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sustained release carrier
相关语句
  缓释体
     Application of sustained release carrier containing antibiotic and anti-inflammatory drugs to firearm wounds of extremities after seawater immersion
     抗菌抗炎药物缓释体在海水浸泡肢体软组织火器伤救治中的应用
短句来源
  缓释载体
     Conclusion:Chitosan can be used as a good sustained release carrier of ADM,CDDP and MTX.
     结论:壳多糖可以作为阿霉素、顺氨氯铂及甲氨蝶呤的良好缓释载体
短句来源
     Conclusion:It can be concluded that CPC showed its characteristics as a sustained delivery system for rhBMP-2 and may be used as a novel sustained release carrier for rhBMP-2 in clinic.
     结论 :CPC能对rhBMP -2有缓慢而持久的体外缓释作用 ,有望充当rhBMP -2的缓释载体 ,但缓释速度尚有待提高
短句来源
     RESULTS The plasticizer was used as the sustained release carrier and improved the characteristics of the commercial material.
     结果 加入的改性剂具有药物缓释载体和改善市售骨修复材料的特性。
短句来源
     Conclusion:Fibrin glue can be used as a good sustained release carrier of MTX or CDDP,except ADM.
     结论:纤维蛋白胶可作为CDDP、MTX而不是阿霉素(ADM)的良好缓释载体,并可增强前两者的药效。
短句来源
     Conclusion: It can be concluded that the loose chitosan showed its characteristics as a sustained delivery system for rhBMP-2 and may be used as a sustained release carrier for rhBMP-2. It provided initial elements for rhBMP-2 continually inducing bone formation in bone tissue engineering.
     结论:多孔壳聚糖支架对rhBMP2有缓慢而持久的体外释放作用,可作为rhBMP2的缓释载体,为rhBMP2持续发挥骨诱导作用提供初步的实验基础。
短句来源
  “sustained release carrier”译为未确定词的双语例句
     The release properties could be expressed by the following equation: Q = 2.1811 t + 13.50 ( r =0.9527). These materials have good prospect as a controlled or sustained release carrier.
     阐明了载体中加入D ,L PLA材料 ,改善了以PHBV单一材料为载体的微球释药性能 ,体外释药方程为Q =2 .1811t +13.5 0 (r =0 .95 2 7)
短句来源
     As new oral sustained release carrier, alginate gel has been highly recommended to controlled-release of many drugs.
     海藻酸盐微粒给药系统是近年来研究较多的一类新型口服药物缓控释载体,已成功应用于多种药物的控制释放。
短句来源
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This article presents 149 cases of peridental diseases treated with carboxymethyl cellulose as peridental sustained release membrane for local application with good therapeutic effect. The results showed that this treatment had the advantages of smaller dose, high local concentration, satisfactory curative effect, no adverse reaetions, being not liable to produce drug-fast bacteria strains and ready reception from the patients. The paper also discusses the merits of taking the carboxymethylcellulose natrium...

This article presents 149 cases of peridental diseases treated with carboxymethyl cellulose as peridental sustained release membrane for local application with good therapeutic effect. The results showed that this treatment had the advantages of smaller dose, high local concentration, satisfactory curative effect, no adverse reaetions, being not liable to produce drug-fast bacteria strains and ready reception from the patients. The paper also discusses the merits of taking the carboxymethylcellulose natrium as peridental sustained release carrier: it can be dissolved in saliva, gingival sulcus fluid and blood; release slowly so that it may mantain a longer effective concentration in the local part, being beneficial to kill the bacteria.

以羧甲基纤维素钠作牙周缓释剂局部应用治疗牙周病149例。结果表明本药具有用药剂量小、局部浓度高、效果好、无副作用、不易形成耐药菌株、且病人易于接受等优点。还进一步讨论了以羧甲基纤维素钠作牙周缓释剂载体材料,能被唾液、龈沟液、血液等溶解而药物缓慢、持久释放,使局部维持有效药物浓度时间较长,有利于杀菌。

Objective: To determine whether chitosan can be used as a drug carrier in treatment of giant cell tumor of bone (GCT). Methods: In vitro chemosensitivities of chitosan and chitosan with adriamycin(ADM),cisplachitin (CDDP), and methotrexate(MTX) to GCT were tested by using MTT method. Results:The only chitosan was had no inhibitory effect on GCT (inhibitory rate:1.8%),the inhibitory rates of chitosan with ADM,CDDP and MTX were higher than that of chitosan with ADM,CDDP and MTX in equal concentration (maximum...

