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   anti idiotype antibody 的翻译结果: 查询用时:0.199秒
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anti idiotype antibody
相关语句
  抗独特型抗体
     RELATIONSHIP BETWEEN ANTI IDIOTYPE ANTIBODY AGAINST ANTI-HBS AND INDIVIDUALS OF DIFFERENT HBV INFECTION
     抗HBs-抗独特型抗体与各型乙肝病毒感染者的关系
短句来源
     The strategy of tumor vaccine involves gene vaccine, peptide or protein vaccine, tumor cell vaccine modified by gene and anti idiotype antibody vaccine.
     肿瘤疫苗策略包括基因疫苗、肽和蛋白疫苗、基因修饰的肿瘤细胞疫苗以及抗独特型抗体疫苗等。
短句来源
     AIM: To study anti idiotype antibody(AId Ab)directed at mAb 3F3 Fab idiotypic determinant with acetylcholinesteras(AchE)activity.
     目的 :研制具有乙酰胆碱酯酶 (AchE)活性的抗独特型抗体
短句来源
  抗个体型抗体
     The result revealed that (1) the anti idiotype antibody only reacted to M protein and serum of the patient, but not to M proteinemia and normaul serum.
     结果提示:(1)抗个体型抗体仅对患者的M蛋白和血清起反应,对其它M蛋白血清和正常人血清不发生反应。
短句来源
  相似匹配句对
     Study on anti-idiotype antibody of AchE
     乙酰胆碱酯酶抗独特型抗体的研制
短句来源
     Anti-Idiotype Antibody and Auto-Immune Disease
     独特型网络与自身免疫病
短句来源
     Anti-H.
     方法:将H.
短句来源
     Anti-H.
     抗H .
短句来源
     the affinity of antibody.
     抗体亲和性。
短句来源
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  anti idiotype antibody
We have used an anti-idiotype antibody vaccine approach, similar to those used by other in vestigators.
      
When used as a vaccine, the anti-idiotype antibody will elicit protective immunity to the original pathogen.
      
The murine Abi antibody 14.G2a generated the Ab2 1A7 anti-idiotype antibody used in this study.
      
The immunogenicity of anti-idiotype antibody is one of the main issues in regard to vaccine candidates.
      
The anti-idiotype antibody might bind the receptors of the assay B cells and inhibit antibody secretion.
      
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Anti-idiotype antibodies (Ab2) weresuccessfully induced by monoclonal anti-HBsantibodies (Ab1) in syngenic BALB/c mice.They(Ab2)were identified by RPHA, ELISAand BASA tests. The results showed thatthe Ab2 were able to combine not onlywith monoclonal anti-HBs from mouse butalso with polyclonal anti-HBs antibodiesfrom horse.It was suggested that a commonantigenic determinant existed both in mo-noclonal anti-HBs from mouse and in poly-clonal anti-HBs antiserum from...

Anti-idiotype antibodies (Ab2) weresuccessfully induced by monoclonal anti-HBsantibodies (Ab1) in syngenic BALB/c mice.They(Ab2)were identified by RPHA, ELISAand BASA tests. The results showed thatthe Ab2 were able to combine not onlywith monoclonal anti-HBs from mouse butalso with polyclonal anti-HBs antibodiesfrom horse.It was suggested that a commonantigenic determinant existed both in mo-noclonal anti-HBs from mouse and in poly-clonal anti-HBs antiserum from horse. Asmonoclonal antibodies can only induce anti-idiotype antibodies in syngenic animals, theinduction of Ab2 with monoclonal Ab1 insyngenic mice is more convenient than thatwith polyclonal Ab1 in different animals.It is a simple and reliable method for pre-paration of Ab2, and it may be suitablefor the study of regulations of idiotypeand anti-idiotype network within bodies.By using Ab2 thus prepared to immunizesyngenic mice,we obtained anti-anti-idiotype antibodies(Ab3 or Ab1') with the spe-cificity of anti-HBs. It is revealed that theidiotype of prepared Ab2 could mimic theantigenic determinant of HBsAg. It seemslikely that Ab2 might be used as a newvaccine for the protection of HBV infection.

