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uterine malignant mixed mesodermal tumor
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  子宫恶性混合性中胚叶肿瘤
     A clinical analysis of uterine malignant mixed mesodermal tumor
     子宫恶性混合性中胚叶肿瘤临床分析
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  子宫恶性中胚叶混合瘤
     Expression of p53, epidermal growth factor receptor and Ki 67 antigen in uterine malignant mixed mesodermal tumor
     p53、EGFR和Ki-67抗原在子宫恶性中胚叶混合瘤中的表达
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     Purpose To study the correlation between expression of p53, EGFR, Ki 67 antigen and stage, histological grade and prognosis of uterine malignant mixed mesodermal tumor.
     目的:研究子宫恶性中胚叶混合瘤p53、EGFR和Ki-67抗原的表达及与肿瘤临床分期、组织学分级和预后的关系。
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  相似匹配句对
     The Evaluation of Malignant Uterine Tumors with MRI
     MRI在子宫恶性肿瘤的诊断价值
短句来源
     Diagnosis of malignant Trophoblashic Dixease of Uterine by Ultrasonograph
     B超诊断子宫恶性滋养细胞疾病
短句来源
     Value of MRI in Diagnosing and Staging Uterine Malignant Tumors
     子宫恶性肿瘤术前MRI检查的价值
短句来源
     A clinical analysis of uterine malignant mixed mesodermal tumor
     子宫恶性混合性中胚叶肿瘤临床分析
短句来源
     MALIGNANT HISTIOCYTOMA
     恶性组织细胞瘤
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Purpose To study the correlation between expression of p53, EGFR, Ki 67 antigen and stage, histological grade and prognosis of uterine malignant mixed mesodermal tumor. Methods Expression of p53, EGFR and Ki 67 antigen were detected and compared by immunohistochemical S P method. Results The positive rates of p53, EGFR and Ki 67 were 61 9%、61 9% and 71 4% respectively. p53 overexpression was significantly more in stage Ⅱ ̄Ⅳ MMMT(10/15) than in stage Ⅰ (3/9) ( P <0 05). Histologically, there...

Purpose To study the correlation between expression of p53, EGFR, Ki 67 antigen and stage, histological grade and prognosis of uterine malignant mixed mesodermal tumor. Methods Expression of p53, EGFR and Ki 67 antigen were detected and compared by immunohistochemical S P method. Results The positive rates of p53, EGFR and Ki 67 were 61 9%、61 9% and 71 4% respectively. p53 overexpression was significantly more in stage Ⅱ ̄Ⅳ MMMT(10/15) than in stage Ⅰ (3/9) ( P <0 05). Histologically, there was more positive expression of p53 in grade Ⅱ carcinoma component than in the grade Ⅰ and EGFR expressed more in the grade Ⅲ sarcoma component than in the grade Ⅱ ( P <0 05). There was a significant difference of p53 staining between those cases who died within one year and those patients who survived for more than 2 years ( P <0 05), EGFR and Ki 67 antigen overexpressions in uterine MMMT were not associated with the stage and survival. Conclusion The expression of p53 was related to tumor stage and the pathological degree. The p53 expression has prognostic value.

目的:研究子宫恶性中胚叶混合瘤p53、EGFR和Ki-67抗原的表达及与肿瘤临床分期、组织学分级和预后的关系。方法:用免疫组化S-P法对21例子宫恶性中胚叶混合瘤的存档资料作染色观察。结果:p53、EGFR和Ki-67抗原的阳性表达率分别为61.9%、61.9%和71.4%。临床分期Ⅱ~Ⅳ期肿瘤(10/12)的p53阳性表达率明显高于Ⅰ期肿瘤(3/9)(P<0.05)、肿瘤癌性成分Ⅱ级的p53阳性表达高于Ⅰ期(P<0.05)。6例在1年内死亡的病例,其中5例p53阳性染色,而5例生存2年以上的肿瘤p53免疫染色全部阴性,两组比较(P<0.05)。肉瘤成分Ⅲ级的EGFR阳性率高于Ⅱ级(P<0.05),除此而外,EGFR和Ki-67的表达和肿瘤分期、预后均无相关性。结论:肿瘤的p53表达具有预后意义

Objective To analyze the clinical features and prognosis of uterine malignant mixed mesodermal tumor (MMMT) Methods Seventeen cases treated in the second hospital and the third hospital of Jilin University were analyzed retrospectively Ten were stage Ⅰ,3 stage Ⅱ,4 stage Ⅲ~Ⅳ Results ①The median age was 62 7 Most patients (94 1%) were postmenopause,and the mean time between menopause and diagnosis was 14 years The patients usually presented abnormal vaginal bleeding (88 2%) ②Nine patients...

Objective To analyze the clinical features and prognosis of uterine malignant mixed mesodermal tumor (MMMT) Methods Seventeen cases treated in the second hospital and the third hospital of Jilin University were analyzed retrospectively Ten were stage Ⅰ,3 stage Ⅱ,4 stage Ⅲ~Ⅳ Results ①The median age was 62 7 Most patients (94 1%) were postmenopause,and the mean time between menopause and diagnosis was 14 years The patients usually presented abnormal vaginal bleeding (88 2%) ②Nine patients (52 9%) were diagnosed preoperatively ③All patients underwent surgery Two received adjuvant chemotherapy ④The survival period was related to clinical stages The prognosis of the patients with early stages was better than advanced ones Conclusions The clinical symptom of uterine MMMT is nonspecific and the preoperative diagnosis rate is low The major treatment is surgery Adjuvant chemotherapy and radiotherapy may be used to prevent recurrence The prognosis is poor and the prognosis is related to clinical stage,the earlier the stage,the better the prognosis

目的 探讨子宫恶性混合性中胚叶肿瘤 (MMMT)的临床病理特征及影响预后的因素。方法 回顾性分析吉林大学第二医院、第三医院自 1990年 1月至 2 0 0 2年 1月收治的子宫MMMT患者共 17例 ,结果 ①子宫MMMT发病中位年龄为 6 2 7岁 (4 6~ 76岁 ) ,其中 94 1% (16 17)为绝经后发病 ,发病年龄距绝经年龄平均为 14年。临床表现以阴道异常出血为主 ,占 88 2 % ;②术前主要经诊断性刮宫确诊 ,术前诊断率为 5 2 9% ;③ 17例患者均行手术治疗。术后 2例Ⅰ期、Ⅱ期患者分别行 1、 4个周期的卡铂加环磷酰胺联合化疗 ,无 1例行术后放射治疗 ;④手术 -病理分期早的子宫MMMT患者预后较好。结论 子宫MMMT临床症状不典型 ,好发于绝经后女性 ,以阴道出血为主。刮宫为术前诊断最可靠的方法 ,但诊断率也较低。治疗以手术为主 ,可辅以化疗、放疗减少局部复发。手术 -病理分期是影响预后的最主要的因素

 
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