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acitretin capsule
相关语句
  阿维a胶囊
     Analysis of Effect on Ordinary Type Psoriasis Treated by Tuiyin Decoction Combined with Acitretin Capsule
     退银汤联合阿维A胶囊治疗寻常型银屑病疗效分析
短句来源
     Formulation Optimization and Stability Study of Acitretin Capsule
     阿维A胶囊处方筛选及稳定性研究
短句来源
     OBJECTIVE:To optimize the best formulation and process of acitretin capsule and to study the stability of its finished preparation.
     目的:筛选阿维A胶囊的最佳处方、工艺,并考察其成品的稳定性。
短句来源
     CONCLUSION:The optimized formulation and technics of acitretin capsule were reasonable and the dissolution,content uniformity and stability of the finished preparation from which were in conformity with China Pharmacopoeia.
     结论:优选的阿维A胶囊处方、工艺合理,由其制备的成品溶出度、含量均匀度、稳定性等均达《中国药典》要求。
短句来源
  “acitretin capsule”译为未确定词的双语例句
     And AUC (0~24) were 2891.97±809.60 and 2883.01±905.60ng·h·ml -1 respectively. The relative bioavailability of domestic acitretin capsule was 100.23±11.03%.
     AUC(0~ 2 4) ,分别为 2 891.97± 80 9.6 0 ,2 883.0 1± 90 5 .6 0ng·h·ml-1,相对生物利用度为 10 0 .2 3±11.0 3%。
短句来源
  相似匹配句对
     Formulation Optimization and Stability Study of Acitretin Capsule
     阿维A胶囊处方筛选及稳定性研究
短句来源
     . and Ranjianduoji capsule.
     1、本草考证与文献考查
短句来源
     Analysis of Effect on Ordinary Type Psoriasis Treated by Tuiyin Decoction Combined with Acitretin Capsule
     退银汤联合阿维A胶囊治疗寻常型银屑病疗效分析
短句来源
     ②capsule formation;
     ②具有包膜 ;
短句来源
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OBJECTIVE:To determine the pharmacokinetic parameters of domestic acitretin capsules so as to provide exˉperimental basis for rational use of the drug.METHODS:The plasma concentrations of acitretin rabbits were determined by HPLC.The pharmacokinetic parameters were calculated with3p97pharmacokinetic program.RESULTS:The concentration-time curve of acitretin fitted in with one-compartment model.The peak plasma level(C max )was(316.33±170.83)ng/ml,the peak time(T max )was(1.92±0.85)h,the T 1/2...

OBJECTIVE:To determine the pharmacokinetic parameters of domestic acitretin capsules so as to provide exˉperimental basis for rational use of the drug.METHODS:The plasma concentrations of acitretin rabbits were determined by HPLC.The pharmacokinetic parameters were calculated with3p97pharmacokinetic program.RESULTS:The concentration-time curve of acitretin fitted in with one-compartment model.The peak plasma level(C max )was(316.33±170.83)ng/ml,the peak time(T max )was(1.92±0.85)h,the T 1/2 Ke was(4.37±3.33)h,and the AUC (0~10) was(1817.74±563.95)ng/(h·ml). CONCLUSION:Acitretin is absorbed rapidly,and is safe.

目的 :测定国产阿维A胶囊的药代动力学参数 ,为临床合理应用该药提供实验依据。方法 :采用高效液相色谱法测定兔血浆中阿维A浓度 ,用3p97软件计算药代动力学参数。结果 :国产阿维A在兔体内呈一室模型分布 ,Cmax 为 (316 33±170 83)ng/ml,Tmax 为 (1 92±0 85)h ,T1/2Ke为 (4 37±3 33)h ,AUC0~10 为 (1817 74±563 95)ng/(h·ml)。结论 :该药易吸收 ,安全性高。

Objective:To study the relative bioavailability and pharmacokinetics of domestic acitretin capsules in 22 healthy male volunteers.Methods:A single dose of 50mg of domestic or imported acitretin was administered by randomized crossover way in 22 volunteers and the plasma concentrations of acitrctin were determined by HPLC.The pharmacokinetic parameters were calculated with 3p97 pharmacokinetic program and the bioequivalency was evaluated.Results:The concentration-time curves of two preparations fitted...

