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aberration of chromosome
相关语句
  染色体畸变
     Results (1) The frequency of numerical aberration of chromosome 7, 9, 11, 17 was 23.5%, 38.2%, 14.7% and 11.8% in urine and 30.0%, 50.0%, 26.7% and 16.7% in bladder washing, respectively.
     结果  (1)膀胱癌患者尿液脱落细胞核中 7,9,11,17号染色体数目畸变阳性率分别为 2 3.5 %、38.2 %、14.7%和 11.8% ; 冲洗液中各号染色体畸变阳性率分别为 30 .0 %、5 0 .0 %、2 6 .7%和 16 .7%。
短句来源
     Loss of chromosome 9 was a most common aberration, without relation to pathological grade and stage of bladder cancer, whereas abnormality of chromosome 7 was associated with the stage of bladder cancer, numerical aberration of chromosome 11,17 was not related to grade and stage of bladder cancer.
     其中9号染色体畸变率较高,但与膀胱癌分级、分期无明显关系。 7号染色体数目畸变与膀胱癌的分期密切相关,11、17号染色体数目畸变与膀胱癌分级、分期无显著相关性。
短句来源
     With treated seeds of sunflower by DES, the ability and rate of germination,rate of emergence, seedling height and index of cell division all reduced, whereas the frequency of aberration of chromosome increased with the increase of DES concentration.
     用0.1%、0.3%、0.5%、0.7%和0.9%的硫酸二乙酯处理向日葵后,其发芽势、发芽率、出苗率、幼苗高度和细胞分裂指数均随着浓度增加而减小,染色体畸变率随浓度增加而提高。
短句来源
  “aberration of chromosome”译为未确定词的双语例句
     Methods GSTT1 genotypes from 61 lung cancer cases and 46 controls were determined by PCR and structural and number aberration of chromosome 15 were detected by FISH.
     方法利用PCR技术分析了61例肺癌患者和46例对照的GSTT1基因型分布,以荧光原位杂交(FISH)技术分析了不同GSTT1基因型的14例肺癌患者和18例对照淋巴细胞15号染色体结构和数目畸变。
短句来源
     Aberration of chromosome 13 is not the only cause of RB;
     13号染色体的畸变不是RB发生的唯一原因;
短句来源
     structural changes of chromosome 21 are not associated with the gain or loss of chromosome 4, 10 or 17, there is a relationship between the numerical aberration of chromosome 21 and trisomies 4, 10 and 17 in patients with ALL.
     21号染色体的畸变与4、10和17染色体数量的变化存在相关性,21号染色体结构的畸变较少合并4、10和17号染色体数目的变化。
短句来源
     Conclusion: The aberration rate of chromosome 9 heterochromatin is 4.2 times for persons suspected to have chromosome abnormalities higher than for normal individuals(P<0.01). This study suggests that the aberration of chromosome 9 heterochromatin may contribute to chromosomal disease.
     结论疑有染色体异常个体的9号染色体异染色质区的变异率高于正常人4.2倍(P<0.01),这说明9号染色体异染色质区的变异可能参与一些染色体病的发生。
短句来源
     Objective:To analysis the aberration of chromosome 9 heterochromatin for persons suspected to have chromosome abnormalities.
     目的分析疑有染色体异常个体的9号染色体异染色质区的变异。
短句来源
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  相似匹配句对
     Chromosome aberration arises from No.
     发生畸变染色体有NO.
短句来源
     Chromosome Aberration in Banana micropropagation
     香蕉苗试管繁殖染色体数量畸变的研究
短句来源
     Aberration analysis of chromosome 9 heterochromatin
     9号染色体异染色质区的变异分析
短句来源
     The rate and type of aberration of chromosome were observed.
     观察染色体畸变率及畸变类型分析。
短句来源
     and the stage of induce chromosome aberration was discussed.
     3C或4E染色体诱导染色体断裂可能是在花粉母细胞减数分裂的多个时期。
短句来源
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  aberration of chromosome
The proportion of patients with multiple numerical aberration of chromosome 17 was significantly higher in HNPCC (9/14) than among SCRC (11/42).
      
Langer-Giedion syndrome, in a child with complex structural aberration of chromosome 8
      
In two patients (one with atelencephaly and one with aprosencephaly) an aberration of chromosome 13 was found.
      
In all, 77.8% (28/36) of the renal malignancies investigated exhibited an aberration of chromosome 3, which seems to serve as a marker for this malignancy.
      


Comparative chromosome studies were carried out by means of short culture of lymphocytes from peripheral blood of 8 cows in which leucosis showed haematologically and serologically negative, 8 with persistent lymphocytosis and 2 with bovine lymphosarcoma. The results of the studies revealed that aberration took place in different degrees in the lymphocyte chromosomes of a11 the cases with lymphocytosis. Diploid accounted for 68.9—83.9% of the total number of cells in the negative cases, averaging...

