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   local plasma drug concentration space time equation 的翻译结果: 查询用时:0.033秒
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local
plasma
drug
concentration
space
time
equation
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Objective:To set up the local plasma drug concentration space time equation of the local embedding.Methods:The cocal drug concentration space time equation was set up to the product of drug concentration time and concentration space position function,and then proved by mathematical methods of weighted mean and multivariate analysis.Results:The general format of local plasma drug...

Objective:To set up the local plasma drug concentration space time equation of the local embedding.Methods:The cocal drug concentration space time equation was set up to the product of drug concentration time and concentration space position function,and then proved by mathematical methods of weighted mean and multivariate analysis.Results:The general format of local plasma drug concentration equation in the fourth dimension was as below: C (t,x,y,z)=F(x,y,z)· C (t),F(x,y,z)=B 0+B 1X+B 2Y+B 3Z+B 4r 3+B 5r 2+B 6r, C (t)=A 1e -K at +A 2e -K et +A 3e -K rt .The simplifying local plasma drug concentration space time equation in two dimension was as below: C (t,ρ)=F(ρ)· C (t),F(ρ)=D 0+D 1ρ+D 2ρ 2+D 3ρ 3 , C (t) is ditto.Conclusion:The deduction was rational and proved in the animal 's elementary experimentation.

目的 :建立局部植入给药的药物浓度时空方程。方法 :将局部药物浓度时空方程构建为空间分布函数和时间分布函数 (药物浓度经时方程 )的积函数 ,并以加权平均及多元分析的数学手段予以证明及推导。结果 :四维时空的局部植入给药的药物浓度时空方程的通式为 :C(t,X ,Y ,Z) =F(X ,Y ,Z)·C(t) ,F(X ,Y ,Z) =B0 +B1X +B2 Y +B3 Z +B4r3 +B5r2 +B6r ,C(t) =A1e-Kat+A2 e-Ket+A3 e-Krt。两维变量的简化的药物浓度时空方程为C(t,ρ) =F(ρ)·C(t) ,F(ρ) =D0 +D1ρ+D2 ρ2 +D3 ρ3 ,C(t)同上。结论 :推导基本合理 ,并在初步的动物实验中得以验证。

Objective:To set up the local plasma drug concentration-space-time equation of the local embedding administration.Methods:The space position function and time function were set up using of local drug concentration,as well as local drug concentration-space-time equation were set up using mathematical methods of weighted mean and multivariate analysis.Results:The local drug concentration...

Objective:To set up the local plasma drug concentration-space-time equation of the local embedding administration.Methods:The space position function and time function were set up using of local drug concentration,as well as local drug concentration-space-time equation were set up using mathematical methods of weighted mean and multivariate analysis.Results:The local drug concentration equation in the fourth dimension according to animal experiments was as below:C(t,X,Y,Z)=(B 0+B 4r3+ B 5r2)×(A 1e -Kat+A 2e -Ket+A 3e -Krt)=(1.343+0.018r3-0.625r2)×(206.08e -0.0038t- 15.48e -0.2184t- 190.60e -0.0444t),r=(X2+Y2+Z2) 1/2.Conclusion:The theory of function was rational via deduction of animal experiments and was value of scientific research,it would be redounded to reveal the pharmacokinetics rule of local administration.

目的 :按实例建立局部植入给药的局部药物浓度时空方程。方法 :以加权平均及多元分析的方法 ,分别求算局部药物浓度的空间和时间分布函数 (药物浓度经时方程 )。结果 :四维时空的局部植入给药的局部药物浓度时空方程为 :C(t ,X ,Y ,Z) =(B0 +B4r3 +B5r2 )× (A1e-Kat+A2 e-Ket+A3 e-Krt) =(1.343+0 .0 18r3 - 0 .6 2 5r2 )×(2 0 6 .0 8e-0 .0 0 3 8t- 15 .4 8e-0 .2 184t- 190 .6 0e-0 .0 444t) ,r =(X2 +Y2 +Z2 ) 1/ 2 。结论 :经实例演算 ,时空方程的理论基本合理 ,有较好科研价值 ,有助于揭示局部给药的药代动力学规律。

AIM To set up the local plasma drug concentration space time equation of the local embedding. METHODS To set up the local plasma drug concentration space time equation with the product of plasma drug concentration time and concentration space position function. Then to prove or understand with mathematical methods of weighted mean and multivariate analysis. RESULTS The general...

AIM To set up the local plasma drug concentration space time equation of the local embedding. METHODS To set up the local plasma drug concentration space time equation with the product of plasma drug concentration time and concentration space position function. Then to prove or understand with mathematical methods of weighted mean and multivariate analysis. RESULTS The general format of local plasma drug concentration equation in the fourth dimension:C(t, X,Y,Z )=F( X,Y,Z ).C(t), F( X,Y,Z ) = B 0+B 1X+B 2Y+B 3Z+B 4r 3+B 5r 2+B 6r, r =(X 2+Y 2+Z 2) 1/2 , C(t)=A 1e -Kat +A 2e -Ket +A 3e -Krt .The simplifying local plasma drug concentration space time equation in two dimension:C(t,ρ)=F(ρ).C(t) F(ρ)=D 0+D 1ρ+D 2ρ 2+D 3ρ 3,C(t) is ditto. CONCLUSIONS The deduction was rational and proved in the animal's elementary experimentation. The theory was value of scientific research and redound to reveal the rule of local pharmacokinetics.

目的 建立局部植入给药的药物浓度时空方程。方法 将局部药物浓度时空方程构建为空间分布函数和时间分布函数(药物浓度经时方程 )的积函数。并以加权平均及多元分析的数学手段予以证明及推导。结果 四维时空的局部植入给药的药物浓度时空方程的通式为 :C(t,X ,Y ,Z) =F(X ,Y ,Z) .C(t) ,F(X ,Y ,Z) =B0 +B1X +B2 Y +B3Z +B4r3+B5r2 +B6 r,C(t) =A1e-Kat+A2 e-Ket+A3e-Krt。两维变量的简化的药物浓度时空方程为 :C(t,ρ) =F(ρ) .C(t)F(ρ) =D0 +D1ρ +D2 ρ2 +D3ρ3,C(t)同上。结论 推导基本合理 ,并在初步的动物试验探索中得以验证。理论有较好科研价值 ,有助于揭示局部给药的药代动力学规律

 

 


 

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