单克隆抗-HBs在同系BALB/c 小鼠体内所诱生的抗独特型抗体,能模拟HBsAg的作用,该抗独特型抗体既能与抗-HBs发生特异性结合,又能在同系动物中添生出抗HBs的独特型抗体,从而为生产乙肝疫苗开辟了一条新的可能的途径。由于单克隆抗-HBs在同系动物体内只诱生抗独特型抗体,故无同种型和同种异型的干扰,且纯化程序简单,避免了许多干扰因素,有利于研究机体免疫网络中各细胞间的相互作用。

Two hybridomas (B3, C2) secreting high-titer monoclonal anti-idiotype antibodies against anti-HBs were produced by fusion of SP2/0 cells and spleen cells of BALB/c mice immunized with mouse monoclonal anti-HBs. It was found that B3 could competitively inhibit the binding of HfisAg with anti-HBs of various origin, B3 colud also neutralized by anti-HBs. B3 could induce anti-anti-idiotypic antibodies when administered into BALB/c mice, Anti-anti-idiotypic...

Two hybridomas (B3, C2) secreting high-titer monoclonal anti-idiotype antibodies against anti-HBs were produced by fusion of SP2/0 cells and spleen cells of BALB/c mice immunized with mouse monoclonal anti-HBs. It was found that B3 could competitively inhibit the binding of HfisAg with anti-HBs of various origin, B3 colud also neutralized by anti-HBs. B3 could induce anti-anti-idiotypic antibodies when administered into BALB/c mice, Anti-anti-idiotypic antibodies induced by B3 could react specifically with HBsAg. Therefore, the anti-idiotype antibodies produced by B3 hybridoma are the anti-idiotype dearing the internal image of HBsAg epitope. The potential of BS as surrogate antigen is discussed.

本文采用鼠单克隆抗-HBs(Ab_1)作抗原免疫同系鼠,取免疫鼠的脾细胞与SP_2/0骨髓瘤细胞融合,经过反复筛选、克隆化获得两株(B_3,C_2)持续分泌单克隆的抗独特型抗体其(Ab_2)。对其中之一B_3作了深入鉴定。B_3的Ig类型为IgG,亚类为IgG_2a。核型分析结果染色体数为106条。通过ELISA抑制试验对B_3进行鉴定,发现B_3一方面能与纯化HBsAg发生阳性的竞争性抑制,另一方面又能与不同来源的抗-HBs发生结合,出现阳性的中和抑制。无论竞争性抑制还是中和抑制,都呈现剂量依赖关系。将B_3Ig免疫同系鼠,经一次免疫后就能诱导出具有抗-HBs活性的抗-抗-独特型抗体(Ab_3)。以上结果表明:B_3株杂交瘤细胞所分泌的单克隆抗独特型抗体是带有HBsAg表位内影像的单克隆抗体。并对B_3Ig的可能应用意义进行了讨论。

In this study, the anti-antibody responses to multiple injections of mouse monoclonal antibodies (McAb) in the sera and cerebrospinal fluids (CSF) of 13 Japanese encephalitis virus (JEV) infected rhesus monkeys were measured. After the first injection of the McAb, the IgM anti-antibodies and their immune complex (IC) began to appear in sera of 5 monkeys and CSF of 3 animals between the third and fourteenth day and most of them disappeared within 1 month. The IgG anti-antibodies...

In this study, the anti-antibody responses to multiple injections of mouse monoclonal antibodies (McAb) in the sera and cerebrospinal fluids (CSF) of 13 Japanese encephalitis virus (JEV) infected rhesus monkeys were measured. After the first injection of the McAb, the IgM anti-antibodies and their immune complex (IC) began to appear in sera of 5 monkeys and CSF of 3 animals between the third and fourteenth day and most of them disappeared within 1 month. The IgG anti-antibodies and their IC began to appear in sera of 6 animals and CSF of 4 animals between the 1st and the 3rd week, and maintained for a long time. In most cases the IC could be detected at the same time. The positive rate of the IC went down at the later stage indicating it's elimilation. The anti-idiotype responses had similar pattern with that of anti-anti-body. Multiple injections of the McAb increased the productions of anti-antibody IgM and IgG and anti-idiotype antibody, but had no obvious changes in IgE levels; the formations of the IC had no evident increase.

本研究对感染日本脑炎病毒的恒河猴注射单克隆抗体后血液及脑脊液中产生的抗抗体进行了测定.第1次注射单克隆抗体后,仅从少数猴的血液和脑脊液中检出IgM类抗抗体或其免疫复合物;最早的第3天出现,最晚为第2周,大多数在1个月内消失.有几只猴的血液和脑脊液中在1周内可检出IgG类抗抗体或其免疫复合物,最晚的于第3周才出现。IgG的维持时间较长.大多数标本可同时检出抗抗体和免疫复合物;随着时间的推移,免疫复合物的检出率减少,这可能与其被清除有关.抗独特型抗体与抗抗体有同步消长的关系。多次注射单克隆抗体,使IgM、IgG类抗抗体及抗独特型抗体的产生增多,但IgE水平却无明显变化,免疫复合物的形成也无明显增多。

 
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