助手标题  
全文文献 工具书 数字 学术定义 翻译助手 学术趋势 更多
查询帮助
意见反馈
   breast cancer families 的翻译结果: 查询用时:0.01秒
图标索引 在分类学科中查询
所有学科
肿瘤学
外科学
更多类别查询

图标索引 历史查询
 

breast cancer families
相关语句
  乳腺癌家系
     Germline mutations in the BRCA1 and BRCA2 genes from breast cancer families in China Han people
     中国汉族乳腺癌家系中BRCA1和BRCA2基因的胚系突变
短句来源
     Early genetic linkage analysis suggested that breast cancer susceptibility gene-1 (BRCA1) would be responsible for 45% the site-specific breast cancer families and the majority of breast-ovarian cancer families. The data to the BRCA1 mostly came from foreign countries.
     研究表明,乳腺癌易感基因-1(breast cancer susceptibility gene-1,BRCA1)可解释45%的乳腺癌家系和大多数的乳腺癌-卵巢癌家系的发病因素。
短句来源
     Four mutations belonged to 4 breast cancer families,and also belonged to 4 of 23 familiar breast cancer patients.
     在乳腺癌家系 23例乳腺癌患者中有 4例 BmA 基因突变,18例志愿者掀现突变。
短句来源
     Objective: To study the mutation of BRCA1 gene in Chinese breast cancer families. Methods: Fifteen families were selected, involving 41 members, consisting of 23 breast cancer patients. Using polymerase chain reaction and single stranded conformation polymorphism (PCR-SSCP), and subsequent DNA sequencing, the mutation of BRCA1 genes were analyzed.
     为了探讨中国乳腺癌家族中BRCAl基因突变情况,我们收集了15个乳腺癌家系,共41个对象,其中23例为乳腺癌患者,采用聚合酶链反应-单链构像多态性分析(PCR-SSCP)、直接DNA测序法对BRCA1编码基因进行了全序列分析。
短句来源
     Results:(1) In this study,41 participants,which including 23 breast cancer patients and 18 volunteers,were obtained from 15 breast cancer families. Average age of patients is 49.7 years.
     结果:(1)本研究共收集了15个乳腺癌家系,包括41个对象,其中有23例为乳腺癌患者,18例为家系中志愿者。
短句来源
更多       
  “breast cancer families”译为未确定词的双语例句
     Mutation Analysis in the BRCA1 Gene in Chinese Breast Cancer Families
     中国乳腺癌家族BRCAl突变分析(英文)
短句来源
     Results: Four mutations were found in all families, and the proportion of mutation was 26.7% (4/15) in breast cancer families.
     结果发现在15个家系中有4例(3种)基因突变,突变比例为26.7%(4/15)。
短句来源
     Objective To detect BRCA1 and BRCA2 gene germline mutation in the Chinese breast cancer families.
     目的 检测中国家族性乳腺癌中BRCA1和BRCA2的胚系突变位点。
短句来源
     Objective: 1. To detect the mutation site of the breast susceptibility genes BRCAl and BRCA2 and to identify SNPs in CYP17 & CYP19 in the Chinese breast cancer families by direct DNA sequencing.
     目的:1、检测中国家族性乳腺癌中BRCA1和BRCA2的突变位点;
短句来源
     Materials and methods: Twenty-six inherited breast cancer patients from 25 breast cancer families , five breast cancer patients who had ever used HRT and seventy-nine sporadic breast cancer patients were selected.
     材料和方法:收集家族性乳腺癌患者26例、曾用HRT的乳腺癌5例、散发性乳腺癌79例和正常对照108名,知情同意后取静脉血10ml提取基因组DNA,完成流行病学问卷调查;
短句来源
更多       
  相似匹配句对
     Inflanmatory breast cancer
     炎性乳腺癌
短句来源
     Neoadjuvant of Breast Cancer
     乳腺癌新辅助化疗
短句来源
     Mutation Analysis in the BRCA1 Gene in Chinese Breast Cancer Families
     中国乳腺癌家族BRCAl突变分析(英文)
短句来源
     Cancer
     恶性肿瘤
短句来源
查询“breast cancer families”译词为用户自定义的双语例句

    我想查看译文中含有:的双语例句
例句
为了更好的帮助您理解掌握查询词或其译词在地道英语中的实际用法,我们为您准备了出自英文原文的大量英语例句,供您参考。
  breast cancer families
A more comprehensive analysis of ATM is needed in large case-control studies, and in multiple-case breast cancer families.
      
