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chromosomal model
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  “chromosomal model”译为未确定词的双语例句
     Chromosome analysis revealed that the chromosomal model number was 45, lost chromosome 22, and the structural abnormalities were del (3) (q21.l), del (7) (q32), del (22) (q13,1) and 4 derivative chromosomes from No.
     结果表明,该瘤株染色体众数45,丢失1个22号染色体;
短句来源
     Results:The chromosomal number of the Hep 2 ranged from 54 to 84 ,and the chromosomal model ranged from 69 to 74. Among the abnormal chromosomes,13 were marker chromosomes with distinguishable and stabile structure.
     结果 :Hep- 2细胞系的染色体数目变化于 5 4~ 84条之间 ,众数为 6 9~ 74条。
短句来源
     Chromosomal instability in Hep-2 cell line was evident: The chromosomal number ranged from 43 to 84 and the chromosomal model ranged from 69 to 74. The structural abnormality was represented by 13 marker chromosomes.
     Hep - 2细胞系中存在显著的染色体不稳定 :染色体数目变化于 4 3~ 84条之间 ,众数为 6 9~ 74条 ,结构畸变主要表现为 13条标记染色体。
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  相似匹配句对
     model.
     模型。
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     Model.
     模型的适用范围。
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     Chromosomal analysis of the tumor cells exhibited human origin with a hyperdiploid model.
     染色体分析以超二倍体为主,核型显示为人类染色体核型。
短句来源
     The Chromosomal Analyses of Human Malignant Glioma Cells from Nude Mice Model (NHG-1)
     裸小鼠人脑胶质瘤模型NHG-1的染色体分析
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  chromosomal model
Our experiments, performed with chromosomal model species, emphasize the need for controlled, non-mutagenic culture conditions.
      


Chromosome and Southern blot analysis of a epithelioid sarcoma (ES) cell line were performed. Chromosome analysis revealed that the chromosomal model number was 45, lost chromosome 22, and the structural abnormalities were del (3) (q21.l), del (7) (q32), del (22) (q13,1) and 4 derivative chromosomes from No. 5,6,9 and 12 in the cell line. Southern blot analysis detected the partial deletion of PCCB gene in the cell line DNA with the PPCC41A2 clone (3q13.1-q22) as a DNA marker. These results suggest that...

Chromosome and Southern blot analysis of a epithelioid sarcoma (ES) cell line were performed. Chromosome analysis revealed that the chromosomal model number was 45, lost chromosome 22, and the structural abnormalities were del (3) (q21.l), del (7) (q32), del (22) (q13,1) and 4 derivative chromosomes from No. 5,6,9 and 12 in the cell line. Southern blot analysis detected the partial deletion of PCCB gene in the cell line DNA with the PPCC41A2 clone (3q13.1-q22) as a DNA marker. These results suggest that del (3) (q21.1) and PCCB gene change may be involved in the development of ES.

对建成的一个上皮样肉瘤(ES)细胞株进行了染色体分析和DNA印迹实验研究。结果表明,该瘤株染色体众数45,丢失1个22号染色体;结构异常为del(3)(q21.1)以及5、6、9和12号衍生染色体。用定位于人染色体3q13.1-q22的pPCC41A2克隆作为DNA标识探针,在该瘤株DNA中检出PCCB基因的部分缺失。本研究结果提示del(3)(q21.1)及PCCB基因的改变可能与ES癌变有关。

A new cell line designated CNE2 was established from a patient with metastaticnasopharygeal carinoma in the liver. The metastatic carcinoma tissue from the liver wassuccessfully hetero-transplanted into the nude mice. The CNE3 cell line was established fromthat tumor in the nude mice by in vitro cultivation in our laboratory.The following biologicalcharacteristics of the cell line were observed: The cell's doubling time was 96 hr;the maximungrowth times were 25 ; chromosomal analysis revealed a human chromosomal...

