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ornidazole capsule
相关语句
  奥硝唑胶囊
     L-1, respectively. There were nosignificant difference between the two formulations (P>0.05). The relativebioavailability of ornidazole capsule was l03.52%±6.59%.
     国产奥硝唑胶囊的相对生物利用度为 103.52%±6.59%,两种制剂主要药代动力学参数均无显著性差异(P>0.05)。
短句来源
     Methods:150 cases of BV were randomly divided into three groups and treated with oral ornidazole capsule(group A),lactobacillus capsule for vagina(group B) and combined administration(group C) respectively. The cost-effectiveness of three strategies was analyzed and evaluated by pharmacoeconomics.
     方法:将150例患者随机分成3组,分别口服奥硝唑胶囊(A组)、阴道内用乳杆菌活菌胶囊(B组)以及两药联用(C组)治疗BV,并运用药物经济学成本及成本-效果分析法进行评价。
短句来源
     Investigation of Curative Effect of Ornidazole Capsule on Trichomonas Vaginitis
     奥硝唑胶囊治疗滴虫性阴道炎疗效观察
短句来源
     Results:The healing rates of Ornidazole Capsule treated groups (B and C groups) were 100% and 95% respectively on re-examination one month later. It is indicated that Ornidazole Capsule therapy superior to metronidazole therapy.
     结果 :奥硝唑胶囊治疗组即甲、乙两组一月后复查痊愈率分别为 1 0 0 %、 95 % ,疗效明显优于甲硝唑组 (P <0 0 5)。
短句来源
     Methods:Controlled stud ies were carried out on the cases of trichomona vaginitis with three different t herapys of metronidazole in a dose of 7-days(A group),Ornidazole Capsule in sin gle dose(B group) and Ornidazole Capsule in a dose of 5-days (C group).
     方法 :采用口服奥硝唑胶囊单剂量治疗法、奥硝唑胶囊 5日治疗法、甲硝唑 7日治疗法进行对照观察。
短句来源
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  相似匹配句对
     Investigation of Curative Effect of Ornidazole Capsule on Trichomonas Vaginitis
     奥硝唑胶囊治疗滴虫性阴道炎疗效观察
短句来源
     . and Ranjianduoji capsule.
     1、本草考证与文献考查
短句来源
     Preparation of Ornidazole
     奥硝唑的合成
短句来源
     Study on Jiangzhiyikang Capsule
     降脂益康胶囊的研究
短句来源
     Conclusion:Ornidazole Capsule is probably recommended to be the dru g of first choice for curing the cases of trichomana vaginitis.
     结论 :奥硝唑胶囊可以作为治疗滴虫性阴道炎的首选药物之一 ,值得推广应用
短句来源
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OBJECTIVE:To study the pharmacokinetic profiles and bioequivalenceof ornidazole in healthy volunteers. METHODS: l.5g single oral dose of domesticornidazole capsules and imported ornidazole tablets were given to l8 healthyvolunteers in an open randomized crossover. Ornidazole concentrations in plasmawere determined by HPLC method. The pharmacokinetic parameters as well asrelative bioavailability were measured. RESULTS: The concentration-time curves ofcapsules and tablets ornidazole...

OBJECTIVE:To study the pharmacokinetic profiles and bioequivalenceof ornidazole in healthy volunteers. METHODS: l.5g single oral dose of domesticornidazole capsules and imported ornidazole tablets were given to l8 healthyvolunteers in an open randomized crossover. Ornidazole concentrations in plasmawere determined by HPLC method. The pharmacokinetic parameters as well asrelative bioavailability were measured. RESULTS: The concentration-time curves ofcapsules and tablets ornidazole were conformed to a two-compartment model witha lag time. The pharmacokinetic parameters of capsules and tablets ornidazole wereas follows:t(1/2)(β),were l6.08±2.32h and l5.85±2.26h;Tmax were l.75±0.49h andl.75±0.48h;Cmax were 2l.94±3.3lmg.L-1 and 22.58±5.94 mg.L-1;AUC0~∞ were 456.22±446.50±55.l4mg.h.L-1 and 433.3l±58.52 mg.h.L-1;AUC0~∞co were 465.22±56.73mg.h.L-1and 45l .67±57.97mg.h.L-1, respectively. There were nosignificant difference between the two formulations (P>0.05). The relativebioavailability of ornidazole capsule was l03.52%±6.59%. CONCLUSION: Theresult of the statistical analysis showed that the two formulations werebioequivalent.

