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characteristics of inhibition
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  “characteristics of inhibition”译为未确定词的双语例句
     Isolation and Culture of Lactobacillus from Human by Characteristics of Inhibition on Helicobacter Pylori in Vitro
     体外抑制幽门螺杆菌的人源乳酸杆菌的选育
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     The results show that the growth of Arabidopsis thaliana cells in vitro was significantly inhibited with Hygromycin B,and different effects and characteristics of inhibition were presented among different culture stages,especially between liquid and solid culture.
     结果表明:潮霉素对拟南芥悬浮细胞生长、愈伤组织诱导及其生长均有极明显的抑制作用,但作用效果和特性均有所不同;
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  相似匹配句对
     And the characteristics of the G.
     通过仿真和实验,也验证了G.
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     characteristics;
     三、发展的特点;
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     The characteristics of G.
     论文首先对语音编码的各种方案进行了比较,并对G.
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     Inhibition
     抑制
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     The Neuropsychological Characteristics of Selective Inhibition in Children with ADHD
     注意缺陷障碍患儿选择性抑制的神经心理特征
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  characteristics of inhibition
Characteristics of inhibition in receptive fields of the cat visual cortex
      
Characteristics of inhibition in the kitten sensory-motor cortex
      
On comparison of the amplitude-temporal characteristics of inhibition of evoked potentials during electrical stimulation of the above-mentioned structures by a current of twice the threshold strength, no significant differences were found.
      
Characteristics of inhibition of gastric electrolyte secretion by insulin
      
Cromolyn sodium did not elevate intracellular cAMP, nor did the characteristics of inhibition resemble those observed using cAMP to inhibit agonist stimulation.
      


ZHI MU (知母 Anemarrhena asphodeloides Bge) is a Chinese herb used as an antipyretic agent in traditional Chinese medicine. It is more effective for the patients with "internal heat" (内热)due to deficiency of YIN(阴). Sarsa-sapogenin, an effective component extracted from ZHI MU, has been demonstrated to be an inhibitor of Na+, K+-ATPase.The mechanism of its antipyretic action was investigated. And the characteristics of inhibition of the sodium-potassium pump by sarsa-sapogenin in human red cells were studied.The...

ZHI MU (知母 Anemarrhena asphodeloides Bge) is a Chinese herb used as an antipyretic agent in traditional Chinese medicine. It is more effective for the patients with "internal heat" (内热)due to deficiency of YIN(阴). Sarsa-sapogenin, an effective component extracted from ZHI MU, has been demonstrated to be an inhibitor of Na+, K+-ATPase.The mechanism of its antipyretic action was investigated. And the characteristics of inhibition of the sodium-potassium pump by sarsa-sapogenin in human red cells were studied.The results indicated that sarsa-sapogenin can inhibit the sodium-potassium pump or Na+, K+-ATPase of human red cells, and SHENQ DI (生地 Radix Rehmanniae) catalpol can also inhibit the sodium-potassium pump in human red cells. The results suggested that the effects of reducing intense internal heat of antipyretics may be related to the inhibition of the sodium-potassium pump.The effect of sarsa-sapogenin inhibition on the sodium-potassium pump in human red cells is reversible and stable. The development of sarsa-sapogenin inhibition on the sodium-potassium pump is slow. Its inhibition is favored by external sodium and is antagonized by external rubidium. Sarsa-sapogenin is a mixed inhibitor to external rubidium in human red cells.The studies of sarsa-sapogenin incorporating into the regealed ghosts suggested that the acting site of its inhibition on the sodium-potassium pump in human red cells may be at the outside of the cell membrane.

