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virulence evolution
相关语句
  毒力进化
     Virulence evolution of malaria
     疟原虫毒力进化
短句来源
     It is the time to call for evolutionary genomics which probe into bacterial diversity, niche adaptation, virulence evolution, and drug resistance from the view of whole genome.
     以比较基因组学为研究手段,细菌进化基因组学可从基因组水平深入认识物种分化、生境适应、毒力进化、耐药性产生蔓延等表型进化过程。
短句来源
  “virulence evolution”译为未确定词的双语例句
     This review dwells on the hypothesis of virulence evolution in malaria parasite and the related molecular mechanisms.
     该文综述了疟原虫毒力进化的假说及其相关的分子机制。
短句来源
  相似匹配句对
     Virulence evolution of malaria
     疟原虫毒力进化
短句来源
     Thoughts on evolution of pathogenic virulence.
     关于病原微生物毒力进化的若干思考
短句来源
     EVOLUTION OF THE SYSTEM OF S.T.IN U.S.S.R.
     苏联科研体制变迁
短句来源
     STELLAR EVOLUTION
     天体物理学讲座 第一讲 恒星的演化
短句来源
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  virulence evolution
Isolates belonging to race 0E0 seem to be the ancestor of a rapid virulence evolution of yellow rust in Ecuador.
      
Whether this challenges the current views of virulence evolution depends on the definitions used.
      
Many models of virulence evolution assume that intrinsic virulence of a parasite genotype is associated with its intrinsic replication rate.
      


Objective To detect the "High Pathogenicitv Island "of Yersinia enterocolitica WA in E. coli, as it is the foundation of its structure and function studying. Methods polymerase chain reaction(PCR), nucleic acid hybridization in situ and DNA sequencing were used. Result The irp2 and fyua genes of Yen HPI were investigated in ETEC strains, among of them, 32 strains were isolated from 93 ETEC strains, in most of these isolates, the HPI bordered by an asntRNA Locus, as in Yersinia sp. Conclusion ETEC is one of the...

Objective To detect the "High Pathogenicitv Island "of Yersinia enterocolitica WA in E. coli, as it is the foundation of its structure and function studying. Methods polymerase chain reaction(PCR), nucleic acid hybridization in situ and DNA sequencing were used. Result The irp2 and fyua genes of Yen HPI were investigated in ETEC strains, among of them, 32 strains were isolated from 93 ETEC strains, in most of these isolates, the HPI bordered by an asntRNA Locus, as in Yersinia sp. Conclusion ETEC is one of the pathogenicity bacterica and many of them baboring the HPI of Yen, It is important to study the structure and function of the HPI and virulent changes in E. coil, even more virulence evolution and regulation of virulence genes.

目的 了解小肠结肠炎耶尔森菌强毒力岛在产毒性大肠杆菌中的分布,以便于进一步深入研究毒力岛在大肠杆菌中的结构的完整性和功能。方法PCR扩增和原位杂交及基因序列分析。结果 在检测的93株产毒性大肠杆菌(ETEC)的毒力岛的检出率为 32.25%(32/93),而且这些阳性菌株中的毒力岛大部分连接到 asntRNA(天门冬氨酸tRNA)位点。结论 产毒性大肠杆菌是致病性较强的病原菌之一,而小肠结肠炎耶尔森菌强毒力岛在产毒性大肠杆菌中阳性率较高的分布.对于进一步研究产毒性大肠杆菌的毒力的变化和毒力的调控以及细菌毒力的进化具有重要意义

Objective To describe the distribution of high-pathogenicity island (HPI) of Yersinia enterocolitica in enterotoxin-genic E.coli (ETEC) and enteropathogenic E.coli (EPEC), and to understand the structure and function of HPI. Methods PCR was used to detect irp2, fyua and asn-intB genes with subsequent sequence analysis of these genes. Nucleic acid in situ hybridization was employed to identify the specificity of irp2 and fyua. Results Thirty irp2-positive strains were isolated from 93 ETEC strains and 3 from...

