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occult hepatitis b
相关语句
  隐匿性乙型肝炎
     Clinical and pathological analysis of 79 patients with occult hepatitis B
     隐匿性乙型肝炎79例临床与病理分析
短句来源
     Objective:To explore the clinical and pathological characteristic of patients with occult hepatitis B.Methods:HBV DNA were detected by real time fluorescence quantitative PCR.
     目的:探讨隐匿性乙型肝炎的临床与病理特征。 方法:应用荧光定量PCR及免疫组织化学方法,对79例不同HBV抗体阳性而肝功能反复异常者的临床与肝组织病理进行分析。
短句来源
     Detection of Occult Hepatitis B in Non A-E Hepatitis and Its Clinical and Histological Features
     隐匿性乙型肝炎在非甲—非戊型肝炎中的检测及其临床和病理特点
短句来源
     Loss of HBsAg in a portion of occult hepatitis B patients was associated with mutations in HBsAg “a” determinant. It is possible that extremely low serum HBsAg levels may result in negative HBsAg by the routine commercial assays in those patients without mutation of HBsAg “a” determinant.
     部分隐匿性乙型肝炎HBsAg阴性的原因是S基因变异引起的 ,而有些患者则可能因为血清HBsAg水平过低 ,导致HBsAg检测阴性。
短句来源
     Occult hepatitis B: immunohistochemistry staining for HBV antigens on liver biopsies and sequence analysis of HBV S gene.
     隐匿性乙型肝炎:免疫组织化学和S基因序列分析
短句来源
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  “occult hepatitis b”译为未确定词的双语例句
     Objective Because now there is no methods in the market to detect occult hepatitis B virus(OHBV) infection in our country and the specificity of OHBV is low level HBV DNA in the serum of HBsAg negative carriers which can not detected by routine methods in the market.
     目的:由于国内目前尚无检测隐匿性乙型肝炎病毒(Occult Hepatitis B Virus;OHBV)感染的试剂盒且OHBV患者的特点是HBsAg阴性,血清中存在低水平的HBV DNA,用常规的检测方法不能检测出来;
短句来源
     Occult hepatitis B virus infection
     隐匿性乙型肝炎病毒感染
短句来源
     Occult hepatitis B virus infection in a North American commun ity-based population
     北美社区人群中隐匿型乙型肝炎病毒感染
短句来源
     Occult hepatitis B virus infection in hemat-opoietic stem cell donors in a hepatitis B virus endemic area
     乙型肝炎病毒流行区中造血干细胞供体的隐匿性乙型肝炎病毒的感染
短句来源
     Clone of S gene in occult hepatitis B virus infection and construction of prokaryotic expression vector
     隐匿性乙型肝炎病毒S基因的克隆及其表达载体的构建
短句来源
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  相似匹配句对
     Occult hepatitis B virus infection
     隐匿性乙型肝炎病毒感染
短句来源
     Clinical analysis of occult infection of hepatitis B virus
     隐匿性乙型肝炎病毒感染的临床分析
短句来源
     Study on the molecular mechanism of hepatitis B virus occult infection
     乙型肝炎病毒隐匿性感染的分子机制研究
短句来源
     Clinical and pathological analysis of 79 patients with occult hepatitis B
     隐匿性乙型肝炎79例临床与病理分析
短句来源
     The Occult Evaluation
     悬乎的评审
短句来源
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  occult hepatitis b
Is Hepatitis C Virus Positivity a Contributing Factor to Occult Hepatitis B Virus Infection in Hemodialysis Patients
      
Previous or occult hepatitis B virus infection may be critical in development of hepatocellular carcinomas in hepatitis C virus-infected patients without hepatic fibrosis.
      
All group 1 patients had previous or occult hepatitis B virus infection.
      