A new cell line designated CNE2 was established from a patient with metastaticnasopharygeal carinoma in the liver. The metastatic carcinoma tissue from the liver wassuccessfully hetero-transplanted into the nude mice. The CNE3 cell line was established fromthat tumor in the nude mice by in vitro cultivation in our laboratory.The following biologicalcharacteristics of the cell line were observed: The cell's doubling time was 96 hr;the maximungrowth times were 25 ; chromosomal analysis revealed a human chromosomal model whichnumbers varied in the range of 73~81 ;the most common numerical alterations weresubtriploidies and triploidies;a positivity was shown by EBNA and Lmp in the culture ; followingretransplantation into the nude mice tumor growth again appeared ; the patholgical features ofthe tumor were similar to those of the original tumor tissue obtained from the patient;repeatedliquid nitrogen frozening and thawing did not change the character istics of the cell line; re-peated search for mycoplasma was negative. The establishment of this cell line is useful in thestudy of cancer biology and the screening of anticancer drugs.It provides an ideal tumor modelforin vivo orin vitro experiments.

从1例鼻咽癌肝转移尸检者取出肝转移之癌组织,经裸鼠异种移植成功,然后又经离体培养建成细胞株,定名为CNE3。对核细胞生物学特性进行观察,结果表明:细胞生长周期最大倍增时间为96h,最大增长倍数为25倍;染色体为人类染色体核型,为三倍体和亚三倍体;有EB病毒基因组存在,以及EBNA-1及晚期末蛋白(Lmp)表达;裸鼠体内回复试验仍具成瘤性,其组织结构与原标本相似,体外培养反复冻融细胞生物学特性不变;经检查,未发现支原体污染。

Objective:Our purpose was to study the chromosomal aberration and characteristics of the karyotype of cell line of laryngeal carcinoma(Hep 2),and to explore the relationship between cytogenetic changes and pathogenesis in laryngeal carcinoma. Methods:An karyotype analysis of Hep 2 was performed with routine and high resolution G banding technique. Results:The chromosomal number of the Hep 2 ranged from 54 to 84 ,and the chromosomal model ranged from 69 to 74. Among the abnormal chromosomes,13 were...

Objective:Our purpose was to study the chromosomal aberration and characteristics of the karyotype of cell line of laryngeal carcinoma(Hep 2),and to explore the relationship between cytogenetic changes and pathogenesis in laryngeal carcinoma. Methods:An karyotype analysis of Hep 2 was performed with routine and high resolution G banding technique. Results:The chromosomal number of the Hep 2 ranged from 54 to 84 ,and the chromosomal model ranged from 69 to 74. Among the abnormal chromosomes,13 were marker chromosomes with distinguishable and stabile structure. DM existed in some of the karyotypes,and it was the cytogenetic marker of the gene amplification. Conclusion:There were aberration of number and structure of the chromosomes as well as marker chromosomes and gene amplification in Hep 2 in which belonged to supertrisomy. The structure aberration of chromosomes included the translocation,deletion,and isochromosome. The break and rejoint of the chromosome resulted in its rearrangement. The deletion and rearrangement of the 3,5,6 and 8 chromosomes were the characteristic changes of the Hep 2.

目的 :探讨喉鳞状细胞癌 Hep- 2细胞系染色体畸变及其核型特征 ,认识喉癌的细胞遗传学改变与其发病机制的相关性。方法 :应用常规和高分辨 G显带方法进行核型分析。结果 :Hep- 2细胞系的染色体数目变化于 5 4~ 84条之间 ,众数为 6 9~ 74条。可识别其结构的稳定的标记染色体为 13条 ,部分核型中存在双微体 ,是基因扩增的细胞遗传学标志。结论 :喉癌 Hep- 2细胞系属超三倍体细胞 ,存在染色体数目和结构畸变并具有稳定的标记染色体及基因扩增。结构畸变涉及易位、缺失和等臂染色体。染色体断裂重接导致染色体重排 ,3、5、6和 8号染色体的缺失与重排是喉癌特征性改变

 
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