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third generation progestogen
相关语句
  第三代孕激素
     Objective To investigate the effectr of combined oral desogestrel (DSG, a third generation progestogen) with testosterone pellets on suppression of spermatogenesis.
     目的 研究口服地索高诺酮 (DSG ,第三代孕激素 )联用睾酮皮下埋植对精子发生的抑制作用。
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  相似匹配句对
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     “代”论
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Objective To investigate the effectr of combined oral desogestrel (DSG, a third generation progestogen) with testosterone pellets on suppression of spermatogenesis. Methods 36 men were divided into two groups, receiving 150 μg or 300 μg DSG. They were followed up at pretreatment, two weeks, four weeks after treatment and then once every four weeks for the measurements of testicular volume, blood pressure and body weight. The semen samples, urinary and blood samples were also collected. Sexual hormone...

Objective To investigate the effectr of combined oral desogestrel (DSG, a third generation progestogen) with testosterone pellets on suppression of spermatogenesis. Methods 36 men were divided into two groups, receiving 150 μg or 300 μg DSG. They were followed up at pretreatment, two weeks, four weeks after treatment and then once every four weeks for the measurements of testicular volume, blood pressure and body weight. The semen samples, urinary and blood samples were also collected. Sexual hormone measurement and semen analysis were performed once every four weeks, whereas clinical biochemistry and haematologic findings once every twelve weeks. Results 90% of subjects showed azoospermia in a mean duration of 12.15±622 weeks. There were no significant differences between the two groups. The group received 300 μg DSG showed azoospermia more rapidly. After discontinuation of the treatment the sperm counts returned to normal. DSG inhibited testosterone production significantly, but the latter remained within two normal range and slowly recovered after discontinuation of the treatment. This treatment was associated with variable increases of body weight, serum HDL, TC, and LDL. There were no significant adverse effects.Conclusion Oral Administration of desogestrel combined with implantation of testosterone pellets could effectively suppress spermatogenesis, and there were no obvious side effects reported.

目的 研究口服地索高诺酮 (DSG ,第三代孕激素 )联用睾酮皮下埋植对精子发生的抑制作用。方法 将 36例研究对象随机分成口服DSG 15 0 μg组和 30 0 μg组 ,对象于治疗前期、治疗后 2周、4周以及以后每隔 4周随访 1次 ,测量睾丸体积、血压、体重 ,留取精液、尿液和血标本。性激素、精液的分析每 4周 1次 ,临床生化和血液学筛查每 12周 1次。结果 达到无精子的有效率为 90 % ,两组差异无显著性 ,平均起效时间为 (12 .15± 6 .2 2 )周 ,30 0 μg组起效快 ,停药后精子计数能恢复至正常值范围 ;DSG对睾酮产生有抑制作用 ,但仍在正常值范围 ,停药后睾酮值恢复较慢 ;用药后体重、高密度脂蛋白 (HDL)、总胆固醇 (TC)、低密度脂蛋白 (LDL)均有不同程度的增加 ,无其它明显不良反应。结论 口服地索高诺酮联用睾酮皮埋对精子发生有明显的抑制作用 ,使用中未发现明显的不良反应

 
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