Objective To observe whether antitumor immune response can be induced in BALB/c mice immunized with a fusion protein (6Bl1mGM) of anti-idiotypic single chain antibody (6B11scFv) and murine granulocyte-macrophage colony-stimulating factor (GM-CSF) instead of ovarian carcinoma antigen.
Objective To observe whether antitumor immune response can be induced in BALB/c mice immunized with a fusion protein (6Bl1mGM) of anti-idiotypic single chain antibody (6B11scFv) and murine granulocyte-macrophage colony-stimulating factor (GM-CSF) instead of ovarian carcinoma antigen.
The levels of IL-6 and TNF-α bearing tumor mice in vivo increased obviously after immunotherapy of tumor lysate-pulsed DCs, which suggests that tumor lysate-pulsed DCs enhance anti-tumor immunity.
Conclusion Combined IL-12 and GM-CSF gene therapy can enhance the anti-tumor immune response of B16 melanoma bearing mice and decrease side-effect of using AdCMVIL-12.
Background &Objective:Chemokines paly an important role in the infiltration of immune cells to t umor tissues. Anti-tumor immune response had been elicited in many tumor models by the chemokine gene transfectio n. The aim of this study was to evaluate the possibility of inducing anti-colorecta l cancer active immune response by tr ansfection of mouse colorectal cancer CMT93cells with c hemokine MCP-3gene.
Expression of interleukin-12 (IL-12) on tumor-cell membranes in a GPI-anchored form induces a strong antitumor immune response that is comparable to the effects of secretory IL-12.
Although there is ample evidence for the presence of tumor-associated antigens on a variety of tumors, they are seemingly unable to elicit an adequate antitumor immune response.
Molecular identification of tumor-associated antigens not only provided the means to activate or monitor anti-tumor immunity, but also gave insights into new and unexpected biochemical processes that are taking place within cells.
Dendritic cells (DC)-derived or tumor-derived exosomes are a population of nanometer sized membrane vesicles that can induce specific anti-tumor immunity.
Our findings suggest that Exo/IL-18 has more potent capability to induce specific anti-tumor immunity, and our strategy of IL-18 modification of exosomes is a feasible approach to develop exosomes-based tumor vaccines.
This apparent stimulation of anti-tumor immunity was observed in treated animals regardless of substrain or site of MER injection, and could not be correlated with the outcome of immunotherapy.
The specific anti-tumor immune response induced by mouse bone marrow dendritic cells (DCs) transfected with recombinant adenovirus carrying mutant k-ras genes was investigated.
The migration of leukocytes is, among other things, of primary importance for an anti-tumor immune response, whereas the migration of tumor cells is a prerequisite for invasion and the development of metastases.
The antigen-specific binding cell (ABC) in EAC-bearing mice were detected by means of specific rosette-forming test after SRBC immunization. It was found that the number of ABC in host decreased gradually with EAC development. The ABC response of normal donors enhanced when thymocytes from the 5th day EAC-bearing mice were transferred into syngeneic mice, but declined while thymocytes transferred from the 10th day host. Contrastly, marrow cells or host spleen cells could not reconstitute the response of let...
Dendritic cells (DC) and macrophages (Mφ) in thirty seven esophageal carcinomas and five samples of normal esophageal mucosa were investigated immunohistochemically, using anti—S100 prtein and anti--lysozyme antibodies. It was found that the number of DC and Mφ increased evidently (P< 0.05) than that in normal tissue. The number of DC was larger in tumor parenchyme where tumor cells infiltrated the whole thickness of esophageal wall and surrounding tissue than that with tumor cell infiltration limited to th...
Histopathological changes of nephroblastoma were studied in 11 eases under electron and light microscopy.In ultrastructtual view, the lymphocytes were found to be attached to the oncocytes by their pseudopodia in 9 cases. Only in 4 cases, however, the oncocyte membrance and cytoplasm adjacent to the lymphocytes were damaged, but the lymphocytes were intact. According to the similar studies of adult malignancies.the phenomenon of infiltrating lymphocytemediated oncocyte lysis probably reflects the presence o...