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p蛋白
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  p protein
    The SLEDAI of 20 NPLE patients with anti-ribosomal P protein antibodies had significantly higher than 15 NPLE patients with negative in anti-ribosomal P protein antibody (P<0.05).
    神经精神性狼疮中20例抗核糖体P蛋白抗体阳性患者疾病活动度(SLEDAI)显著高于 15例阴性患者(P<0.05);
    The clinical study of anti-ribosomal P protein antibodies to neuropsychiatric lupus erythematosus
    抗核糖体P蛋白抗体与狼疮精神病的相关性
    Results : Sera anti-ribosomal P protein antibodies 'levels were significantly elevated in patients with SLE , with the sensitivity of 30.43%; and there was significant difference between NPLE(57.14%) and non-NPLE(2.94%) in plasma (P<0.05) .
    结果:血清中抗核糖体P蛋白抗体在系统性红斑狼疮患者中的阳性率为30.43%,在神经精神性狼疮患者中的阳性率为57.14%,在无神经精神症状的狼疮患者中的阳性率仅为2.94%,二者在抗体水平和阳性率上存在显著差异(P<0.05)。
    CSF anti-ribosomal P protein antibodies were elevated in 12 NPLE, all were negative.
    12例神经精神行狼疮患者脑脊液中抗核糖体P蛋白抗体均为阴性。
    objective:To study the clinical value of anti -ribosomal P protein antibodies to neuropsychiatric lupus erythematosus (NPLE)methods: All 69 sera(35 with NPLE ,34 no neuropsychiatric manifestations of SLE ) and 12 cerebrospinal fluids of NPLE were examined for anti-ribosomal P protein antibodies by ELISA method.
    目的:探讨抗核糖体P蛋白抗体在神经精神性狼疮中的意义及应用价值。 方法:采用 ELISA方法,检测69份血清(包括神经精神性狼疮患者35例,无神经精神症状的狼疮患者34例) 和12份神经精神性狼疮患者的脑脊液中的抗核糖体P蛋白抗体。
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  “p73蛋白”译为未确定词的双语例句
    Conclusion: The expression of NSE and S-100β increased significantly in the cerebral tissue after reperfusion of focal cerebral ischemia;
    结论脑缺血再灌流损伤后大鼠神经功能有自动恢复的趋势,脑组织NSE、S一100p蛋白表达增强;
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    Methods ELISA was used to test P-Glu-proleit(PGP) in the serum and CSF of IE patients(which had been diagnosed), and compared with epilepsy patients which reacted well to medicine and healthy subjects. Furthermore, OD was analysed as the parameter.
    方法 采用ELISA方法检测临床确诊为难治性癫痫的 12例患者血清及脑脊液P 蛋白 (P Glu proteis,PGP) ,并与用药物控制良好的 15例癫痫患者和 11例正常人比较 ,用OD值做为参数进行分析。
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  p protein
The possible mechanisms of the formation of the modified ADH-P protein are discussed in connection with the differential activity of genes in the microgametophytes of angiosperms.
      
The immunoblot analysis with RSV-infected and non-infected HEp-2 cells as antigen revealed the expected age-dependent low prevalence of G protein antibodies and clear seroconversion of N and P protein antibodies.
      
Are anti-ribosomal P protein antibodies relevant in systemic lupus erythematosus
      
Cellular expression pattern of the glycine decarboxylase P protein in leaves of an intergeneric hybrid between the C3-C4 interme
      
The densities of NF150D and NF150P protein spots on the Coomassie blue-stained two-dimensional gels of the normal and injured cords also displayed alterations similar to the immunocytochemical data.
      
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Objective To investigate the pathogenesis of intractable epilepsy(IE), it provides the theory basis for new therapy methods of IE.Methods ELISA was used to test P-Glu-proleit(PGP) in the serum and CSF of IE patients(which had been diagnosed), and compared with epilepsy patients which reacted well to medicine and healthy subjects. Furthermore, OD was analysed as the parameter.Results The level of PGP in the serum and CSF in IE group were significantly higher than those in epilepsy group and normal control...