Previous or Occult Hepatitis B Virus Infection in Hepatitis C Virus-Associated Hepatocellular Carcinoma Without Hepatic Fibrosis
      
Previous or Occult Hepatitis B Virus Infection in Hepatitis B Surface Antigen-Negative and Anti-Hepatitis C-Negative Patients wi
      
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Objective To investigate the incidence of occult hepatitis B among chronic liver diseases of unknown etiology, the mechanisms and histopathologic characteristics of occult HBV infection. Methods 20 patients with chronic liver diseases of unknown etiology were enrolled in this study. Liver histology was analyzed and immunohistochemistry staining for HBV antigens (HBsAg and HBcAg) and HCV antigen (NS3 and NS4) was performed on liver biopsies. HBV DNA levels were quantified by real time fluorescence...

Objective To investigate the incidence of occult hepatitis B among chronic liver diseases of unknown etiology, the mechanisms and histopathologic characteristics of occult HBV infection. Methods 20 patients with chronic liver diseases of unknown etiology were enrolled in this study. Liver histology was analyzed and immunohistochemistry staining for HBV antigens (HBsAg and HBcAg) and HCV antigen (NS3 and NS4) was performed on liver biopsies. HBV DNA levels were quantified by real time fluorescence PCR assay, the S gene was amplified by a nested PCR and the purified PCR products were directly sequenced. The nucleotides and predicted amino acid sequences of S gene were analyzed. Results Liver biopsies from these patients showed chronic hepatitis in 5 cases, non alcoholic steatohepatitis in 15 cases. Of the 5 patients with chronic hepatitis, three were positive for both HBsAg and HBcAg, two for HBcAg only. Analysis of amino acid sequences of S gene showed that a stop codon at position 74 occurred in one patient, 2 amino acid changed (T131N, M133S) in the HBV “a” determinant in another patient, and the rest of patients had no mutation in the HBV “a” determinant.Conclusion Occult HBV infections may account for a high proportion of chronic liver diseases of “unknown” etiology. Low serum level of HBV DNA may cause disease progression. Loss of HBsAg in a portion of occult hepatitis B patients was associated with mutations in HBsAg “a” determinant. It is possible that extremely low serum HBsAg levels may result in negative HBsAg by the routine commercial assays in those patients without mutation of HBsAg “a” determinant.

目的 了解不明原因慢性肝病中隐匿性乙型肝炎所占比例 ,隐匿性乙型肝炎的发病机制及临床、病理特点。方法 给予 2 0例不明原因慢性肝病患者肝穿刺病理检查 ,应用免疫组织化学方法检测肝组织内的乙型肝炎病毒表面抗原 (HBsAg)、核心抗原 (HBcAg) ,丙型肝炎病毒NS3、NS4抗原。采用荧光定量PCR方法对血清HBVDNA进行定量 ,用套式PCR方法扩增HBVS基因 ,对PCR产物进行直接测序 ,比较S基因的核苷酸和推导出的氨基酸序列的差异。结果  5例患者经肝脏病理检查表现为慢性炎症 ,3例在肝组织内HBsAg、HBcAg同时阳性 ,2例仅HBcAg阳性。S基因的氨基酸序列分析显示 ,1例患者S基因的 74位密码子发生终止变异 ,另 1例在HBsAg的“a”决定簇内有 2个氨基酸发生变异 (T13 1N ,M 13 3S) ,其他 3例患者HBsAg的“a”决定簇内未发现变异。 结论 在我国隐匿性乙型肝炎是不明原因肝病的主要原因之一 ,低水平的血清HBVDNA可以引起慢性肝炎。部分隐匿性乙型肝炎HBsAg阴性的原因是S基因变异引起的 ,而有些患者则可能因为血清HBsAg水平过低 ,导致HBsAg检测阴性。

Objective:To explore the clinical and pathological characteristic of patients with occult hepatitis B.Methods:HBV DNA were detected by real time fluorescence quantitative PCR.Specimen of the liver biopsy were examined by immunochemistry.Results:HBV DNA were positive in the serum of 27 and in the specimen of the liver of 59 among the 79 patients,respectively;HBsAg and HBcAg in the specimen of the liver of 11 and 32 among the 79 patients were positive,respectively;77 patients with chronic hepatitis...