Objective:To study the relative bioavailability and pharmacokinetics of domestic acitretin capsules in 22 healthy male volunteers.Methods:A single dose of 50mg of domestic or imported acitretin was administered by randomized crossover way in 22 volunteers and the plasma concentrations of acitrctin were determined by HPLC.The pharmacokinetic parameters were calculated with 3p97 pharmacokinetic program and the bioequivalency was evaluated.Results:The concentration-time curves of two preparations fitted one-compartment model.The peak plasma levels(C max )of domestic and imported acitretin were 490.51±136.50 and 470.91±118.59ng/ml respectively.The peak time(T max ) were 4.13±1.16 and 3.75±1.18h respectively.And AUC (0~24) were 2891.97±809.60 and 2883.01±905.60ng·h·ml -1 respectively.The relative bioavailability of domestic acitretin capsule was 100.23±11.03%.Conclusion:The result of two one-sided tests suggests that the domestic capsule is bioequivalent to the imported capsule.

目的 :对重庆华邦制药有限公司研制的阿维A胶囊 (国产阿维A胶囊 )与瑞士罗氏制药厂生产的阿维A胶囊 (进口阿维A胶囊 )进行人体相对生物利用度评价。方法 :2 0名男性健康志愿者随机交叉单剂量口服国产或进口的阿维A胶囊 ,高效液相色谱法测定血浆中阿维A浓度 ,经 3p97生物利用度和生物等效性计算程序处理拟合。结果 :国产或进口的阿维A胶囊体内药时曲线符合一室模型 ,国产或进口的阿维A胶囊 :Cmax分别为 4 90 .5 1± 136 .5 0 ,4 70 .91± 118.5 9ng/ml;Tmax分别为4 .13± 1.16和 3.75± 1.18h ;AUC(0~ 2 4) ,分别为 2 891.97± 80 9.6 0 ,2 883.0 1± 90 5 .6 0ng·h·ml-1,相对生物利用度为 10 0 .2 3±11.0 3%。结论 :经方差分析和单双侧t检验 ,表明国产或进口的两种胶囊具有生物等效性。

OBJECTIVE:To optimize the best formulation and process of acitretin capsule and to study the stability of its finished preparation.METHODS:The orthogonal experiment was conducted with the formula quantity of amylum pregelaˉtinisatum,lactose and low-substituted hydroxypropyl cellulose(L-HPC)as the determination factors,the comprehensive eˉvaluation was conducted with dissolution rate,flowability,content uniformity and so on as the quality determination index of finished preparation;The stability of the...

OBJECTIVE:To optimize the best formulation and process of acitretin capsule and to study the stability of its finished preparation.METHODS:The orthogonal experiment was conducted with the formula quantity of amylum pregelaˉtinisatum,lactose and low-substituted hydroxypropyl cellulose(L-HPC)as the determination factors,the comprehensive eˉvaluation was conducted with dissolution rate,flowability,content uniformity and so on as the quality determination index of finished preparation;The stability of the finished preparation was determined under illumination,high temperature and high-moisture.RESULTS:The best formulation was composed of the following,amylum pregelatinisatum20%,lactose20%,L-HPC1%,which was prepared by granulating process;The finished preparation was stable in quality.CONCLUSION:The optimized formulation and technics of acitretin capsule were reasonable and the dissolution,content uniformity and stability of the finished preparation from which were in conformity with China Pharmacopoeia.

目的:筛选阿维A胶囊的最佳处方、工艺,并考察其成品的稳定性。方法:以可压性淀粉、乳糖、低取代羟丙基纤维素(L-HPC)处方用量为考察因素进行正交试验,以溶出度、流动性、含量均匀度等为成品质量考察指标进行综合评价;在光照、高温、高湿条件下对成品进行稳定性考察。结果:最佳处方组成为可压性淀粉20%、乳糖20%、L-HPC1%,采用制粒工艺制备;所得成品质量稳定。结论:优选的阿维A胶囊处方、工艺合理,由其制备的成品溶出度、含量均匀度、稳定性等均达《中国药典》要求。

 
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