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   p73蛋白 在 内分泌腺及全身性疾病 分类中 的翻译结果: 查询用时:0.692秒
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p蛋白
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  p protein
    Association between anti-ribosomal P protein antibody and lupus nephritis
    抗核糖体P蛋白抗体与狼疮肾炎的临床表现和血清学的关系
短句来源
    Significance of detection of anti-ribosomal P protein antibody in SLE
    抗核糖体P蛋白抗体对系统性红斑狼疮的临床意义
短句来源
    Detection and clinical significance of serum antibody to ribosomal P protein in patients with systemic lupus erythematosus
    系统性红斑狼疮患者血清抗核糖体P蛋白抗体的检测及其临床意义
短句来源
    By indirect immunofluorescence, the stain reaction for Rib p protein antibody, Jo 1 antibody and AMA antibody was positive in 10 mg·kg -1 and 5 mg·kg -1 groups but negative in 2.5 mg·kg -1 group.
    与LPS 2 .5mg·kg-1ip组一致 . 间接免疫荧光法 :LPS 5mg·kg-1ip与 2 .5mg·kg-1组动物血清中均能检测出核糖体 (Rib) p 蛋白抗体、Jo 1抗体和线粒体 (AMA)抗体阳性 ,荧光强度较强 .
短句来源
    AIM: To observe the positive rate and its clinical significance of serum antibody to ribosomal P protein(anti-P) in patients with systemic lupus erythematosus (SLE).
    目的: 观察抗核糖体P蛋白抗体(抗P蛋白抗体)在系统性红斑狼疮 (SLE)患者中的阳性率及其意义。
短句来源
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  “p73蛋白”译为未确定词的双语例句
    The positive rate of antiribosomal P in patients with diffuse CNS involvement of SLE was significantly higher than that in patients without CNS involvement ( P <0.01).
    (4) 弥漫型CNS的SLE中抗核糖体P蛋白(rRNP)抗体阳性率显著高于非CNS的SLE( P< 0.01)。
短句来源
    METHODS: Anti-P protein antibody was detected by EURO blot with synthetic full-length ribosomal proteins, and then correlation between anti-P antibody, other autoantibodies and clinical characters was analysed.
    方法:以含有核糖体磷酸蛋白P0、P1、P2全序列的合成蛋白作为抗原, 采用欧盟斑点法(EUROblot), 测定 150份SLE患者血清抗核糖体P蛋白抗体的阳性率, 并分析其与其他自身抗体(抗dsDNA抗体、抗Sm抗体和抗RNP抗体等), 以及患者的临床特征的相关性。
短句来源
    RESULTS: In 150 SLE patients 36 cases(24%)were positive for anti-P antibody.
    结果: 150份患者血清中, 有 36例(24% )抗P蛋白抗体呈阳性。
短句来源
    Objective To study the diagnosis significance of anti-ribosomal P antibody in systemic lupus erythematosus (SLE).
    目的研究抗核糖体P蛋白(Rib-P)肽抗原抗体对系统性红斑狼疮(SLE)的临床诊断意义。
短句来源
    Results Of the 90 SLE patients, 71.1% were seropositive for ANuA, 25.6% were seropositive for ARPA. Only 6.7% and 4.4% control patients were seropositive. The positive rate of ANuA and ARPA in SLE was obviously higher than patients with other diseases.
    结果90例SLE患者中64例血清ANuA阳性,阳性率为71.1%,ARPA阳性23例,阳性率25.6%,疾病对照组仅6.7%及4.4%,SLE患者ANuA、抗核糖体P蛋白抗体显著高于疾病对照组。
短句来源
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  p protein
The possible mechanisms of the formation of the modified ADH-P protein are discussed in connection with the differential activity of genes in the microgametophytes of angiosperms.
      
The immunoblot analysis with RSV-infected and non-infected HEp-2 cells as antigen revealed the expected age-dependent low prevalence of G protein antibodies and clear seroconversion of N and P protein antibodies.
      
Are anti-ribosomal P protein antibodies relevant in systemic lupus erythematosus
      
Cellular expression pattern of the glycine decarboxylase P protein in leaves of an intergeneric hybrid between the C3-C4 interme
      
The densities of NF150D and NF150P protein spots on the Coomassie blue-stained two-dimensional gels of the normal and injured cords also displayed alterations similar to the immunocytochemical data.
      
