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Objective:To set up the local plasma drug concentration space time equation of the local embedding.Methods:The cocal drug concentration space time equation was set up to the product of drug concentration time and concentration space position function,and then proved by mathematical methods of weighted mean and multivariate analysis.Results:The general format of local plasma drug...
Objective:To set up the local plasma drug concentration space time equation of the local embedding.Methods:The cocal drug concentration space time equation was set up to the product of drug concentration time and concentration space position function,and then proved by mathematical methods of weighted mean and multivariate analysis.Results:The general format of local plasma drug concentration equation in the fourth dimension was as below: C (t,x,y,z)=F(x,y,z)· C (t),F(x,y,z)=B 0+B 1X+B 2Y+B 3Z+B 4r 3+B 5r 2+B 6r, C (t)=A 1e -K at +A 2e -K et +A 3e -K rt .The simplifying local plasma drug concentration space time equation in two dimension was as below: C (t,ρ)=F(ρ)· C (t),F(ρ)=D 0+D 1ρ+D 2ρ 2+D 3ρ 3 , C (t) is ditto.Conclusion:The deduction was rational and proved in the animal 's elementary experimentation.
Objective:To set up the local plasma drug concentration-space-time equation of the local embedding administration.Methods:The space position function and time function were set up using of local drug concentration,as well as local drug concentration-space-time equation were set up using mathematical methods of weighted mean and multivariate analysis.Results:The local drug concentration...
Objective:To set up the local plasma drug concentration-space-time equation of the local embedding administration.Methods:The space position function and time function were set up using of local drug concentration,as well as local drug concentration-space-time equation were set up using mathematical methods of weighted mean and multivariate analysis.Results:The local drug concentration equation in the fourth dimension according to animal experiments was as below:C(t,X,Y,Z)=(B 0+B 4r3+ B 5r2)×(A 1e -Kat+A 2e -Ket+A 3e -Krt)=(1.343+0.018r3-0.625r2)×(206.08e -0.0038t- 15.48e -0.2184t- 190.60e -0.0444t),r=(X2+Y2+Z2) 1/2.Conclusion:The theory of function was rational via deduction of animal experiments and was value of scientific research,it would be redounded to reveal the pharmacokinetics rule of local administration.
AIM To set up the local plasma drug concentration space time equation of the local embedding. METHODS To set up the local plasma drug concentration space time equation with the product of plasma drug concentration time and concentration space position function. Then to prove or understand with mathematical methods of weighted mean and multivariate analysis. RESULTS The general...
AIM To set up the local plasma drug concentration space time equation of the local embedding. METHODS To set up the local plasma drug concentration space time equation with the product of plasma drug concentration time and concentration space position function. Then to prove or understand with mathematical methods of weighted mean and multivariate analysis. RESULTS The general format of local plasma drug concentration equation in the fourth dimension:C(t, X,Y,Z )=F( X,Y,Z ).C(t), F( X,Y,Z ) = B 0+B 1X+B 2Y+B 3Z+B 4r 3+B 5r 2+B 6r, r =(X 2+Y 2+Z 2) 1/2 , C(t)=A 1e -Kat +A 2e -Ket +A 3e -Krt .The simplifying local plasma drug concentration space time equation in two dimension:C(t,ρ)=F(ρ).C(t) F(ρ)=D 0+D 1ρ+D 2ρ 2+D 3ρ 3,C(t) is ditto. CONCLUSIONS The deduction was rational and proved in the animal's elementary experimentation. The theory was value of scientific research and redound to reveal the rule of local pharmacokinetics.