我们对中药清热药(知母、生地)的作用机理和知母的有效成分菝葜皂甙元抑制人红细胞钠、钾泵的特性进行了研究。结果表明菝葜皂甙元和生地梓醇对人红细胞钠、钾泵具有显著的抑制作用,提示清热药的清热作用可能与钠、钾泵被抑制有关。 菝葜皂甙元对人红细胞钠、钾泵的抑制作用是可逆的,抑制作用的发生是比较缓慢的,并可被细胞外Na~+所增强,而被细胞外K~+所拮抗。菝葜皂甙元对红细胞摄取Rb~+的抑制属混合性抑制。菝葜皂甙元掺入重新封闭的人红细胞影泡的研究,提示菝葜皂甙元抑制红细胞钠、钾泵的作用部位可能在细胞膜的外侧面。

Fatty acid synthase (FAS) is reported as a potential new therapeutic target for obesity. However, there are limited known FAS inhibitors presently. It is shown that extract of Chinese medicine tuber fleeceflower root (TFR) inhibited FAS activity by both strong reversible fast binding and irreversible slow binding inhibitions. 40% ethanol was the optimal solvent for extraction. Half inhibition concentration( IC 50 ) of TFR to FAS overall reaction was 0.005 mg/ml calculated on the basis of TFR weight...

Fatty acid synthase (FAS) is reported as a potential new therapeutic target for obesity. However, there are limited known FAS inhibitors presently. It is shown that extract of Chinese medicine tuber fleeceflower root (TFR) inhibited FAS activity by both strong reversible fast binding and irreversible slow binding inhibitions. 40% ethanol was the optimal solvent for extraction. Half inhibition concentration( IC 50 ) of TFR to FAS overall reaction was 0.005 mg/ml calculated on the basis of TFR weight in the extraction. The time course of irreversible inhibition by TFR extract was biphasic. In the presence of 0.46 mg/ml of TFR the inhibition in fast phase led to over 50% activity loss which was completed within 30 s while the slow phase inactivation led to 90% activity loss within 32 min. TFR extract strongly inhibited ketoacyl reduction of FAS with 0.018 mg/ml of IC 50 , and weakly inhibited enoyl reduction. The assay of inhibition kinetics showed that the inhibition to FAS by extract of TFR was non competitive against substrate NADPH, nearly competitive against malonyl CoA and un competitive against acetyl CoA. It was speculated that an inhibitor in TFR reacted on malonyl thansacylase of FAS. Treatment of TFR extract by oral incubation reduced body weight and food intake of rats significantly. The FAS activity in livers of the tested group rats was lower than that of the control rats at the end of the animal test. These results showed that FAS inhibitor in TFR had a stronger inhibition ability than the known inhibitors. Its characteristics of inhibition kinetics were much different from the known inhibitors. It is expected to be a new effective FAS inhibitor, and may be of great value for the study of FAS mechanism and the control of obesity.

最新报道脂肪酸合酶 (FAS)是治疗肥胖症的潜在靶部位 ,但目前已知的FAS抑制剂还很少 .测定表明 ,中药何首乌提取物对FAS同时具有很强的快结合可逆抑制和慢结合不可逆抑制作用 .萃取的最佳溶剂为 4 0 %乙醇水溶液 .该提取物对FAS全反应的半抑制浓度为 0 .0 0 5mg ml(以萃取时中药重量计 ) ;不可逆抑制过程为两相 ,在 0 4 6mg ml浓度下在 0 5min内快相失活超过 5 0 % ,慢相在 32min时失活达 90 % .该提取物对FAS中的酮酰还原反应有强抑制 ,半抑制浓度为 0 0 18mg ml,对烯酰还原反应有弱抑制作用 .抑制动力学分析表明 ,何首乌提取物对FAS的抑制和底物NADPH之间呈非竞争性关系 ,和丙二酰辅酶A接近竞争性关系 ,而与乙酰辅酶A为反竞争性关系 .推测何首乌还含有作用于FAS中的丙二酰转酰酶的抑制剂 .用何首乌提取物口服饲喂大鼠 ,可明显减低大鼠摄食量和降低大鼠体重 ;实验结束时实验组大鼠肝脏FAS活性低于对照组 .以上结果表明 ,中药何首乌提取物对FAS有很强的抑制作用 ,其抑制能力明显强于已知抑制剂 ,其动力学表现也和已知抑制剂完全不同 ...