Comparative chromosome studies were carried out by means of short culture of lymphocytes from peripheral blood of 8 cows in which leucosis showed haematologically and serologically negative, 8 with persistent lymphocytosis and 2 with bovine lymphosarcoma. The results of the studies revealed that aberration took place in different degrees in the lymphocyte chromosomes of a11 the cases with lymphocytosis. Diploid accounted for 68.9—83.9% of the total number of cells in the negative cases, averaging 76.6%, and 32,4—58.7% in the cases with lymphocytosis, 46.3% on an average. There was an extremely marked difference between them (P<0.01). In most of the cases with lymphocytosis the proportions of hypodiploid and hyperdiploid were higher than those in the negative cases. The increases in the proportions of hypodiploid were notabler than those in hyperdiploid. By comparison with the cases with persistent lymphocytosis, the proportions of diploid in the cases with lymphosarcoma presented a further decrease trend (28.6% and 34.4% respectively), the increases of the proportion of hyperdiploid being notabler in aneuploid, The increase of the proportion of hypodiploid approached that of hyperdiploid in one case, The proportion (42.9%) of diploid in the other case with lymphosarcoma whose chromosome specimen was prepared with marrow cells was higher than that in the two cases with blood lymphocytes the aneuploids in this case being mostly hyperdiploids. The frequency of structural aberration of chromosomes in the haematologically and serologically negative cases, cases with persistent lymphocytosis and cases with lymphosarcoma was 2.1%, 5.2% and 8% of the cells respectively. The chromosome aberrations of cows with leucosis presented a phasic nature at the two stages of persistent lymphocytosis and lymphosarcoma.A similar abnormal chromosome was found in nearly half of the cells in metaphase in two cases with persistent lymphocytosis.An abnormal clone was discovered in a case with lymphosarcoma. One chromosome of the 29th pair was deformed, and the other was lost. According to the researches of predecessors and the results of this experiment a tentative idea was advanced on the possibility of the existence of marker chromosome in lymphosarcoma.

采用外周血淋巴细胞短期培养法对8例血液学检查及琼扩实验阴性牛、8例持续性淋巴细胞增生牛和2例淋巴肉瘤牛进行的染色体比较研究表明,造白细胞组织增生牛的淋巴细胞染色体都发生了不同程度的畸变。阴性牛二倍体细胞的比例处于68.9%—83.9%之间,平均为76.6%;持续性淋巴细胞增生牛二倍体细胞的比例处于32.4%—58.7%之间,平均为46.3%,二者之间有极显著差异(P<0.01)。大部分持续性淋巴细胞增生病例亚二倍体和超二倍体细胞的比例都较阴性牛增高。亚二倍体细胞增多比超二倍体显著。与持续性淋巴细胞增生牛比较,淋巴肉瘤牛二倍体细胞的比例呈现出进一步降低趋势(分别为28.6%和34.4%),非整倍体细胞的增加以超二倍体细胞比例的增高较为显著,有1例亚二倍体比例的增高和超二倍体接近。采取骨髓细胞制备染色体标本的另一例淋巴肉瘤牛二倍体细胞的比例比采取外周血的两例要高(42.9%),非整倍体细胞多半为超二倍体细胞。阴性牛、持续性淋巴细胞增生牛和淋巴肉瘤牛染色体形态变异的频率分别为2.1%,5.2%和8%。造白细胞组织增生牛的染色体畸变在持续性淋巴细胞增生和淋巴肉瘤这两个不同时期存在着阶段性变化。 另外两例持续性淋巴细胞...

采用外周血淋巴细胞短期培养法对8例血液学检查及琼扩实验阴性牛、8例持续性淋巴细胞增生牛和2例淋巴肉瘤牛进行的染色体比较研究表明,造白细胞组织增生牛的淋巴细胞染色体都发生了不同程度的畸变。阴性牛二倍体细胞的比例处于68.9%—83.9%之间,平均为76.6%;持续性淋巴细胞增生牛二倍体细胞的比例处于32.4%—58.7%之间,平均为46.3%,二者之间有极显著差异(P<0.01)。大部分持续性淋巴细胞增生病例亚二倍体和超二倍体细胞的比例都较阴性牛增高。亚二倍体细胞增多比超二倍体显著。与持续性淋巴细胞增生牛比较,淋巴肉瘤牛二倍体细胞的比例呈现出进一步降低趋势(分别为28.6%和34.4%),非整倍体细胞的增加以超二倍体细胞比例的增高较为显著,有1例亚二倍体比例的增高和超二倍体接近。采取骨髓细胞制备染色体标本的另一例淋巴肉瘤牛二倍体细胞的比例比采取外周血的两例要高(42.9%),非整倍体细胞多半为超二倍体细胞。阴性牛、持续性淋巴细胞增生牛和淋巴肉瘤牛染色体形态变异的频率分别为2.1%,5.2%和8%。造白细胞组织增生牛的染色体畸变在持续性淋巴细胞增生和淋巴肉瘤这两个不同时期存在着阶段性变化。 另外两例持续性淋巴细胞增生牛的近半数中期细胞都出现了一条相似的异常染色体。 发现在1例淋巴肉?

