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   p73蛋白 在 肿瘤学 分类中 的翻译结果: 查询用时:0.082秒
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p蛋白
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  p protein
    The S100P protein expression in pancreatic cancer tissue, cell lines, blood serum.
    S100P蛋白在胰腺癌组织中的表达率高于癌旁组织,在胰腺癌血清的表达率高于慢性胰腺炎。
短句来源
    The results showed when diluted to 1:16000, the prepared polyclonal antibody had better immunoreactivity. It strongly testified the high purification of S100P protein as well as high specificity of polyclonal antibody.
    通过Western blot印迹实验结果显示,在抗S100P的多克隆抗体以1:16000稀释的情况下,免疫印迹显示了相当好的效果,证明了S100P蛋白的高纯度及多克隆抗体的高特异性。
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  “p73蛋白”译为未确定词的双语例句
    6. Western-blot assay for expression change of COX-2 cyclinD cyclinE bcl-1 bax erk erk-p before and after treatment with NS398.
    6.Western一blot实验:观察NS398对PC一3细胞的COX一、cyelinD,、cy-elinE、bel佗、bax、ERK、ERK一p蛋白表达的影响。
短句来源
    Cathepsin E,Maspin,S100P was analyzed with immunohistochemical analysis ,PCR,ELISA ,Western blotting in the specimens obtained by EUS-FNA.
    免疫印迹法检测胰腺癌EUS-FNA活检物中Cathepsin E、Maspin、S100P蛋白含量。
短句来源
    The expression of Cathepsin E (83.3%, p=0.029) 、 Maspin (79.2 %,p=0.023)、 S100P(91.7%,p=0.036)was observed in specimens of EUS-FNA but less in serum in cases with pancreatic carcinoma.
    胰腺癌EUS-FNA活检物中Catheps in E蛋白(p=0.029)、Maspin蛋白(p=0.023)、S100P蛋白(p=0.036)表达的阳性率都明显高于胰腺癌血清。
短句来源
    Polyclonal antibody against S100P was generated by immunizing mice with purified S100P recombinant fusion protein.
    将纯化的S100P蛋白免疫BALB/C小鼠,制备抗S100P蛋白的多克隆抗体;
短句来源
    Western blotting indicated that the antiserum against S100P could bind with the expressed recombinant protein specifically and as well as make a foundation of validate the relationship between S100P and gastric cancer.
    进而通过Western印迹,在验证抗S100P蛋白多克隆抗体特异性的同时,即可为验证S100P基因在蛋白水平上是否与胃癌的发生、进展密切相关提供研究基础。
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  p protein
The possible mechanisms of the formation of the modified ADH-P protein are discussed in connection with the differential activity of genes in the microgametophytes of angiosperms.
      
The immunoblot analysis with RSV-infected and non-infected HEp-2 cells as antigen revealed the expected age-dependent low prevalence of G protein antibodies and clear seroconversion of N and P protein antibodies.
      
Are anti-ribosomal P protein antibodies relevant in systemic lupus erythematosus
      
Cellular expression pattern of the glycine decarboxylase P protein in leaves of an intergeneric hybrid between the C3-C4 interme
      
The densities of NF150D and NF150P protein spots on the Coomassie blue-stained two-dimensional gels of the normal and injured cords also displayed alterations similar to the immunocytochemical data.
      
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Multidrug resistance is the main obstacle in tumor chemotherapy.Among its complex contributing factors,overexpression of PgP membrane protein is a key one. According to this cell mark,we set up ELISA method to detect mdr1 gene level and use antisense oligonucleotides(ASON) to regulate mdr1 expression.The results at present show that with the help of lipofectin,natural ASON can inhibit the expression of mdr1 to a certain extent.

多药抗性现象是肿瘤有效化疗的主要障碍 ,其中 mdr1基因过量表达产生膜蛋白 Pg P是最关键的一种。利用该多药抗性表型标志建立了 ELISA法定量检测 mdr1的表达水平 ,并用反义寡核苷酸对基因的表达进行调控。结果表明天然寡核苷酸在 Lipofectin的介导下能一定程度地抑制 Pg P蛋白的合成

Objective To study the expression of P 53 protein and p-glycoprotein and its relationship in colorectal carcinoma.Methods Thirty one cases with colorectal cancer were subjected to immunohistochemical to obseve the expression of P 53 protein and p-glycoprotein and its relationship.Results The positive expression of P 53 protein was found in 54.8% and the positive expression of p-glycoprotein was found in 51.6% in colorectal carcinoma.It was indicated that the positive expression rate of P ...

Objective To study the expression of P 53 protein and p-glycoprotein and its relationship in colorectal carcinoma.Methods Thirty one cases with colorectal cancer were subjected to immunohistochemical to obseve the expression of P 53 protein and p-glycoprotein and its relationship.Results The positive expression of P 53 protein was found in 54.8% and the positive expression of p-glycoprotein was found in 51.6% in colorectal carcinoma.It was indicated that the positive expression rate of P 53 protein with the positive expression of p-glycoprotein was higher than the positive expression rate of P 53 protein with the negative expression of p-glycoprotein in carcinoma (P< 0.01 ).The expression of P 53 protein and p-glycoprotein was interrelated to each other.Conclusions The result show that the P 53 protein correlated with the multidrug resistance in colorectal colorectal carcinoma.

