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   p 73 polymorphism 的翻译结果: 查询用时:0.006秒
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p polymorphism
相关语句
  p73基因多态性
     Application of PCR-CTPP for P73 Polymorphism in Cervical Carcinoma
     PCR-CTPP技术在宫颈癌P73基因多态性研究中应用
短句来源
  “p 73 polymorphism”译为未确定词的双语例句
     For example, because there was p73 polymorphism and loss of heterozygosity (LOH) frequently, the normal presence of p73 gene was key importance, and p73 was very important anti-oncogene in the neuroblastoma, cancer of colon, melanoma and mammary cancer et al.
     而癌旁组织、区域淋巴结与对应的食管正常组织之间 P73蛋白阳性检出率比较,均无显著性差异…川.05\ 同样,P73蛋白阳性表达检出率与食管癌临床病理特征之间的关系均无显著性差异(p>0.05)。
短句来源
     (2) Frequencies of GC/GC, AT/AT and GC/AT in p73 polymorphism were 70.29% (71/101), 1.98% (2/101) and 27.73% (28/101) in cervical carcinoma cases and77% (77/100), 4% (4/100) and 19% (19/100) in control cases, respectively.
     (4)维族宫颈癌p53Arg72Pro多态性、p73G4A多态性与HPV感染、年龄及病理组织学分级的分层分析显示p53 Arg/ Arg基因型在HPV16感染组中的分布频率明显高于Arg/Pro和Pro/Pro基因型,统计学分析差异具有显著性(χ2=7.177,P=0.028),p73G4A多态性与HPV16感染无明显相关性。
短句来源
  相似匹配句对
     Jovial (J73) to C Translator
     JOVIAL(J73)到C的转换程序
短句来源
     73 references were quoted.
     引用文献73篇。
短句来源
     Expressionofmorethantwokindsofoncogeneproteinswerepresentin73casesofbladdertransitionalcelcarcinoma.
     73例膀胱移行细胞癌存在两种以上蛋白共同表达。
短句来源
     p73 Gene and Tumor
     p73基因与肿瘤
短句来源
     limited polymorphism;
     有限的分子多态性;
短句来源
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Objective A functional single nucleotide polymorphism (SNP) at codon 72 of the gene for p53 protein (p53 R72P) has been implicated in a variety of human cancers, but the relationship between this SNP and hepatocellular carcinoma (HCC) remains obscure despite the fact that the critical role of p53 protein in HCC has been documented. This study was conducted to evaluate the link between the polymorphism with HCC stratified by chronic hepatitis B infection status in a Chinese...

Objective A functional single nucleotide polymorphism (SNP) at codon 72 of the gene for p53 protein (p53 R72P) has been implicated in a variety of human cancers, but the relationship between this SNP and hepatocellular carcinoma (HCC) remains obscure despite the fact that the critical role of p53 protein in HCC has been documented. This study was conducted to evaluate the link between the polymorphism with HCC stratified by chronic hepatitis B infection status in a Chinese population. Methods Four hundred and sixty-nine HCC cases (359 HBsAg-positive, 110 HBsAg-negative) and 567 controls (137 HBsAg-positive, 430 HBsAg-negative) were studied. The p53 genotypes were determined by a PCR based restriction fragment lergth polymorphism (RFLP) method. Results Overall, no correlation between HCC and the R72P genotypes was found when comparing all cases to controls or when comparing the HBsAg-positive HCC subgroup to controls. However, in HBsAg-negative subjects, the 72P allele was significantly associated with the presence of HCC (P=0.01) and had a higher risk (OR=1.69, 95% CI:1.25-2.27) of HCC as compared to the 72R allele. By comparison to R/R homozygotes, the R/P heterozygotes and P/P homozygotes had a 1.73-fold (95% CI:0.96-3.11) and a 3.29-fold (95% CI:1.58-6.86) increased risk for HCC, respectively. The subjects with the 72P allele and a family history of HCC and those with the 72P allele and male gender also yielded an 11.14-fold (95% CI:1.62-76.67) and a 9.39-fold (95% CI:3.08-28.62) increased risk of HCC, respectively. Conclusion The P allele of the p53 R72P polymorphism has an increased risk for HCC in HBsAg-negative subjects, and exerts a synergistic influence on the risk for HCC when combined with HCC family history and the male gender.