目的:研究国产奥硝唑胶囊在人体内的药代动力学参数和生物等效性。方法:18名健康男性志愿者随机交叉口服国产奥硝唑胶囊1.5g和进口奥硝唑片1.5g,采用HPLC法测定给药后不同时间点血浆奥硝唑的浓度,评价两种制剂的生物等效性。结果:两种制剂的血药浓度曲线均符合二室模型,主要药代动力学参数:t(1/2)(β)分别为16.08±2.32h和15.85±2.26h,Tmax分别为1.75±0.49h和1.75±0.48h,Cmax分别为21.94±3.31mg·L-1和 22.58±5.94mg·L-1AUC0~72分别为446.50±55.14mg·h·L-1和433.31±58.52mg·h·L-1,AUC0~∞分别为465.22±56.73mg·h·L-1和451.67±57.97mg·h·L-1。国产奥硝唑胶囊的相对生物利用度为 103.52%±6.59%,两种制剂主要药代动力学参数均无显著性差异(P>0.05)。结论:双单侧t检验结果提示,国产奥硝唑胶囊和进口奥硝唑片具有生物等效性。

Objective: To study the bioequivalence of domestic ornidazole tablet/capsule in healthy volunteers. Methods: Eighteen volunteers were randomly divided into 3 groups(test 1,test 2 and reference ),6 in each,with three crossover design. Blood samples were collected at 0, 0.5,1, 1.5 ,2,3,4,6,8,12,24,36,48and 72 h after single oral dose of 1.5 g domestic ornidazole tablet/capsule and imported ornidazole tablet, respectively.The time-concentrations of ornidazole were determined by HPLC and pharmarcokinetic parameters...

Objective: To study the bioequivalence of domestic ornidazole tablet/capsule in healthy volunteers. Methods: Eighteen volunteers were randomly divided into 3 groups(test 1,test 2 and reference ),6 in each,with three crossover design. Blood samples were collected at 0, 0.5,1, 1.5 ,2,3,4,6,8,12,24,36,48and 72 h after single oral dose of 1.5 g domestic ornidazole tablet/capsule and imported ornidazole tablet, respectively.The time-concentrations of ornidazole were determined by HPLC and pharmarcokinetic parameters were calculated with 3P97 practical pharmacokinetic programme. Results: The pharmarcokinetic parameters of domestic ornidazole tablet, capsule and imported ornidazole tablet were as follows: t _ 1/2(β) ( 16.29 ± 2.199 ), ( 16.08 ± 2.317 ) and ( 15.849 ± 2.264 ), t _ peak ( 1.75 ± 0.493 ),( 1.75 ± 0.493 ) and ( 1.75 ± 0.479 )h, C _ max ( 21.534 ± 3.53 ),( 21.936 ± 3.314 )μg/ml and ( 20.85 ± 5.939 )μg·ml, AUC _ 0~72 ( 444.56 ± 55.872 ),( 446.498 ± 55.138 ) and (433.309±58.521)μg/ml·h, AUC _ 0~∞ ( 462.949 ± 55.354 ),( 465.221 ± 56.731 ) and ( 451.668 ± 57.971 )μg·ml -1 ·h -1 . The relative bioavailability of ornidazole tablet was ( 103.52% ± 6.59% )and that of ornidazole capsule was ( 102.91% ± 8.93% ). Conclusion: The statistical analysis showed that the tests and reference were bioquivalent.

目的 :比较试验制剂国产奥硝唑片及国产奥硝唑胶囊与参比制剂进口奥硝唑片的生物等效性。方法 :18名健康志愿者 ,单剂三交叉口服试验制剂奥硝唑片、奥硝唑胶囊和参比制剂 1.5 g ,于药前和药后0 .5 ,1,1.5 ,2 ,3,4 ,6 ,8,12 ,2 4 ,36 ,4 8,72h取肘静脉血 ,用高效液相色谱法测定奥硝唑经时血药浓度 ,数据经 3P97处理得药代动力学参数 ,根据试验制剂和参比制剂AUC计算相对生物利用度。同时对主要药代动力学参数进行方差分析、双单侧t检验和 (1- 2α)置信区间分析 ,评价试验制剂和参比制剂的生物等效性。结果 :试验制剂奥硝唑片、奥硝唑胶囊和参比制剂主要药代动力学参数t1/ 2 ( β) 分别为 (16 .2 9± 2 .199) ,(16 .0 8± 2 .317)和 (15 .84 9± 2 .2 6 4 ) ,tpeak分别为 (1.75± 0 .4 93) ,(1.75± 0 .4 93)和 (1.75± 0 .4 79)h ,Cmax分别为(2 1.5 34± 3.5 3) ,(2 1.936± 3.314 ) ,(2 0 .85± 5 .939) μg·ml-...