目的研究大肠癌P53蛋白与P-糖蛋白表达的相互关系及临床意义。方法通过免疫组织化学方法测定31例大肠癌P53蛋白和P-糖蛋白的表达。结果其中P53蛋白表达阳性者54.8%;P-糖蛋白表达阳性者51.6%。P-糖蛋白表达阳性者在P53蛋白表达阳性组比P53蛋白表达阴性组者比率增高(P<0.01)。P蛋白和P-糖蛋白表达间呈正相关。结论大肠癌多药耐药性随P53阳性率增高而增加。

AIM To establish human multidrug resistant hepatocellular carcinoma cell line (7721/Adm) and to study its characteristics. METHODS Using intermittent administration of high dose ADM, human hepatocellular carcinoma cell line (7721) was induced to human multidrug resistant hepatocellular carcinoma cell line (7721/Adm). The multidrug resistance of 7721/Adm to multianticarcinogen was detected by MTT assay, and the distribution of its cell cycle, the expressions of P gp, multidrug resistance associated...

AIM To establish human multidrug resistant hepatocellular carcinoma cell line (7721/Adm) and to study its characteristics. METHODS Using intermittent administration of high dose ADM, human hepatocellular carcinoma cell line (7721) was induced to human multidrug resistant hepatocellular carcinoma cell line (7721/Adm). The multidrug resistance of 7721/Adm to multianticarcinogen was detected by MTT assay, and the distribution of its cell cycle, the expressions of P gp, multidrug resistance associated protein (MRP) and GSH/GST were also detected by flow cytometry. RESULTS ①7721/Adm was resistant to many anti tumor agents. Its IC50 of ADM was 4.65 times higher than that of 7721 and its drug resistance to ADM was 2-6 times higher than that of 7721; ②The multiplication time of 7721/Adm prolonged, and the number of cells in S phase decreased while that in G1 and G2 phase increased; ③The expressions of P gp and MRP were enhanced significantly (94.6% and 69.4% respectively), but the expression of GSH/GST kept stable. CONCLUSION ①We successfully established a multidrug resistant cell line (7721/Adm) which has the basic characteristics of drug resistance cells; ②Compared with that of its parent cell line 7721, IC50 of 7721/Adm increased 4.65 times, and its multiplication time prolonged 4.6 times, drug accumulation decreased remarkably and distribution of its cell cycle changed.

目的 培养建立耐药肝癌细胞模型 - 772 1/ Adm并研究其生物学特性 .方法 应用人肝癌细胞株 - 772 1(以下简称772 1细胞 ) ,采用阿霉素 (Adm )大剂量间歇诱导法 ,建立耐药人肝癌细胞模型 - 772 1/ Adm (以下简称 772 1/ Adm ) .观察该细胞的生长规律 ;用 MTT法鉴定该耐药细胞模型对多种抗癌药物的多药耐药性 ;以流式细胞技术检测该耐药细胞模型细胞周期分布、细胞表面多药耐药基因 (MDR)的表达产物 - P-蛋白 (P- gp)、多药耐药相关蛋白 MRP及谷胱甘肽硫转移系统(GSH/ GST)的表达等 .结果  1经 MTT法鉴定 772 1/ Adm细胞较 HCC- 772 1细胞的阿霉素半数致死浓度 (IC5 0 )增大4.6 5倍 ,并对多种抗癌药物产生耐药性 ,其耐药性提高了 2~6倍不等 ;2耐药细胞倍增时间明显延长 ,S期细胞减少 ,而G2期细胞增多 ;3该耐药模型 P- gp,MRP表达有非常显著的升高 (P<0 .0 1) :P- gp表达为 94.6 % ,MRP表达为 6 9.4% ,而 GSH/ GST的表达无明显变化 (P<0 .0 ...

目的 培养建立耐药肝癌细胞模型 - 772 1/ Adm并研究其生物学特性 .方法 应用人肝癌细胞株 - 772 1(以下简称772 1细胞 ) ,采用阿霉素 (Adm )大剂量间歇诱导法 ,建立耐药人肝癌细胞模型 - 772 1/ Adm (以下简称 772 1/ Adm ) .观察该细胞的生长规律 ;用 MTT法鉴定该耐药细胞模型对多种抗癌药物的多药耐药性 ;以流式细胞技术检测该耐药细胞模型细胞周期分布、细胞表面多药耐药基因 (MDR)的表达产物 - P-蛋白 (P- gp)、多药耐药相关蛋白 MRP及谷胱甘肽硫转移系统(GSH/ GST)的表达等 .结果  1经 MTT法鉴定 772 1/ Adm细胞较 HCC- 772 1细胞的阿霉素半数致死浓度 (IC5 0 )增大4.6 5倍 ,并对多种抗癌药物产生耐药性 ,其耐药性提高了 2~6倍不等 ;2耐药细胞倍增时间明显延长 ,S期细胞减少 ,而G2期细胞增多 ;3该耐药模型 P- gp,MRP表达有非常显著的升高 (P<0 .0 1) :P- gp表达为 94.6 % ,MRP表达为 6 9.4% ,而 GSH/ GST的表达无明显变化 (P<0 .0 5 ) .结论  1HCC-772 1/ Adm是一个明确的多药耐药细胞模型 ;2 772 1/ Adm细胞具有耐药细胞的基本生物学特性

 
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