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microbial models
相关语句
  微生物模型
     Study on Microbial Models of Verapamil Metabolism
     维拉帕米代谢的微生物模型研究
短句来源
     Verapamil was used as a structural probe to compare the similarities and differences between microbial models and mammals on drug metabolism, and to investigate the feasibility to partly replace mammals by microbial models in drug metabolism studies.
     本文的主要目的是以维拉帕米为模型药物,考察微生物模型和哺乳动物在药物代谢方面的异同,探讨采用微生物模型部分替代哺乳动物进行药物代谢研究的可行性;
短句来源
     The metbolites in the microbial model and human were investigated. 8 metabolites were found in microbial model and 5 mono-hydroxylated metabolits of them were also found in human metabolites. It was indicated that microbial models have the abilities to minic human metabolism of drug and could partly replace the mammals in drug metabolism study.
     采用液相色谱—电喷雾离子阱质谱联用技术,系统研究了格列齐特在微生物模型中的代谢情况,将检测到代谢产物与格列齐特在人体内的代谢产物进行比较,发现有5种单羟基代谢产物与人体单羟基代谢产物相同,说明微生物模型具备一定的模拟人体药物代谢的能力,能够部分替代哺乳动物进行药物代谢研究。
短句来源
     Microbial microsomes were prepared using ultracentrifuge method, and in vitro incubation proved that the phase I metabolic reactions in microbial models were catalyzed by CYP450 en2ymes, which was the material base at subcellular level of the abilities of microbial models to mimic mammalian metabolism of drug.
     制备微生物微粒体并进行体外孵化实验,直接证明了维拉帕米在微生物模型中的Ⅰ相代谢反应是由菌体内的CYP450酶催化的,从亚细胞水平阐述了微生物模型能够模拟哺乳动物药物代谢的物质基础; 利用微生物模型制备萘普生和甲苯磺丁脲的代谢产物,考察微生物模型用于制备药物代谢产物的通用性。
短句来源
     Now, this biotechnology has been widely used in synthesis, but the biotransformation of active natural products still needs systematic investigation, especially for the characteristics of biocatalytic enzymes, the synthesis of bioactive components and the metabolism in vivo by the microbial models.
     目前,生物转化在有机合成领域的应用比较广泛,而该技术用于中药活性成分的结构修饰还处于初级阶段,尤其缺乏对某类中药活性成分系统的生物转化研究,因此有很多方面的研究值得关注,尤其是生物催化酶的研究将是生物转化的重要发展方向。 此外,生物转化在中药活性化合物合成中的应用以及利用“微生物模型”研究中药活性的体内代谢,也将成为今后生物转化研究中不可忽视的领域。
短句来源
更多       
  “microbial models”译为未确定词的双语例句
     THREE MICROBIAL MODELS FOR SCREENING β-LACTAM ANTIBIOTICS
     β-内酰胺类抗生素的微生物筛选模型
短句来源
  相似匹配句对
     MATHEMATICAL MODELS OF MICROBIAL FLOODING
     微生物驱油数学模型
短句来源
     models;
     五、发展的模式;
短句来源
     Study on Microbial Models of Verapamil Metabolism
     维拉帕米代谢的微生物模型研究
短句来源
     POTENTIAL MODELS
     潜模型
短句来源
     R & D OF MICROBIAL MEDICINES
     微生物药物的研究开发
短句来源
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  microbial models
Microbial models are useful for the study of mammalian metabolism of xenobiotics.
      
Microbial Models of Mammalian Metabolism: Stereoselective Metabolism of Warfarin in the Fungus Cunninghamella elegans
      
Microbial models of soil metabolism: biotransformations of danofloxacin
      
Good predictive microbial models can be built with appropriate data from well-designed experiments.
      
To answer this question, the panel advised using Earth-based microbial models, with subsequent validation by in-flight Shuttle data.
      


In this paper We consider a class of microbial model of nutrient consumption and give some conditions of cxistcrcc and stability, existence and unique stability of limiting cycic, entire stability, fan-shapes stability of equilibrium point amd no closed trajectory.

