助手标题  
全文文献 工具书 数字 学术定义 翻译助手 学术趋势 更多
查询帮助
意见反馈
   bioequivalence 在 有机化工 分类中 的翻译结果: 查询用时:0.15秒
图标索引 在分类学科中查询
所有学科
有机化工
药学
中药学
医药卫生方针政策与法律法规研究
计算机软件及计算机应用
基础医学
生物医学工程
数学
临床医学
更多类别查询

图标索引 历史查询
 

bioequivalence
相关语句
  生物等效性
    The bioequivalence and pharmacokinetics of domestic dextromethorphan hydrobromide extended release suspension was investigated in 18 healthy man volunteers, according to randomized crossover design.
    在 18名男性健康受试者中研究国产右美沙芬缓释混悬液的药物动力学特性及生物等效性
短句来源
    Bioequivalence of Dextromethorphan Hydrobromide Extended Release Suspension
    右美沙芬缓释混悬液的生物等效性研究
短句来源
    Bioequivalence of tinidazole tablets in healthy volunteers
    国产替硝唑片的人体生物等效性研究
短句来源
    Preparation and Bioequivalence Evaluation of Chrysanthemum Morfolium Sustained-release Tablets
    菊花提取物缓释片的研制及生物等效性评价
短句来源
  相似匹配句对
    Bioequivalence of tinidazole tablets in healthy volunteers
    国产替硝唑片的人体生物等效性研究
短句来源
    Bioequivalence of Dextromethorphan Hydrobromide Extended Release Suspension
    右美沙芬缓释混悬液的生物等效性研究
短句来源
查询“bioequivalence”译词为用户自定义的双语例句

    我想查看译文中含有:的双语例句
例句
为了更好的帮助您理解掌握查询词或其译词在地道英语中的实际用法,我们为您准备了出自英文原文的大量英语例句,供您参考。
  bioequivalence
The method was successfully applied to investigate the bioequivalence between two kinds of tablets (test versus reference products) in 18 healthy male Chinese volunteers.
      
Bioanalytical laboratories support a range of regulatory studies ranging from early toxicology studies through Phase 1,2 and 3 clinical studies to definitive bioequivalence and bioavailabity studies in support of the marketed product.
      
With a total run-time of 6 minutes, the method was suitable for supporting clinical studies and applied to the analysis of samples from a bioequivalence study.
      
A new sensitive HPLC-FLD method has been developed and validated for the determination of cisapride in human plasma for a bioequivalence study.
      
This method has been successfully used to support a bioequivalence clinical study.
      
更多          


The bioequivalence and pharmacokinetics of domestic dextromethorphan hydrobromide extended release suspension was investigated in 18 healthy man volunteers, according to randomized crossover design. The plasma concentration of dextrophan, the active metabolite of dextromethorphan, was determined by RP HPLC with fluorescence detection. The pharmacokinetic parameters for the single oral dose of 60 mg dextromethorphan hydrobromide extended release suspension were c max 436.8 ± 116.7 and ...

The bioequivalence and pharmacokinetics of domestic dextromethorphan hydrobromide extended release suspension was investigated in 18 healthy man volunteers, according to randomized crossover design. The plasma concentration of dextrophan, the active metabolite of dextromethorphan, was determined by RP HPLC with fluorescence detection. The pharmacokinetic parameters for the single oral dose of 60 mg dextromethorphan hydrobromide extended release suspension were c max 436.8 ± 116.7 and 409.5 ± 113.7 ng/ml ; T max 3.3 ± 1.0 and 3.4 ± 0.8 h ; T 1/2 7.5 ± 2.7 and 7.5 ± 3.1 h ±; AUC 0→ t n 3435± 664.2 and 3269± 626.0 ng·ml -1 ·h , for testing and imported reference formulations, respectively. For the multiple dosing, the degree of fluctuation ( DF ) was (121.9 ± 37.1) % and (133.2±40.6)%, respectively. The results of two one side test showed that the two formulations may be considered as bio equivalent. The relative bioavailability for the test formulation was (105.9±13.8)%.