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Objective:To investigate the association between anti-ribosomal P protein antibody(anti-Rib-P) and clinical characteristics of lupus nephritis(LN).Methods:Clinical and serological characteristics of 36 patients with systemic lupus erythematosus(SLE) who had positive anti-Rib-P test were reviewed and compared to those of 195 anti-Rib-P negative counterparts.Results:The incidence of arthritis,photosensitivity,and neurological lesions were more common in anti-Rib-P positive group than in negative group.Furthermore,anti-Rib-P...

Objective:To investigate the association between anti-ribosomal P protein antibody(anti-Rib-P) and clinical characteristics of lupus nephritis(LN).Methods:Clinical and serological characteristics of 36 patients with systemic lupus erythematosus(SLE) who had positive anti-Rib-P test were reviewed and compared to those of 195 anti-Rib-P negative counterparts.Results:The incidence of arthritis,photosensitivity,and neurological lesions were more common in anti-Rib-P positive group than in negative group.Furthermore,anti-Rib-P was found to be correlated to anti-Sm,SSA,SSB,and rheumatoid factor.However,no differences in renal involvement were found.Conclusion:Anti-Rib-P is one of the important markers of SLE,associated with neurological involvement and arthritis.

目的 :探讨系统性红斑狼疮 (SLE)中抗核糖体 P蛋白抗体 (抗 Rib- P)与临床表现和血清学的关系。方法 :将 36例抗 Rib- P阳性患者的临床表现和血清学特征与 195例阴性患者进行比较。结果 :抗 Rib- P阳性组关节炎、光敏感和神经系统损害显著高于阴性组。抗 Rib- P和抗 Sm、抗 SSA、抗SSB和类风湿因子等血清学指标关系密切 ,但两组间肾损害无差异。结论 :抗 Rib- P是诊断 SL E的重要指标 ,它与 SLE神经系统损害、关节炎有关。

Objective To investigate central nervous system (CNS)involvements in systemic lupus erythematosus (SLE) so as to enhance our knowledge in diagnosing and treating CNS involvement of SLE. Methods The clinical data of 171 in patients with CNS involvement of SLE in our hospital were retrospectively reviewed. Results The mean SLE disease duration at onset of CNS involvement was (2.21±1.87) years and in 163(95.3%) it was associated with active disease. Cerebralspinal fluid abnormality was seen in 91.4%(138/151)...

Objective To investigate central nervous system (CNS)involvements in systemic lupus erythematosus (SLE) so as to enhance our knowledge in diagnosing and treating CNS involvement of SLE. Methods The clinical data of 171 in patients with CNS involvement of SLE in our hospital were retrospectively reviewed. Results The mean SLE disease duration at onset of CNS involvement was (2.21±1.87) years and in 163(95.3%) it was associated with active disease. Cerebralspinal fluid abnormality was seen in 91.4%(138/151) of the patients with CNS involvement of SLE. Among them protein elevation was found in 113, pressure elevation in 69, white cell elevation in 51 and glucose reduction in 6. For the evaluation of CNS involvement of SLE, the sensitivity of cranial CT and MRI was 77.4% and 81.4% respectively ( P >0.50). The positive rate of antiribosomal P in patients with diffuse CNS involvement of SLE was significantly higher than that in patients without CNS involvement ( P <0.01). On the contrary, the positive rate of ACL in focal CNS involvement of SLE was significantly higher than that in diffuse type or in patients without CNS involvement ( P <0.01). The total mortality rate in 171 patients with CNS involvement of SLE was 18.7%. The Mortality rate in the period of 1993 to 1998(4.0%,3/75)was significantly lower than that of 1980 to 1992(30.2%,29/96), P <0.01. 24 SLE patients with CNS involvement received intrathecal dexamethasone and methotrexate, 22 cases (91.7%) improved considerably. Conclusion CNS involvement occurs in the early stage of SLE, most of the cases are associated with active disease. Cerebralspinal fluid analysis is the most essential test and cranial imaging serves as a supplementary approach, of which CT is preferred. ACL is associated with focal CNS involvement of SLE while antiribosomal P with diffuse CNS involvement of SLE, suggesting there might be different mechanisms in CNS involvement of SLE. Intrathecal therapy is an useful alternative for patients with CNS involvement of SLE refractory to conventional therapy.

