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hypertension
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  相似匹配句对
     Masked Hypertension
     被掩盖的高血压
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     Renovascular Hypertension
     肾血管性高血压
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     Adrenomedullin(ADM) and Pulmonary Hypertension
     肾上腺髓质素与肺动脉高压
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  hypertension
We recognized and honoured the important contributions of these Chinese pioneers in portal hypertension, recurrent pyogenic cholangitis, hepatocellular carcinoma and liver transplantation.
      
Splenic autotransplantation and oesophageal transection anastomosis in patients with portal hypertension (26 years clinical obse
      
The surgical treatment methods for cirrhosis patients complicated with portal hypertension are complicated.
      
From 1979 to 2005, 274 cirrhosis patients with portal hypertension who underwent the new treatment strategy were followed up to observe different clinical indexes, which were then compared with those of the traditional surgery treatment.
      
Splenic auto transplantation and esophageal transection anastomosis are a safe, effective, and reasonable treatment strategy for portal hypertension with varicial bleeding.
      
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Right heart catheterization was performed 120 times in 112 cardiac cases admitted into Chung-Shan Hospital of Shanghai First Medical College in a period of 13 months from September 1957 to September 1958. Catheterization was done in this series of cases chiefly for the purpose of studying the hemodynamic changes in the lesser circulation and as an aid to diagnosis in congenital heart diseases and rheumatic mitral valvular disease, when cardiac surgery was considered for treatment. In 8 of them catheterization...

Right heart catheterization was performed 120 times in 112 cardiac cases admitted into Chung-Shan Hospital of Shanghai First Medical College in a period of 13 months from September 1957 to September 1958. Catheterization was done in this series of cases chiefly for the purpose of studying the hemodynamic changes in the lesser circulation and as an aid to diagnosis in congenital heart diseases and rheumatic mitral valvular disease, when cardiac surgery was considered for treatment. In 8 of them catheterization was repeated 6 weeks after surgical repair of an interauricular septal defect or valvotomy of a stenotic pulmonic valve. In this paper the entire procedure of catheterization has been described in detail, particuhrly with regard to some technics of manipulation of the catheter in order to let it get through the tricuspid and pulmonic orifice, and to wedge it into the "pulmonary capillary". Indications, contraindications, complications and results of catheterization in our cases have been dicussed. Among the complications, cardiac arrhythmia was the most common but it was seldom serious. Electrocardiographic observation during the procedure showed that premature beats especially of ventricular origin occured nearly in every case. Two patients developed pulmonary edema shortly after catheterization. One of them survived, while the other unfortunately died in spite of energetic treatment. Both were cases of mitral stenosis with marked pulmonary hypertension. In the entire series of 112 cases, catheterization helped us to establish the diagnosis in 107 of them, among which 68 patients were operated upon after catheterization, and in 66 of them the preoperative diagnoses proved to be correct. According to the material presented, right heart catheterization appears to be a comparatively safe and useful procedure in the diagnosis of cardiac diseases.

一、本文分析报告112例住院心脏病病人,120次右心导管檢查的結果。二、本组病例檢查的指征主要是对先天性心脏病及二尖瓣病的診断和外科治疗的选擇。三、对檢查方法加以描述,对影响檢查成敗的因素加以討論。四、分析檢查的結果,认为右心导管檢查对上述心脏病的診断有重大的价值,而危險性不大,但檢查时仍应提高警惕,掌握禁忌証并注意安全防止严重并发症的发生。

The "Compound Mixture of Two Fairies" has been used clinically for treatment of hypertension. It is composed of Curculigo ensifolio, Epimedium, sp., Morinda officinalis, Phellodendron chinense, Anemarrhena asphodeloides, and Angelica sinensis. In normal dogs, intragastric administrations of 6g (crude drugs) per kg t.i.d, for 20 days produced no toxic reactions: If the dosage was increased 3—4 times, emesis and diarrhea occurred, probably due to alimentary disorder from the bulk of the decoction. When the...

