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-cis retinoic acid
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  “13-cis retinoic acid”译为未确定词的双语例句
     All trans retinoic acid(ATRA), 13-cis retinoic acid (CRA) and vitamin A (Vit A)were investigated in the plasma, leukocytes and erythrocytes from leukemia patients and healthy individuals by reverse phase high pressure liquid chromatography(HPLC).
     应用反相高压液相色谱(HPLC)技术,检测了正常人和白血病病人血浆、白细胞及红细胞内生理性全反式维甲酸(ATRA)、13-顺式维甲酸(13-cis-RA,CRA)和维生素A(VitA)的含量。
短句来源
     Efficacy of inhaling isotretinoin(13-cis retinoic acid) for chemopreventing lung cancer
     吸入异维甲酸用于预防肺癌的疗效观察
短句来源
     Many experiments and clinical investigations found that RA could resist proliferation、induce differentiation and start apoptosis . Now all trans retinoic acid (ATRA) and 13-cis retinoic acid (13-cRA) have been successfully used in the clinical therapy of many cancers such as leukemia、carcinoma of kidney、mammary cancer and so on.
     体外实验及临床研究表明,RA可抑制癌细胞增殖、诱导癌细胞分化和凋亡,研究和应用较多的RA是全反式视黄酸(ATRA)和13-顺式视黄酸(13-cRA),目前ATRA和13-cRA已用于白血病、肾癌、乳腺癌、黑色素细胞瘤、皮肤癌等多种癌症的临床治疗,并有较好的疗效。
短句来源
     Conclusion: The occurrence of microtia may be induced by some ri sk factors, such as viral infection, immune diseases, administration of Chinese herbal medicine and 13-cis retinoic acid before pregnancy and in the first trim ester of gestation.
     结论 小耳畸形综合征的发生与其父母年龄无明显的相关性 ,而患儿母亲在孕前及孕早期患病毒性感染、免疫性疾病及服用中草药、维甲酸类药物可能是小耳畸形综合征发生的危险因素
短句来源
  相似匹配句对
     The Preparation of Cis-retinoic Acid
     异维A酸的制备方法
短句来源
     Synthesis and Characterization of 13-cis-Retinoic Acid Derivatives
     异维A酸衍生物合成与结构表征
短句来源
     Synthesis, Characterization and Anticancer Activity of 13-cis-Retinoic Acid Derivatives
     13-cis-异维A酸衍生物的合成、表征及抗癌活性研究
短句来源
     Research on the Synthesis and Characterization of 13-cis-Retinoic Acid Derivatives Containing N, O-Funcitons
     含氮、氧多官能团异维A酸衍生物合成及结构表征研究
短句来源
     Efficacy of inhaling isotretinoin(13-cis retinoic acid) for chemopreventing lung cancer
     吸入异维甲酸用于预防肺癌的疗效观察
短句来源
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  -cis retinoic acid
The impact of pretransplant cytoreductive treatment, such as intensive chemotherapy, splenectomy, or 13-cis retinoic acid, is unclear.
      
However, 13-cis retinoic acid (RA) and SAHA, a histone deacetylase inhibitor, have each been shown to induce apoptosis in medulloblastoma cultures and mouse models.
      
Response of preclinical medulloblastoma models to combination therapy with 13-cis retinoic acid and suberoylanilide hydroxamic a
      
According to in vitro and in vivo clinical studies, 13-cis retinoic acid (cRA) may be a promising agent for maintenance therapy in these patients.
      
Palatal epithelia from CD-1 embryonic mice on Day 12 of gestation were isolated from the mesenchyme and cultured in serum-free media, with all-trans retinoic acid or 13-cis retinoic acid, with or without epidermal growth factor (EGF).
      
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The effect of inhibition of proliferation of a novel human megakaryoblastic leukemia cell line (HIMeg) by two physiological factors, 1.25-dihydroxyvitamin D3 [1,25(OH)2 D3] and 13-cis-retinoic acid (RA), was investigated. At the range of 10-9 - 10-6 mol/L, 1,25(OH)2 D3 and RA showed significant inhibition of proliferation of the megakaryoblastic leukemia cells,which was demonstrated by count of survival cells,incorporation of [3H]-TdR and [3H]-UR, and cloning efficiency. From above, it can...

The effect of inhibition of proliferation of a novel human megakaryoblastic leukemia cell line (HIMeg) by two physiological factors, 1.25-dihydroxyvitamin D3 [1,25(OH)2 D3] and 13-cis-retinoic acid (RA), was investigated. At the range of 10-9 - 10-6 mol/L, 1,25(OH)2 D3 and RA showed significant inhibition of proliferation of the megakaryoblastic leukemia cells,which was demonstrated by count of survival cells,incorporation of [3H]-TdR and [3H]-UR, and cloning efficiency. From above, it can further explain the m.echanism of differentiation-inducers and the effect of 1,25(OH)2D3 on myelofibrosis. It is possible for 1,25(OH)2D3 and RA to be used for a new -treatment.

