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dna damage repair genes
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  “dna damage repair genes”译为未确定词的双语例句
     DNA damages of liver cells and expressions of DNA damage repair genes in rats exposed to vinyl chloride monomer
     氯乙烯致大鼠肝细胞DNA损伤与DNA修复基因表达
短句来源
     In 5 mg/L LSPC group, expression level of ERCC1, DNA-PKcs, hMSH2 increased significantly (P < 0.01 ), but MGMT level was not changed. In 10 mg/L and 25 mg/L LSPC groups, all the 4 DNA damage repair genes had no difference compared with ethanol-treated groups (P > 0.05 ).
     5 mg/L的 LSPC可显著增加乙醇处理细胞中ERCC1、DNA-PKcs、hMSH2的表达(P<0.01),但对MGMT的表达无影响(P>0.05), 10、25 mg/L的LSPC与乙醇组比较,所有4种DNA损伤修复酶的表达均无明显改变。
短句来源
     Morerecently there have been few studies done on the association between DNA damageand polymorphisms of DNA damage repair genes;
     接触组进一步根据 DNA 损伤情况分为 DNA 损伤组和对照组。
短句来源
     The differentially expressed genes include the genes related to metabolism enzymes, immune response-related genes, DNA damage repair genes, stress response genes and membrane proteins. Phase I enzyme p450IIC13 and phase II enzymes GSTA2, SULTLE2 were up-regulated. IL1B, HSPB1 were down-regulated.
     诱导I相代谢酶P450IIC13和II相代谢酶GSTA2、SULTLE2和促进DNA修复GADD45A基因表达上调,部分代谢酶、免疫、应激有关基因表达下调。
短句来源
     [ Conclusion ] The mechanism of subchronic triazophos poisoning may be involved in metabolism enzymes, immune response-related genes, DNA damage repair genes, stress response genes and membrane proteins.
     [结论]三唑磷农药亚慢性毒性可能累及代谢酶、免疫、应激和细胞结构成分等方面的变化。
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  相似匹配句对
     DNA damage repair.
     浓度为40 mg/L的HGS能够抑制HL-60细胞DNA损伤后的修复;
短句来源
     Progress in the Recognition and Repair of DNA Damage
     错配核酸识别修复的研究进展
短句来源
     Study of P53 and DNA damage repair
     P53与DNA损伤修复研究
短句来源
     Establishment of thymocytes DNA damage and repair model
     MNNG诱导小鼠胸腺细胞DNA损伤修复模型的建立
短句来源
     Progress of Studies on the DNA Damage Repair and Mutation
     DNA损伤、修复与突变的研究进展
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  dna damage repair genes
Among these genes, 33 are tumor suppressor genes, 100 are proto-oncogenes and 37 are DNA damage repair genes.
      


With the increasing of the incidence rate of breast carcinoma year after y ear,the susceptibility genes of breast carcinoma was paid more and mo re attention.The study on susceptib ility genes play an important role in early diagnosis and prevention for the individuals with family history of brea st carcinoma,elucidation of pathologic mechanism of sporadic breast carcinoma,early di agnosis and adjudging prognosis,re search on drug sensitivity,differe ntial diagnosis of benign and malignant disease,etc.T...

With the increasing of the incidence rate of breast carcinoma year after y ear,the susceptibility genes of breast carcinoma was paid more and mo re attention.The study on susceptib ility genes play an important role in early diagnosis and prevention for the individuals with family history of brea st carcinoma,elucidation of pathologic mechanism of sporadic breast carcinoma,early di agnosis and adjudging prognosis,re search on drug sensitivity,differe ntial diagnosis of benign and malignant disease,etc.T here were many studies on the high-penetrance susceptibility genes(BRCA1,BRCA2).However,some low-penetrance susc eptibility gene,for example,the me mbers of hormone metabolism related enzymes genes CYP family(CYP17,CYP19,CYP1A1,etc.),the carcinogen metabolism related gene(GSTM1,NAT1,NAT2),and DNA damage repair gene(ATM)were not clearly understood.The aim of this study was to review the presen t research situation of common suscep tibility genes of breast carcinoma f ound already.

随着乳腺癌发病率逐年的增加,对乳腺癌的易感基因的研究越来越受到重视。通过乳腺癌易感基因的研究,对有乳腺癌家族史的个体进行早期诊断和预防,对阐明散发性乳腺癌的发病机理、早期诊断和判断预后、药物敏感性、良恶性疾病的鉴别诊断有重要意义。人们对高外显率的乳腺癌易感基因BRCA1、BRCA2等的研究较多,但对一些低外显率的易感基因如参与激素代谢的酶类基因CYP家族成员(CYP17、CYP19、CYP1A1等)参与致癌物代谢的基因(GSTM1、NAT1、NAT2)和DNA损伤修复基因(ATM)等了解较少。本文就目前发现的乳腺癌常见易感基因研究现状作一综述。

The pathogenesis of esophageal cancer has not been clarified yet.What deserves our attention is genetic factors may play a role in the mechanisms of EC.The investigation progress of some related genes including metabolismase genes involved in carcinogen metabolism(CYP,GST,NAT,ALDH2) and DNA damage-repairing genes(XRCC1,MGMT,hOGG1) were introduced in this article so as to discuss the relationship between their polymorphisms and susceptibility to esophageal cancer.

食管癌的发病机制尚未完全阐明,值得关注的是遗传因素在食管癌发生中所起的作用。本文介绍了相关的一些基因的研究进展,包括参与致癌物代谢的相关基因(CYP、GST、NAT、ALDH2 )和参与DNA损伤修复的相关基因(XR CC1、MGMT、hOGG1) ,探讨它们的多态性与食管癌易感性的关系。

Objective: To explore the association between the susceptibility of hepatocellular carcinoma (HCC) and the genetic polymorphism Ser326Cys of DNA repair gene hOGG1. Metholds: Ninety six patients with HCC and ninety six subjects of control group in DNA damage repair gene hOGG1 Ser326Cys polymorphism were genotyped. Results: It was found that the OR of heterozygote Ser/Cys subjects was 1.5 and that of homozygosity Cys/Cys was 1.9. Conclusion: Allele Cys for hOGG1 gene...

Objective: To explore the association between the susceptibility of hepatocellular carcinoma (HCC) and the genetic polymorphism Ser326Cys of DNA repair gene hOGG1. Metholds: Ninety six patients with HCC and ninety six subjects of control group in DNA damage repair gene hOGG1 Ser326Cys polymorphism were genotyped. Results: It was found that the OR of heterozygote Ser/Cys subjects was 1.5 and that of homozygosity Cys/Cys was 1.9. Conclusion: Allele Cys for hOGG1 gene may increase the genetic susceptibility of HCC.

目的:探索DNA损伤修复基因hOGG1的遗传多态Ser326Cys与肝细胞肝癌易感性的关系。方法:对96例原发性肝细胞肝癌患者和96例对照外周血DNA进行测序分型。结果:Ser/Cys杂合子个体的OR值为1.5,Cys/Cys纯合子个体的OR值为1.9,表现出剂量效应。结论:DNA修复基因hOGG1的Cys等位基因可能增加肝细胞肝癌的遗传易感性。

 
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