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chronic visceral hypersensitivity
相关语句
  慢性内脏高敏性
     Increased expression of SP and NK1 receptor in rat colon of chronic visceral hypersensitivity
     慢性内脏高敏性大鼠结肠内P物质及其NK1受体表达的改变
短句来源
     Objective: To investigate the changes of expression of Mast cell (MCs)、 Substance P (SP) and NK1 receptor in the rats colon of chronic visceral hypersensitivity compared with control rats, discuss the possible mechanism of visceral hypersensitivity associated with irritable bowel syndrome (IBS).
     目的:1.运用新生期结直肠扩张刺激建立慢性内脏高敏性大鼠动物模型,并进行肠道敏感性评估。 2.研究慢性内脏高敏性大鼠和正常大鼠结肠内肥大细胞、P物质(SP)及其NK1受体表达的改变,探讨内脏高敏感性产生的可能机制。
短句来源
  内脏感觉过敏
     A animal model of chronic visceral hypersensitivity in irritable bowel syndrome
     肠易激综合征内脏感觉过敏动物模型的建立
短句来源
     Conclusion With colon mechanical irritation during the periods of postnatal development, the adult rats can develop chronic visceral hypersensitivity.
     结论 新生大鼠给予结直肠机械刺激在成年后可导致慢性内脏感觉过敏 ;
短句来源
  “chronic visceral hypersensitivity”译为未确定词的双语例句
     Increased Expression of Mast Cell、SP and NK1 Receptor in the Rats Colon of Chronic Visceral Hypersensitivity
     内脏高敏性大鼠结肠内肥大细胞、SP及其受体的实验研究
短句来源
     Conclusions: The persistent visceral pain to neonatal rats can indeed result in chronic visceral hypersensitivity that persists through adulthood despite the absence of any identifiable histopathology.
     结论:对新生大鼠采取结肠扩张可以在成年引起慢性内脏高敏感性,而不伴有明确的肠道组织病理学改变,是模拟IBS的较好模型。
短句来源
     Objective To investigate the changes of expression of Substance P (SP) and NK1 receptor in rat colon of chronic visceral hypersensitivity and discuss the possible mechanism of visceral hypersensitivity associated with IBS.
     目的 研究慢性应激刺激所致内脏高敏性大鼠和正常大鼠结肠内P物质 (substanup)及其NK1受体表达的改变 ,探讨内脏高敏感性产生的可能机制。
短句来源
  相似匹配句对
     A animal model of chronic visceral hypersensitivity in irritable bowel syndrome
     肠易激综合征内脏感觉过敏动物模型的建立
短句来源
     The mechanism of visceral hypersensitivity in IBS
     肠易激综合征内脏感觉过敏的发生机制研究进展
短句来源
     Increased expression of SP and NK1 receptor in rat colon of chronic visceral hypersensitivity
     慢性内脏高敏性大鼠结肠内P物质及其NK1受体表达的改变
短句来源
     Conclusion Both acute and chronic PRS induce visceral hypersensitivity,but their effects may be transient.
     结论急性和慢性束缚应激都可以导致大鼠内脏敏感性增高,但其作用可能是短暂的。
短句来源
     Progress in visceral hypersensitivity in irritable bowel syndrome
     肠易激综合征内脏高敏感性研究现状和展望
短句来源
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  chronic visceral hypersensitivity
A rat model of chronic visceral hypersensitivity was induced by mechanical colorectal irritation during postnatal development.
      
Chronic Visceral Hypersensitivity Renders Defecation More Susceptible to Stress via a Serotonergic Pathway in Rats
      


Objective Chronic visceral hypersensitivity is one of the most important mechanisms of irritable bowel syndrome. A animal model of chronic visceral hypersensitivity with Wistar rats was established . Methods Neonatal male and female Wistar rats received mechanical colonic stimulation between postnatal days 8 and 21 .The abdominal withdrawal reflex were recorded during colon distention when they became adults. At the end of the experiment, the sections from the descending colons were examined. Results Neonatal...

Objective Chronic visceral hypersensitivity is one of the most important mechanisms of irritable bowel syndrome. A animal model of chronic visceral hypersensitivity with Wistar rats was established . Methods Neonatal male and female Wistar rats received mechanical colonic stimulation between postnatal days 8 and 21 .The abdominal withdrawal reflex were recorded during colon distention when they became adults. At the end of the experiment, the sections from the descending colons were examined. Results Neonatal rats treated with repetitive colon distention showed a significant increase in AWR compared with control rats. No significant change in AWR among different colon distention pressure groups was detected. Compared with male rats,female rats showed a significant increases in AWR. No significant structural damage and mucosa inflammation were obtained in all groups. Conclusions These results demonstrate that the persistent visceral hypersensitivity in the absence of identifiable pathology can be modeled with Wistar rats neonatally treated with persistent colon distention. Furthermore female rats have more susceptibility of visceral hypersensitivity compared with the male.