最新报道脂肪酸合酶 (FAS)是治疗肥胖症的潜在靶部位 ,但目前已知的FAS抑制剂还很少 .测定表明 ,中药何首乌提取物对FAS同时具有很强的快结合可逆抑制和慢结合不可逆抑制作用 .萃取的最佳溶剂为 4 0 %乙醇水溶液 .该提取物对FAS全反应的半抑制浓度为 0 .0 0 5mg ml(以萃取时中药重量计 ) ;不可逆抑制过程为两相 ,在 0 4 6mg ml浓度下在 0 5min内快相失活超过 5 0 % ,慢相在 32min时失活达 90 % .该提取物对FAS中的酮酰还原反应有强抑制 ,半抑制浓度为 0 0 18mg ml,对烯酰还原反应有弱抑制作用 .抑制动力学分析表明 ,何首乌提取物对FAS的抑制和底物NADPH之间呈非竞争性关系 ,和丙二酰辅酶A接近竞争性关系 ,而与乙酰辅酶A为反竞争性关系 .推测何首乌还含有作用于FAS中的丙二酰转酰酶的抑制剂 .用何首乌提取物口服饲喂大鼠 ,可明显减低大鼠摄食量和降低大鼠体重 ;实验结束时实验组大鼠肝脏FAS活性低于对照组 .以上结果表明 ,中药何首乌提取物对FAS有很强的抑制作用 ,其抑制能力明显强于已知抑制剂 ,其动力学表现也和已知抑制剂完全不同 ,预计为新的抑制剂 ,对研究FAS的作用机理及在防治肥胖症的应用上可能具有重要的价值

Objective:For development of drugs for the treatment or preention of arterial thrombosis.Methods:The single chain antibody with high affinity to vWF-A1 was screened with phage display technology;and high-level expression vector(pET20b-ScFv) was constructed,then was transformed into E.coli (DE3),and induced by IPTG.Sandwich ELISA was applied to identification of the ScFv binding to antigens.Ristocetin-induced platelet aggregation assay was adopted to detect the inhibitory effect of the ScFv on RIPA.Results:High...

Objective:For development of drugs for the treatment or preention of arterial thrombosis.Methods:The single chain antibody with high affinity to vWF-A1 was screened with phage display technology;and high-level expression vector(pET20b-ScFv) was constructed,then was transformed into E.coli (DE3),and induced by IPTG.Sandwich ELISA was applied to identification of the ScFv binding to antigens.Ristocetin-induced platelet aggregation assay was adopted to detect the inhibitory effect of the ScFv on RIPA.Results:High level ScFv was expressed in DE3,the target protein amounted to 41% of total protein,the yield of ScFv was 850 mg/L.The resulting protein was refolded by dialysis.The ScFv specially reacted with vWF,rvWF-A1,rvWF-A1/A3,not with rvWF-A3,BSA,meanwhile,it inhibited with an IC 50 of 0.83 μmol/L,its maximal inhibiting rate was 73.7%.Conclusion:Our data suggest that the single chain antinody with high affinity to vWF-A1 possess characteristic of inhibition of RIPA,and it could be a new agent for the treatment or prevention of arterial thrombosis.

目的:为了研制新型特异性抗血栓制剂。方法:利用噬菌体展示文库技术筛选与vWF- A1区有高亲合力单链抗体(ScFv) ;基因重组的方法构建高效表达载体pET 2 0b(+) ScFv ,在大肠杆菌中诱导表达;夹心ELISA方法鉴定此单抗的抗原结合活性;瑞斯脱霉素诱导的血小板聚集试验(RIPA)测定ScFv对血小板聚集的抑制作用。结果:噬菌体展示技术筛选的ScFv在大肠杆菌中成功地诱导表达,表达的ScFv占菌体总蛋白的4 1% ,以包涵体形式存在;经纯化复性的ScFv可以与vWF、rvWF- A1、rvWF- A1 A3结合,但不与rvWF A3、BSA反应;ScFv具有抑制RIPA功能,抑制率为73. 7%。结论:在大肠杆菌中高效表达的噬菌体展示技术筛选的抗vWF A1区ScFv可特异性与vWF- A1区结合,而抑制瑞斯脱霉素诱导的血小板聚集,显示出很好的应用前景,为研制新型抗栓药物奠定基础。

 
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