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fulminant hepatitis failure
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  “fulminant hepatitis failure”译为未确定词的双语例句
     Methods Serum samples were obtained from 112 patients with chronic hepatitis B virus infection; 22 with chronic carries(ASC),30 with chronic mild or moderate hepatitis(CH),60 with fulminant hepatitis failure(FHF). HBV qusispecies populations were separated by the single strand conformation polymorphism (SSCP) method targeted the S region and DNA sequencing analysis.
     方法 选择HBVDNA阳性患者共 112例 ,其中慢性重型肝炎 (FHF) 6 0例 (同时有肝硬化者 38例 ) ,慢性轻、中型肝炎 (CH) 30例 ,病毒携带者 (ASC) 2 2例 ,采用单链构像多态性(SSCP)和DNA序列分析方法检测HBVS区准种。
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     Methods Serum sample from 257 patients with chronic HBV infection,including 49 asymptomatic HBV carriers(ASC),52 mild chronic hepatitis B,38 moderate chronic Hepatitis B,32 severe chronic hepatitis B,22 fulminant hepatitis failure(FHF),41 liver cirrhosis(LC),and 23 hepatocellular carcinoma(HCC) patients were collected and tested for HBV genotypes by polymerase chain reaction(PCR) micro-board nucleic acid hybridization-enzyme-linked-immunosorbent assay(ELISA).
     方法选择镇江地区HBV感染者257例,其中慢性HBV携带者49例,慢性乙型肝炎轻度52例、中度38例、重度32例,重型肝炎22例,肝硬化41例,原发性肝癌23例。 应用聚合酶链反应(PCR)微板核酸杂交-酶联免疫吸附(ELISA)技术检测HBV的基因型。
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  相似匹配句对
     Computer Forecast of Fulminant Hepatitis
     电子计算机预报重症肝炎
短句来源
     STUDY OF TREATMENT FOR FULMINANT HEPATITIS
     重症肝炎治疗的研究
短句来源
     SERIOUS COMPLICATIONS OF FULMINANT VIRAL HEPATITIS WITH HEPATIC FAILURE
     重症病毒性肝炎肝功能衰竭时的严重并发症
短句来源
     Hepatitis C and Detection for it
     丙型肝炎及其检测
短句来源
     Study of prevention and treatment of fulminant hepatitis with multiple organs failure
     重型肝炎并发多器官功能衰竭分析
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Objective To study the complexity of S region qusispecies in various disease stages of chronic hepatitis B virus(HBV) infection and its relation to disease activity. Methods Serum samples were obtained from 112 patients with chronic hepatitis B virus infection;22 with chronic carries(ASC),30 with chronic mild or moderate hepatitis(CH),60 with fulminant hepatitis failure(FHF). HBV qusispecies populations were separated by the single strand conformation polymorphism (SSCP) method targeted the S region...

Objective To study the complexity of S region qusispecies in various disease stages of chronic hepatitis B virus(HBV) infection and its relation to disease activity. Methods Serum samples were obtained from 112 patients with chronic hepatitis B virus infection;22 with chronic carries(ASC),30 with chronic mild or moderate hepatitis(CH),60 with fulminant hepatitis failure(FHF). HBV qusispecies populations were separated by the single strand conformation polymorphism (SSCP) method targeted the S region and DNA sequencing analysis. Results The number of SSCP bands detected in the patients with ASC、CH and FHF was 1.45±0.13,3.70±0.22 and 5.93±0.24, respectively. There was a statistically significant difference in the number of quasispecies among various disease stages ( P <0.01). The complexity of quasispecies showed an increasing trend from ASC, CH to FHF group. SSCP bands in HBeAg positive, HBeAg nagative and HBV genotype B and C patients were 3.41±0.27, 5.27±0.30和4.71 ±2.36, 3.06±1.76 respectively. The number of viral quasispecies in HBeAg nagative and HBV genotype B group were significantly higher than that in HBeAg positive and HBV genotype C group ( P <0.01). ALT values(U/L)changed from 567.2,462.3 to nomal or near nomal leavels respectively, and SSCP bands number from 9,7 to 5,1 respectively in 2 with FHF after following up one year. SSCP bands maintained the same in 1 with ASC after following up one year. The results of SSCP analysis were identified by DNA sequencing. Conclusions The complexity of HBV S region quasispecies increased with disease progressing and was associated weth HBeAg nagative, disease activity and HBV genotype.

