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recombinant fsh
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  重组fsh
     However,compared to urinary FSH,the total dose of FSH was significantly lower with recombinant FSH (P<0.0001) in a significantly shorter treatment period (P<0.01).
     然而,与尿源FSH相比,重组FSH总给药剂量明显减少(P<0.0001),治疗的总时间明显缩短(P<0.01)。
短句来源
     The Use of Recombinant FSH (Follitropin-β Solution) in Assisted Reproductive Techniques
     重组FSH-β注射液在辅助生殖中的应用
短句来源
     3. The recombinant FSH stimulated the growth of Kunming mouse's follicle.
     3.重组FSH对促进昆明小鼠卵泡发育有一定效果,可促进次级卵泡向成熟卵泡的发育;
短句来源
     These results would be the basis of production of recombinant FSH and study of long-acting hormone for the future.
     为重组FSH制剂生产及长效激素的研究奠定了基础。
短句来源
     Conclusions:Recombinant FSH (follitropin-β solution) is efficient and safe among Chinese women in COH for IVF with a lower overall total FSH dose and shorter treatment duration.
     结论:在IVF的控制性促排卵中重组FSHβ注射液的总给药剂量少,治疗时间短,有效而安全。
短句来源
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  基因重组卵泡刺激素
     Methods Comparative analysis of 1049 patients undergoing IVF and ICSI cycles,who receiving urinary FSH(uFSH),highly purified urinary FSH(hpFSH) or recombinant FSH(rFSH) in combination with different GnRH agonist(GnRHa) regimens.
     方法在促性腺激素释放激素激动剂(GnRHa)长或短方案下,分别应用尿卵泡刺激素(uFSH)、高纯度尿卵泡刺激素(hpFSH)和基因重组卵泡刺激素(rFSH)促排卵,回顾性分析1049例实施IVF和ICSI的治疗周期。
短句来源
     Patients receiving urinary FSH(uFSH),highly purified urinary FSH(hpFSH) or recombinant FSH(rFSH) in combination with two different GnRH agonist(GnRHa) regimens(long and stop GnRHa protocols). Main outcome measures:Peak estradiol(E_2) levels,number of gonadotropin ampoules administered,number of mature oocytes recovered,fertilization and pregnancy rates.
     方法对1049例实施IVF或ICSI的不孕患者作回顾性分析,在2种促性腺激素释放激素激动剂(GnRHa)方案下,分别给予尿卵泡刺激素(uFSH)、高纯度尿卵泡刺激素(hpFSH)和基因重组卵泡刺激素(rFSH)促排卵,比较3组雌二醇(E2)峰值水平、FSH剂量、成熟卵母细胞数、受精率和妊娠率。
短句来源
     Conclusion This study demonstrated that a recombinant FSH appeared to be superior than urinary FSH preparations in regard to ovarian response and IVF/ICSI outcome.
     结论本研究说明,在卵巢的反应性和IVF/IC-SI妊娠结局的层面上,基因重组卵泡刺激素较尿卵泡刺激素更显优越性。
短句来源
  “recombinant fsh”译为未确定词的双语例句
     During the IVF cycle,the number of cycle D2 and D6 follicles count were determined by transvaginal color Doppler. Ovarian stimulation was commenced at day 3 with recombinant FSH.
     于治疗周期第2d和第6d行经阴道彩色超声检查,测量CD2-AFC及CD6-AFC,于本周期第2d行GnRH-α短方案超排卵治疗,观察获卵数。
短句来源
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  recombinant fsh
Purpose: to compare the efficacy of recombinant LH supplementation for controlled ovarian stimulation in recombinant FSH and GnRH-agonist protocol.
      
Purpose:: To compare the efficiency and efficacy of two starting doses of recombinant FSH (follitropin-β, Puregon) in women undergoing IVF treatment.
      
Purpose: To determine FSH concentration behavior before and after cetrorelix 0.25 mg administration in the GnRH-antagonist multiple-dose protocol on day 6 of ovarian stimulation with 150-300 IU daily recombinant FSH.
      
Purpose: To compare the efficacy, efficacy and safety of a fixed daily dose of recombinant FSH (Puregon?) of a 100- and 200-IU regimen in Asian women undergoing ovarian stimulation for IVF/ICSI.
      
Purpose: To analyze the relative cost-effectiveness of recombinant FSH (rFSH) and urinary FSH (uFSH) in assisted reproduction techniques (ART).
      
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The pituitary gonadotropin follicle stimulating hormone (FSH) and luteinizing hormone (LH) play important roles in regulating gonad function and are essential for normal reproductive function in mammals. In this paper, by comparing the FSH/LH common α, FSH β and LH β cDNA sequences reported from humans, cattle, sheep, pigs, rats and mice, three pairs of primers were designed and synthesized according to the conserved region. Using these primers, the genes encoding α, FSH β and LH β in...