本文报道了两种生理性诱导剂——活性维生素D_3[1,25(OH)_2D_3,简称D_3]和维甲酸(RA)对原始巨核白血病细胞的增殖抑制作用。采用活细胞计数、[~3H]-TdR和[~3H]-UR参入以及克隆形成率测定3项指标,对一株新建的人原始巨核白血病细胞系(HIMeg)进行实验,结果表明:10~(-9)~10~(-6)mol/LD_3和RA对巨核白血病细胞的生长抑制作用呈明显量效与时效关系,10~(-7) mol/L D_3可使其克隆形成率减少90%以上。从而进一步说明了诱导分化剂对白血病及D_3对骨髓纤维化的治疗机制,提示D_3和RA可能有新的治疗用途。

The action of 13-cis-retinoic acid(RA)in combination with 1,25-dihydroxyvitaminD_3(D_3)on two kinds of leukemia cell lines in vitro is reported.At the concentrationof 10~(-7) mol/L,RA and D_3 could inhibit the cell proliferation and they have additiveeffect on the human promyelocytic leukemia cell line(HL-60),and also have synergiceffect on the human megakaryoblastic leukemia cell line(HIMeg)in inducing celldifferentiation.The results suggest that RA in combination with D_3 may be used forthe...

The action of 13-cis-retinoic acid(RA)in combination with 1,25-dihydroxyvitaminD_3(D_3)on two kinds of leukemia cell lines in vitro is reported.At the concentrationof 10~(-7) mol/L,RA and D_3 could inhibit the cell proliferation and they have additiveeffect on the human promyelocytic leukemia cell line(HL-60),and also have synergiceffect on the human megakaryoblastic leukemia cell line(HIMeg)in inducing celldifferentiation.The results suggest that RA in combination with D_3 may be used forthe treatment of acute megakaryoblastic leukemia and acute promyelocytic leukemia.It ispresumed that they had additive or synergic action in the differentiation of hemopoieticcells in vivo.

本文报道了13-顺式维甲酸(RA)和[1,25-二羟维生素 D_3 1,25(OH)_2D_3]合用对两种白血病细胞系的体外实验结果。在10~(-7)mol/L 浓度下,应用 ~3H-TdR 掺入、NBT 还原试验、流式细胞分析等技术,测得:RA 和1,25(OH)_2D_3合用后可进一步抑制细胞的增殖;在诱导分化作用方面,二者对人原始巨核白血病细胞株(HIMeg)有相加作用,而对人早幼粒细胞白血病细胞系(HL-60)则有一定协同作用。上述结果提示可将 RA 联合1,25(OH)_2D_3试用于治疗白血病;推测二者在体内巨核系和粒单系造血细胞分化中发挥着相加或协同的促进效应。

Changes of cell cycle kinetics of HL-60 cell line after ALL-trans retinoic acid(ATRA)and 9-cis retinoic acid(9-cis RA)induction were studied with BrdU/DNA bivariated flow cytometry. HL-60 cells were exposed to ATRA or 9-cis RA for 96 h. During the exposure, the RA-treated cells were obtained at 24,48,72 and 96 h and then the cell cycle kinetics was meas ured with BrdU/DNA bivariated flow cytometry.Data from 4 parameters of cell cycle showed that treatment with ATRA or 9-cis RA for 96...

Changes of cell cycle kinetics of HL-60 cell line after ALL-trans retinoic acid(ATRA)and 9-cis retinoic acid(9-cis RA)induction were studied with BrdU/DNA bivariated flow cytometry. HL-60 cells were exposed to ATRA or 9-cis RA for 96 h. During the exposure, the RA-treated cells were obtained at 24,48,72 and 96 h and then the cell cycle kinetics was meas ured with BrdU/DNA bivariated flow cytometry.Data from 4 parameters of cell cycle showed that treatment with ATRA or 9-cis RA for 96 h resulted in a decrease in the cell BrdU LI,production rate and an increase in Ts and Tpot. Mean while the ability of the cell to reduce NBT was enhanced by RA induction, and the percentage of matured cells was increased by cell morphology assessment.These results suggested that both ATRA and 9-cis-RA may induce HL-60 cell differentiation.

用Brdu/DNA双参数流式细胞仪技术研究了HL-60细胞经全反式维甲酸(ATRA)和9-顺式维甲酸(9-cisRA)诱导24,48和96h后,细胞周期动力学各参数,BrdULI,Ts,Tpot和PR的变化,同时测定细胞NBT还原试验和细胞形态学的变化,发现随着维甲酸诱导时间的延长,BrdULI逐渐降低,PR亦是逐渐减少,而Ts和Tpot则逐渐延长。NBT还原试验结果表明NBT阳性细胞百分比呈现上升趋势:细胞形态学观察显示稍成熟阶段细胞百分比上升,早幼粒阶段细胞所占百分比下降。本文观察了ATRA和9-cisRA在诱导HL-60细胞过程中以上各参数的变化,结果提示两类维甲酸对HL-60细胞均有诱导分化功能。

 
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