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Endothelin(ET)is a potent vasocontrictor peptide released from vascular endothelial cells.ET also has other biological functions relevant to tumorgenesis,including mitogenic and angiogenic activities. The expression of ET in human bladder cancer tissues and bladder cancer BIU-87 cell line was detected,and the effect of ET on the proliferation of BIU-87 was studied. Northern blot showed that the level of ET-1 mRNA expression was more than 4-fold higher in tumor tissues than the surrounding...

Endothelin(ET)is a potent vasocontrictor peptide released from vascular endothelial cells.ET also has other biological functions relevant to tumorgenesis,including mitogenic and angiogenic activities. The expression of ET in human bladder cancer tissues and bladder cancer BIU-87 cell line was detected,and the effect of ET on the proliferation of BIU-87 was studied. Northern blot showed that the level of ET-1 mRNA expression was more than 4-fold higher in tumor tissues than the surrounding noncancerous tissues (n=4).Using radioimmunoassay,it was also found that the content of ET in tumor tissues was 6-8 fold higher than the surrounding noncancerous tissues (n=4). In BIU-87 cells, the level of ET concentration was increased (38%and 47%) after TPA (100 ng/mL) treatment (4 h and 8 h). The secretion level of ET in BIU-87 cells was also slightly stimulated by TPA (100 ng/mL,8 h). After treated with ET-antiserum,the  ̄3H-TdR incorporation was markedly decreased (57%) in BIU-87 cells whereas it was also decreased (35%) after treated BIU-87 with ET receptor A antagonist──BQ_(123).In conclusion,ET was markedly expressed both in human bladder cancer tissues and BIU-87 cells, especially when the cells were induced by TPA. It seems that ET has proliferative effgct on bladder cancer cells and this effect can be depressed by ET-antiserun or ET receptor A antagonist──BQ_(123).

应用Northernblot杂交技术及放射免疫方法对人膀胱移行细胞癌组织中内皮素-1mRNA及内皮素活性分子的表达水平进行检测,研究了佛波酯对人膀胱移行细胞癌BIU-87细胞中内皮素活性分子表达水平的调节作用,并探讨了内皮素抗血清及内皮素A型受体竞争性拮抗剂BQ_(123)对BIU-87细胞DNA合成的影响。结果表明,人膀胱移行细胞癌组织中内皮素-lmRNA及内皮素活性分子的表达水平明显高于相应的癌旁组织,佛波酯可促进BIU-87细胞合成和分泌内皮素,内皮素抗血清及BQ_(123)可抑制BIU-87细胞合成DNA。提示内皮素在膀胱癌发展及BIU-87细胞恶性增殖中可能起重要作用。

Objective: To investigate the effect of burned serum on the endothelin(ET) receptor in cardiac microvascular endothelial cells(CMEC).Methods: CMEC were isolated and cultured. Following incubation of CMEC with the culture medium containing 20% normal and burned rat(30% TBSA Ⅲ°)serum for 12h, respectively, the affinity and binding capacity of ET receptor in CMEC membranes were measured by radioligand binding assay.Results: Only ETB receptor was distributed in rat CMEC membranes .with a...

Objective: To investigate the effect of burned serum on the endothelin(ET) receptor in cardiac microvascular endothelial cells(CMEC).Methods: CMEC were isolated and cultured. Following incubation of CMEC with the culture medium containing 20% normal and burned rat(30% TBSA Ⅲ°)serum for 12h, respectively, the affinity and binding capacity of ET receptor in CMEC membranes were measured by radioligand binding assay.Results: Only ETB receptor was distributed in rat CMEC membranes .with a maximal binding capacity(Bmax)of 142±27 fmol/mg protein and a dissociation constant(Kd) of 119±22pmol/L.Burned rat serum induced an increase in Bmax of ETB receptor by 68%. without concomitant changes in Kd value. Conclusion: Burned serum may up-regulate ETB receptor.

目的:探讨烧伤血清对心脏微血管内皮细胞内皮素受体的影响。方法:分离和培养大鼠心脏微血管内皮细胞,分别用含20%正常大鼠和烧伤大鼠(30%TBSAⅢ度)伤后6h血清的培养基培养心脏微血管内皮细胞12h,用放射性配基结合分析法,测定内皮细胞膜内皮素受体亲和力及结合容量。结果:大鼠心脏微血管内皮细胞膜上只有亚型B内皮素受体分布,该受体的最大结合容量(Bmax)为142±27fmol/mg,平衡解离常数(Kd)为119±22pmol/L。烧伤血清不影响该受体的Kd值,但使Bmax增加68%。结论:烧伤血清可上调亚型B内皮素受体。

The changes of the quantity and distribution of mRNA of endothelin receptor A (ETA) and endothelin receptor B (ETB) in rat kidneys at different time phases during the early stage after severe burns were dynamically observed. It was found that the percentages of ETA and ETB mRNA in kidneys were significantly elevated at the 1st hour postburn (the former reached its climax on the 3rd while the latter did so on the 6th hour postburn) and ETA mainly expressed in cortex and ETB in medulla. Our findings...

The changes of the quantity and distribution of mRNA of endothelin receptor A (ETA) and endothelin receptor B (ETB) in rat kidneys at different time phases during the early stage after severe burns were dynamically observed. It was found that the percentages of ETA and ETB mRNA in kidneys were significantly elevated at the 1st hour postburn (the former reached its climax on the 3rd while the latter did so on the 6th hour postburn) and ETA mainly expressed in cortex and ETB in medulla. Our findings suggest that the changes of ET receptors participate in damage of the renal function.

动态观察大鼠烧伤早期肾脏各时相点内皮素受体A(ETA)、内皮素受体B(ETB)mRNA定量和分布的变化规律,发现肾脏ETA、ETBmRNA百分占有率在烧伤后1h已明显升高,前者3h达高峰,后者6h达高峰,皮质以ETA为主,髓质以ETB为主,提示烧伤后内皮素受体改变参与了肾功能损害

 
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