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   genes p 16 在 肿瘤学 分类中 的翻译结果: 查询用时:0.176秒
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  “genes p 16”译为未确定词的双语例句
    The Protein Overexpression of the Tumor Suppressor Gene p53 and Prognosis in Lung Cancer Patients Surgically Treated
    抑癌基因p53蛋白表达与肺癌预后的关系
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    Study on Tumor Suppressor Gene p53 and Its Antagonist Oncogene MDM2 in Acute Leukemia
    肿瘤抑制基因p53及其拮抗基因mdm2在急性白血病发病机制中作用的研究
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    EXPRESSION OF ras ONC0GENE p21 IN PROSTATE CANCER
    ras癌基因p21在前列腺癌中的表现
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    Immunohistochemical study on expression of tumor suppressor gene P_53 protein in the precancerous lesions of human esophagus
    食管癌前病变的肿瘤抑制基因蛋白P_(53)的免疫组化研究
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    Studies of the point mutation of ras oncogene and suppressor gene P~(53) in43 cases of hepatocellular carcinoma
    原发性肝癌组织癌基因ras和抑癌基因P~(53)点突变研究
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  genes p
Comparative analysis of Homo sapiens and Mus musculus cyclin-dependent kinase (CDK) inhibitor genes P16 (MTS1) and P15 (MTS2)
      
Frequent alterations in the expression of tumor suppressor genes p16INK4A and pRb in esophageal squamous cell carcinoma in the I
      
Also frequently lost are the cell cycle control genes p16 and p15.
      
Mutations in coding and regulatory regions, as well as aberrantexpression patterns of several oncogenes (c-myc, ras) andtumor suppressor genes (p16, p15) have been reported.
      
In almost all pancreas cancers at least one alteration will occur out of a combination of K-ras mutations and inactivation of the tumor suppressor genes p16/MTS1/ink4a, p53 and DPC4/Smad4.
      
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The point mutation of ras oncogenes and suprressor gene P~(53) were studied in 43 formalin-fixed and paraffin embedded specimens of primary hepatocellular carcinoma with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). It was found that the overall rate of the point mutation of ras genes was 41.9% (18/43). Mutation at codon 12 of N-ras and codon 12 of c-Ki-ras were identifiedin 37.2%(16/43) and 6.9%(3/43)of cases but no mutation could be detected at codon 13 of c-Ki-ras...

The point mutation of ras oncogenes and suprressor gene P~(53) were studied in 43 formalin-fixed and paraffin embedded specimens of primary hepatocellular carcinoma with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). It was found that the overall rate of the point mutation of ras genes was 41.9% (18/43). Mutation at codon 12 of N-ras and codon 12 of c-Ki-ras were identifiedin 37.2%(16/43) and 6.9%(3/43)of cases but no mutation could be detected at codon 13 of c-Ki-ras and codon 12 and 61 of c-Ha-ras. Mutation at codon 249 of P ̄(53)was found in 20.9%(9/43)of cases but none at codon 248.These findings suggest that the point mutation at codon 12 of N-ras and codon 249 of P ̄(53) is common in hepatocellular carcinoma.

应用多聚酶链延伸反应──限制性片段长度多态性分析法(PCR-RFLP)对43例福尔马林固定、石蜡包埋肝癌组织癌基因ras和抑癌基因P~(53)点突变进行分析。结果表明,ras基因总突变率为41.9(18/43),其中N-ras第12位密码子突变率为37.2%(16/43),c-Ki-ras第12位密码子突变率为6.9%(3/43),c-Ki-ras第13位、c-Ha-ras第12和61位密码子未发现有突变者。P~(53)基因第249密码子突变率为20.9%(9/43),第248密码子未发现有突变者。结果提示N-ras第12密码子和P~(53)第249密码子突变参与了肝癌的发生和发展

PCR direct sequencing is a method which com-bined PCR amplification with nucleic acid se-quencing technique. According to this tech-nique, direct sequencing DNA strand of PCRamplification using PCR primer, a- ̄(35) S dATPand Taq DNA polymerase. The experimentshowed that it is simple, rapid and stable.This method was used to analvze the tumorsuppressor gene p53 mutation in humanesophageal eancer. It was found that therewere point mutation.insertion and deletionframeshift mutation of p53 gene...

PCR direct sequencing is a method which com-bined PCR amplification with nucleic acid se-quencing technique. According to this tech-nique, direct sequencing DNA strand of PCRamplification using PCR primer, a- ̄(35) S dATPand Taq DNA polymerase. The experimentshowed that it is simple, rapid and stable.This method was used to analvze the tumorsuppressor gene p53 mutation in humanesophageal eancer. It was found that therewere point mutation.insertion and deletionframeshift mutation of p53 gene in humanesophageal cancer. Intron 5 and 8 sequences of p53 gene in human and Rhesus monkey weresequenced and in monkey they are 81 and 92nucleotides respectively.

PCR直接测序技术是PCR扩增与核酸测序技术相结合的一种方法。根据此技术的原理,建立了一种以PCR扩增引物为测序引物,α ̄(-35)SdATP直接掺入,TaqDNA聚合酶直接测序PCR扩增产物的方法。实验表明:该方法简便、快速、稳定。用此方法对人食管癌组织中的抗癌基因p53进行了突变测序分析,发现食管癌组织中p53存在点突变,插入、丢失移码突变。并用此方法对人和恒河猴的p53内含子序列进行了测定,发现猴第5内含子为81个核苷酸,第8内含子为92个核苷酸。

With nucleic acid in situ hybridization and immunohistochemical methods, the p53 gene fragment and its protein expression were determined.In 13 cases of bladder tumor showing positive results with in situ hybridization, the expression of the P53 protein is detected in 53.9%. The results suggested that in about 50%of bladder cancers, mutation of the suppressor gene P53 was associated with carcinogenesis. No positive correlation between the pathologic grading and clinical staging with the...

With nucleic acid in situ hybridization and immunohistochemical methods, the p53 gene fragment and its protein expression were determined.In 13 cases of bladder tumor showing positive results with in situ hybridization, the expression of the P53 protein is detected in 53.9%. The results suggested that in about 50%of bladder cancers, mutation of the suppressor gene P53 was associated with carcinogenesis. No positive correlation between the pathologic grading and clinical staging with the expression of the protein has been noted.

以光敏生物素-金标链亲和素核酸原位杂交及免疫组化方法检测膀胱癌病理标本中P53基因片段及其蛋白表达。13例原位杂交阳性膀胱癌中,P53蛋白表达阳性率53.9%,提示约半数膀胱癌的发生可能与P53基因突变有关;P53蛋白表达与病理分级、临床分期无明显关系。

 
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