Objective:To explore the clinical and pathological characteristic of patients with occult hepatitis B.Methods:HBV DNA were detected by real time fluorescence quantitative PCR.Specimen of the liver biopsy were examined by immunochemistry.Results:HBV DNA were positive in the serum of 27 and in the specimen of the liver of 59 among the 79 patients,respectively;HBsAg and HBcAg in the specimen of the liver of 11 and 32 among the 79 patients were positive,respectively;77 patients with chronic hepatitis and 2 patients with early hepatocirrhosis among 79 patients were showed by pathological examination of the liver biopsy.Conclusion: The positive rate of HBV DNA in the specimen of the liver is higher than that of in the serum;There are different damage in the liver of the patients with occult hepatitis B.These patients needto be treated.

目的:探讨隐匿性乙型肝炎的临床与病理特征。方法:应用荧光定量PCR及免疫组织化学方法,对79例不同HBV抗体阳性而肝功能反复异常者的临床与肝组织病理进行分析。结果:79例患者中,血清HBV DNA阳性27例(34.2%),肝组织中HBV DNA阳性59例(74.7%),差异具有显著性意义(χ2=26.1,P<0.01);肝组织病理检查结果显示慢性肝炎77例,其中大多数为轻中度损害,肝硬化早期2例;免疫组化检测结果显示肝组织中HB-sAg阳性11例,HBcAg阳性32例。结论:①隐匿性乙型肝炎患者肝组织中HBV DNA阳性率明显高于血清;②隐匿性乙型肝炎患者大多数存在不同程度肝损害,需要及时治疗。

Objective To evaluate the relationship between infectious status of occult hepatitis B virus (HBV) and cryptogenic cirrhosis/liver cancer. Methods HBV nucleic acids were extracted from sera of the HBV surface antigen (HBsAg) negative patients including cryptogenic cirrhosis and liver cancer and patients without liver disease as control in tbe same period, these patients' age sex and living-region also matched with cryptogenic cirrhosis/liver cancer. The HBV X DNA was amplified by PCR method . It was set...

Objective To evaluate the relationship between infectious status of occult hepatitis B virus (HBV) and cryptogenic cirrhosis/liver cancer. Methods HBV nucleic acids were extracted from sera of the HBV surface antigen (HBsAg) negative patients including cryptogenic cirrhosis and liver cancer and patients without liver disease as control in tbe same period, these patients' age sex and living-region also matched with cryptogenic cirrhosis/liver cancer. The HBV X DNA was amplified by PCR method . It was set as the expose factor of the occult infection of HBV, we analyze synthetically the odds rate ( OR) of expose factor with epidemiological case control study. Results The occult infection of HBV was highly related with liver cancer (OR=8.1429,95%CI=2.98~22.30) and cryptogenic cirrhosis (OR=4.75, 95%CI=1.62~13.90).There was significant difference in these two groups. Conclusion The occult infection of HBV may be an important cause of cryptogenic cirrhosis and liver cancer.

目的探讨隐匿型乙肝感染与隐源性肝癌、肝硬化的关系。方法应用PCR技术从HBsAg阴性的隐源性肝硬化与肝癌患者血清中检测HBV X DNA。应用流行病学的病例对照研究方法,以年龄、性别、生存地区等相匹配非肝病住院患者为对照,把检测到的HBV XDNA作为隐匿型HBV感染的暴露因素,分别统计分析隐源性肝硬化、肝癌患者组与对照组暴露因素的比数比(OR)。结果隐匿型乙肝感染在隐源性肝癌、肝硬化中比数比分别是OR=8.1429,(95%CI=2.98~22.30)和OR=4.75(95%CI=1.62~13.90),在统计学上有显著性意义。结论隐匿型乙肝感染可能是部分隐源性肝癌、肝硬化的病因。

 
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