目的 内脏感觉过敏是肠易激综合征(IBS)的主要发病机制之一,本文利用大鼠建立一种内脏感觉过敏的动物模型。方法 8~21天雌雄Wistar大鼠每天接受不同压力的结肠机械刺激,成年后直肠扩张时记录大鼠腹肌收缩反应(AWR)评分,并进行降结肠的组织学检查。结果 ①新生儿时期接受不同压力结肠机械刺激的大鼠成年后直肠扩张时AWR评分明显高于对照组,不同压力机械刺激组间AWR评分无明显差异,雌性大鼠AWR评分明显高于雄性大鼠。②各组大鼠降结肠常规病理切片未见明显异常。结论 Wistar大鼠在新生儿时期接受的结肠刺激可造成无明显病理改变的慢性内脏感觉过敏模型,雌性大鼠更具有易感性。

Objective To investigate the effects of colorectal dilatation on visceral sensation and the role of tegaserod in regulating visceral sensitivity in rats. Methods In study group, SD rats during postnatal days 8 to 21 were received balloon colorectal distension (CRD) every day (pressure 60 mm Hg), while in the control group, merely using catheter to touch perianus lightly. During postnatal 8 to 10 weeks, the rats were studied by using self made balloon to distend descending colon and rectum. In addition,...

Objective To investigate the effects of colorectal dilatation on visceral sensation and the role of tegaserod in regulating visceral sensitivity in rats. Methods In study group, SD rats during postnatal days 8 to 21 were received balloon colorectal distension (CRD) every day (pressure 60 mm Hg), while in the control group, merely using catheter to touch perianus lightly. During postnatal 8 to 10 weeks, the rats were studied by using self made balloon to distend descending colon and rectum. In addition, the abdominal withdrawal reflex (AWR) was observed, and visceral sensation was measured. SD rats between postnatal 8 and 10 weeks were divided into CRD group, control group, and vehicle group. The AWR scores of three groups were recorded before and after intraperitoneal administration of tegaserod. Results There was significant correlation between distension pressure and AWR scores( P <0.01). At pressure 40, 60 and 80 mm Hg, the AWR scores in rats with CRD were significantly higher than that in control group (1.96±0.16 vs. 1.36±0.16, 2.82± 0.13 vs. 2.17±0.14, 3.21 ±0.14 vs. 2.59±0.14, P <0.01). Compared with the vehicle or control, tegaserod significantly reduced the AWR scores at the does of 0.3 mg/kg when the distension pressure was 40, 60 and 80 mm Hg (1.95±0.50 vs. 1.32±0.55, 3.05±0.48 vs. 2.32±0.54, 3.25±0.63 vs. 2.77 ±0.51, P <0.05). There was no significant difference between the AWR scores of control group and vehicle group before or after intraperitoneal administration of tegaserod. Conclusion With colon mechanical irritation during the periods of postnatal development, the adult rats can develop chronic visceral hypersensitivity. Tegaserod has an anti nociceptive property on visceral sensitivity by increasing pain threshold to CRD group.

目的 了解结直肠机械刺激对大鼠内脏感觉功能的影响以及替加色罗对大鼠内脏感觉功能的调节作用。方法  8~ 2 1日龄大鼠每天行结直肠扩张 (CRD组 ,压力 6 0mmHg) ,对照组仅用导管在肛门周围轻微接触。 8~ 1 0周龄时用自制气囊扩张大鼠降结肠和直肠 ,观察动物的腹壁回撤反射(AWR)以测定内脏感觉。选取 8~ 1 0周龄的雄性大鼠分为CRD组、对照组和溶媒对照组 ,观察腹腔注射替加色罗前后的AWR评分。结果 扩张压力与AWR评分显著相关 (P <0 .0 1 ) ;CRD组在 4 0、6 0、80mmHg的压力扩张下 ,AWR评分明显高于对照组 (1 .96± 0 .1 6比 1 .36± 0 .1 6、2 .82± 0 .1 3比 2 .1 7± 0 .1 4、3.2 1± 0 .1 4比 2 .5 9± 0 .1 4 ,P <0 .0 1 ) ;在 4 0、6 0、80mmHg扩张压力下 ,CRD组的AWR评分在用替加色罗后较用药前明显降低 (1 .95± 0 .5 0比 1 .32± 0 .5 5、3.0 5± 0 .4 8比 2 .32± 0 .5 4、3.2 5± 0 .6 3比 2 ....