目的 :比较试验制剂国产奥硝唑片及国产奥硝唑胶囊与参比制剂进口奥硝唑片的生物等效性。方法 :18名健康志愿者 ,单剂三交叉口服试验制剂奥硝唑片、奥硝唑胶囊和参比制剂 1.5 g ,于药前和药后0 .5 ,1,1.5 ,2 ,3,4 ,6 ,8,12 ,2 4 ,36 ,4 8,72h取肘静脉血 ,用高效液相色谱法测定奥硝唑经时血药浓度 ,数据经 3P97处理得药代动力学参数 ,根据试验制剂和参比制剂AUC计算相对生物利用度。同时对主要药代动力学参数进行方差分析、双单侧t检验和 (1- 2α)置信区间分析 ,评价试验制剂和参比制剂的生物等效性。结果 :试验制剂奥硝唑片、奥硝唑胶囊和参比制剂主要药代动力学参数t1/ 2 ( β) 分别为 (16 .2 9± 2 .199) ,(16 .0 8± 2 .317)和 (15 .84 9± 2 .2 6 4 ) ,tpeak分别为 (1.75± 0 .4 93) ,(1.75± 0 .4 93)和 (1.75± 0 .4 79)h ,Cmax分别为(2 1.5 34± 3.5 3) ,(2 1.936± 3.314 ) ,(2 0 .85± 5 .939) μg·ml-1,AUC0~ 72 分别为 (44 4 .5 6± 5 5 .872 ) ,(44 6 .4 98± 5 5 .138)、(433.30 9± 5 8.5 2 1) μg·ml-1·h-1,AUC0~∞ 分别为 (46 2 .94 9± 5 5 .35 4 ) ,(46 5 .2 2 1± 5 6 .73) ,(45 1.6 6 8± 5 7.971) μg·ml-1·h-1,奥硝唑片、奥硝唑胶囊相对生物利用度分别为 10 2 .91± 8.93%

Objective:To study the curative effects of Ornidazole Caps ul e on patients with trichomonas vaginitis.Methods:Controlled stud ies were carried out on the cases of trichomona vaginitis with three different t herapys of metronidazole in a dose of 7-days(A group),Ornidazole Capsule in sin gle dose(B group) and Ornidazole Capsule in a dose of 5-days (C group). Results:The healing rates of Ornidazole Capsule treated groups (B and C groups) were 100% and 95% respectively on re-examination...

Objective:To study the curative effects of Ornidazole Caps ul e on patients with trichomonas vaginitis.Methods:Controlled stud ies were carried out on the cases of trichomona vaginitis with three different t herapys of metronidazole in a dose of 7-days(A group),Ornidazole Capsule in sin gle dose(B group) and Ornidazole Capsule in a dose of 5-days (C group). Results:The healing rates of Ornidazole Capsule treated groups (B and C groups) were 100% and 95% respectively on re-examination one month later.It is indicated that Ornidazole Capsule therapy superior to metronidazole therapy.Conclusion:Ornidazole Capsule is probably recommended to be the dru g of first choice for curing the cases of trichomana vaginitis.

目的 :观察奥硝唑胶囊治疗滴虫性阴道炎的疗效。方法 :采用口服奥硝唑胶囊单剂量治疗法、奥硝唑胶囊 5日治疗法、甲硝唑 7日治疗法进行对照观察。结果 :奥硝唑胶囊治疗组即甲、乙两组一月后复查痊愈率分别为 1 0 0 %、 95 % ,疗效明显优于甲硝唑组 (P <0 0 5)。结论 :奥硝唑胶囊可以作为治疗滴虫性阴道炎的首选药物之一 ,值得推广应用

 
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