Objective To describe the distribution of high-pathogenicity island (HPI) of Yersinia enterocolitica in enterotoxin-genic E.coli (ETEC) and enteropathogenic E.coli (EPEC), and to understand the structure and function of HPI. Methods PCR was used to detect irp2, fyua and asn-intB genes with subsequent sequence analysis of these genes. Nucleic acid in situ hybridization was employed to identify the specificity of irp2 and fyua. Results Thirty irp2-positive strains were isolated from 93 ETEC strains and 3 from 10 EPEC strains, making a positivity rate of 32.25% and 30% respectively, and the positivity rates of fyua gene in ETEC and EPEC were 21.51% and 30% respectively. In most of these positive isolates, HPI was bordered by an asn tRNA locus, as in Yersinia sp. Conclusions This study demonstrates that the high positivity rate of HPI of Yersinia enterocolitica in ETEC and EPEC strains may be crucial to the virulence changes, virulence evolution and virulence regulation in E.coli.

目的 了解小肠结肠炎耶尔森菌强毒力岛在产毒性和致病性大肠杆菌中的分布,探讨毒力岛在大肠杆菌中的结构和功能。方法 对毒力岛的关键基因irp2、fyua和asn-intB进行PCR扩增和DNA测序,并对irp2和fyua进行原位杂交。结果 在检测的93株肠产毒性大肠杆菌和10株肠致病性大肠杆菌基因irp2的检出率分别为32.25%(30/93)和30%(3/10),fyua的阳性率为21.51%(20/93)和30%(3/10),而且这些阳性菌株中的毒力岛大部分连接到天门冬氨酸tRNA(asn tRNA)位点。结论 小肠结肠炎耶尔森菌强毒力岛在产毒性和致病性大肠杆菌中较高的阳性率,对于大肠杆菌毒力的变化和毒力的调控以及细菌毒力的进化可能具有重要意义。

Objective To detect the "high pathogenicity island" of Yersinia enterocolitica WA in E.coli and the to provide evidence for theory base of bacterial evolution peocess and the different structures in different E.coil. Methods Polymease chain reaction (PCR),nucleic acid hybridization in situ were used to detect and identify HPI. DNA sequencing was used to compare the gene homology of HPI among E.coli with Yersinia enterocolitica (Yen). Results The irp2 and fyua genes of Yen HPI were investigated...

Objective To detect the "high pathogenicity island" of Yersinia enterocolitica WA in E.coli and the to provide evidence for theory base of bacterial evolution peocess and the different structures in different E.coil. Methods Polymease chain reaction (PCR),nucleic acid hybridization in situ were used to detect and identify HPI. DNA sequencing was used to compare the gene homology of HPI among E.coli with Yersinia enterocolitica (Yen). Results The irp2 and fyua genes of Yen HPI were investigated in E.coli strains. Among them,30 strains were isolated from 93 Enterotoxigenic E.coli (ETEC) strains and 3 strains were positive in 10 strains Enteropathogenic (EPEC). HPI was also detected in Enteroaggregative E.coli (EAggEC) strain. In most of these isolates, HPI was bordered by an asntRNA locus,as in Yersinia sp. Through sequential comparasion,the gene sequence homology was higher between in EPEC and EAggEC than ETEC and Yersinia enterocolica. Conclusions ETEC,EPEC and EAggEC were pathogenicity bactericas and many of them haboring HPI of Yen and the HPI had the same position in E.coli chromosome as Yersinia enterocolitica but the diversity of structure and sequence in these E.coli might suggest that the HPI of these different serotype E.coli were from different ancient bacterias. At the same time, the high positivty rate of HPI in E.coli might be crucial to virulence change, virulence evolution and virulence regulation in E.coli.

目的 了解小肠结肠炎耶尔森菌强毒力岛在产毒性 (ETEC)和致病性大肠埃希菌(EPEC)中的分布。方法 用聚合酶链反应扩增和原位杂交方法。结果 在检测的 93株ETEC和 10株EPEC的毒力岛的检出率分别为 3 2 .2 5 % ( 3 2 93 )和 3 0 .0 0 % ( 3 10 ) ,1株肠聚集性大肠埃希菌(EAggEC)也检出了毒力岛 ,而且这些阳性菌株中的毒力岛大部分连接到天门冬氨酸tRNA(asntRNA)位点。结论 ETEC、EPEC以及EAggEC是致病性较强的病原菌 ,而小肠结肠炎耶尔森菌强毒力岛在ETEC和EPEC中具有阳性率较高的分布 ,对于进一步研究大肠埃希菌毒力变化和毒力的调控以及细菌毒力的进化具有重要意义

 
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