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hydrogen peroxide urea
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     Synthesis of Urea Hydrogen Peroxide
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     Urea Peroxide--New Derivative of Hydrogen Peroxide
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Hydrogen peroxide urea is an adduct of hydrogen peroxide and urea.Suspension quantitative germicidal test and animal test were used to carry out experimental study on its germicidal efficacy and toxicological effects.Results: The contact lens disinfection solution containing hydrogen peroxide urea 50 g/L with a 10 min contact time killed over 99.9% in average of Escherichia coli and Staphylococcus aureus.10%(v/v) calf serum had certain influence on its efficacy in killing Escherichia coli.The acute oral...

Hydrogen peroxide urea is an adduct of hydrogen peroxide and urea.Suspension quantitative germicidal test and animal test were used to carry out experimental study on its germicidal efficacy and toxicological effects.Results: The contact lens disinfection solution containing hydrogen peroxide urea 50 g/L with a 10 min contact time killed over 99.9% in average of Escherichia coli and Staphylococcus aureus.10%(v/v) calf serum had certain influence on its efficacy in killing Escherichia coli.The acute oral toxicity of the disinfectant in mice was LD_(50) >5000 mg/kg body weight,so it was practicelly non-toxic.Its stock solution was non-irritating to rabbit skin and eye.Guinea pig skin sensitization test showed that it was a weak sensitizing substance.Conclusion: This contact lens disinfection solution has good efficacy in killing vegetative forms of bacteria.It is non-toxic and non-irritating to animal skin and has weak sensitizing effect.

过氧化氢脲是过氧化氢与尿素的加合物,采用悬液定量杀菌试验和动物试验对其杀菌效果和毒理学效果进行了试验研究。结果,以含过氧化氢脲50 g/L的隐型眼镜消毒液作用10 m in,对大肠杆菌和金黄色葡萄球菌平均杀灭率达到99.9%以上;含体积分数10%小牛血清对其杀灭大肠杆菌效果有一定影响。该消毒液对小鼠急性口服毒性为LD50>5000 mg/kg.bw,属实际无毒类;其原液对家兔皮肤、眼睛无刺激性;豚鼠皮肤致敏试验,属弱致敏物。结论,该隐型眼镜消毒液对细菌繁殖体杀灭效果较好,属无毒级物质,对动物皮肤无刺激性,为弱致敏性。

 
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