The pituitary gonadotropin follicle stimulating hormone (FSH) and luteinizing hormone (LH) play important roles in regulating gonad function and are essential for normal reproductive function in mammals. In this paper, by comparing the FSH/LH common α, FSH β and LH β cDNA sequences reported from humans, cattle, sheep, pigs, rats and mice, three pairs of primers were designed and synthesized according to the conserved region. Using these primers, the genes encoding α, FSH β and LH β in Panthera tigris altaica were amplified by reverse transcript polymerase chain reaction (RT PCR) from pituitary total RNA and were cloned, sequenced and submitted to GenBank, with accessions Nos. AF408393, AF540937 and AF540935 respectively. It was revealed that the open reading region (ORF) of subunit α from Panthera tigris altaica was 369 bp encoding a precursor containing a 24 amino acid signal peptide and a 96 amino acid mature peptide. Similarly, the ORF of FSH β was 390 bp encoding a 19 amino acid signal peptide and 110 amino acid mature protein. The ORF of the LH β subunit was 429 bp encoding a 141 amino acid protein which had an additional Leu residue in the 21 amino acid signal peptide sequence compared to other species. The mature protein of the LH β subunit contained 121 amino acids just like those of other species. The predicted primary structure of the three subunits were similar to those of other mammals with conserved cysteines (10 for the α subunit and 12 for the β subunit) and putative N glycosylation sites (2 for the α and FSH β subunits, 1 for the LH β subunit). When nucleotide sequences and deduced amino acids were compared with homologous sequences from available mammals including humans, cattle, sheep, pigs, rats and mice, they displayed a fairly high (64 7%~96 6%) degree of conservation. Among all species compared, pigs exhibited the highest degree of amino acid similarity of 96 6%, 91 5% and 86 6% with Panthera tigris altaica . Sequence alignment indicative of some distinct amino acid diversity, which could be related to the species specific characteristics of gonadotropins, was also found in the Panthera tigris altaica sequence, such as position 39 of the α subunit, 20, 24, 68 and 96 of the FSH β subunit and 27 and 119 of the LH β subunit. Our results not only provide an insight into the characteristics of FSH and LH in Panthera tigris altaica that can make a practical contribution to its conservation, but also lay the foundation for further research towards producing recombinant FSH and LH which could increase the efficiency of artificial breeding technology.

本研究首次从东北虎 (Pantheratigrisaltaica)脑垂体提取总RNA ,利用RT PCR技术扩增出东北虎垂体促性腺激素α亚基、促卵泡激素 (FSH) β亚基和促黄体激素 (LH) β亚基的编码区序列 ,并进行克隆、测序和比较分析。结果表明 ,其α亚基、FSHβ亚基、LHβ亚基基因的开放阅读框分别为 36 3bp、 390bp和 4 2 9bp ,分别编码 12 0、 12 9和 14 2氨基酸的前体蛋白。与已发表的人、牛、绵羊、猪、大鼠、小鼠等物种相应序列比较 ,无论在核苷酸水平 ,还是在氨基酸水平都显示出较高的同源性 (6 4 7%~ 96 6 %) ,其中与猪的同源性最高(86 %~ 96 6 %)。东北虎的基因序列还具有其明显的特异性 ,首次发现LHβ亚基cDNA编码的前体蛋白在信号肽部分比其它物种相应序列多一个亮氨酸残基 (Leu)。

Objective To assess the outcomes of IVF-ET (in vitro fertilization and embryo transfer) and analyze the factors of failure in IVF-ET. Methods The outcomes of 28 patients treated by IVF-ET were retrospectively studied. Controlled ovarian hyperstimulation (COH) was accomplished with long or short GnRH agonist protocols with recombinant FSH or hMG, or with clomiphene (CC) recombinant hMG. The oocytes were fertilized in vitro and cultured. The embryos at cleavage-stage were transferred into uterine...

