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   bioequivalence 在 药学 分类中 的翻译结果: 查询用时:0.116秒
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bioequivalence
相关语句
  生物等效性
    Development of LDP Sustained-release Tablets and Evaluation of Bioequivalence
    LDP缓释片的研制及生物等效性评价
短句来源
    Relative Bioavailability and Bioequivalence Assessment of Domestic Amiloride Tablet
    国产氨氯吡咪片的相对生物利用度及其生物等效性评价
短句来源
    THE APPLICATION OF MIC RELATED PARAMETERS IN THE BIOEQUIVALENCE TEST OFCEFADROXIL GRANULES
    MIC关联的参数在头孢羟氨苄颗粒剂生物等效性试验中的应用
短句来源
    Studies on Bioequivalence of Domestic and Imported Tablets of Ibuprofen
    国产与进口布洛芬糖衣片生物等效性研究
短句来源
    Objective To study the relative bioavailability and bioequivalence of compound glipizide in healthy volunteers.
    目的研究复方格列吡嗪片人体生物利用度及生物等效性
短句来源
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  “bioequivalence”译为未确定词的双语例句
    OBJECTIVE To evaluate the bioequivalence of domestic tropisetron preparations and imported tablets.
    目的评价国产盐酸托烷司琼片、胶囊与进口参比制剂是否生物等效。
短句来源
    the pharmacokinetic parameters and relative bioavailability were calculated and the bioequivalence of the 2 preparations were evaluated. Results: The pharmacokinetic parameters for experimental and the reference preparations were: C_max(6.21±1.88) vs(6.03±1.08) ng/ml; AUC_0-120(250.68±52.61) vs(246.14±52.11) ng h/ml;
    结果:苯磺酸氨氯地平供试制剂和参比制剂主要药代动力学参数如下:Cmax分别为(6.21±1.88)(、6.03±1.08)ng/ml,AUC0-120分别为(250.68±52.61)、(246.14±52.11)ng.
短句来源
    The relative bioequivalence of the test preparation was(97±12)%.
    t_(1\2β)分别为(1.9±2.3)h和(1.9±1.5)h,2种制剂的主要药动学参数无显著差异(P>0.05),受试制剂的相对生物利用度为(97±12)%。
短句来源
    The concentrations of ciprofloxacin in serum samples were determined by RP-HPLC, and the bioequivalence were evaluated. RESULTS: The main pharmacokinetic parameters of the test and reference in volunteers were as follows, AUC0-t were 10.889±1.385 μ g ·h ·ml-1 and 12.406±1.384 μ g ·h ·ml-1;
    结果单剂口服给药试验制剂和参比制剂环丙沙星时间-浓度曲线下面积(AUC0-t)分别为10.889±1.385 μg ·h·ml-1和12.406±1.384 μg ·h ·ml-1;
    Comparative study on bioavailability and bioequivalence of clarithromycin disperse tablets andlimaixian tablets in healthy volunteers
    克拉霉素分散片与克拉霉素片人体生物利用度比较研究
短句来源
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  bioequivalence
The method was successfully applied to investigate the bioequivalence between two kinds of tablets (test versus reference products) in 18 healthy male Chinese volunteers.
      
Bioanalytical laboratories support a range of regulatory studies ranging from early toxicology studies through Phase 1,2 and 3 clinical studies to definitive bioequivalence and bioavailabity studies in support of the marketed product.
      
With a total run-time of 6 minutes, the method was suitable for supporting clinical studies and applied to the analysis of samples from a bioequivalence study.
      
A new sensitive HPLC-FLD method has been developed and validated for the determination of cisapride in human plasma for a bioequivalence study.
      
This method has been successfully used to support a bioequivalence clinical study.
      
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This paper deals with the formulation, preparation and evaluation of sustained-release theophylline tablet (SRTT) by measuring in vitro/in vivo release. The serum levels of theophylline in 12 healthy adult volunteers after oral administration of SRTT were determined by a modified UV spectrophotometric method. The pharmac0kinetic parameters were fitted by non-linear least square method with Sharp PC-1211 pocket-computer on the basis of one compartment model. The result showed that the therapeutic serum levels...