Objective To investigate the pathogenesis of intractable epilepsy(IE), it provides the theory basis for new therapy methods of IE.Methods ELISA was used to test P-Glu-proleit(PGP) in the serum and CSF of IE patients(which had been diagnosed), and compared with epilepsy patients which reacted well to medicine and healthy subjects. Furthermore, OD was analysed as the parameter.Results The level of PGP in the serum and CSF in IE group were significantly higher than those in epilepsy group and normal control group.Conclusion PGP may be an important reason for contributing to epilepsy resistance to medicine, and it can be considered as an objective index of resistance to medicine in epilepsy patients.

目的 探讨难治性癫痫发病机制 ,为寻找难治性癫痫新的治疗方法提供理论依据。方法 采用ELISA方法检测临床确诊为难治性癫痫的 12例患者血清及脑脊液P 蛋白 (P Glu proteis,PGP) ,并与用药物控制良好的 15例癫痫患者和 11例正常人比较 ,用OD值做为参数进行分析。结果 难治性癫痫组血清及脑脊液PGP明显高于癫痫组和正常对照组。结论 PGP可能是促成癫痫耐药的重要因素 ,并可作为癫痫患者耐药的一个客观指标。

Objective: To explore significative immunologic parameter which contribute to neuropsychiatric lupus erythematosus(NPLE) genesis for early diagnosing NPLE. Methods: The retrospective analysis about C3,C4,IgG, IgA, IgM, antinuclear antibody(ANA), anti-ribosome P antibody(ARPA), nuclear ribonuclear protein antibody(anti-NRNP), anti-brain antibody(ABA) and anti-dsDNA were curried on in 104 cases systemic lupus erythematosus(SLE) including NPLE. In NPLE group, association of psychiatric symptoms with part of above...

Objective: To explore significative immunologic parameter which contribute to neuropsychiatric lupus erythematosus(NPLE) genesis for early diagnosing NPLE. Methods: The retrospective analysis about C3,C4,IgG, IgA, IgM, antinuclear antibody(ANA), anti-ribosome P antibody(ARPA), nuclear ribonuclear protein antibody(anti-NRNP), anti-brain antibody(ABA) and anti-dsDNA were curried on in 104 cases systemic lupus erythematosus(SLE) including NPLE. In NPLE group, association of psychiatric symptoms with part of above immunologic parameter was analyzed in two groups divided by accompanying with or without psychiatric sympotums. The data were dealed with SPSS 12.0. Results: The number of ABA positive cases in NPLE group(51 out of 62) was higher than that of in non-NPLE group(12 out of 42), and it was higher in NPLE group with psychiatric symptoms than that of in NPLE group without psychiatric symptoms(χ2=4.885,P=0.027). Compared the other immunologic parameters, no significant difference existed either between with and without NPLE groups or between with and without psychiatric sympotums group. Conclusion: The decreasing of C3 and C4, the increasing of IgG,IgA,IgM and the positive changes of ANA,APRA,anti-NRNP,anti-dsDNA are all have no specificity for forecasting and diagnosing NPLE. They are common characters of SLE. ABA plays an important role in NPLE genesis and in psychiatric symptoms development.

目的:探讨对神经精神性狼疮的发生和早期诊断有意义的免疫学指标。方法:对伴发神经精神性症状和不伴有神经精神性症状的104例红斑狼疮患者C3、C4、IgG、IgA、IgM、抗核抗体(Antinuclear antibody,ANA)、抗核糖体P蛋白(Anti-ribosome P antibody,ARPA)、抗核糖核酸蛋白抗体(Nuclear ribonuclear protein antibody,anti-NRNP)、抗脑神经抗体(Anti-brainantibody,ABA)及抗双链DNA(anti-dsDNA)进行回顾性分析,并在NPLE组将患者按有无合并精神症状进行分组,考查精神症状与上述部分指标的关联。SPSS12.0进行数据处理。结果:ABA阳性例数在NPLE组(62例中51例阳性)分布明显高于非NPLE组(42例中12例阳性),在合并精神症状的NPLE组比无精神症状组比例高(χ2=4.885,P=0.027),其余各项指标组间比较均无显著性差异。结论:C3、C4水平的降低,IgG、IgA、IgM升高及ANA、APRA、anti-NRNP、anti-dsDNA阳性变化不具有NPLE诊断...