目的 了解结直肠机械刺激对大鼠内脏感觉功能的影响以及替加色罗对大鼠内脏感觉功能的调节作用。方法  8~ 2 1日龄大鼠每天行结直肠扩张 (CRD组 ,压力 6 0mmHg) ,对照组仅用导管在肛门周围轻微接触。 8~ 1 0周龄时用自制气囊扩张大鼠降结肠和直肠 ,观察动物的腹壁回撤反射(AWR)以测定内脏感觉。选取 8~ 1 0周龄的雄性大鼠分为CRD组、对照组和溶媒对照组 ,观察腹腔注射替加色罗前后的AWR评分。结果 扩张压力与AWR评分显著相关 (P <0 .0 1 ) ;CRD组在 4 0、6 0、80mmHg的压力扩张下 ,AWR评分明显高于对照组 (1 .96± 0 .1 6比 1 .36± 0 .1 6、2 .82± 0 .1 3比 2 .1 7± 0 .1 4、3.2 1± 0 .1 4比 2 .5 9± 0 .1 4 ,P <0 .0 1 ) ;在 4 0、6 0、80mmHg扩张压力下 ,CRD组的AWR评分在用替加色罗后较用药前明显降低 (1 .95± 0 .5 0比 1 .32± 0 .5 5、3.0 5± 0 .4 8比 2 .32± 0 .5 4、3.2 5± 0 .6 3比 2 .77± 0 .5 1 ,P <0 .0 5 ) ;对照组和溶媒对照组的AWR评分在用药前后差异无显著性。结论 新生大鼠给予结直肠机械刺激在成年后可导致慢性内脏感觉过敏 ;替加色罗通过提高对结直肠扩张的疼痛阈值 ,具有抗伤害性感觉作用

Objective To investigate the changes of expression of Substance P (SP) and NK1 receptor in rat colon of chronic visceral hypersensitivity and discuss the possible mechanism of visceral hypersensitivity associated with IBS. Methods Fourty SD rats were randomly divided into two groups:chronic irritation models and controls. The model was established by colorectal distention daily in the neonatal rats between postnatal 8 and 21 days. The threshold of abdominal withdrawal reflex(AWR)...

Objective To investigate the changes of expression of Substance P (SP) and NK1 receptor in rat colon of chronic visceral hypersensitivity and discuss the possible mechanism of visceral hypersensitivity associated with IBS. Methods Fourty SD rats were randomly divided into two groups:chronic irritation models and controls. The model was established by colorectal distention daily in the neonatal rats between postnatal 8 and 21 days. The threshold of abdominal withdrawal reflex(AWR) during rectal distension and the time of glass pellets output was evaluated at postnatal 8 and 12 weeks respectively, the expression of SP and NK1 receptor mRNA in the colon was studied by RT PCR, and the distribution of NK1 receptors were identified by immunohistochemistry (IHC) in the colon wall of rats. Results In contrast to the controls, chronic irritation models showed decrease in the threshold of AWR and time of glass pellets output; the levels of SP and NK1 receptors mRNA was significantly increased; simultaneously, the NK1 immunoreaction positive products were densely distributed in the smooth muscle layer and epithelium of colon wall of chronic irritation models. Conclusion Increased expression of SP and NK1 receptor might play an important role in the pathogenesis of visceral hypersensitivity associated with IBS in the chronic irritation models.

目的 研究慢性应激刺激所致内脏高敏性大鼠和正常大鼠结肠内P物质 (substanup)及其NK1受体表达的改变 ,探讨内脏高敏感性产生的可能机制。方法  40只新生SD大鼠 ,随机分为 2组 :慢性应激模型组、正常对照组 ,每组 2 0只。模型组大鼠在出生后第 8天到 2 1天 ,每天接受结直肠扩张刺激 ;分别在第 8周、12周观察大鼠的腹部回缩反射 (AWR)和玻璃小球排出情况 ,进行肠道敏感性评估 :采用RT PCR方法检测二组大鼠结肠组织内P物质及其NK1受体mRNA的表达 ,并运用免疫组化SABC法观察NK1受体的分布。结果 模型组较正常对照组大鼠腹部收缩阈值明显降低 (P <0 .0 1) ,玻璃小球排出时间缩短 (P <0 .0 1) ;P物质及其NKl受体mRNA的表达明显增加 (P <0 .0 1) ,NK1受体免疫反应阳性产物显著浓密 ,以平滑肌层和黏膜层为著。结论 SP及其NK1受体表达增加在大鼠肠道高敏感性、动力紊乱的产生机制中可能起重要作用

 
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