ALT and SB (serum bilirubin) of 78 cases ill with hepatitis,the plasma endotoxin level of severe hepatitis and hepatic carcinoma were the same with the increase of ALT and SB. ALT were 174. 89±96. 60u/L and 134.30± 63. 75u/L respectively;
The TNF level in subacute fulminant hepatitis (19.38±13.25u/ml) increased significantly than chsonic active hepatitis (2.68±0.86n/ml), acute hepatitis (2.17±0.05u/ml) and healthy donors (<2u/ml) P<0.05.
RESULTS SENV-DNA positive rates were 14.7%(28/191) totally, from which 36.7% in plasmapheresis patients, 33.3% in intravenous drug users, 11.1% in chronic hepatitis B patients, 9.4% in hepatitis non A-E patients, 8.3% in fulminant hepatitis patients, respectively, in comparison with 5.6% in normal populations.
Results:Compared with that in normal subjects ,the level of total serum bile acid was significantly high in patients with acute hepatitis,chronic activated hepatitis,serious hepatitis,cirrhosis of liver,liver cancer,fatty hepatitis , and ethanol hepatitis,with positive rates of TBA being 90 9%,89 2%,100%,100%,100%,41 7% and 47 4% respectively.
The serum levels of T and LHRH were reduced but E 2 increased in patients with cirrhosis,which showed high estrogen with low testoid. (P<0.01,P<0.05,P<0.01). In serious hepatitis,T,FSH,LH,LHRH levels were reduced and E 2,PRL were increased.
Serum C_(3d)/C_3,C_3,C_4 levels in severe viral hepatitis(SVH)and chronic activehepatitis(CAH),acute hepatitis,normal control showed significant statisticaldifferences. These suggested that there were large number of complement C_3breakdown products in SVH patients,whose complement systems were activatedintensively.
Only two of the 13 superinfected patients showed a severe hepatitis, but a high percentage (78%) of them developed chronic hepatitis one year after HDV infection.
A clinically more severe hepatitis was seen significantly more often among the HDV co-infected patients than among the solely HBV infected.
The HDAg detection rate in chronic liver diseases and severe hepatitis was higher than in other liver diseases.
Among 276 patients, there were 78 cases of HBV asymptomatic carriers, 110 cases of chronic hepatitis B (CHB), 62 cases of severe hepatitis (SH) or liver cirrhosis (LC) and 26 cases of hepatocellular carcinoma (HCC).
Without any clinical or laboratory signs of severe hepatitis, the patient developed a histologically proven complete liver cirrhosis within 8 months after reinfection of the graft.