The "Compound Mixture of Two Fairies" has been used clinically for treatment of hypertension. It is composed of Curculigo ensifolio, Epimedium, sp., Morinda officinalis, Phellodendron chinense, Anemarrhena asphodeloides, and Angelica sinensis. In normal dogs, intragastric administrations of 6g (crude drugs) per kg t.i.d, for 20 days produced no toxic reactions: If the dosage was increased 3—4 times, emesis and diarrhea occurred, probably due to alimentary disorder from the bulk of the decoction. When the Compound Mixture was introduced 6. g/kg into the lumen of duodenum in anesthetized cats, the blood pressure began to descend at 30 minutes, and lowered an average of 30% below the original level in 2 hours. Four Goldblatt renal hypertensive dogs were given the Compound Mixture by stomach tube. The dose for the first 10 days Was 9 g/kg/day, and doubled for the next, 10 days. The post-medication observation period was another 10 days. Blood pressure was measured daily by auscultation on the carotid loop. The average reduction of the diastolic pressure in the space of 30 days was 10 mm Hg (8%), and that for the lowest 5 days running was 16 mm Hg (12%). A therapeutic action (a reduction of at least 11 mm Hg diastolic) was demonstrated in 3 dogs. Among them 2 dogs received a second course of treatment which appeared to be equally efficacious. Intraperitoneal injections of the Compound Mixture 6 g/kg to anesthetized dogs resulted in a decrease of cardiac output during the hypotension, while the dilatation of peripheral vessels was insignificant. Comparative experiments on the 6 ingredients revealed that the hypotensive action of "Compound Mixture of Two Fairies" could be primarily attributed to Phellodendron chinense and Epimedium sp., whereas Curculigo ensifolio alone had little effect. Eight hypertensive dogs were fed daily the Compound Mixture or a mixture of 6 decoctions of the components. Analysis of variance disclosed that the hypotensive potency of the former was no better than the latter. Hypertensive dogs were fed the Compound Mixture which was devoid of Morinda officinalis, and the therapeutic potency was shown to be no less than that of "Compound Mixture of Two Fairies". Hence, we deem that Morinda officinalis is dispensable.

复方“二仙合剂”由仙茅、淫羊藿、巴戟天、黃蘗、知母及当归組成,所用药液均为水煎剂。正常狗每日灌胃給二仙合剂18克/公斤,連服20天,无毒性反应。增加剂量3—4倍,則有嘔吐泄泻,可能由于药液容量过大,影响消化道的机能。麻醉猫十二指腸注射二仙合剂6克/公斤,30分钟后血压开始下降,2小时后平均降低原水平的30%。慢性腎型高血压狗斗只,每日灌胃給二仙合剂2次,第1—10天剂量为9克/公斤/天,第11—20天剂量为18克/公斤/天,停药10天。舒张压“30天平均降压值”平均为10毫米汞柱(8%),“最低5天降压值”平均为16毫米汞柱(12%)。4狗中3狗呈現疗效(舒张压下降11毫米汞柱或以上),其中2狗重复一次試驗依然降压有效。麻醉狗腹腔注射二仙合剂6克/公斤,在急性降压时有心脏指数的减少,而外周血管的扩张并不明显。单味药的比較試驗証明黃蘗和淫羊藿为二仙合剂降压作用的主要有效成分,而仙茅几无降压效能。高血压狗8只,每天服二仙合剂或分煎合剂,变异数分析証明分煎合剂的降压效果不亚于二仙合剂。高血压狗灌胃試驗二仙減巴合剂,降压效果并不較二仙合剂为弱,所以我們建議复方二仙合剂中可減省巴戟天。

Cardiac output was determined according to Fick's principle, while renaI blood flow (RBF) and glomerular filtration rate (GFR) were measured from the clearances of PAH and creatinine. One hour after an i.v. injection of guanethidine 5 mg/kg, normal dogs showed a very slight hypotension, which was relatively more noticeable in renal hypertensive dogs. The cardiac output, stroke volume, and ventricular work tended to decrease tn normotensive dogs, but tended to augment in hypertensive dogs. These alterations,...