Objective To assess the outcomes of IVF-ET (in vitro fertilization and embryo transfer) and analyze the factors of failure in IVF-ET. Methods The outcomes of 28 patients treated by IVF-ET were retrospectively studied. Controlled ovarian hyperstimulation (COH) was accomplished with long or short GnRH agonist protocols with recombinant FSH or hMG, or with clomiphene (CC) recombinant hMG. The oocytes were fertilized in vitro and cultured. The embryos at cleavage-stage were transferred into uterine cavity on post-retrieval day 2. The serum or urine HCG was tested in 2 weeks after ET. Embryos were examined in 6 weeks after ET. Results Among the 28 patients, no oocytes was retrieved from 2 patients, so the cycles were cancelled. Only one oocyte was obtained from 1 patient and gamete intra-uterine transfer (GIUT) was carried out. Twenty-five patients obtained more than one embryo for ET. After ET, 9 patients got clinical pregnancy, 2 patients chemical pregnancy, and 14 patients did not get pregnant. The clinical pregnancy rate was 36.0% and chemical rate was 44.0%. Implantation rate (IR) was 16.4%. Fertilization rate (FR), multi-sperm fertilization rate (MSFR), cleavage rate (CR), high quality embryo rate (HER) and average number of ET showed no significant difference between the clinical pregnancy group (CP group) and non-pregnancy group (NP group). However, the serum E_2 levels in clinical pregnancy patients were markedly higher and the ET rate was lower than those in non-pregnancy group. The clinical pregnancy patients retried more oocytes than in non-pregnancy group. The hydrosalpinx, difficulty in transfer, thin endometrium and abnormal-shape uterine only presented in non-pregnancy patients. Conclusion Our results show the infertility treatment with IVF-ET is effective. The failure in IVF-ET may be related to COH protocol,patients' lower or poor response to drugs of controlled ovarian hyperstimulation, empty follicle syndrome, hydrosalpinx, difficulty in transfer, thin endometrium and abnormal-shape uterine.

目的 评价IVF ET治疗不孕症的效果,分析IVF ET失败的相关因素。方法 回顾性分析2 8个IVF治疗周期结局。2 8例不孕症患者接受GnRH a结合FSH hMG或CC结合hMG等药物进行超促排卵后,将卵细胞在体外授精(IVF) ,取卵后2d进行胚胎移植(ET)。ET 2周后测血或尿HCG ,6周后B超监测胚胎情况。结果 2 8例患者中,2例因未取到卵细胞而终止周期,1例仅得到1枚卵进行宫腔内配子移植,其余2 5个周期获得胚胎移植,其中临床妊娠9例,生化妊娠后流产2例,14例未获得妊娠。临床妊娠率为3 6 0 % ,生化妊娠率为44 0 % ,胚胎着床率16 4%。临床妊娠组与未妊娠组(除外生化妊娠和临床妊娠)受精率、卵裂率、高质量胚胎率、平均ET数等无明显差别,但临床妊娠组血清E2 水平明显高于未妊娠组,卵泡生长数和平均获卵数也多于未妊娠组,而胚胎移植率低于未妊娠组。输卵管积液、移植管插入困难、子宫内膜薄、子宫形态异常等情况仅见于非妊娠组。此外,临床妊娠组与非妊娠组在促排卵方案方面存在一定差异。结论 IVF ET治疗不孕症是有效的,IVF ET失败的原因主要与促排卵方案、患者对超排卵药物反应低、空卵...

目的 评价IVF ET治疗不孕症的效果,分析IVF ET失败的相关因素。方法 回顾性分析2 8个IVF治疗周期结局。2 8例不孕症患者接受GnRH a结合FSH hMG或CC结合hMG等药物进行超促排卵后,将卵细胞在体外授精(IVF) ,取卵后2d进行胚胎移植(ET)。ET 2周后测血或尿HCG ,6周后B超监测胚胎情况。结果 2 8例患者中,2例因未取到卵细胞而终止周期,1例仅得到1枚卵进行宫腔内配子移植,其余2 5个周期获得胚胎移植,其中临床妊娠9例,生化妊娠后流产2例,14例未获得妊娠。临床妊娠率为3 6 0 % ,生化妊娠率为44 0 % ,胚胎着床率16 4%。临床妊娠组与未妊娠组(除外生化妊娠和临床妊娠)受精率、卵裂率、高质量胚胎率、平均ET数等无明显差别,但临床妊娠组血清E2 水平明显高于未妊娠组,卵泡生长数和平均获卵数也多于未妊娠组,而胚胎移植率低于未妊娠组。输卵管积液、移植管插入困难、子宫内膜薄、子宫形态异常等情况仅见于非妊娠组。此外,临床妊娠组与非妊娠组在促排卵方案方面存在一定差异。结论 IVF ET治疗不孕症是有效的,IVF ET失败的原因主要与促排卵方案、患者对超排卵药物反应低、空卵泡综合征、输卵管积液、移植困难及子宫内膜或子宫形态异常等有关。

Objective To study the values of cycle day 2 antral follicle count(CD2-AFC) and cycle day 6 antral follicle count(CD6-AFC) on the prediction of poor ovarian response in women with normal basal follicle-stimulating hormone levels in our center undergoing an in vitro fertilization(IVF) or intra cytoplasmic sperm injection(ICSI) cycle with GnRH-α analogue(a short protocol).Methods The retrospective analysis consisted of 72 cycles of 51 patients with an indication for IVF/ICSI.Women older than 35 years old or with...

