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   colicin ia 的翻译结果: 查询用时:0.166秒
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colicin ia
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  大肠菌素
     The pheromones can auto-recognize membrane receptor of the identical types of bacteria. We had constructed a fusion protein named Pheromonicin by introducing a staphylococcal pheromone AgrD at the C-terminal of the Colicin Ia.
     丘小庆等利用信息素的自主导向特性和大肠菌素Ia的致死性通道特性构建了由金黄色葡萄球菌信息素AgrD和大肠菌素Ia组成的融合蛋白,命名为Pheromonicin,该蛋白表现出了信息素和大肠菌素Ia都不具有的抗金黄色葡萄球菌活性。
短句来源
     Colicin Ia was demanstrated that forming voltage-dependent ion channel on the target cell membrane result in bacteria death because of leakage of cell content, energe failure.
     大肠菌素Ⅰa属于可形成离子通道的E1族大肠菌素,1978年证实其工作机制是在靶细胞膜上形成电压依赖性离子通道,造成细胞内容物泄漏,能量衰竭,而致细菌死亡。
短句来源
  “colicin ia”译为未确定词的双语例句
     This mode of damage is very efficient, when Colicin Ia
     这种杀伤方式极为有效,当大
短句来源
  相似匹配句对
     This mode of damage is very efficient, when Colicin Ia
     这种杀伤方式极为有效,当大
短句来源
     It ia A.
     A.
短句来源
     funmigatus is the main payhogen of IA.
     烟曲霉为 IA 的常见致病菌。
短句来源
     Colicin Ia was demanstrated that forming voltage-dependent ion channel on the target cell membrane result in bacteria death because of leakage of cell content, energe failure.
     大肠菌素Ⅰa属于可形成离子通道的E1族大肠菌素,1978年证实其工作机制是在靶细胞膜上形成电压依赖性离子通道,造成细胞内容物泄漏,能量衰竭,而致细菌死亡。
短句来源
     Interaction of Colicin E_1 with Lipid Membranes
     毒素蛋白ColicinE_1与磷脂膜的相互作用
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  colicin ia
The selective and extensive 13C labeling of mostly hydrophobic amino acid residues in a 25 kDa membrane protein, the colicin Ia channel domain, is reported.
      
Previous work has shown that Colicin Ia gating is associated with the translocation of a region representing 4 of its alpha helices across the membrane.
      
Both colicin A and colicin Ia belong to a subfamily of the bacterial colicins that act by forming a voltage-dependent channel in the inner membrane of target bacteria.
      
Gating Movements of Colicin A and Colicin Ia Are Different
      
Our results show that the water lumen of the colicin Ia channel has a funnel-like structure with a small trans-entrance, with a diameter of about 1.0 nm, and a large cis-entrance, with a diameter of approximately 1.8 nm.
      
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Objective To construct a targeting bactericidal peptide machine by fusing two minidomains with different bioactivities and different protein origins. Methods Such fusion peptide was constructed by linking the gene of Staphylococcal AgrD pheromone with the gene of C terminal (I626) of colicin Ia pore forming region(K544 I626) with site directed mutation. Mutated plasmid was transformed into E.coli TG1 cells to produce fusion peptide, peptides were purified by CM sepharose ion exchange column....

Objective To construct a targeting bactericidal peptide machine by fusing two minidomains with different bioactivities and different protein origins. Methods Such fusion peptide was constructed by linking the gene of Staphylococcal AgrD pheromone with the gene of C terminal (I626) of colicin Ia pore forming region(K544 I626) with site directed mutation. Mutated plasmid was transformed into E.coli TG1 cells to produce fusion peptide, peptides were purified by CM sepharose ion exchange column. in vitro bactericidal assays were made to identify the bioactivity of fusion peptide. Results Fusion peptide presented a specific bactericidal activity which was over one hundred times as effective as that of penicillin/oxacillin against tested Staphylococcus aureus strains. Conclusion Fusion peptide behaved with a targeting bactericidal activity against Staphylococcus aureus which was lacking at two precursors, Staphylococcal pheromone and colicin Ia pore forming region. These results suggest that an engineered multidomain protein machine with specific bactericidal activity has been constructed in the present study.

目的 将两个不同种来源 ,不同生物活性的蛋白质结构域构建成为一种具有靶向抗菌活性的工程多肽。方法 利用质粒重组 ,将金黄色葡萄球菌 Agr D信息素 (8肽 )基因连接在大肠菌素 Ia水性孔道结构域 (K5 4 4 -I6 2 6 )羧基端基因上 ,将重组的质粒转化入工程菌生产构建的工程多肽 ,离子交换柱纯化后经体外抗菌试验检测其抗菌活性。结果 构建的工程多肽具有强于青霉素类抗生素上百倍的抗耐药金黄色葡萄球菌的活性。结论 构建的工程多肽表现出了两个结构域前体都不具备的靶向抗金黄色葡萄球菌活性 ,从而构建成功了一种具有特异抗菌功能的人造多结构域蛋白质分子机器

 
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