在 18名男性健康受试者中研究国产右美沙芬缓释混悬液的药物动力学特性及生物等效性。采用双周期交叉设计 ,反相高效液相色谱 -荧光检测法测定血浆中右美沙芬活性代谢物去甲右美沙芬的浓度。单剂量口服 6 0 m g右美沙芬缓释混悬液与进口对照品的 cmax分别为 4 36 .8± 116 .7和 4 0 9.5± 113.7ng/m l;Tmax为 3.3± 1.0和 3.4±0 .8h;T1 /2 为 7.5± 2 .7和 7.5± 3.1h;AUC0→ tn为 3435± 6 6 4 .2和 32 6 9± 6 2 6 .0 ng· ml- 1 · h。多剂量服药达稳态后两制剂的波动度分别为 (12 1.9± 37.1% )和 (133.2± 4 0 .6 ) %。主要药动学参数经统计学检验表明 :国产右美沙芬缓释混悬液与进口同类产品具生物等效性 ,相对生物利用度为 (10 5 .9± 13.8) %。

Objective To evaluate the relative bioavailability and bioequivalence of tset tinidazole tablets.Methods 18 male healthy volunteers orally took a single dose of 1 000 mg tablets of test and reference in randamized self-crossover ways.The plasma concentrations of tinidazole determined by RP-HPLC with UV detector.Results The pharmacokinetic parameters of reference and test drugs were as follow : t_(max)(1.72±0.45)and(1.97±0.66) h;C_(max)(21.39±3.36) and(20.56±2.98) μg·mL~(-1);t_(1/2)(17.83±2.24) and(17.71±2.65)...

Objective To evaluate the relative bioavailability and bioequivalence of tset tinidazole tablets.Methods 18 male healthy volunteers orally took a single dose of 1 000 mg tablets of test and reference in randamized self-crossover ways.The plasma concentrations of tinidazole determined by RP-HPLC with UV detector.Results The pharmacokinetic parameters of reference and test drugs were as follow : t_(max)(1.72±0.45)and(1.97±0.66) h;C_(max)(21.39±3.36) and(20.56±2.98) μg·mL~(-1);t_(1/2)(17.83±2.24) and(17.71±2.65) h;Ke((0.039)±0.005) and(0.04±0.006) h~(-1);AUC_((0→t))(502.56±83.83)and(505.48±84.91) μg·h·mL~(-1),respectively.There was no statistical difference between test and reference tinidazole tablets in pharmacokinetic parameters(P>0.05).The relative bioavailability of tinidazole tablets was 99.42%.Conclusion Two preparations of tinidazole tablet are bioequivalent.

目的评价不同厂家替硝唑片的相对生物利用度和生物等效性。方法18名男性健康受试者采用随机、自身对照、交叉试验方法,单剂量口服不同厂家的替硝唑片后,用RP-HPLC法测定血浆中替硝唑质量浓度。结果单剂量口服替硝唑1 000 mg受试和参比制剂的达峰时间tmax分别为(1.72±0.45)和(1.97±0.66)h;血药浓度峰值Cmax分别为(21.39±3.36)和(20.56±2.98)μg.mL-1;t1/2分别为(17.83±2.24)和(17.71±2.65)h;Ke分别为(0.039±0.005)和(0.04±0.006)h-1;药时曲线下面积AUC(0→t)分别为(502.56±83.83)和(505.48±84.91)μg.h.mL-1。两种片剂的药物动力学参数均无显著性差异(P>0.05),受试制剂的相对生物利用度(F)为99.42%。结论两种制剂生物等效。

 
图标索引 相关查询

 


 
CNKI小工具
在英文学术搜索中查有关bioequivalence的内容
在知识搜索中查有关bioequivalence的内容
在数字搜索中查有关bioequivalence的内容
在概念知识元中查有关bioequivalence的内容
在学术趋势中查有关bioequivalence的内容
 
 

CNKI主页设CNKI翻译助手为主页 | 收藏CNKI翻译助手 | 广告服务 | 英文学术搜索
版权图标  2008 CNKI-中国知网
京ICP证040431号 互联网出版许可证 新出网证(京)字008号
北京市公安局海淀分局 备案号:110 1081725
版权图标 2008中国知网(cnki) 中国学术期刊(光盘版)电子杂志社