In recent years, with the advancesin research work on chromosome oftumor cells, it was revealed thatthe aberration of chromosome oftumor cells was nonrandom. It hasbeen proved that retinoblastoma(RB)in some patients is associated withdeletion of one chromosome 13q ofsomatic cells and some data concern-ing the chromosomal behavior ofRB tumor cells reported in literatureare found to be similar to those con-cerning somatic cells. The aim ofthe present study was to analyzethe chromosome constitution...

In recent years, with the advancesin research work on chromosome oftumor cells, it was revealed thatthe aberration of chromosome oftumor cells was nonrandom. It hasbeen proved that retinoblastoma(RB)in some patients is associated withdeletion of one chromosome 13q ofsomatic cells and some data concern-ing the chromosomal behavior ofRB tumor cells reported in literatureare found to be similar to those con-cerning somatic cells. The aim ofthe present study was to analyzethe chromosome constitution of tu-mor cells and compare the charac-teristics of chromosome of the malig-nant cells with histological and clini-cal findings of the tumor. Results of chromosome study of so-lid tumor cells from 9 patients withRB are presented in this paper. Noneof the patients had a family historyof RB, and the examination of themetaphase of chromosome of peripher-al blood lymphocytes in 5 patientsrevealed nothing abnormal. Chromo-some preparations of the tumor cellswere obtained by using direct tech-nique and short-term culture (2 and24 h). Chromosome banding wasachieved in 4 cases only. The chromosomes in metaphase oftumor cells in all 9 cases were foundabnormal both in number and struc-ture. 30-206 metaphases of tumorcells were counted in each individualcase. The modal chromosome numberwas 45 in 3 cases, 46 in 2, 47, 66and 92 in 3 cases respectively, andhyper-tetraploidy in 1. Karyotypeanalysis revealed a considerable vari-ability. However, one to five markerchromosomes were found in each case.Six of these cases had aberrations ofD-group chromosome. Six of thesecases lost one E-group chromosome(chromosome 16) and had a metacen-tric chromosome in size similar to C-group chromosome [in some cases, itwas probably i(17q)].Four cases haddouble minutes. These results suggest-ed that the aberration of chromosomeD and E-group were probably relatedto the development and progression ofRB. The investigation of chromoso-mal, histological and clinical findingssuggested that some undifferentiatedtumors tended to have polyploid chro-mosome modes and the chromosomalpolyploidy was probably related toprotracted evolution of tumor cells inconsiderably long duration of malig-nancy too.

本文对9例视网膜母细胞瘤患者实体瘤细胞作染色体研究。瘤细胞染色体数目和结构均有畸变。据检查结果,推测D组和E组染色体的异常可能与视网膜母细胞瘤的发生有一定联系;染色体的多倍化可能与病程较长,瘤细胞长期演化有关。

The cytogenetics of the biopsies from human nasopharyngeal carcinoma (NPC) has been investigated by chromosome G-banding technique. Chromosome preparations were made directly from 28 patients with NPC. The higher frequency in the gains of chromosome No. 19 and the losses of No. 14, 22, 3, 15 indicated non-random change in numerical aberration of chromosomes. The structural aberration of chromosomes mainly focused on several chromosomes of No. 1, 2, 3, 5, 7, 12 and 14, in which...

The cytogenetics of the biopsies from human nasopharyngeal carcinoma (NPC) has been investigated by chromosome G-banding technique. Chromosome preparations were made directly from 28 patients with NPC. The higher frequency in the gains of chromosome No. 19 and the losses of No. 14, 22, 3, 15 indicated non-random change in numerical aberration of chromosomes. The structural aberration of chromosomes mainly focused on several chromosomes of No. 1, 2, 3, 5, 7, 12 and 14, in which the frequency involving No. 1 was the highest. Seven marker chromosomes: Iq-, 2q+, 3q-, 7q-, 12q - large subacrocentrie chrofosome and large chromosome involving No. 3 were found in NPC. 1q- was the most common in seven markers as was observed in 22 patients. The breakpoint of No. 1 was at 1q21-25 or 1q32. Three marker chromosomes previously found in NPC biopsies in our laboratory have been observed repeatedly. There-suits by G-banding analysis show that the formation of giant group A chromosome was not consistent and at least there were several origins, mainly concerned with rearrangement between chromosomes No. 1, 2, 3 or 5.

采用直接法制备28例鼻咽癌活检组织的染色体标本进行G带分析。结果表明,鼻咽癌染色体畸变具有类型广泛、畸变率高等特点。14、22、3及15号染色体丢失和额外19号的出现频率较高反映了染色体数目畸变的非随机性。染色体结构畸变主要集中在1、2、3、5、7、12和14号染色体上,其中以1号受累最为突出。在发现的7种标记染色体中1q-的出现频率最高。1q断裂的热点分别在1q21—1q25和1q32。此外,过去在鼻咽癌活检组织中发现的3种异常染色体本实验均重复见到。显带分析结果表明,“巨A”的形成有多种来源,主要由A、B组染色体参与的易位和重组所形成。

 
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