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release carrier
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  释载体
    Evaluation of polylactic-co-glycolic acid copolymer as triamcinolone acetonide controlled release carrier
    聚乳酸-羟基乙酸共聚物作为曲安奈德控释载体的评价
短句来源
    Conclusion: It can be concluded that the loose chitosan showed its characteristics as a sustained delivery system for rhBMP-2 and may be used as a sustained release carrier for rhBMP-2. It provided initial elements for rhBMP-2 continually inducing bone formation in bone tissue engineering.
    结论:多孔壳聚糖支架对rhBMP2有缓慢而持久的体外释放作用,可作为rhBMP2的缓释载体,为rhBMP2持续发挥骨诱导作用提供初步的实验基础。
短句来源
    AIM: By preparing new type triamcinolone acetonide sustained release system to detect its form,drug delivery and drug release in vitro,evaluate the feasibility of applying biodegradable polylactic-co-glycolic acid (PLGA) copolymer as triamcinolone acetonide controlled release carrier.
    目的:通过制备新型的曲安奈德缓释系统,对其形态、载药及体外释药性进行检测,评估应用生物可降解的聚乳酸-羟基乙酸共聚物作为曲安奈德控释载体的可行性。
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  release carrier
Protein incorporation within Ti scaffold for bone ingrowth using Sol-gel SiO2 as a slow release carrier
      
The average pore size of PVA sponges used in this study was 30, 60, 110, 250, 350, and 700 μm and gelatin microspheres were employed as release carrier of bFGF.
      
Characteristics of clay as a slow-release carrier of Zn by direct implantation into tree trunks
      
EO105PO27EO105 copolymer is expected to be useful as a novel sustained-release carrier that maintains constant release rates for the volatility of perfume compounds over a wide temperature range.
      
Poly(ethylene oxide)/poly(propylene oxide)/poly(ethylene oxide) triblock copolymer as a sustained-release carrier for perfume co
      
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Objective:To prepare recombinant human morphogenetic protein 2 (rhBMP 2)/coral composite attificial bone and to determine its osteoinductivity.Methods:The composite artificial bone was prepared by combining coral with rhBMP-2,and was implanted into the muscle pouches of mice.Sixty six mices were divited into three groups:Group 1, the composite bone (coral:rhBMP 2(w/w)=20∶1)transplanted;Group 2, the composite bone (coral∶rhBMP 2(w/w)=40∶1);and Group 3 the coral alone.All the animals were killed at intervals...

Objective:To prepare recombinant human morphogenetic protein 2 (rhBMP 2)/coral composite attificial bone and to determine its osteoinductivity.Methods:The composite artificial bone was prepared by combining coral with rhBMP-2,and was implanted into the muscle pouches of mice.Sixty six mices were divited into three groups:Group 1, the composite bone (coral:rhBMP 2(w/w)=20∶1)transplanted;Group 2, the composite bone (coral∶rhBMP 2(w/w)=40∶1);and Group 3 the coral alone.All the animals were killed at intervals of 1,3,5 weeks after operation.The speciments were evaluated by light microscope and image analysis.Results:Cartilage growth in the pores or on the surface of the implants was observed one week after operation, woven bone three weeks and lamellar bone with bone marrow six weeks,partial coral absorption was observed,the amount of induced endochondral bone was time and rhBMP 2 dose dependent.Conclusion:The results indicate that the composite possesses a superior osteoinductivity and coral may act as one of the most suitable rhBMP 2 slow releasing carriers currently available.

目的:制备珊瑚(coral)与重组人骨形成蛋白-2(rhBMP-2)复合人工骨并测试其骨诱导活性。方法:将rhBMP-2与珊瑚复合后植入鼠肌袋内。66只小鼠随机分为3组:第1组为复合骨(1∶20w/w);第2组为复合骨(1∶40w/w);第3组为单独珊瑚。术后1、3、6周处死动物,光镜下观察,并用图象分析法作成骨定量测定,结果:术后1周,可见复合材料表面及孔洞内有软骨形成。3周出现编织骨。6周形成含骨髓的板层骨。珊瑚被部分吸收。诱导成骨的量有时间依赖性和rhBMP-2剂量依赖性。结论:rhBMP-2/coral复合人工骨具有良好的诱导成骨能力;珊瑚可能是目前能使用的rhBMP-2最合适的缓释载体。