1,437 unaffected women from high risk breast cancer families completed questionnaires and interviews.
      
Predictors of Cancer Worry in Unaffected Women from High Risk Breast Cancer Families: Risk Perception is not the Primary Issue
      
The literature on risk perception in women from high-risk breast cancer families reveals persistent over-estimation of risk, even after counseling.
      
One hundred and fifty women from high-risk breast cancer families attending their first genetic counseling consultation completed pre and post-consultation self-report questionnaires.
      
更多          


Objective: To analyze the mutations of BRCA1 in 9 Chinese familiar breast cancer patients. Methods: Peripheral blood samples were obtained from 9 patients enrolled from 9 breast cancer families, one normal control, 32 sporadic breast cancer patients and 33 normal donors. DNA extracted from lymphocytes was amplified by polymerase chain reaction (PCR). The 22 exons and partial introns of BRCA1 were screened by PCR denaturing high performance liquid chromatography (PCR-DHPLC) and confirmed...

Objective: To analyze the mutations of BRCA1 in 9 Chinese familiar breast cancer patients. Methods: Peripheral blood samples were obtained from 9 patients enrolled from 9 breast cancer families, one normal control, 32 sporadic breast cancer patients and 33 normal donors. DNA extracted from lymphocytes was amplified by polymerase chain reaction (PCR). The 22 exons and partial introns of BRCA1 were screened by PCR denaturing high performance liquid chromatography (PCR-DHPLC) and confirmed by direct sequencing. Results: Among these 9 familiar breast cancer patients, a deleterious mutation was detected in one case in exon 11 (3870delTGTC) which was a 4 base deletion and caused a frameshift in turn. One novel and unique amino acid substitution (E867R) was detected in one case. Eight patients were detected to have a known variation in intron 18 (IVS18+65G→A), and the ratio of this variation detected was 88.9%(8/9). The ratio of this variation was 37.5%(12/32) in sporadic breast cancer patients or 33.3%(11/33) in normal control. This variation was found to be accompanied all the time with a known missense variation in exon 11 (P871L) and a polymorphism in intron 9 (IVS8 57delT). Those three variants were also detected in homozygous in one case, which implies the linkage of the 3 sites. The linkage had not been reported. Two patients had been found with a known polymorphism in exon 13 (S1436S). Another known polymorphism was found in one case (L771L). In addition, intronic variants (IVS2+48C→T, IVS2+133C→T, IVS12+112C→A) were detected. Conclusion: The mutations of BRCA1 in Chinese familiar breast cancer patients are different from the hot spots reported in Caucasian and Jewish. It is important that further study be conducted to seek for specific mutations of this gene or other possible relevant genes in Chinese familiar breast cancer patients.

目的 :研究中国汉族家族性乳腺癌 (familiarbreastcancer ,FBC)患者BRCA1的突变情况。方法 :选取中国汉族 9个乳腺癌家系中各 1例乳腺癌患者 ,1例无肿瘤家族史的正常人 ,32例散发性乳腺癌患者和 33例正常献血者。从外周血淋巴细胞中提取DNA ,经PCR扩增后 ,以变性高效液相色谱 (denaturinghighperformanceliquidchromatography ,DHPLC)初筛BRCA1所有编码外显子及部分内含子的多态性 ,对异常峰型者直接测序。 结果 :在9例家族性乳腺癌患者中 ,1例患者在外显子 11上发现一处致病性突变 (3870delTGTC) ,该突变因缺失 4个碱基导致框架移位。 1例患者发现尚未见报道的密码子 86 7单个碱基替换导致编码氨基酸的变异 (E86 7R)。 8例患者在内含子 18(IVS18+6 5 )上检出已知的G→A变异 ,变异率为 88.9% (8/ 9)。该位点变异在散发性乳腺癌和一般人群中的检出率分别为 37.5 % (12 / 32 )和 33.3% (11/ 33)。该 8例患者同时检出密码子 871已知的错义变异(P8...