Objective To study the values of cycle day 2 antral follicle count(CD2-AFC) and cycle day 6 antral follicle count(CD6-AFC) on the prediction of poor ovarian response in women with normal basal follicle-stimulating hormone levels in our center undergoing an in vitro fertilization(IVF) or intra cytoplasmic sperm injection(ICSI) cycle with GnRH-α analogue(a short protocol).Methods The retrospective analysis consisted of 72 cycles of 51 patients with an indication for IVF/ICSI.Women older than 35 years old or with a high (>8 IU/L) basal serum FSH level were not offered IVF/ICSI treatment in the study.During the IVF cycle,the number of cycle D2 and D6 follicles count were determined by transvaginal color Doppler.Ovarian stimulation was commenced at day 3 with recombinant FSH.Ovarian response was evaluated according to the number of mature oocytes retrieved.Women were then divided into two groups with normal response and poor response.Results In treatment cycle of short protocol with GnRH analogue,CD2-AFC and CD6-AFC of patients with poor ovarian response were lower than that of pantients with normal ovarian response.Also CD6-AFC was found a better predictor of poor ovarian response than CD2-AFC.Predition efficiency was strongly elevated through combination of CD2-AFC and CD6-AFC.When a combined CD2-AFC and CD6-AFC evaluation was used with the optium cutoff values of 5 and 8,specificity improved to 89%.Conclusions During a short IVF protocol CD6-AFC is helpful in predicting ovarian response in combination with CD2-AFC.This combination has higher specificity than single predictors.This may help clinicians and women to cancel invalid cycles earlier and decrease the psychological,financial and medical burden of a later cancellation.

目的探讨辅助生殖技术的促性腺激素释放激素激动剂(GnRH-α)短方案超排卵治疗周期中,经阴道超声监测周期第2d窦卵泡计数(cycleday2antralfolliclecount,CD2-AFC)及治疗周期第6d的窦卵泡计数(cycleday6antralfolliclecount,CD6-AFC)对卵巢低反应的预测价值。方法接受体外受精或单精子胞浆内注射助孕治疗的不孕症患者51例共72例次治疗周期,年龄和基础促卵泡激素水平为我中心行体外受精的正常范围。于治疗周期第2d和第6d行经阴道彩色超声检查,测量CD2-AFC及CD6-AFC,于本周期第2d行GnRH-α短方案超排卵治疗,观察获卵数。按Orhan标准根据获卵数目判断卵巢反应性并分卵巢反应正常组和低反应组。结果在GnRH-α短方案超排卵治疗周期中,卵巢反应低下组CD2-AFC、CD6-AFC分别为(4.4±3.2)个、(4.5±3.0)个,均显著低于反应正常组的CD2-AFC、CD6-AFC[分别为(10.0±4.1)和(12.0±5.5)个,P<0.01]。CD6-AFC是一个比CD2-AFC更好的预测卵巢低反应的指标。二者结合可明显提高卵巢低反应预测...

目的探讨辅助生殖技术的促性腺激素释放激素激动剂(GnRH-α)短方案超排卵治疗周期中,经阴道超声监测周期第2d窦卵泡计数(cycleday2antralfolliclecount,CD2-AFC)及治疗周期第6d的窦卵泡计数(cycleday6antralfolliclecount,CD6-AFC)对卵巢低反应的预测价值。方法接受体外受精或单精子胞浆内注射助孕治疗的不孕症患者51例共72例次治疗周期,年龄和基础促卵泡激素水平为我中心行体外受精的正常范围。于治疗周期第2d和第6d行经阴道彩色超声检查,测量CD2-AFC及CD6-AFC,于本周期第2d行GnRH-α短方案超排卵治疗,观察获卵数。按Orhan标准根据获卵数目判断卵巢反应性并分卵巢反应正常组和低反应组。结果在GnRH-α短方案超排卵治疗周期中,卵巢反应低下组CD2-AFC、CD6-AFC分别为(4.4±3.2)个、(4.5±3.0)个,均显著低于反应正常组的CD2-AFC、CD6-AFC[分别为(10.0±4.1)和(12.0±5.5)个,P<0.01]。CD6-AFC是一个比CD2-AFC更好的预测卵巢低反应的指标。二者结合可明显提高卵巢低反应预测的特异性,达89%。结论经阴道彩色超声动态监测CD2-AFC及CD6-AFC可提高GnRH-α短方案超排卵治疗患者卵巢低反应的预测率,有助于指导临床更合理地选择超排卵治疗用药及更早地取消无效超排卵治疗周期。

 
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