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   rb 1 gene 的翻译结果: 查询用时:0.008秒
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rb gene
相关语句
  rb1基因
     Thereinto,the probability of LOH occurrence on three loci including D13S265,D13S263 and D13S153(in Rb1 gene) was the highest.
     其中3个位点D13S265、D13S263和D13S153(位于Rb1基因内)LOH发生机率最高。
短句来源
     Low-penetrance retinoblastoma due to exons 24 and 25 deletions in the Rb1 gene
     Rb1基因第24和25外显子缺失导致低外显性视网膜母细胞瘤
短句来源
     Results: Four new germline mutations in the RB1 gene were identified in newly collected genomic DNA from RB patients: G→ T(GGA→ TGA)/Gly86stop;
     结果:在新收集的RB患者中,确定4例RB1基因生殖细胞性突变:G→T(GGA→TGA)/Gly86stop;
短句来源
     A same mRNA splice site deletion of Rb1 gene in two bilateral retinoblastoma patients
     两例同一位点处的相同Rb1基因缺失
短句来源
     A noval 21 base pair heterozygous deletion of Rb1 gene in a bilateral retinoblastoma patient
     Rb1基因第16内含子内21个碱基缺失1例
短句来源
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  “rb 1 gene”译为未确定词的双语例句
     A constitutional mutation screening of the RB1 gene in patients with retinoblastoma
     视网膜母细胞瘤患者RB1基因突变筛选
短句来源
     Mutations analysis of RB1 gene in Chinese patients with retinoblastoma
     国人视网膜母细胞瘤患者RB1基因突变的特性
短句来源
     AIM: To understand the effect of the RB1 gene mutation on the function of pRB (the protein product of the RB1 gene) in the patients with retinoblastoma (RB).
     目的 :了解成视网膜细胞瘤 (RB)患者RB1基因突变至RB发生中RB蛋白 (pRB)的变化。
短句来源
     TT→ A(ATTCCT→ ATACT)/codon369~ 370. Together with our previous work, there are 21 germline mutations identified in the RB1 gene in Chinese and Japanese RB patients, which spread in 11 exons and 3 introns.
     TT→A(ATTCCT→ATACT)/codon369~370。 结合以前的报道,我们共确定了21个突变,散发11个外显子及3个内含子。
短句来源
     A Study on the Mutation Analysis of Rb1 Gene and the Screening of Differential Proteins in Retinoblastoma
     视网膜母细胞瘤Rb1基因突变的检测及血清中差异性标志蛋白的筛选
短句来源
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  相似匹配句对
     1;
     Contina积分:侧支循环差者4.89士1 .99;
短句来源
     L-1.
     L-1花生四烯酸(arachidonic acid,
短句来源
     Discussion for RB functions
     RB功能探讨
短句来源
     The gene of xylanase B from T.
     但编码该酶的基因xynB在大肠杆菌中的表达较困难。
短句来源
     Rb, 0.18;
     Rb,0.18;
短句来源
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  rb gene
Presence of LOH at the RB1 gene locus and the increased levels of RB1 RNA and protein and increased percentage of hyperphosphorylated form of pRb are indicative of an overall deregulation of pRb pathway in human brain tumors.
      
Southern blot analysis revealed loss of heterozygosity (LOH) at the intron 1 locus of RB1 gene in 19.4% of informative cases and this is the first report showing LOH at this locus in human brain tumors.
      
A total of 40 human brain tumor samples were analyzed for tumor-specific alterations at the RB1 gene locus.
      
These results suggest that the RB1 gene has a major role in the development of human vestibular schwannomas.
      
Further, increased levels of RB1 mRNA, total pRb and the phosphorylated form of pRb suggests that RB1gene in these tumors may have anti-apoptotic function.
      
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Retinoblastoma(Rb)is a malignant eye tumor of childhood and a desirable model for the genetic study of oncogenesis in human being. The results of genetic investigation of RB since 1982 in WCUMS were summerized in this paper. 1.Clinical genetic studies of RB The records of 327 patients with RB between 1958 and 1986 were reviewed.The clinical investiga- tion included the laterality of the involved eyes,the mean age at diagnosis,the secondary malignant neoplasm in survivors,the spontaneous...

