也趋于增强。非特异性酯酶的活性明显的降低。4.碱性磷酸酶的变化不一致。酸性磷酸酶、三磷酸腺苷酸酶的活性以及脱氧核糖核酸的含量均无变化。脂类含量及琥珀酸脱氢酶的活性也无改变。

 
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