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   retinoblastoma susceptibility gene (rb) 在 肿瘤学 分类中 的翻译结果: 查询用时:0.292秒
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  “retinoblastoma susceptibility gene (rb)”译为未确定词的双语例句
    Objective: To study the expression of retinoblastoma susceptibility gene(Rb) and minichromosome maintenance protein 2(MCM2) in primary prostate cancer(PCa) and its clinical significance.
    目的:探讨视网膜母细胞瘤易感基因(Rb)和微染色体维持蛋白2(MCM2)在前列腺癌发病机制中的作用及其临床意义。
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    The retinoblastoma susceptibility gene(Rb) was the firstly identified tumor suppressor gene. But the expression of Rb and its product. PRb, in oral carcinogenesis has not been reported.
    视网膜母细胞用易感基因(Rb)是第一个被确认的抑癌基因,但Rb基因及其产物PRb在口腔粘膜癌前损害癌变过程中的改变和表达未见阐述。
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  retinoblastoma susceptibility gene rb
Since the human retinoblastoma susceptibility gene (RB1)along with the gene for esterase D is on chromosome 13q14, these data indicate this linkage group is conserved in man and mouse.
      
A human cDNA probe was used to screen a panel of mouse-Chinese hamster somatic cell hybrids to determine the chromosomal location of the retinoblastoma susceptibility gene (Rb-1)in mouse.
      
The retinoblastoma susceptibility gene (RB), the prototype of the class of tumor suppressor genes, is inactivated in a number of human malignancies.
      
Ethnic variations of a retinoblastoma susceptibility gene (RB1) polymorphism in eight Asian populations
      
The retinoblastoma susceptibility gene (Rb) was either rearranged or deleted in 7 of 37 osteosarcomas, 1 of 7 soft-tissue sarcomas and 1 of 4 Ewing sarcomas.
      
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The retinoblastoma susceptibility gene(Rb) was the firstly identified tumor suppressor gene. But the expression of Rb and its product. PRb, in oral carcinogenesis has not been reported. It was found immunohistochemically that the positive reactions of PRboccurred in cellular nuclei and cytoplasms of tissues in each stage of oral carcinogenesis.The positive staining in nuclei was stronger than that in cytoplasms and positive patterns showed heterogenecity.It seemed that PRb...

The retinoblastoma susceptibility gene(Rb) was the firstly identified tumor suppressor gene. But the expression of Rb and its product. PRb, in oral carcinogenesis has not been reported. It was found immunohistochemically that the positive reactions of PRboccurred in cellular nuclei and cytoplasms of tissues in each stage of oral carcinogenesis.The positive staining in nuclei was stronger than that in cytoplasms and positive patterns showed heterogenecity.It seemed that PRb expression associaseiated with the differential degrees of invasive squamous cell carcinomas. These results support to some extent our speculations from the research on P16 expression in oral carcinogenesis and indicate that it is necessary to study further the changes and effects of Rb gene and its product PRb on the development of oral carciongenesis.

视网膜母细胞用易感基因(Rb)是第一个被确认的抑癌基因,但Rb基因及其产物PRb在口腔粘膜癌前损害癌变过程中的改变和表达未见阐述。本研究应用LSAB免疫组织化学染色技术观察到口腔粘膜癌前损害发生、发展过程中的各阶段组织中均存在PRb在胞核和胞浆中的阳性反应,且胞核表达强于胞浆,并具有异质性;至口腔粘膜鳞状细胞癌阶段,PRb的表达与鳞癌的分化程度有关;这些结果在一定程度上支持作者在P16蛋白研究中的有关推论,Rb、PRb在口腔粘膜癌前损害癌变过程中的改变及其作用值得进一步探讨。

Objective: To study the expression of retinoblastoma susceptibility gene(Rb) and minichromosome maintenance protein 2(MCM2) in primary prostate cancer(PCa) and its clinical significance.Methods: The expression of MCM2 protein and pRb were detected in 49 cases of PCa,20 cases of benign prostate hyperplasia(BPH),10 cases of normal prostate tissues(NP) by EliVisionTM plus immunohistochemical staining.Results: The positive expression rate of pRb in PCa,BPH,NP were 44.90%,80% and 90% respectively.The...

Objective: To study the expression of retinoblastoma susceptibility gene(Rb) and minichromosome maintenance protein 2(MCM2) in primary prostate cancer(PCa) and its clinical significance.Methods: The expression of MCM2 protein and pRb were detected in 49 cases of PCa,20 cases of benign prostate hyperplasia(BPH),10 cases of normal prostate tissues(NP) by EliVisionTM plus immunohistochemical staining.Results: The positive expression rate of pRb in PCa,BPH,NP were 44.90%,80% and 90% respectively.The expression level of pRb in PCa was significantly lower than that in BPH(P<0.05) and NP(P<0.05),and was negatively correlated with pathological grades(P<0.05) and clinical stages(P<0.05) of PCa.The positive expression rate of MCM2 in PCa,BPH,NP were 67.35%,25% and 10% respectively,however,the expression level of MCM2 in PCa was significantly higher than that in BPH(P<0.05) and NP(P<0.05),and was positively correlated with pathological grades(P<0.05) and clinical stages(P<0.05) of PCa.The expression level of MCM2 in PCa was negatively correlated with pRb(rs =-0.596,P <0.01).Conclusion: Rb might be involved in the occurrence and development of PCa.The determination of Rb and MCM2 can be an index for estimating the level of malignancy and prognosis of PCa.

目的:探讨视网膜母细胞瘤易感基因(Rb)和微染色体维持蛋白2(MCM2)在前列腺癌发病机制中的作用及其临床意义。方法:应用免疫组化EliVisionTM plus二步法,检测49例前列腺癌(PCa)组织,20例良性前列腺增生(BPH)及10例正常前列腺组织(NP)中pRb蛋白与M CM 2的表达。结果:pRb在PCa,BPH与NP组织中的阳性表达率分别为44.90%,80%,90%,PCa中pRb的水平明显低于BPH(P<0.05)及NP(P<0.05),且与PCa病理分级(P<0.05)和临床分期(P<0.05)呈负相关。M CM 2在PCa,BPH与NP组织中的阳性表达率分别为67.35%,25%和10%,PCa中M CM 2的水平明显高于BPH(P<0.05)及NP(P<0.05),且与PCa病理分级(P<0.05)和临床分期(P<0.05)呈正相关。M CM 2表达与pRb表达呈负相关(rs=-0.596,P<0.01)。结论:Rb基因参与了前列腺癌的发生、发展过程,检测Rb基因和M CM 2有助于判定前列腺癌恶性程度及预后。

 
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