This paper deals with the formulation, preparation and evaluation of sustained-release theophylline tablet (SRTT) by measuring in vitro/in vivo release. The serum levels of theophylline in 12 healthy adult volunteers after oral administration of SRTT were determined by a modified UV spectrophotometric method. The pharmac0kinetic parameters were fitted by non-linear least square method with Sharp PC-1211 pocket-computer on the basis of one compartment model. The result showed that the therapeutic serum levels after single dose of SRTT (300 mg) appeared at 3.8 h and maintained over 5 μg/ml for up to 23 h, while that of multiple dose of SRTT (300 mg/every 12 h)appeared at 3 h and reached steady state (13.78±0.47 μg/ml) on the third day.By comparing the pharmacokinetic parameters between SRTT and an imported sustained-release product (Theo-Dur), a good bioequivalence was demonstrated. The correlation between dissolution rates and serum levels was mathematically treated by deconvolution method, and the calculated theoretical values was consistent with the observed data.

本文研究了长效茶碱片(SRTT)的处方组成,制备工艺,溶出速率;并应用改进的紫外分光光度法测定了l2名健康受试者口服SRTT后的体内血药浓度,实验数据按单室模型用电子计算机进行处理得各药物动力学参数。SRTT单剂量给药(300 mg),3.8小时达有效血药浓度,可维持5μg/ml以上23小时;多剂量给药,3小时达有效血药浓度,至第三天已达稳态血药浓度13.78±0.47μg/ml。将SRTT与世界名牌产品Theo-Dur进行对照试验,表明两制剂为生物等效。本文采用脱卷积法计算体内外相关性,理论值与实测值基本相符。

The concentration of OFLX in urine of six heaithy volunteers was determined after the tablets of foreign product anddomestic product were orally given by single-dose.The results showed that both products had same pharmacokinetic parametersand bioequivalence.The pharmacokinetic parameters were K(hr~(-1)):0.1185;0.1180;T 1/2(hr):5.94,6.11;Xu~(0.24)(mg):174.66,167.69;and eliminative rate:87.33%,83.89%.

本文用尿药浓度法测定六名志愿者单剂量口服国产、进口两种氧氟沙星片剂的尿药浓度,结果表明:国产与进口两种片剂具有相同的药动学特征及生物等效性。其药动学参数分别为:k(h~(-1)):0.1185、0.1180;T_(1/2)(h):5.94、6.11;(?)—24(mg):174.66、167.79;排泄率:87.33%、83.89%

The concentration of isosorbide 5-minonitrate in human plasma were determined by capillary column gas-liquid chromatography. This method has high selectivity and reproducibility. The relation between hight and concentration was very good r=0.9999. The limit of detection was 0.03 ng. The average of within-day and without-day CV was<5 %.The curve of concertration-time fitted a two-compartment open model after oral dose of 1 tablet of Chinese-made and Holland-made of isosorbide 5-minonitrate (20 mg/tablet) in the...

The concentration of isosorbide 5-minonitrate in human plasma were determined by capillary column gas-liquid chromatography. This method has high selectivity and reproducibility. The relation between hight and concentration was very good r=0.9999. The limit of detection was 0.03 ng. The average of within-day and without-day CV was<5 %.The curve of concertration-time fitted a two-compartment open model after oral dose of 1 tablet of Chinese-made and Holland-made of isosorbide 5-minonitrate (20 mg/tablet) in the healthy, The result of pharmacokinetics of them has no difference. Ka were 4. 69, 4. 91 h-1 respectively, Cmax were 225.18,222.80μg/l, T1/2βwere 5.60and 5.61; Vd were 0.063 and 0.070 L; Cls were 13.01 and 12.401/h . The bioequivalence F= 98.28 ±9.76%.

本文报道了应用毛细管气相色谱法以ECD(Ni-63)为检测器,采用外标法测定人血浆中的5-单硝基异山梨醇酯(IS-5-MN).结果表明该方法精密度好,灵敏度高,线性关系良好;r=0.9999(n=6),最低检测限为0.03ng,日内和日间平均变异系数<6%。10名健康志愿者口服国产和进口IS-5-MN片所得的药时曲线均符合二室模型,其药代动力学参数无显著性差异。吸收速率常数分别为4.69,4.91h ̄-1;达峰时间为0.89,0.81h;峰浓度为225.18,222.80μg/l;半衰期T1/2β为5.60,5.61h;表观分布容积为0.063和0.0701;平均总体清除率为13.01和12.401/h,生物利用度F=98.28±9.76%。

 
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