To investigate the validity of hydroxyapatite bone cement (HAC) as a slow-release carrier of bioactive factor. Experimental samples were divided to three groups:(1) Part drug group: the hydroxyapatite bone cement/norvancomyicn (HAC/NVCM) compound was implanted to tibiae of rabbit. (2)Total body drug group: the hydroxyapatite bone cement without NVCM were implanted to tibiae of rabbit, NVCM were injectived from the oto vein of rabbit. Then the drug concentrations were determined in blood and bone of animals...

To investigate the validity of hydroxyapatite bone cement (HAC) as a slow-release carrier of bioactive factor. Experimental samples were divided to three groups:(1) Part drug group: the hydroxyapatite bone cement/norvancomyicn (HAC/NVCM) compound was implanted to tibiae of rabbit. (2)Total body drug group: the hydroxyapatite bone cement without NVCM were implanted to tibiae of rabbit, NVCM were injectived from the oto vein of rabbit. Then the drug concentrations were determined in blood and bone of animals at a series different time.(3) BMP group:After prepare of the HAC/rhBMP-2 compounds, witch were implanted to latissimus dorsal muscle pouches of rabbit, then dystopy induction of bone were viewed at 4 weeks. The experiment Results show that the drug concentrations of Part drug group in blood were all lower than that of Total body drug group at every time. But the drug concentration of Part drug group in bone were marked higher than that of Total body drug group, even at 2 weeks,the drug concentration had still 3.96μg/mg. On the surface of the HAC/rhBMP-2 compounds, the new build bone could be observed. As a slow-release carrier of drug and BMP, HAC throw out a good release characteristic.

探讨羟磷灰石骨水泥(HAC)作为生物活性因子缓释载体的有效性。实验组分为(1)局部用药组:HAC中加入去甲万古霉素,植入家兔胫骨上端;(2)全身用药对照组:通过耳缘静脉注射去甲万古霉素,植入家兔胫骨的 HAC 中不加药;术后分时段对动物血药浓度和骨药浓度测定。(3)BMP组:HAC中加入 rh BMP 2后置入家兔背阔肌肌袋,术后 4 周观察异位诱导成骨效果。实验结果显示局部用药组各时段的血药浓度均低于全身用药对照组,而局部用药组的骨药浓度显著超过全身用药组,即使到第 2 周其骨药浓度仍有3.96μg/mg。HAC/rhBMP 2复合体植入家兔背阔肌肌袋后第4周即可观察到复合体表面形成包绕的新生骨质。这表明 HAC作为药物和 BMP 缓释载体显示出良好的缓释特性。

Introduced the blend membranes consisted of SF and synthetic or natural polymers,such as poly-(vinyl alcohol)(PVA),polyacrylamide,chitosan,sodium alginate,cellulose and so forth,its structure and mechanical properties were compared and analyzed,potential applications were further summarized in biomedical fields as culture medium of cells,controllable medicine-releasing carriers,artificial skins,artificial joints,an immobilisation matrix for enzymes and so on.The potential values of this blending system...

Introduced the blend membranes consisted of SF and synthetic or natural polymers,such as poly-(vinyl alcohol)(PVA),polyacrylamide,chitosan,sodium alginate,cellulose and so forth,its structure and mechanical properties were compared and analyzed,potential applications were further summarized in biomedical fields as culture medium of cells,controllable medicine-releasing carriers,artificial skins,artificial joints,an immobilisation matrix for enzymes and so on.The potential values of this blending system were expatiated in biomedical and pharmaceutical materials.

介绍丝素与聚乙烯醇、聚丙烯酰胺、壳聚糖、海藻酸钠和纤维素等聚合物的共混膜,比较分析丝素共混膜的结构、力学性能;综述了丝素共混膜作为细胞培养底物、可控药物释放载体、人工皮肤、人工肌腱、酶固定材料等在生物医学领域的应用研究进展;阐述丝素与聚合物共混制膜在生物医学和药学材料上应用的潜在价值。

 
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