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transplanted mouse tumors
相关语句
  小鼠移植性肿瘤
     Antitumor Effect of Na-Glycyrrhetinate on Transplanted Mouse Tumors
     甘草次酸钠对小鼠移植性肿瘤作用的实验观察
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  “transplanted mouse tumors”译为未确定词的双语例句
     Chinese Stellera(Stellera chamaejsme L. ,ScL)inhibited the growth of transplanted mouse tumors S- 180, HePS and Lewis lung cancer markedly. The active substance extracted with water,5 -20g/kg(equivalent crude drug) ip for 10d. the inhibition rates of it against S-180,HePS and Lewis lung cancer were 16. 2-47. 8,20. 1 - 45. 8 and 10. 9 -40. 6% respectively.
     瑞香狼毒水提物5-20g/kg(相当生药)ip 10d对小鼠移植肿瘤S-180、HePS、lewis肺癌生长抑制率分别为16.2~47.8、20.1~45.8、10.9~40.6%;
短句来源
     Effects of Chinese Stellera (Stellera chamaejasme L. ) on Growth of Transplanted Mouse Tumors
     瑞香狼毒对小鼠移植肿瘤生长的影响
短句来源
     clonal formation and MTT formazan formation of P388 celis in vitro Were studied. It was found that Cur inhibited the growth of transplanted mouse tumors U14. The active substance extracted with water. 5- 20g · kg-1(equivalent crude drug)ip for 10d.
     蓬莪术水提物(Cur)抑制小鼠移植肿瘤宫颈癌U14生长,5~20g·kg-1(相当生药)ip10d,抑制率为11.8~44.8%。
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  相似匹配句对
     Mouse
     鼠标
短句来源
     Effect of SJAMP and Cortisone on Transplanted Mouse S180 Tumor
     刺参粘多糖及考的松对小鼠移植瘤S180的作用
短句来源
     Pathological observations on the hypertrophic scars transplanted to the nude mouse
     肥厚性瘢痕移植至裸鼠后的病理学观察
短句来源
     Antitumor Effect of Na-Glycyrrhetinate on Transplanted Mouse Tumors
     甘草次酸钠对小鼠移植性肿瘤作用的实验观察
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     CAT AND MOUSE
     猫和老鼠
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  transplanted mouse tumors
Inhibition of transplanted mouse tumors by heterologous transfer RNA
      


Sodium glycyrrhetinate (GC-Na) was studied in the transplanted mouse tumors. The experiments showed. that S_(180) and Hep were significantly in- hibited by GC-Na. The inhibition rates of GC-Na, ip 10 mg/kg×10d for S_(180) and Hep in mice were 53.13%(P<0.05) and 40.10%(P<0.05). Moreover, the inhibition rate of mitotic indices of hepatoma cells were moderately in- creased affter ip administration of GC-Na with 36.81% for 1h and 43.15% after 24h (P<0.05). Electron microscopic observation: Vacuolations...

Sodium glycyrrhetinate (GC-Na) was studied in the transplanted mouse tumors. The experiments showed. that S_(180) and Hep were significantly in- hibited by GC-Na. The inhibition rates of GC-Na, ip 10 mg/kg×10d for S_(180) and Hep in mice were 53.13%(P<0.05) and 40.10%(P<0.05). Moreover, the inhibition rate of mitotic indices of hepatoma cells were moderately in- creased affter ip administration of GC-Na with 36.81% for 1h and 43.15% after 24h (P<0.05). Electron microscopic observation: Vacuolations were found inside the cytoplasm of tumor cells. The mitoc- honderia of hepatoma cells showed s W- elling, dissolution and disapperance of cristae. The combining administrations of GC-Na with camptothecine, 5-Fu and Cis-DDP were studied. GC-Na and camptothecine at suitable interval of 5 min showed significant antitumor effect. Furthermore, GC-Na could improve leukopenia caused by campt- othecine.

本文观察了甘草次酸钠对小鼠移植性肿瘤的抑制作用,并在此基础上观察了其对瘤细胞分裂指数和超微结构的影响,以及对抗肿瘤药物作用的影响。甘草次酸钠腹腔给药对小鼠S180、HepS具有不同程度的抑制作用,在10mg/kg时,抑制率分别为53.13%和40.10%(P值<0.05)。该药对HepA细胞分裂指数有抑制作用,24小时时,分裂指数抑制率为43.15%。电镜观察发现;使HepA细胞线粒体空泡变性,甚至界膜破损,细胞质中糖元颗粒减少,粗面内质网腔缩小,核染色质变细疏,膜完整性示踪剂镧颗粒进入胞质和核内。该药与抗肿瘤药物合用因不同药物和给药时间相异其增效作用亦不同,以ip喜树碱5分钟后投与本药为佳。此外本药对喜树碱引起的白细胞减少亦有保护作用。

The antiumor activity of a new podophyllotoxin spin-labeled derivative, 4 -C 4 "-( 2 ", 2", C", 6"-tetramethyl- 1 "-piperidinyoxy ) amino]-4'-demethylepipodophyllotoxin ( GP-7 ) was studied. It was found that the growth of transplanted mouse tumors S180, HePS and Lewis lung cancer was markedly inhibited by GP-7. At a dose of 7.5-20 mg/kg, the inhibition rates of it against Sl80, HePS and Lewis lung cancer were 36.0-58.4, 29.6-60.0, and 27.2-46.5 % respectively. The toxicity of GP-7 was low, as indicated...