目的探讨在有无慢性乙型肝炎的不同背景下p53基因第72密码子多态性(R72P)与中国人肝细胞癌(hepatocellular carcinoma,HCC)遗传易感性的关系。方法采用聚合酶链反应-限制性片段长度多态方法,检测469例HCC(HBsAg阴性110例、HBsAg阳性359例)与567名对照(HBsAg阴性430例、HBsAg阳性137例)的p53R72P基因型分布及差异。结果全样本以及HBsAg阳性样本的HCC与对照间的基因型分布差异均无统计学意义。但在HBsAg阴性人群中,72P是HCC发生的危险因素(OR=1.69,95%CI=1·25~2.27)。与R/R基因型相比,R/P的HCC风险增加至1.73倍(95%CI=0.96~3.11),P/P的HCC风险显著增加至3.29倍(95%CI=1.58~6.86)。携带72P的男性个体、HCC家族史阳性个体的HCC风险分别进一步增加至9.39倍(95%CI=3.08~28.62)和11.14倍(95%CI=1.62~76.67)。结论p5372P增加HBsAg阴性中国人的HCC风险,并与男性、HCC家族史在增加HCC风险中有协同作用。

Objective: The thrombospondin-4(TSP-4) gene G29926C(A387P) polymorphism was recently reported to be associated with an increased risk of MI(myocardial infarction) in American population. However, several subsequent studies produced controversial findings. The aim of this study was to explore the possible association between TSP-4 A387P polymorphism and ACS(acute coronary syndrome) in Chinese Han population. Methods:A case-control study including 412 patients with ACS and 337 controls free from...

Objective: The thrombospondin-4(TSP-4) gene G29926C(A387P) polymorphism was recently reported to be associated with an increased risk of MI(myocardial infarction) in American population. However, several subsequent studies produced controversial findings. The aim of this study was to explore the possible association between TSP-4 A387P polymorphism and ACS(acute coronary syndrome) in Chinese Han population. Methods:A case-control study including 412 patients with ACS and 337 controls free from CAD(coronary artery disease) was conducted. TSP-4 A387P polymorphism was determined by PCR(polymerase chain reaction) and RFLP(restriction fragment length polymorphism) analysis. Results:Slightly decreased frequency of GC genotype was observed in patients with ACS, compared with controls(5.3% vs. 7.1%), but the difference did not reach statistical significance(P = 0.31). Similarly, the prevalence of C allele was 2.7% and 3.6% for ACS and control groups, respectively (P = 0.32). None of homozygote was detected for C allele. Further analyses in subjects subgrouped according to sex and age also showed no association of TSP-4 A387P polymorphism with ACS. Furthermore, after adjustment for conventional risk factors by multiple logistic regression analysis, the carrier prevalence of C allele did not differ significantly between ACS and control groups(OR = 0.85; 95% CI:0.45-1.59; P = 0.60). Conclusion:The present study suggested that the TSP-4 A387P variant showed a low prevalence compared with western populations and failed to associate with an altered risk of ACS in Chinese Han population. The findings further supplement experimental data for TSP-4 gene study of coronary disease.

Objective: The thrombospondin-4(TSP-4) gene G29926C(A387P) polymorphism was recently reported to be associated with an increased risk of MI(myocardial infarction) in American population. However, several subsequent studies produced controversial findings. The aim of this study was to explore the possible association between TSP-4 A387P polymorphism and ACS(acute coronary syndrome) in Chinese Han population. Methods:A case-control study including 412 patients with ACS and 337 controls free from CAD(coronary ...

Objective: The thrombospondin-4(TSP-4) gene G29926C(A387P) polymorphism was recently reported to be associated with an increased risk of MI(myocardial infarction) in American population. However, several subsequent studies produced controversial findings. The aim of this study was to explore the possible association between TSP-4 A387P polymorphism and ACS(acute coronary syndrome) in Chinese Han population. Methods:A case-control study including 412 patients with ACS and 337 controls free from CAD(coronary artery disease) was conducted. TSP-4 A387P polymorphism was determined by PCR(polymerase chain reaction) and RFLP(restriction fragment length polymorphism) analysis. Results:Slightly decreased frequency of GC genotype was observed in patients with ACS, compared with controls(5.3% vs. 7.1%), but the difference did not reach statistical significance(P = 0.31). Similarly, the prevalence of C allele was 2.7% and 3.6% for ACS and control groups, respectively (P = 0.32). None of homozygote was detected for C allele. Further analyses in subjects subgrouped according to sex and age also showed no association of TSP-4 A387P polymorphism with ACS. Furthermore, after adjustment for conventional risk factors by multiple logistic regression analysis, the carrier prevalence of C allele did not differ significantly between ACS and control groups(OR = 0.85; 95% CI:0.45-1.59; P = 0.60). Conclusion:The present study suggested that the TSP-4 A387P variant showed a low prevalence compared with western populations and failed to associate with an altered risk of ACS in Chinese Han population. The findings further supplement experimental data for TSP-4 gene study of coronary disease.

 
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