目的 :研究中国汉族家族性乳腺癌 (familiarbreastcancer ,FBC)患者BRCA1的突变情况。方法 :选取中国汉族 9个乳腺癌家系中各 1例乳腺癌患者 ,1例无肿瘤家族史的正常人 ,32例散发性乳腺癌患者和 33例正常献血者。从外周血淋巴细胞中提取DNA ,经PCR扩增后 ,以变性高效液相色谱 (denaturinghighperformanceliquidchromatography ,DHPLC)初筛BRCA1所有编码外显子及部分内含子的多态性 ,对异常峰型者直接测序。 结果 :在9例家族性乳腺癌患者中 ,1例患者在外显子 11上发现一处致病性突变 (3870delTGTC) ,该突变因缺失 4个碱基导致框架移位。 1例患者发现尚未见报道的密码子 86 7单个碱基替换导致编码氨基酸的变异 (E86 7R)。 8例患者在内含子 18(IVS18+6 5 )上检出已知的G→A变异 ,变异率为 88.9% (8/ 9)。该位点变异在散发性乳腺癌和一般人群中的检出率分别为 37.5 % (12 / 32 )和 33.3% (11/ 33)。该 8例患者同时检出密码子 871已知的错义变异(P871L)与内含子 9(IVS8 5 7delT)的变异 ,且有 1例患者在此 3处的变异为纯合变异。这 8例患者的检测结果提示 ,IVS18+6 5G→A、IVS8 5 7delT与 2 731C→T这 3个位点存在连锁。该连锁情况尚未见报道。 2例患者在密码子 14 36发现已知为多态的改变 (S14 36S)。 1例患?

Objective: To study the mutation of BRCA1 gene in Chinese breast cancer families. Methods: Fifteen families were selected, involving 41 members, consisting of 23 breast cancer patients. Using polymerase chain reaction and single stranded conformation polymorphism (PCR-SSCP), and subsequent DNA sequencing, the mutation of BRCA1 genes were analyzed. Results: Four mutations were found in all families, and the proportion of mutation was 26.7% (4/15) in breast cancer families....

Objective: To study the mutation of BRCA1 gene in Chinese breast cancer families. Methods: Fifteen families were selected, involving 41 members, consisting of 23 breast cancer patients. Using polymerase chain reaction and single stranded conformation polymorphism (PCR-SSCP), and subsequent DNA sequencing, the mutation of BRCA1 genes were analyzed. Results: Four mutations were found in all families, and the proportion of mutation was 26.7% (4/15) in breast cancer families. One of the 4 mutations was 2228 insC, resulting in chain termination at codon 711. The remaining 3 mutations were 1884A→T and 3232A→G, resulting in single amino acid change respectively. Conclusion: BRCA1 is a breast cancer susceptibility gene. The relatively low proportion and frequency of BRCA1 mutations in our study hints additional BRCA genes existed.

为了探讨中国乳腺癌家族中BRCAl基因突变情况,我们收集了15个乳腺癌家系,共41个对象,其中23例为乳腺癌患者,采用聚合酶链反应-单链构像多态性分析(PCR-SSCP)、直接DNA测序法对BRCA1编码基因进行了全序列分析。结果发现在15个家系中有4例(3种)基因突变,突变比例为26.7%(4/15)。其中一例2228insC为插入突变,致编码子711处蛋白截短;另3例(2种)突变为1884A→T和3232 A→G,分别引起单个氨基酸改变。我们认为BRCA1为家族性乳腺癌的遗传基因;在BRCA1以外还存在其他的乳腺癌易感基因。

Objective To detect BRCA1 and BRCA2 gene germline mutation in the Chinese breast cancer families. Methods Samples of peripheral blood were collected to prepare genomic DNA by conventional techniques from 15 inherited breast cancer patients from 14 breast cancer families, 76 sporadic breast cancer patients, and 100 healthy controls based on informed consent. Exons 4, 8, 11 and 18-20 of BRCA1, and exons 1-14, 17-24 and 27 of BRCA2, were analyzed using DNA direct sequencing....

Objective To detect BRCA1 and BRCA2 gene germline mutation in the Chinese breast cancer families. Methods Samples of peripheral blood were collected to prepare genomic DNA by conventional techniques from 15 inherited breast cancer patients from 14 breast cancer families, 76 sporadic breast cancer patients, and 100 healthy controls based on informed consent. Exons 4, 8, 11 and 18-20 of BRCA1, and exons 1-14, 17-24 and 27 of BRCA2, were analyzed using DNA direct sequencing. Results Six single nucleotide polymorphisms (SNPs) were found on the exon 11 of BRCA1, 2 being silent changes without change of amino acid coding, and 4 with change of amino acid coding among which 2 were polymorphic amino acid alterations and 2 were pathogenic SNPs, i.e. mutational sites. One novel BRCA1 mutation, C1196T(Pro 359 Leu), was identified in a family breast cancer patients, who was diagnosed at the age of 37. Another BRCA1 mutation, Trp 372 stop was found in a breast cancer patient who was diagnosed at the age 29. Eight SNPs were found on the exon3, 10 and 11 of BRCA2, among which 5 were silent changes and 3 were polymorphic amino acid alterations. A1093C(Asn289His)in exon 10 and A 3199G(Asn991Asp)in exon 11 being found simultaneously in the patients of 2 families but not appearing in pool DNA sample, and Asn 371 His appearing as A/C heterozygote in pool DNA sample. Conclusion Two pathogenic SNPs have been found in BRCA1 and may be related to early-onset breastcancer. One of them may be a novel mutation characterized of familial breast cancer in China.