目的:探讨对神经精神性狼疮的发生和早期诊断有意义的免疫学指标。方法:对伴发神经精神性症状和不伴有神经精神性症状的104例红斑狼疮患者C3、C4、IgG、IgA、IgM、抗核抗体(Antinuclear antibody,ANA)、抗核糖体P蛋白(Anti-ribosome P antibody,ARPA)、抗核糖核酸蛋白抗体(Nuclear ribonuclear protein antibody,anti-NRNP)、抗脑神经抗体(Anti-brainantibody,ABA)及抗双链DNA(anti-dsDNA)进行回顾性分析,并在NPLE组将患者按有无合并精神症状进行分组,考查精神症状与上述部分指标的关联。SPSS12.0进行数据处理。结果:ABA阳性例数在NPLE组(62例中51例阳性)分布明显高于非NPLE组(42例中12例阳性),在合并精神症状的NPLE组比无精神症状组比例高(χ2=4.885,P=0.027),其余各项指标组间比较均无显著性差异。结论:C3、C4水平的降低,IgG、IgA、IgM升高及ANA、APRA、anti-NRNP、anti-dsDNA阳性变化不具有NPLE诊断和预测特异性,是SLE免疫损伤的共有表现;ABA对NPLE的发生及NPLE伴发的精神症状的出现有重要作用。

>=objective:To study the clinical value of anti -ribosomal P protein antibodies to neuropsychiatric lupus erythematosus (NPLE)methods: All 69 sera(35 with NPLE ,34 no neuropsychiatric manifestations of SLE ) and 12 cerebrospinal fluids of NPLE were examined for anti-ribosomal P protein antibodies by ELISA method.Results : Sera anti-ribosomal P protein antibodies 'levels were significantly elevated in patients with SLE , with the sensitivity of 30.43%; and there was significant difference between NPLE(57.14%)...

>=objective:To study the clinical value of anti -ribosomal P protein antibodies to neuropsychiatric lupus erythematosus (NPLE)methods: All 69 sera(35 with NPLE ,34 no neuropsychiatric manifestations of SLE ) and 12 cerebrospinal fluids of NPLE were examined for anti-ribosomal P protein antibodies by ELISA method.Results : Sera anti-ribosomal P protein antibodies 'levels were significantly elevated in patients with SLE , with the sensitivity of 30.43%; and there was significant difference between NPLE(57.14%) and non-NPLE(2.94%) in plasma (P<0.05) . Sera anti-ribosomal P protein antibodies' levels were significantly elevated in NPLE , with acute confusional state or psychiatric disorder had relatively higher levels (66.67%) of anti-ribosomal P protein antibodies than other NPLE(14.29%) , (P<0.05). The SLEDAI of 20 NPLE patients with anti-ribosomal P protein antibodies had significantly higher than 15 NPLE patients with negative in anti-ribosomal P protein antibody (P<0.05). The psychiatric disorder had significant difference between positive patients and negative patients (P<0.05) . CSF anti-ribosomal P protein antibodies were elevated in 12 NPLE, all were negative.Conclusion : Sera anti-ribosomal P protein antibody has high specificity for NPLE , and anti-ribosomal P protein antibodies were associated with diseases activity and psychiatric disorder of NPLE.

目的:探讨抗核糖体P蛋白抗体在神经精神性狼疮中的意义及应用价值。方法:采用 ELISA方法,检测69份血清(包括神经精神性狼疮患者35例,无神经精神症状的狼疮患者34例) 和12份神经精神性狼疮患者的脑脊液中的抗核糖体P蛋白抗体。结果:血清中抗核糖体P蛋白抗体在系统性红斑狼疮患者中的阳性率为30.43%,在神经精神性狼疮患者中的阳性率为57.14%,在无神经精神症状的狼疮患者中的阳性率仅为2.94%,二者在抗体水平和阳性率上存在显著差异(P<0.05)。弥漫性神经精神性狼疮患者抗体阳性率为66.67%,显著高于局灶性神经精神性狼疮患者14.29% (P<0.05)。神经精神性狼疮中20例抗核糖体P蛋白抗体阳性患者疾病活动度(SLEDAI)显著高于 15例阴性患者(P<0.05);阳性患者精神症状(类精神分裂症、抑郁症)出现率明显高于阴性患者 (P<0.05)。12例神经精神行狼疮患者脑脊液中抗核糖体P蛋白抗体均为阴性。结论:血清中抗核糖体P蛋白抗体水平与神经精神性狼疮的精神症状及病情活动度高度相关。

 
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