Cardiac output was determined according to Fick's principle, while renaI blood flow (RBF) and glomerular filtration rate (GFR) were measured from the clearances of PAH and creatinine. One hour after an i.v. injection of guanethidine 5 mg/kg, normal dogs showed a very slight hypotension, which was relatively more noticeable in renal hypertensive dogs. The cardiac output, stroke volume, and ventricular work tended to decrease tn normotensive dogs, but tended to augment in hypertensive dogs. These alterations, however, were statistically insignificant. The total peripheral resistance was not much influenced by guanethidine in normal dogs, yet markedly diminished in hypertensive dogs. Diuresis was evident during the 1-hour postmedication period in both models. In hypertensive dogs, i.v. administrations of guanethidine caused a conspicuous rise of RBF and GFR, but a great reduction of the renal vascular resistance. In normal rats, following an i.p. injection of 20 mg/kg, the circulating blood volume (studied with I~(131)-labeled serum protein) exhibited a slight but non-significant increase within 3 hours, and returned to the original level at 24 hours. No significant change was found in DOCA-treated rats. Normal rats receiving guanethidine revealed an increase of blood volumes in all organs, especially spleen and kidney. These results demonstrate that the hypotensive action of guanethidine is not via the reduction of blood volume, but by way of a vasodilator action, which particularly amends the ischemic state of kidney and thus alleviates the pathologic process of renal hypertension.

本文用正常血压及腎型高血压狗研究胍乙啶对心和腎的血流动力作用,并用大白鼠試驗其对循环及器官血容量的影响。根据Fick氏原則測定心輸出量,同时从腎脏对于对氨基馬尿酸及肌酐的清除率計算腎血流量及腎小球滤过率。靜脉注射胍乙啶5毫克/公斤1小时后,正常狗血压略有降低,高血压狗降压則較为明显。胍乙啶对正常血压狗的心輸出量、心搏量及心室作功量有減 低的趋向,而对腎型高血压狗則略有增加,但均不显著。胍乙啶不影响正常狗的外周血管阻力,而能显著降低腎型高血压狗的总外周阻力,扩张其外周血管。注射胍乙啶后,正常血压及腎型高血压狗的尿量增加均非常显著。腎型高血压狗的腎小球滤过率及腎血流量都非常显著地低于正常狗,腎血管阻力則大大地高于正常狗,靜脉注射胍乙啶后,滤过率及血流量均明显增加,而血管阻力則大大降低。正常大白鼠腹腔注射胍乙啶20毫克/公斤后,3小时內循环血量略有增加,但不显著,6小时后开始恢复,2斗小时后回至原水平。对注射DOCA的大白鼠的循环血量則沒有明显影响。正常大白鼠注射胍乙啶后,各器官及組織內合血量普遍有增加趋势,其中以脾及腎的血容量增加最为明显,說明胍乙啶对这些部位的血管有扩张作用。上述資料証明:胍乙啶的降压作用并非通...

本文用正常血压及腎型高血压狗研究胍乙啶对心和腎的血流动力作用,并用大白鼠試驗其对循环及器官血容量的影响。根据Fick氏原則測定心輸出量,同时从腎脏对于对氨基馬尿酸及肌酐的清除率計算腎血流量及腎小球滤过率。靜脉注射胍乙啶5毫克/公斤1小时后,正常狗血压略有降低,高血压狗降压則較为明显。胍乙啶对正常血压狗的心輸出量、心搏量及心室作功量有減 低的趋向,而对腎型高血压狗則略有增加,但均不显著。胍乙啶不影响正常狗的外周血管阻力,而能显著降低腎型高血压狗的总外周阻力,扩张其外周血管。注射胍乙啶后,正常血压及腎型高血压狗的尿量增加均非常显著。腎型高血压狗的腎小球滤过率及腎血流量都非常显著地低于正常狗,腎血管阻力則大大地高于正常狗,靜脉注射胍乙啶后,滤过率及血流量均明显增加,而血管阻力則大大降低。正常大白鼠腹腔注射胍乙啶20毫克/公斤后,3小时內循环血量略有增加,但不显著,6小时后开始恢复,2斗小时后回至原水平。对注射DOCA的大白鼠的循环血量則沒有明显影响。正常大白鼠注射胍乙啶后,各器官及組織內合血量普遍有增加趋势,其中以脾及腎的血容量增加最为明显,說明胍乙啶对这些部位的血管有扩张作用。上述資料証明:胍乙啶的降压作用并非通过循环血量的減少,而是由于外周血管的扩张所致。胍乙啶能扩张腎血管,改善腎缺血状态,从而緩解腎型高血压的病理生理过程。

 
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