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Purpose To explore the ultrastructural alterations of the liver complicated in gallstone. Methods Liver biopsies were taken from 22 patients suffered from gallstone and in half of these cases the interlobular bile ductuli were found. Their ultrastructural changes were observed with electron microscope. Results Mucinous metaplasia of the epithelium lined the mucous membrane appeared in 4 cases. It was particularly worth to raise that in one case mucinous metaplasia appeared at liver cell. Degeneration... Purpose To explore the ultrastructural alterations of the liver complicated in gallstone. Methods Liver biopsies were taken from 22 patients suffered from gallstone and in half of these cases the interlobular bile ductuli were found. Their ultrastructural changes were observed with electron microscope. Results Mucinous metaplasia of the epithelium lined the mucous membrane appeared in 4 cases. It was particularly worth to raise that in one case mucinous metaplasia appeared at liver cell. Degeneration and necrosis of ductuli epithelium obviously increased in number in great majority of these cases. Rupture of ductulus were occasionally found. Conclusions The appearances of mucinous epithelial metaplasias and numerous epithelial degenerations are the important signs of chronic inflammation of the interlobular bile ductulus. Rupture of the ductulus and overflow of the bile will destroy the surrounding parenchyma of portal tract and even the ductulus itself. 目的 :了解胆囊结石症引起的肝细胞和小叶间胆小管上皮黏液上皮化生的超微改变。方法 :用电镜观察 11例胆囊结石患者肝活检标本中小叶间胆小管的超微结构变化。结果 :4例黏膜层发现黏液上皮化生 ,1例肝细胞有罕见的黏液上皮化生。大多数病例黏膜上皮变性和坏死增多 ,1例小叶间胆小管破裂。结论 :黏液上皮化生和上皮变性、坏死的增多是小叶间胆小管慢性炎症的重要标志。胆小管破裂和胆汁外溢会损害门管区实质 ,甚至胆小管自身
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