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  “genes p 16”译为未确定词的双语例句
     Influence Of Ganoderm applanatum polysaccharide on tumor suppressor genes P16, P27 and Rb in mice
     树舌多糖对小鼠HepA P16 P27 Rb基因表达的影响
短句来源
     Expression and Significance of Suppressor Genes P16 and Rb on Renal Carcinoma
     抑癌基因P16和Rb在肾癌中的表达和意义
短句来源
     Comparison of the effectiveness of eukaryotic expression vectors expressing tumor suppressor genes p16~(INK4a) and p53 in inhibiting leukemic cells proliferation
     抑癌基因p16~(INK4a)与p53抑制白血病细胞株生长作用的比较
短句来源
     Objective: To study expression of product of genes p16 and Rb in non parvicellular lung carcinoma (NPCLC), and relation ship between genes P16 and Rb and cell proliferation. Methods: Using S-P immunohistochemical methods, the expressions of P16\ Rb and PCNA protein in 68 cases of NPCLC were studied ,and the proliferation index(PI) was calculated.
     目的:探讨抑癌基因的P16、Rb基因产物在非小细胞肺癌化S-P法,检测68例NPCLC 患者的手术切除标本的 P16、Rb的表达情况,并进行PCNA检测,计算细胞增殖指数(PI, proliferation index)。
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     We found thattreatment with 2.0μmol/L or 5 μmol/L As2O3 for 24h, 48h and 72h, could obviously induce a G2/M and G0/G1 phase arrest in 786-0 cells, decreased protein expression of cyclinA, B1, D1, E (P <0.05) and increased activities of CDKI genes p16, p21WAF!
     2.0μmol/L以上浓度As2O3作用786-0细胞24h后开始发生细胞凋亡,出现凋亡的形态学改变、DNA片段化和特征性亚二倍体峰(凋亡峰),使786-0细胞内p53活性升高(P<0.05),而bcl-2、c-myc和c-fos基因表达降低(P<0.05)。
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  相似匹配句对
     marker genes;
     外来基因标记 ;
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     RADIOSENSITIVITY AND GENES
     辐射敏感性和基因
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     ? genes were overexpressed in E.
     亚基及其突变体能在E.
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     Flowers, Genes, and Poaceae
     花、基因、禾本科
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     (16) D.
     ⒃马毛虱D.
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  genes p
Comparative analysis of Homo sapiens and Mus musculus cyclin-dependent kinase (CDK) inhibitor genes P16 (MTS1) and P15 (MTS2)
      
Frequent alterations in the expression of tumor suppressor genes p16INK4A and pRb in esophageal squamous cell carcinoma in the I
      
Also frequently lost are the cell cycle control genes p16 and p15.
      
Mutations in coding and regulatory regions, as well as aberrantexpression patterns of several oncogenes (c-myc, ras) andtumor suppressor genes (p16, p15) have been reported.
      
In almost all pancreas cancers at least one alteration will occur out of a combination of K-ras mutations and inactivation of the tumor suppressor genes p16/MTS1/ink4a, p53 and DPC4/Smad4.
      
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This is the first report of cytogenetic study of flag leaf position in common wheat, Triti-cum aestivum L. F1 and F2 analyses by monosomics and telocentrics indicated that 2D chromosome of Chinese Spring carried at least two genes for pendulous flag leaves, ie. P1 on 2DL and P3 on 2DS; gene (s) E for erect flag leaves on the same chromosome of Xiaoyan No. 6. Gene P1 expressed fully, and P2 partially. Relativizing gene E, P1 and P2 were dominant and recessive...

This is the first report of cytogenetic study of flag leaf position in common wheat, Triti-cum aestivum L. F1 and F2 analyses by monosomics and telocentrics indicated that 2D chromosome of Chinese Spring carried at least two genes for pendulous flag leaves, ie. P1 on 2DL and P3 on 2DS; gene (s) E for erect flag leaves on the same chromosome of Xiaoyan No. 6. Gene P1 expressed fully, and P2 partially. Relativizing gene E, P1 and P2 were dominant and recessive respectively, and vice versa. The chromosome manipulation of these genes was also discussed.

本文首次对小麦旗叶姿态进行了比较系统的细胞遗传学研究。单体、端体的F_1及F_2分析表明:中国春2D染色体上至少有两个旗叶下披基因,即位于2DL上的P_1和2DS上的P_2,前者表达能力很强,后者则较弱,与小偃6号旗叶直立基因共存时分别表现为显性和隐性;小偃6号的旗叶直立基因E也位于2D染色体上,同(P_1+P_2)共存时表现为隐性,仅与P_2共存时则表现为显性。文章还就这些基因的染色体操作等进行了讨论。

Allelotype and point mutation of p53 exon 7 were detected in 45 pairs of primary hepatocellular carcinoma (PHC) by restriction fragment length polymorphism (RFLP) and polymerase chain reaction (PCR). Thirty -one gene markers covered 14 chromosomes were used including suppressor genes p53 and RB1. The results showed 19 gene markers covered 8 chromosomes revealed loss of heterozygosity. Six of 28 informative cases showed loss on 6q21 using probe pJCZ30, which had not been reported before. The allele...