The antiumor activity of a new podophyllotoxin spin-labeled derivative, 4 -C 4 "-( 2 ", 2", C", 6"-tetramethyl- 1 "-piperidinyoxy ) amino]-4'-demethylepipodophyllotoxin ( GP-7 ) was studied. It was found that the growth of transplanted mouse tumors S180, HePS and Lewis lung cancer was markedly inhibited by GP-7. At a dose of 7.5-20 mg/kg, the inhibition rates of it against Sl80, HePS and Lewis lung cancer were 36.0-58.4, 29.6-60.0, and 27.2-46.5 % respectively. The toxicity of GP-7 was low, as indicated by the LD50 value of 231.2 mg/kg which was 3.3 times higher than that of etoposide ( VP-16 ) . On the other hand, the effects of GP-7 on spleen index and thymus index of mice bearing S180 tumor were remarkably lower than that of VP-16. In vitro GP-7 exhibited marked inhibition effects against L1210 and SGC-7901 cells. After exposure of L1210 cells to GP-7 and VP-16 5 mg/L for 24 h, the. inhibition rates were 75.5 and 73.6 %. after exposure of SGC-7901 cells to GP-7 and VP-16 5 mg/L for 72 h, the inhibition rates were 81.4 and 84.2 %. The new podophyllotoxin derivative GP-7 was similar to its structure analogues, clinical drug VP-16, in antitumor activity, while the toxicity of it was much lower than that of VP-16.

新合成的鬼臼毒素氮氧自由基衍生物4-[4”-(2”,2”,6”,6”-四甲基哌啶氮氧自由基)氨基]-4’-去甲表鬼臼毒(GP-7)显著抑制小鼠移植性肿瘤S180、实体型HePS和Lewis肺癌生长;7.5~20mg/kg,给药10d,抑瘤率分别为36.0%~58.4%、29.6%~60.0%和27.2%~46.5%;抑制作用和鬼臼乙叉甙(VP-16)相似。GP-7小鼠一次ip,LD_(50)为231.2mg/kg,是VP-16的3.3倍;连续给药10d,对小鼠脾和胸腺指数的影响较VP-16小,对小鼠WBC的影响和VP-16相同。GP-7和VP-165mg/L处理L1210细胞24h,抑瘤率分别为75.5%和73.6%;处理SGC-7901细胞72h,抑瘤率分别为81.4%和84.2%。

Chinese Stellera(Stellera chamaejsme L. ,ScL)inhibited the growth of transplanted mouse tumors S- 180, HePS and Lewis lung cancer markedly. The active substance extracted with water,5 -20g/kg(equivalent crude drug) ip for 10d.the inhibition rates of it against S-180,HePS and Lewis lung cancer were 16. 2-47. 8,20. 1 - 45. 8 and 10. 9 -40. 6% respectively. The active substance extracted with 95% ethanol,2. 5-10g/kg ip 10d, the inhibition rates were 8. 1 - 47. 0,4. 9 - 20. 8 and 20. 1 - 40. 8% respectively....

Chinese Stellera(Stellera chamaejsme L. ,ScL)inhibited the growth of transplanted mouse tumors S- 180, HePS and Lewis lung cancer markedly. The active substance extracted with water,5 -20g/kg(equivalent crude drug) ip for 10d.the inhibition rates of it against S-180,HePS and Lewis lung cancer were 16. 2-47. 8,20. 1 - 45. 8 and 10. 9 -40. 6% respectively. The active substance extracted with 95% ethanol,2. 5-10g/kg ip 10d, the inhibition rates were 8. 1 - 47. 0,4. 9 - 20. 8 and 20. 1 - 40. 8% respectively. Mice were administrated ip with the active substances extracted with water and 95% ethanol.the LD50 of ScL were 184. 3 and 132. 7g/kg respectively.

瑞香狼毒水提物5-20g/kg(相当生药)ip 10d对小鼠移植肿瘤S-180、HePS、lewis肺癌生长抑制率分别为16.2~47.8、20.1~45.8、10.9~40.6%;醇提物2.5~10g/kg ip 10d对S-180、HePS、lewis肺癌生长抑制率分别为8.1~47.0、4.9~20.8、20.1~40.8%;并和剂量呈正相关。瑞香狼毒水提物及醇提物一次腹腔注射小鼠LD50分别为184.3和132.7g/kg。

 
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