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This paper summarizes characteristics and advantages of plasmin medicines from microbial metabolites. It is a traditional, simple and economical way. Microbial metabolite is a important source of plasmin medicine. 目的 :探讨从微生物代谢产物中寻找溶栓药物制备的研究方法和动态。方法 :从大量的近期文献中阐述了来源于微生物代谢产物溶栓药物的性质和优缺点。结果 :从微生物代谢产物中寻找溶栓药物是传统而又简单的方法 ,比较经济实惠。结论 :微生物代谢产物是溶栓药物或其他药物的重要来源。 This paper discusses bioherbicide development and the bioherbicides that have been commercialized forcontrol of special weed problems in field crops and woody plants. Biologically active compounds from biological sourcesare important in developing new herbicides. Examples include bialaphos, the product of a soil-borne Actinomycete,which has been developed into the herbicide glufosinate, and leptospermone from a species of Callistemon that gave riseto the triketone herbicides. In addition, recent discoveries... This paper discusses bioherbicide development and the bioherbicides that have been commercialized forcontrol of special weed problems in field crops and woody plants. Biologically active compounds from biological sourcesare important in developing new herbicides. Examples include bialaphos, the product of a soil-borne Actinomycete,which has been developed into the herbicide glufosinate, and leptospermone from a species of Callistemon that gave riseto the triketone herbicides. In addition, recent discoveries of microbial metabolites with herbicidal activity are introduced. 论述了生物除草剂的发展,介绍了已商品化的防治作物与木本植物田特殊杂草的生物除草剂品种。生物活性化合物作为开发新除草剂的先导化合物是十分重要的,如从土壤放线菌产物双丙氨膦(bialaphos)开发出除草剂草铵膦(glufosinate),从红千层(Callistemonspp.)植株中的纤精酮(leptospermone)开发出三酮类除草剂等。此外还报导了最近已经分离出的具有除草活性的微生物代谢产物。 Antibiotics have been playing important roles in hu man therapeutics ov er the past fifty years. They are likely to remain crucial in the coming decades . Despite the fact that microbial metabolites are being found continually throug h targeted screening programs, fewer and fewer fundamentally new types of drugs have been found in this way during the past two decades. Combinatorial biosynthe sis seems to help change this situation through genetic engineering, the goal of which is to make new antibiotics... Antibiotics have been playing important roles in hu man therapeutics ov er the past fifty years. They are likely to remain crucial in the coming decades . Despite the fact that microbial metabolites are being found continually throug h targeted screening programs, fewer and fewer fundamentally new types of drugs have been found in this way during the past two decades. Combinatorial biosynthe sis seems to help change this situation through genetic engineering, the goal of which is to make new antibiotics by exploiting the microbial genes and enzymes that make these substances, thereby aiming to discover drugs that cannot be foun d in nature. 50年来抗生素在人类疾病治疗中发挥了重要作用 ,今后的几十年里它们也将是关键的治疗剂。尽管在过去的 2 0年中通过靶向筛选发现了一些微生物药物 ,但是这种筛选方法很难发现新类型药物。组合生物合成可以弥补这种不足 ,通过基因工程方法改造微生物基因和酶 ,产生新的抗生素 ,发现那些在自然界中不能发现的药物。
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