Retinoblastoma(Rb)is a malignant eye tumor of childhood and a desirable model for the genetic study of oncogenesis in human being. The results of genetic investigation of RB since 1982 in WCUMS were summerized in this paper. 1.Clinical genetic studies of RB The records of 327 patients with RB between 1958 and 1986 were reviewed.The clinical investiga- tion included the laterality of the involved eyes,the mean age at diagnosis,the secondary malignant neoplasm in survivors,the spontaneous regression of the tumor and RB in twins. 2.Cytogenetic studies of RB (1)Among 56 patients examined for chromosome constitution,4 cases showed abnormal or variant karyotypes:46,XY/46,XY,del(13)(q14.1 q14.3).46, XY,var(15)(p13,F55)mat.46,X,del(Y)(q12)pat. 46,XY,inv(9)(P13q13). (2)Chromosome fragility study in 14 RB patients and their parents showed an increased frequency of chromosome aberration in contrast with control group.Several chromosome fragile sites in RB patients were found. (3)The results of chromosomal study of solid tumor cells from 50 samples of RB showed that in all cases there were aberration of chromosome both in number and in structure.The commonest aber- ration was an i(6p)chromosome,and double minutes (DM),homogeneously staining regions(HSR)were found. 3.The esterase D(EsD)activity and phenotype of the red blood cells in 34 patients with RB were examined,but the EsD activity showed no differ- ence between the patients and the control groups. The same examinations performed in the RB tumor cells form 11 patients revealed that either one or both EsD alleles in tumor cells were inactivated,or that the tumor cells exhibited only one of the two isozvmic types of the EsD,but the red blood cells showed heterozygous at the EsD locus.These observations indicated that in RB tumor cells there were loss,inactivation or reduction to homozygosity at RB and EsD locus on 13q,this may be important for oncogenesis. 4.With the review of literature,it was thought that the Rb gene located at 13q14 may be a pair of allelic inhibitive genes which controls some potential cancer genes(proto-oncogene).If the allelic in hibi tive genes are inactivated or lost with some reasons, the cancer genes will be freed from the inhibitive gene,and cause the induction of RB.

视网膜母细胞瘤(简称 RB)是研究肿瘤遗传学的理想的天然模式。本文总结了自1982年以来对 RB 遗传学的研究。内容包括患病年龄、患病眼别、存活者的第二恶性肿瘤、肿瘤的自发消退、双生子患者等临床遗传学问题;RB 患者外周血淋巴细胞和肿瘤细胞染色体改变、染色体脆性部位等细胞遗传学问题;以及患者红细胞和瘤细胞酯酶 D 活性和表型改变等生化遗传学问题。对 RB 的发病机理进行了初步探讨,认为癌基因和抗癌基因平衡失调是 RB 为代表的一大类恶性肿瘤发病的关键。

We found the change of proliferation with 6.2kb Hind ⅠⅡ fragment of Rb gene inretinoblastoma while the Rb gene was detected.The existence of proliferation of Rb genein retinoblastoma is first reported by us.It is contrary to the current theory that Rb geneis an antioncogene and the deletions of Rb gene is responsible for the tumorigenesis ofretinoblastoma.It is possible that the proliferation of Rb gene plays an important rolefor the tumorigenesis,so we discuss the finding preliminarily...

We found the change of proliferation with 6.2kb Hind ⅠⅡ fragment of Rb gene inretinoblastoma while the Rb gene was detected.The existence of proliferation of Rb genein retinoblastoma is first reported by us.It is contrary to the current theory that Rb geneis an antioncogene and the deletions of Rb gene is responsible for the tumorigenesis ofretinoblastoma.It is possible that the proliferation of Rb gene plays an important rolefor the tumorigenesis,so we discuss the finding preliminarily

在对视网膜母细胞瘤病人的Rb 基因存在状态进行检测时,发现一例患者体细胞Rb 基因有明显扩增改变。Rb 基因在视网膜母细胞瘤患者中的扩增改变,为首次报导,是否意味着Rb 基因扩增与肿瘤发生有着某种关联。

The deletion and rearrangement of p53 and Rb genes were studied in gastric cancer with Southern blot hybridization and the point mutation in 248 and 249 codons of p53 was studied with PCR-RFLP.It was found that deletion or rearrangement of p53 was seen in 9 cases out of 30 cases of gastric cancer and point mutation at 248 codon of p53 in 2 cases out of 42 cases,and deletion and rearrangement of Rb gene were seen in 2 cases out of 15 cases.

本文使用Southern杂交方法分析了胃癌组织中p53基因和Rb基因的缺失和重排;使用PCR-RFLP技术分析了p53基因第248位、249位密码子的点突变。研究结果显示:30例胃癌组织中9例有p53基因的缺失或重排;42例胃癌组织中两例有p53基因第248位密码子的点突变;15例胃癌组织中两例有Rb基因的缺失和重排。

 
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