目的 对系统性红斑狼疮(SLE) 患者中枢神经系统病变(CNS) 的诊治经验进行总结。方法 对北京协和医院171 例有CNS的SLE住院病例进行回顾性分析。结果 (1)171 例发病时SLE病程为(2 .21 ±1 .87) 年,163 例(95.3% ) 伴狼疮活动;(2)151 例行脑脊液检查,异常138 例(91.4% )。其中蛋白、压力及白细胞增高者分别为113、69 及51 例,糖降低仅6 例;(3) 对有CNS的SLE,头颅CT及核磁共振检查(MRI)异常者分别为77.4 % 及81 .4% ( P> 0.50) ;(4) 弥漫型CNS的SLE中抗核糖体P蛋白(rRNP)抗体阳性率显著高于非CNS的SLE( P< 0.01)。而抗心脂抗体(ACL) 在局灶型CNS的SLE中阳性率显著高于弥漫型CNS的SLE及非CNS的SLE( P<0.01) ;(5)171 例CNS的SLE总病死率为18 .7 % 。其中1980 ~1992 年、1993 ~1998 年病死率分别为30.2% (29/96) 及4 .0% (3/75),P< 0.01;(6)24 例有CNS的SLE行鞘内联合注射甲氨...

目的 对系统性红斑狼疮(SLE) 患者中枢神经系统病变(CNS) 的诊治经验进行总结。方法 对北京协和医院171 例有CNS的SLE住院病例进行回顾性分析。结果 (1)171 例发病时SLE病程为(2 .21 ±1 .87) 年,163 例(95.3% ) 伴狼疮活动;(2)151 例行脑脊液检查,异常138 例(91.4% )。其中蛋白、压力及白细胞增高者分别为113、69 及51 例,糖降低仅6 例;(3) 对有CNS的SLE,头颅CT及核磁共振检查(MRI)异常者分别为77.4 % 及81 .4% ( P> 0.50) ;(4) 弥漫型CNS的SLE中抗核糖体P蛋白(rRNP)抗体阳性率显著高于非CNS的SLE( P< 0.01)。而抗心脂抗体(ACL) 在局灶型CNS的SLE中阳性率显著高于弥漫型CNS的SLE及非CNS的SLE( P<0.01) ;(5)171 例CNS的SLE总病死率为18 .7 % 。其中1980 ~1992 年、1993 ~1998 年病死率分别为30.2% (29/96) 及4 .0% (3/75),P< 0.01;(6)24 例有CNS的SLE行鞘内联合注射甲氨蝶呤加氟美松,22 例(91.7 %) 缓解。结论 对诊断?

Objective: To investigate the incidence, clinical manifestations and immunological features of lupus liver involvement in 520 cases of systemic lupus erythematosus (SLE). Methods: 520 patients with SLE were analyzed retrospectively for liver involvement. Results: Thirty-two patients (6.1%) with liver involvement could be etiologically attributed to SLE itself. 75% showed no related symptoms and increase of light-medium degree transaminase, but jaudice was found in four patients. The positive rate of anti-ribosomal...

Objective: To investigate the incidence, clinical manifestations and immunological features of lupus liver involvement in 520 cases of systemic lupus erythematosus (SLE). Methods: 520 patients with SLE were analyzed retrospectively for liver involvement. Results: Thirty-two patients (6.1%) with liver involvement could be etiologically attributed to SLE itself. 75% showed no related symptoms and increase of light-medium degree transaminase, but jaudice was found in four patients. The positive rate of anti-ribosomal P protein antibody (anti-Rib-P) in patients with lupus liver involvement was higher than those without lupus liver involvement, however, the both patients had no difference in the other opectrum of serum autoantibodies. The incidence of arthritis and cerebral lesion in patients with lupus liver involvement was higher than those without lupus liver involvement. Conclusions: Lupus liver involvement in SLE isn't rarely seen, the majority of clinical manifestations is liver dysfunction of light-medium degree, but some patients have severe clinical manifestations. Anti-Rib-Phase close relation with lupus liver involvement and may be associated with pathogenesis of lupus liver involvement.

研究系统性红斑狼疮 (SLE)性肝损害的发生率、临床表现及免疫学特点。方法 :对符合SLE诊断的5 2 0例病人的肝损害进行回顾性调查分析。结果 :5 2 0例病人中狼疮性肝损害者有 32例 (6 .1% ) ,其中 75 %病人无肝损害的临床症状 ,主要表现为轻、中度的转氨酶升高 ,4例出现黄疸 ;狼疮性肝损者血清抗核糖体P蛋白抗体 (抗Rib -P)阳性率显著高于无肝损者 ,而ANA、抗Sm抗体、抗dsDNA抗体等自身抗体阳性率两者无差异 ;有肝损者关节炎、脑损害的发生率高于无肝损者。结论 :系统性红斑狼疮本身所致的肝损害发生率并不低 ,临床上大多表现为轻、中度的肝功能异常 ,有小部分临床症状较重。抗Rib -P与狼疮性肝损害关系密切 ,可能与狼疮性肝损害发生有关。

 
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