Objective: To determine whether chitosan can be used as a drug carrier in treatment of giant cell tumor of bone (GCT). Methods: In vitro chemosensitivities of chitosan and chitosan with adriamycin(ADM),cisplachitin (CDDP), and methotrexate(MTX) to GCT were tested by using MTT method. Results:The only chitosan was had no inhibitory effect on GCT (inhibitory rate:1.8%),the inhibitory rates of chitosan with ADM,CDDP and MTX were higher than that of chitosan with ADM,CDDP and MTX in equal concentration (maximum concentration in plasma),but there were no marked differences (P>0.05). Conclusion:Chitosan can be used as a good sustained release carrier of ADM,CDDP and MTX.As the chemotherapeutic concentration of GCT is high (the inhibitory rates of ADM,CDDP,MTX in maximum concentration in plasma were 17.06%,15.87%,7.09%),usual injection in vein or local giving is not suited,and so it may be useful for sensitivity chemical drugloaded chitosan drug delivery system used for local treatment of GCT to reduce the recurrent rate after operation.

目的:确定壳多糖(几丁糖)是否可作为骨巨细胞瘤治疗的药物载体。方法:用壳多糖及壳多糖联合阿霉素、顺氨氯铂及甲氨蝶呤对骨巨细胞瘤进行体外敏感实验(MTT法)。结果:单纯壳多糖对骨巨细胞瘤在体外无抑制作用(抑制率为1.8%),壳多糖联合阿霉素、顺氨氯铂及甲氨蝶呤分别较单独应用相同浓度(血浆峰值浓度)药物的抑制率要高,但无显著差异(P>0.05)。结论:壳多糖可以作为阿霉素、顺氨氯铂及甲氨蝶呤的良好缓释载体。由于骨巨细胞瘤要求化疗药物浓度较高(阿霉素、顺氨氯铂及甲氨蝶呤的血浆峰值浓度的抑制率分别为17.06%,15.87%,7.09%),不适合常规的静脉及局部给药。故壳多糖与敏感药物制成的缓释系统用于局部治疗可在降低术后复发率上起到较为积极的作用。

Giant cell tumor of bone (GCT)is a semi—malignant tumor.There are high recurrentrates in this tumor after operation.7 specimens of GCT proved by pathology were cultured,then the chemosensisitivity of the primary cultures were tested by using MTT method,The results showed there were middle degree sensitivity to GCT in usual dose (1/250 of one clinical dose )of cisplachitin (CDDP)and adriamycin (ADM),The results of chemosensitivity test of echelon dense of chemical drug showed the lowest effective dense of ADM,CDDP...

Giant cell tumor of bone (GCT)is a semi—malignant tumor.There are high recurrentrates in this tumor after operation.7 specimens of GCT proved by pathology were cultured,then the chemosensisitivity of the primary cultures were tested by using MTT method,The results showed there were middle degree sensitivity to GCT in usual dose (1/250 of one clinical dose )of cisplachitin (CDDP)and adriamycin (ADM),The results of chemosensitivity test of echelon dense of chemical drug showed the lowest effective dense of ADM,CDDP and MTX were 0.4ug/ml, 2ug/ml, 3ug/ml, It is concluded GCT may be treated by ADM and CDDP to reduce the recurrent rate of GCT after operation. As the effeective dense of the drug is high,usual injection in vein and local giving are not suited,and the local treatment by drug delivery system made out by good sustained release carrier and sensitivity chemical drug may be the only effective mothed.

骨巨细胞瘤是一种半恶性的肿瘤,术后复发率较高。作者取经病理证实的骨巨细胞瘤标本(共7例)进行体外培养,并用MTT法进行原代细胞的化疗药物敏感试验及梯度浓度的化疗药物的敏感试验,结果显示,在常规剂量下(临床一次用量的1/250)骨巨细胞瘤对阿霉素及顺氨氯铂中度敏感,梯度试验表明,阿霉素、顺氨氯铂及甲氨蝶吟的最低有效抑制浓度分别为0.4ug/ml、2ug/ml和3us/ml,因此,骨巨细胞瘤可以应用阿霉素、顺氨氯铂等进行治疗以降低术后复发率,但由于有效浓度较高,不适合常规的静脉及局部给药,而仅适用于良好缓释载体与敏感化疗药物制成的缓释制剂的局部应用。

 
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