本文讨论了一类营养基消耗的微生物模型,给出了极限环存在稳定、存在碓一稳定奇点全局稳定、奇点扇形稳定、无闭轨的条件。

Studies on biotransformation of benproperine by Cunninghamella blakesleana AS 3.153 were conducted. The observed transformation products were metabolites of mono hydroxylation (approx.65%), di hydroxylation and sulfate conjugation of mono hydroxylated derivatives of benproperine by LC/MS n data. Compared with data of metabolites in urine of healthy male volunteers, similarities were found between microorganism and humans in the transformation of benproperine. The transformation organism produced phase Ⅰ...

Studies on biotransformation of benproperine by Cunninghamella blakesleana AS 3.153 were conducted. The observed transformation products were metabolites of mono hydroxylation (approx.65%), di hydroxylation and sulfate conjugation of mono hydroxylated derivatives of benproperine by LC/MS n data. Compared with data of metabolites in urine of healthy male volunteers, similarities were found between microorganism and humans in the transformation of benproperine. The transformation organism produced phase Ⅰ and a part of phase Ⅱ metabolites in humans. Influences of the mono hydroxylation were investigated, and the optimized conditions were pH 6.5, 0.05% of substrate concentration, and 72 h of incubation. Semi preparative HPLC was used to isolate two major transformation products, and their structures were then identified as 4 hydroxybenproperine and 4′ hydroxybenproperine by NMR, respectively. Microbial model of transformation is shown to be a suitable in vitro model for benproperine metabolism.

选用短刺小克银汉霉菌AS 3.15 3对苯丙哌林进行微生物转化研究 .根据液相色谱和质谱数据推测 ,转化产物分别为苯丙哌林单羟基化物 (约6 5 % ) ,苯丙哌林双羟基化物和苯丙哌林单羟基化物的硫酸酯结合物 .发现苯丙哌林的微生物转化与其在人体内的药物代谢有很多相似之处 ,转化菌株能产生人体Ⅰ相代谢产物和部分Ⅱ相代谢产物 .考察了影响单羟基转化产物形成的因素 ,发现以pH 6 .5 ,底物浓度 0 .0 5 % ,转化反应持续 72h等条件较为适宜 .通过半制备高效液相色谱法分离出两种主要转化产物 ,经核磁共振光谱分析确证其结构分别为 4 羟基苯丙哌林和 4′ 羟基苯丙哌林 .结果表明 ,微生物转化模型是研究苯丙哌林代谢适宜的体外模型

Objective To study phase Ⅱ metabolites of osalmide in the microbial model. Method Metabolites produced by 7 filamentous fungi screened were identified by liquid chromatography-tandem mass spectrometry (LC-MSn). Result Transformed by 7 fungi screened, the osalmide was converted to two phase Ⅱ metabolites:glucosides and pentosides,in which glucosides were the major product with the highest yield of 83%. In addition,no phase Ⅰ metabolites were produced. Conclusion The specific microorganism may serve...

Objective To study phase Ⅱ metabolites of osalmide in the microbial model. Method Metabolites produced by 7 filamentous fungi screened were identified by liquid chromatography-tandem mass spectrometry (LC-MSn). Result Transformed by 7 fungi screened, the osalmide was converted to two phase Ⅱ metabolites:glucosides and pentosides,in which glucosides were the major product with the highest yield of 83%. In addition,no phase Ⅰ metabolites were produced. Conclusion The specific microorganism may serve as useful models for the study on phase Ⅱ metabolism of the osalmide.

目的以微生物为模型 ,对柳胺酚的二相药物代谢产物进行研究。方法选用 7株丝状真菌为转化菌株 ,利用液相色谱 质谱联用技术对药物代谢产物进行检测。结果柳胺酚经过所选真菌转化后 ,形成葡萄糖结合物和五碳糖结合物 2种二相药物代谢结合产物 ,其中葡萄糖结合物为主要产物 ,产率最高可达 83 %左右 ;且无一相药物代谢产物形成。结论利用特定的微生物可建立研究柳胺酚二相代谢适宜的体外模型。

 
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