目的 通过对慢性乙型肝炎不同病型患者S区准种复杂性差异的分析 ,探讨S区准种与疾病活动性的关系。方法 选择HBVDNA阳性患者共 112例 ,其中慢性重型肝炎 (FHF) 6 0例 (同时有肝硬化者 38例 ) ,慢性轻、中型肝炎 (CH) 30例 ,病毒携带者 (ASC) 2 2例 ,采用单链构像多态性(SSCP)和DNA序列分析方法检测HBVS区准种。结果 不同疾病期SSCP条带数不同 ,分别为ASC( 1.4 5± 0 .13) ,CH( 3.70± 0 .2 2 ) ,FHF( 5 .93± 0 .2 4 )。准种复杂性随疾病进展而增加 ,组间比较差异有显著性 ,F =72 .73,P <0 .0 1。HBeAg阳性与HBeAg阴性患者SSCP条带数分别为 3.4 1± 0 .2 7和 5 .2 7± 0 .30 ,两组差异有显著性 (t =4 .5 3,P <0 .0 1)。HBV基因型B、C患者SSCP条带数分别为 4 .71± 2 .36和 3.0 6± 1.76 ,差异有显著性 (t =2 .6 6 ,P <0 .0 1)。 2例重型肝炎患者随访 1年后丙氨酸转氨酶 (ALT)分别由 5 6 ...

目的 通过对慢性乙型肝炎不同病型患者S区准种复杂性差异的分析 ,探讨S区准种与疾病活动性的关系。方法 选择HBVDNA阳性患者共 112例 ,其中慢性重型肝炎 (FHF) 6 0例 (同时有肝硬化者 38例 ) ,慢性轻、中型肝炎 (CH) 30例 ,病毒携带者 (ASC) 2 2例 ,采用单链构像多态性(SSCP)和DNA序列分析方法检测HBVS区准种。结果 不同疾病期SSCP条带数不同 ,分别为ASC( 1.4 5± 0 .13) ,CH( 3.70± 0 .2 2 ) ,FHF( 5 .93± 0 .2 4 )。准种复杂性随疾病进展而增加 ,组间比较差异有显著性 ,F =72 .73,P <0 .0 1。HBeAg阳性与HBeAg阴性患者SSCP条带数分别为 3.4 1± 0 .2 7和 5 .2 7± 0 .30 ,两组差异有显著性 (t =4 .5 3,P <0 .0 1)。HBV基因型B、C患者SSCP条带数分别为 4 .71± 2 .36和 3.0 6± 1.76 ,差异有显著性 (t =2 .6 6 ,P <0 .0 1)。 2例重型肝炎患者随访 1年后丙氨酸转氨酶 (ALT)分别由 5 6 7.2U/L、4 6 2 .3U/L降至正常和接近正常 ( 4 2 .8U/L) ,SSCP条带数分别由 9、7条减至 5、2条 ;1例ASC随访 1年SSCP方式仍维持 1条带不变 ,ALT水平高低与SS CP条带数多少相一致。经DNA序列分析 ,证实了SSCP显示的HBV准种性。结论 HBVS基因准种随疾病病情加重而复杂性增加 ,其增加程度与HBeAg阴性、病情轻重及基因型

Objective To investigate the distribution of hepatitis B virus genotype in Zhenjiang city and its clinical significance.Methods Serum sample from 257 patients with chronic HBV infection,including 49 asymptomatic HBV carriers(ASC),52 mild chronic hepatitis B,38 moderate chronic Hepatitis B,32 severe chronic hepatitis B,22 fulminant hepatitis failure(FHF),41 liver cirrhosis(LC),and 23 hepatocellular carcinoma(HCC) patients were collected and tested for HBV genotypes by polymerase chain reaction(PCR) micro-board...