Allelotype and point mutation of p53 exon 7 were detected in 45 pairs of primary hepatocellular carcinoma (PHC) by restriction fragment length polymorphism (RFLP) and polymerase chain reaction (PCR). Thirty -one gene markers covered 14 chromosomes were used including suppressor genes p53 and RB1. The results showed 19 gene markers covered 8 chromosomes revealed loss of heterozygosity. Six of 28 informative cases showed loss on 6q21 using probe pJCZ30, which had not been reported before. The allele loss was low frequent on the other chromosomes including p53 and RBI.Fourty-five cases of PHC from areas of low aflatoxin Bl (AFB1) exposure but high risk to HBV were examined for identifying point mutation of p53 exon 7 by PCR and restriction enzyme analysis using Rsa Ⅰ, Msp Ⅰ, Hae Ⅲ site at codon 229, 247 and 249, respectively. Two of 45 cases showed point mutation at codon 247 and 249, respectively. Our results indicated that changes of molecular genetics on PHC is a complex event, and there are multiple steps, and multiple genes are involved in hepatocarcinogenesis. Meanwhile, the results supported the postulated role of AFB1 together with HBV in the generation of specific mutation of the p53 gene provide evidence to suggest that HBV infection alone-or exposure to AFB1 alone do not contribute to these base changes.

作者应用Southern杂交和PCR扩增技术,分析了45例配对的原发性肝癌及其癌旁肝组织的等位基因型和p53第七外显子的突变状况.共应用了位于14对染色体的31个基因标志,结果在8对染色体的19个基因位点出现不同程度的杂合型丢失(LOH),丢失频率3.2%~23.5%.其中第6对染色体的pJCZ30位点的LOH为首次报告.应用PCR扩增后限制性酶切,分析了p53第七外显子的229,247和249三个密码子,结果仅2例癌组织分别在247和249密码子出现点突变.本实验结果表明,原发性肝癌的分子遗传学变化是复杂的,不同原因(HBV,黄曲霉毒素)相关的原发性肝癌,其等位基因的变化和LOH的频率存在差异,特别是p53基因第249密码子的特征性点突变差别显著,说明原发性肝癌的发生是一多基因变化,多步骤的过程.

24 female Goats were superovulated with Gonadotrophins. About 48h after first mating,total 155 ova were recovered from 16 stimulated donors. The ova recovery rate was 79.08%(155/196).The average number of ova produced by per donor was about 12.25%(196/16). Pronuclei or nuclei in atotal of 65 one-celled zygotes and 29 two-four cell stage embryos were visualized under Normarski IC microscope, and microinjected with Human Growth Hormone Gene(p~(SMGHI)/BamHI) respectively. 91 injected zygotes and embryos...

24 female Goats were superovulated with Gonadotrophins. About 48h after first mating,total 155 ova were recovered from 16 stimulated donors. The ova recovery rate was 79.08%(155/196).The average number of ova produced by per donor was about 12.25%(196/16). Pronuclei or nuclei in atotal of 65 one-celled zygotes and 29 two-four cell stage embryos were visualized under Normarski IC microscope, and microinjected with Human Growth Hormone Gene(p~(SMGHI)/BamHI) respectively. 91 injected zygotes and embryos were transferred surgically into 14 synchronized recipients. After embryotransfer, 7 recipients became pregnant, and total 12 lambs were born, 11 alive and one dead at parturition.The frequency of hGH integration was examinated by using DNA probes labeled with NonradioactiveDigoxigenin. Results showed that 4 in 12 tested lambs carried the foreign genes, the integration frequencywas 33.33%(4/12). Gene expression in 4 living lambs (2 hGH gene integration positive, 2 negative) wasdetected by ELISA, and no one exprcsscd humane Growth Hormone in plasma.

对24头供体山羊进行超数排卵处理,16头超排有效。在第1次配种后48h左右取卵,共收集到卵155个。回收率79.08%(155/16)。平均每头供体排卵12.25个(196/16)。在Normarski干涉相差显微镜下观察65个单细胞受精卵及29个2~4细胞期胚胎的原核及细胞核,并分别注射人生长激素基因(p~(SMGHI)/BamHI),其中91枚移植到经同期发情处理的14头受体中。结果7头妊娠,共产活羔11头,死胎1头。经用Digoxigcnin标记核酸探针对转移基因羊检测,4头整合了外源基因。整合频率为33.33%(4/12)。采用酶联免疫吸附法(ELISA)对仍存活的2头未整合、2头整合羊检测是否表达外源基因,全为阴性。

 
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