目的 检测中国家族性乳腺癌中BRCA1和BRCA2的胚系突变位点。方法 对象为来自汉族的 14个乳腺癌家系中的 15例乳腺癌患者、散发性乳腺癌患者 76例和正常对照 10 0名 ,知情同意后取其外周静脉血 ,提取基因组DNA ,用 15例家族性乳腺癌患者和 2份poolDNA(每份poolDNA含5 0名正常对照者的等量DNA)作为样本 ,对BRCA1基因外显子 4、8、11、18、19、2 0和部分内含子区域 ,BRCA2基因外显子 1~ 14、外显子 17~ 2 4和外显子 2 7及部分内含子区域进行序列测定。用DNAStar软件进行序列比较分析 ,筛查基因突变位点及多态性位点 ,对有意义的突变位点在正常对照和散发性乳腺癌患者中进行基因分型。结果 在BRCA1的外显子 11上发现 6个单核苷酸多态性 (SNP)位点 ,2个不改变氨基酸编码 ,4个改变氨基酸编码。其中 2个为致病性位点 :一个致病位点为G 12 35A(Trp372stop) ,导致蛋白质合成终止 ,该位点仅在 1例 2 9岁的家族性乳腺癌患者中发现 ;另一致病位点C1196T(Pro 35 9Leu)也只在 1例 37岁的家族性乳腺癌患者...

目的 检测中国家族性乳腺癌中BRCA1和BRCA2的胚系突变位点。方法 对象为来自汉族的 14个乳腺癌家系中的 15例乳腺癌患者、散发性乳腺癌患者 76例和正常对照 10 0名 ,知情同意后取其外周静脉血 ,提取基因组DNA ,用 15例家族性乳腺癌患者和 2份poolDNA(每份poolDNA含5 0名正常对照者的等量DNA)作为样本 ,对BRCA1基因外显子 4、8、11、18、19、2 0和部分内含子区域 ,BRCA2基因外显子 1~ 14、外显子 17~ 2 4和外显子 2 7及部分内含子区域进行序列测定。用DNAStar软件进行序列比较分析 ,筛查基因突变位点及多态性位点 ,对有意义的突变位点在正常对照和散发性乳腺癌患者中进行基因分型。结果 在BRCA1的外显子 11上发现 6个单核苷酸多态性 (SNP)位点 ,2个不改变氨基酸编码 ,4个改变氨基酸编码。其中 2个为致病性位点 :一个致病位点为G 12 35A(Trp372stop) ,导致蛋白质合成终止 ,该位点仅在 1例 2 9岁的家族性乳腺癌患者中发现 ;另一致病位点C1196T(Pro 35 9Leu)也只在 1例 37岁的家族性乳腺癌患者中发现 ,该位点在正常对照和散发性乳腺癌患者中进行基因分型后均为野生型 ,并在相关的文献和乳腺癌信息中心网站的突变数据库中均未检索到 ,为一新的中国家族性乳腺癌特有的致病位点。在BRCA2的外显子 3、10及

 
图标索引 相关查询

 


 
CNKI小工具
在英文学术搜索中查有关breast cancer families的内容
在知识搜索中查有关breast cancer families的内容
在数字搜索中查有关breast cancer families的内容
在概念知识元中查有关breast cancer families的内容
在学术趋势中查有关breast cancer families的内容
 
 

CNKI主页设CNKI翻译助手为主页 | 收藏CNKI翻译助手 | 广告服务 | 英文学术搜索
版权图标  2008 CNKI-中国知网
京ICP证040431号 互联网出版许可证 新出网证(京)字008号
北京市公安局海淀分局 备案号:110 1081725
版权图标 2008中国知网(cnki) 中国学术期刊(光盘版)电子杂志社