Objective To investigate the distribution of hepatitis B virus genotype in Zhenjiang city and its clinical significance.Methods Serum sample from 257 patients with chronic HBV infection,including 49 asymptomatic HBV carriers(ASC),52 mild chronic hepatitis B,38 moderate chronic Hepatitis B,32 severe chronic hepatitis B,22 fulminant hepatitis failure(FHF),41 liver cirrhosis(LC),and 23 hepatocellular carcinoma(HCC) patients were collected and tested for HBV genotypes by polymerase chain reaction(PCR) micro-board nucleic acid hybridization-enzyme-linked-immunosorbent assay(ELISA).Results Of the 257 patients with chronic HBV infection,112(43.6%) were genotype B and 140((54.5%)) were genotype C.Genotype C was more prevalent in the severe chronic hepatitis B,FHF,LC and HCC patients than in the ASC patients(P<0.05);the ALT,TBIL,the rate of HBeAg positive and the HBV DNA level were significantly higher in genotype C than in genotype B patients(P<0.05);the ALB、the rate of anti-HBe were significantly higher in genotype B than in genotype C patients(P<0.05).Conclusion The system we used seems to be a useful tool for testing HBV genotypes.Genotype B,genotype C and genotype B+C combination exist in Zhenjiang city,and genotype C is the major genotype in this area especially in FHF and HCC patients.It increase ALT,TBIL,the level of viremia and HBeAg lasts longer,so the prognosis is poor.

目的了解镇江地区乙型肝炎病毒(HBV)基因型的分布及与临床的相关性。方法选择镇江地区HBV感染者257例,其中慢性HBV携带者49例,慢性乙型肝炎轻度52例、中度38例、重度32例,重型肝炎22例,肝硬化41例,原发性肝癌23例。应用聚合酶链反应(PCR)微板核酸杂交-酶联免疫吸附(ELISA)技术检测HBV的基因型。结果257例HBV感染者中B基因型112例(43.6%),C基因型140例(54.5%),B+C基因型5例(1.95%),未发现A、D、E、F、G和H基因型。C基因型在慢性乙型肝炎重度、重型肝炎、肝硬化、肝细胞癌中占绝对优势,分别占65.6%、72.7%、68.3%、78.3%,显著高于慢性HBV携带者的38.8%,P<0.05。C基因型HBV感染者的血清丙氨酸氨基转移酶(ALT)水平(262.3±319.7u/L)、总胆红素(TBIL)水平(69.9±35.8μmol/l)、HBeAg阳性率(67.1%)、HBV DNA定量中位数绝对值(6.02±1.34)显著高于B基因型(141.5±206.1u/L)、(38.3±22.4μmol/l)、46.4%和4.18±1.10,P<0.05。B基因...

目的了解镇江地区乙型肝炎病毒(HBV)基因型的分布及与临床的相关性。方法选择镇江地区HBV感染者257例,其中慢性HBV携带者49例,慢性乙型肝炎轻度52例、中度38例、重度32例,重型肝炎22例,肝硬化41例,原发性肝癌23例。应用聚合酶链反应(PCR)微板核酸杂交-酶联免疫吸附(ELISA)技术检测HBV的基因型。结果257例HBV感染者中B基因型112例(43.6%),C基因型140例(54.5%),B+C基因型5例(1.95%),未发现A、D、E、F、G和H基因型。C基因型在慢性乙型肝炎重度、重型肝炎、肝硬化、肝细胞癌中占绝对优势,分别占65.6%、72.7%、68.3%、78.3%,显著高于慢性HBV携带者的38.8%,P<0.05。C基因型HBV感染者的血清丙氨酸氨基转移酶(ALT)水平(262.3±319.7u/L)、总胆红素(TBIL)水平(69.9±35.8μmol/l)、HBeAg阳性率(67.1%)、HBV DNA定量中位数绝对值(6.02±1.34)显著高于B基因型(141.5±206.1u/L)、(38.3±22.4μmol/l)、46.4%和4.18±1.10,P<0.05。B基因型HBV感染者的血清白蛋白(ALB)水平(39.6±9.6g/)显著高于C基因型(30.1±7.3g/l),P<0.05。结论PCR微板核酸杂交—ELISA技术可用于HBV基因型的临床检测。镇江地区HBV感染者基因型以单一的B型或C型为主,含少量B+C型。C基因型为本地区优势基因型,并在严重肝病和原发性肝癌中比例较高,其引起的ALT、TBIL、病毒血症水平均较高,HBeAg血症持续时间长,故预后较差。

 
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