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anti implantation
相关语句
  抗着床
    HISTOCHEMICAL OBSERVATION ON ANTI IMPLANTATION EFFECT OF MIFEPRISTONE ON THE RATS ENDOMETRIUM
    米非司酮对大白鼠子宫内膜抗着床作用的组织化学观察
短句来源
  抗着床
    HISTOCHEMICAL OBSERVATION ON ANTI IMPLANTATION EFFECT OF MIFEPRISTONE ON THE RATS ENDOMETRIUM
    米非司酮对大白鼠子宫内膜抗着床作用的组织化学观察
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  anti implantation
While orally administered from day 1 to day 4 of pregnancy it showed dose-dependent anti-implantation activity.
      
Presence of anti Implantation OP-I and anti-collagen antibodies did not correlate with clinical observations.
      


A remarkable anti-implantation effect of Norethisterone-oxime-acetate was observedin experimental animals.In mice,rats and rabbits implantation was totally inhibitedwhen the drug was orally administered from day 2 of pregnancy at a daily dose of 0.51,and 2 mg/kg respectively for 3 days.The same effect could also be demonstrated in rats receiving a single dose of 5 or 10mg/kg of the drug on day 2 or 3 of pregnancy.4 healthy rabbits used for testing the toxicity received the drug orally at a...

A remarkable anti-implantation effect of Norethisterone-oxime-acetate was observedin experimental animals.In mice,rats and rabbits implantation was totally inhibitedwhen the drug was orally administered from day 2 of pregnancy at a daily dose of 0.51,and 2 mg/kg respectively for 3 days.The same effect could also be demonstrated in rats receiving a single dose of 5 or 10mg/kg of the drug on day 2 or 3 of pregnancy.4 healthy rabbits used for testing the toxicity received the drug orally at a dose of 10mg/kg/day(about 500 times as much as the clinical dose)for 3 weeks,and all were nor-mal in blood routine and renal function tests but a raised change was shown in their liverfunction(completely restored 2 weeks after cessation of the drug).3 dogs were given the drug at the dose of 1-2 mg/kg/day(about 50-100 times as muchas the clinical dose )for 14 months,no obvious toxic effect being observed.

醋炔诺酮肟对实验动物有明显的抗着床作用。小鼠、大鼠和家兔在妊娠第2天起,分别给予醋炔诺酮肟0.5、1和2毫克/公斤,每天一次,连续3天,均有显著的抗着床作用。大鼠在妊娠第2或3天一次给醋炔诺肟酮5或10毫克/公斤,亦有明显的抗着床作用。家兔4只,每日灌服醋炔诺酮肟10毫克/公斤(约为临床剂量500倍),连续3周,给药后肝功能升高,停药2周后恢复正常,血象和肾功能均无明显变化。犬3只,每日灌服醋炔诺酮肟1~2毫克/公斤(约为临床剂量50~100倍),连服14个月,无明显毒性。

The effects of Gossypol acetic acid on implantation,ovary steroid-3β-ol-dehydro-genase activity and serum progesterone of female rats were observed.On Days 1-5 ofPregnancy of rats,the Gossypol acetic acid suspension was given at a dose level of 100 mg/kgorally daily,while the same amount of distilled water was given to the control animals.The animals were sacrificed on Day 10 of pregnancy.It was found that the Gossypol acetic acid could effectively inhibit the implantationin rats with a rate of 85.7% and...

The effects of Gossypol acetic acid on implantation,ovary steroid-3β-ol-dehydro-genase activity and serum progesterone of female rats were observed.On Days 1-5 ofPregnancy of rats,the Gossypol acetic acid suspension was given at a dose level of 100 mg/kgorally daily,while the same amount of distilled water was given to the control animals.The animals were sacrificed on Day 10 of pregnancy.It was found that the Gossypol acetic acid could effectively inhibit the implantationin rats with a rate of 85.7% and decrease serum progesterone.If progesterone(5 mg)orhCG(50 IU)was injected S.C.simultaneously with the Gossypol,the inhibitory effectsof the Gossypol could no longer be observed.But,if LH-RH (20 μg)was injected insteadof progesterone or hCG,the anti-implantation effects of the Gossypol remained.It was observed that the Gossypol acetic acid could not inhibit the effects of estradiolinducing the implantation of blastocysts in delayed implantation in rats.Accordingly,it seems that the anti-implantation effects of the Gossypol might be dueto the blocking of the supporting effects of endogenous LH on corpus luteum.

本工作观察了醋酸棉酚对大鼠早期妊娠的影响。于大鼠妊娠的第1—5天,每鼠每天灌服一次醋酸棉酚混悬液(100毫克/公斤体重),对照组灌服等量蒸馏水。于妊娠第10天处死,处死前取血测定血清孕酮,处死后取卵巢测定⊿~5-3β-羟甾脱氢酶活性并记录妊娠动物数及正常着床胎数。结果表明,醋酸棉酚对大鼠具有明显的抗着床作用,抗着床率达85.7%,同时伴有血清孕酮水平下降。若同时皮下注射5毫克孕酮或是同时皮下注射50国际单位的hCG 均能有效地对抗醋酸棉酚的抗着床作用,而同时注射20微克的LH-RH 类似物并不能对抗醋酸棉酚的抗着床作用。在延缓着床的大鼠,醋酸棉酚不能对抗外源性雌二醇的致着床作用。以上结果提示,对抗LH 对黄体功能的支持有可能是醋酸棉酚抗着床作用的机理之一。

The alcoholic extract of Aristolochia mollissima H., a Chinese medicinal herb, was reported to have anti-implantation activity in mice and rats. Aristolochic acid A, a nitrophenanthrene, was obtained from the plant by extracting with acidic chloroform, followed by chromatography on silica gel columns. Aristolochic acid A given orally to mice showed significant anti-implantation and early pregnancy interrupting effects. However, these effects were not observed in rats. Aristolochic acid...

The alcoholic extract of Aristolochia mollissima H., a Chinese medicinal herb, was reported to have anti-implantation activity in mice and rats. Aristolochic acid A, a nitrophenanthrene, was obtained from the plant by extracting with acidic chloroform, followed by chromatography on silica gel columns. Aristolochic acid A given orally to mice showed significant anti-implantation and early pregnancy interrupting effects. However, these effects were not observed in rats. Aristolochic acid A showed neither estrogenic nor antiestrogenic actions. Treatment with exogenous progesterone failed to provent its pregnancy-interrupting action. In addtion, intraamniotie injection of Aristolochie acid A in mid-term pregnant dogs and rats led to termination of pregnancy. No significant changes were found in blood counts, blood sugar, cholesterol, SGOT, alkaline phosphatase, acid phosphatase, fibrinogen content, thrombinogen time, hepatic and renal functions as well as the morphology of the main viscera when Aristoloehie acid A was administered intraamniotically to dogs at a single dose in the range of 0.2~2 mg.

中药寻骨风醇提物对大鼠和小鼠具有显著的抗着床作用。从寻骨风中提得的马兜铃酸A对小鼠具有显著的抗着床和抗早孕活性,对大鼠则无。马兜铃酸A无雌性素和抗雌性素作用,而外源性的孕酮不能阻止它的抗早孕作用。此外羊膜囊注射此药可终止犬和大鼠的中期妊娠;同时检测血像、临床生化和主要脏器的形态学诸方面,均无明显异常。

 
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