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endothelin- et
相关语句
  相似匹配句对
     RADIOIMMUNOASSAY OF ENDOTHELIN
     内皮素的放射免疫分析
短句来源
     Changes in endothelin
     大鼠多脏器功能失常综合征肝细胞中内皮素1与糖原含量变化的观察
短句来源
     endothelin (ET) group;
     (5 )内皮素 (ET)灌注组 (n=7) ;
短句来源
     DETERMINATIONS OF ENDOTHELIN IN NORMAL PREGNANCY
     正常妊娠中内皮素的测定
短句来源
     The Roles of Endothelin in Proliferative Vitreoretinopathy
     内皮素在增生性玻璃体视网膜病变中作用的研究
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Concentrations of plasma endothelin(ET) were measured by radioimmuno-assay in 10 cases of primary hypertension and 19 oases of uremia resulting from various kidney diseases and compared with those in 87 normal humans, The concentrations of plasma ET in the normal controls were 45.5±17.6pg/ml. No significant difference in ET concentrations could be found among various age groups. Compared with the controls, the values of ET in patients with primary hypertension and uremia were slightly...

Concentrations of plasma endothelin(ET) were measured by radioimmuno-assay in 10 cases of primary hypertension and 19 oases of uremia resulting from various kidney diseases and compared with those in 87 normal humans, The concentrations of plasma ET in the normal controls were 45.5±17.6pg/ml. No significant difference in ET concentrations could be found among various age groups. Compared with the controls, the values of ET in patients with primary hypertension and uremia were slightly and markedly increased respectively (P<0.01). These results suggest that the plasma ET level is constant in normal children and adults. The pathegenesis of primary hypertension may be related to ET. High plasma ET levels may result in further damage to renal function in patients with uremia.

放射免疫方法检测10例原发性高血压和19例各种肾脏病所致尿毒症患者血浆内皮素(ET)浓度,与87例正常人值相比。正常对照组血浆ET浓度为45.5:k17.6Pg/ml;不同年龄正常人血浆ET值无差别。与对照组相比,原发性高血压与尿毒症患者血浆ET值分别呈中度和明显升高(P均<0.01)。结果表明正常儿童至成人血浆ET水平较为恒定;提示血浆ET值与原发性高血压发病有一定关系,尿毒症患者血浆ET值升高可加重肾功能损害。

On the hypoxic perfusion model of in situ rat liver, we observed that 10~(-8) mol/L endothelin (ET)exerted a severe vasoconstrictor effect on the portal venous vasculature and significantly augmented thetissue hypoxic damage: augmentation of liver edema, increased production of lipid peroxidation productand leakage of lysosomal enzyme. When 10~(-8) mol/L calcitonin gene-related peptide (CGRP) was addedtogher with ET to the perfusion fluid, it effectively antagonized the damaging effect of ET...

On the hypoxic perfusion model of in situ rat liver, we observed that 10~(-8) mol/L endothelin (ET)exerted a severe vasoconstrictor effect on the portal venous vasculature and significantly augmented thetissue hypoxic damage: augmentation of liver edema, increased production of lipid peroxidation productand leakage of lysosomal enzyme. When 10~(-8) mol/L calcitonin gene-related peptide (CGRP) was addedtogher with ET to the perfusion fluid, it effectively antagonized the damaging effect of ET on thehypoxic liver. The possible pathophysiologic significance of ET and CGRP on hypoxia or anoxia as apathologic process is discussed.

本实验在大鼠肝脏原位缺氧灌流模型上,发现10~(-8)mol/L内皮素(ET)灌流,不仅强烈收缩门静脉血管,而且明显加重组织缺氧损伤:加重肝脏水肿、增加组织脂质过氧化物生成和溶酶体酶漏出。应用10~(-8)mol/L降钙素基因相关肽(CGRP)与ET同时灌流,有效地拮抗了ET对缺氧肝脏的损伤作用。

Endothelin(ET) is known as a most potent constrictor of blood vessel. The molecular structure of ET is similar to sarafotoxin S6b. In present study we examined the effects of ET on blood vessels and heart in rats in vitro and vivo and the effect of ET on regional cerebral blood flow (rCBF) in rabbits. Our results show that in vitro ET(10mol/L) strongly constricted all arteries we used including basal cerebral artery, coronary artery and femoral artery which were isolated from...

Endothelin(ET) is known as a most potent constrictor of blood vessel. The molecular structure of ET is similar to sarafotoxin S6b. In present study we examined the effects of ET on blood vessels and heart in rats in vitro and vivo and the effect of ET on regional cerebral blood flow (rCBF) in rabbits. Our results show that in vitro ET(10mol/L) strongly constricted all arteries we used including basal cerebral artery, coronary artery and femoral artery which were isolated from human. The effect of ET was more than 1000 times as strong as noradrenaline and serotonin and much stronger than CCK. The contractile effect of ET lasted more than 2 hours and the effect could be attenuated by CGRP and BNP. The administration of ET at a dose no less than 110pg through the internal carotid artery induced a decline of rCBF in rabbits, The effect was dose-dependent. The intravenous injection of ET(32μg/kg) elicited various ECG abnormalities from T wave change to ventricular arrest and a decline of blood pressure in rats. The cardiac-toxicity caused by ET could be prevented by the administration of CGRP (46μg) or Sodium Nitroprusside (1mg/kg). However, the cardiac-toxicity caused by isoadrenalin could not be prevented by CGRP, it indicated that the cardiac-toxisity of ET is a result of vasoconstriction of ET on coronary arteries. We also found that the intracerebroventricular injection of ET (5ng, 10μl) elevated plasma aldosterone in rats. In vitro, the perfusion experiment showed that ET inhibited vasopresin secretion from hypothalamus. We conclude that ET plays a most important role in regulation of blood pressure and blood flow.

内皮素(endothelin,ET)是两年前才发现的一种强有力的缩血管物质。我们通过离体血管收缩试验观察到,猪内皮素(pET)对人和大鼠的多种血管都有强烈的收缩作用。这种作用较5-羟色胺、去甲肾上腺素、神经肽Y等多种缩血管物质明显而持久,给大鼠注射ET,血压明显升高。家兔实验表明,少至110pg的ET注入颈内动脉即可使脑血流量减少。11ng的ET可以使脑血流量减少80%。局部脑血流量减少的程度和ET剂量相关。给大鼠静脉内注射大剂量ET(32μg/kg),心电图显示心肌缺血、传导阻滞和心脏停搏,大鼠几分钟内死亡。ET的这种心脏毒性可被早期应用降钙素基因相关肽(CGRP)或硝普钠(SNP)所防止。表明ET的心脏毒性可能是通过引起冠状动脉强烈而持久的收缩所致。ET可使血浆醛固酮升高,但抑制下丘脑分泌加压素(AVP)。因此,ET是一个极为重要的血压和血流的调节因子。

 
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