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n myc
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  nmyc
     Conclusions 8 Br cAMP down regulates the gene expression of c fos,N myc and p21ras to inhibit the HXO Rb44 cell growth and proliferation.
     结论(1)8BrcAMP可抑制人HXORb44细胞的生长增殖; (2)8BrcAMP可下调cfos、Nmyc及p21ras癌基因的表达;
短句来源
     Results In the HXO Rb44 cells the signals for c fos mRNA,N myc mRNA,and p21ras mRNA were localized in the cytoplasm. The c Fos IR,N Myc IR were localized in the nuclei,while P 21ras IR localized in the cytoplasm.
     结果在人HXORb44细胞,cfosmRNA、NmycmRNA及p21rasmRNA定位于胞质,cFosIR及NMycIR定位于胞核,而P21rasIR则位于胞质。
短句来源
     The abnormal L myc and C myc gene were positive in 47%(15/32) of laryngeal cancers and 41%(13/32) of the cancers shown the N myc gene amplification.
     结果正常组织细胞Myc基因无扩增,32例喉癌中47%(15/32)有Cmyc和Lmyc扩增,41%(13/32)有Nmyc基因扩增。
短句来源
     Objective To establish a simple method for detecting abnomal amplification of Myc gene family included 3 members(L myc, N myc and C myc) at the same time.
     目的建立同时检测Myc基因3个成员Lmyc、Nmyc及Cmyc异常扩增的简便方法。
短句来源
     Myc gene amplification was not related to age,sex and differentiation ( P >0.05),but the N myc amplification was higher in patients with lymph node metastesis ( P <0.05).
     Myc基因扩增率与年龄、性别、喉癌临床分期及分化程度无关(P>0.05),但有淋巴结转移的患者的Nmyc扩增率明显高于无淋巴结转移者(P<0.01)。
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  n-myc
     Results Amplification of N myc oncogene was found in 24 of 25 cases (96.0%). The N myc copy number in oculometastasis group (51.3±32.4) was higher than that in non oculometastasis group (4.3±2.8) ( P <0.05), and the 2 year survival rate of the former was significantly lower than that of the latter ( P <0.05).
     结果25例中有24例(96%)出现N-myc扩增,眼部转移组平均拷贝数(51.3±32.4)显著高于无眼部转移组的平均拷贝数(4.3±2.8),P<0.05,且前者两年生存率明显低于后者。
短句来源
     Objective To study the effects of amplification of N myc oncogene on the oculometastasis and prognosis of neuroblastoma (NB).
     目的通过定量研究小儿神经母细胞瘤(NB)N-myc基因扩增倍数,观察NB眼部转移以及与预后的关系。
短句来源
     The multiples of amplification were 2.1 7.3 In cervical metastasis lymph nodes, one case had C myc amplification and one had amplification of mixed band of N myc and L myc.
     在颈淋巴结转移癌中有1例C-myc扩增,1例N-myc和L-myc融合带扩增。
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  “n myc”译为未确定词的双语例句
     Ocular metastasis of neuroblastoma and amplification of N myc oncogene
     神经母细胞瘤眼部转移与N-myc癌基因扩增的临床意义
短句来源
     Results In UH group,the positive rate of Trk A (6/14) was significantly lower than that of the FH group (27/32),but that of the N myc staining was higher (8/14 to 10/32). The expression of NSE and CD44 showed no difference.
     UH型的Trk A阳性率 ( 6/ 14 )明显低于FH型 ( 2 7/ 3 2 )、N myc阳性率 ( 8/ 14 )则高于FH型 ( 10 / 3 2 ) ,NSE和CD4 4检测无明显差异。
短句来源
     Methods FISH was used to observe N myc gene amplifiction, RT PCR and immunohistochemistry techniques were used to detect N myc mRNA and N myc protein respectively.
     方法 应用荧光原位杂交 (FISH)技术检测N myc基因扩增 ,应用RT PCR和免疫组化技术分别检测N myc转录和蛋白水平表达。
短句来源
     The c fos mRNA,N myc mRNA,p21ras mRNA,Rb mRNA,wild type (w) p53 mRNA,mutant type (m)p53 mRNA,p16 mRNA and p21 waf1 mRNA were detected with respective biotin labeled cDNA probes by intact cell RNA dot blot.
     结果 :wp5 3 ,Rb ,p16及p2 1waf1的mRNA信号为EG >CG(P <0 0 5~ 0 0 1) ;
短句来源
     Using immunohistochemical SP TM kits, effects of UVB irradiation on the expression of bcl 2、n myc、c fos in NIH3T3 cell were detected.
     用免疫组织化学 SPTM试剂盒标记 ,用 Quantimet5 2 0型图像分析仪定量分析 B波段紫外线照射对 NIH3T3细胞bcl- 2、 n- m yc、 c- fos三种基因表达的影响。
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  n myc
We have demonstrated in this paper that N-myc is not the downstream target through which RXR function is manifest.
      
We speculate that the role of N-myc in screeningpositive neuroblastomas may be different from that in aggressive tumors.
      
We demonstrate here that a novel mechanism by which NO interferes with cell proliferation is through inhibition of N-Myc expression.
      
We are currently testing NO involvement in cerebellar neurogenesis and its correlation with N-Myc expression during neonatal rat development.
      
We therefore measured the apparent half-lifes of N-Myc mRNAs in parental and clone-4 cells treated with RA.
      
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Neuroblastoma is one of the most common pediatric solid tumors. In approximately 50% of clinically advanced cases N-myc oncogene is amplified. Nerve gro-wth factor (NGF)is capable to induce differentiation of some neuroblastoma cell lines. But the cerl lines with amplified N-myc usually failed to respond to NGF. It may be due to the shortage of NGF receptors in these cell lines. The amplification of N-myc oncogene may also be responsible. We introduced the recombinant NGF...

Neuroblastoma is one of the most common pediatric solid tumors. In approximately 50% of clinically advanced cases N-myc oncogene is amplified. Nerve gro-wth factor (NGF)is capable to induce differentiation of some neuroblastoma cell lines. But the cerl lines with amplified N-myc usually failed to respond to NGF. It may be due to the shortage of NGF receptors in these cell lines. The amplification of N-myc oncogene may also be responsible. We introduced the recombinant NGF receptor gene into the human neuroblastoma cell line (IMR-32),which was lack of NGF receptor and had N-myc amplification. The trans-formant line (IMR-32/NGFR) expressed NGF receptor both in mRNA and receptor protein levels. The parent line (IMR-32) and the control transformant line (IMR-32/NEO) , obtained by infection with empty viral vector were all negative for NGFR expression in mRNA and receptor protein levels as shown by Northern Blotting and Flow Cytometry using fluorescent labeled monoclonal antibodies against NGFR. After NGF treatment, transformant cell line (IMR-32/NGFR) did not show significant change in morphology. The expression of neurofilament light chain mRNA only increased slightly. No significant alteration was found in the expression of "N-myc and K-ras oncogenes among IMR-32, IMR-32/NEO and IMR-32/NGFR before and after NGF treatment. These results indicate the amplification of N-myc oncogene may still limit NGF responce in this cell line even after the restoration of NGF receptor.

神经母细胞瘤是儿童期的常见恶性肿瘤之一。临床上,半数以上神经母细胞瘤有明显的N-myc癌基因扩增。神经生长因子(NGF)可使某些神经母细胞瘤细胞分化成神经元样的细胞。但对有N-myc扩增的神经母细胞瘤则可能因NGF受体缺乏而无明显促分化反应。本研究运用重组DNA技术将人NGF受体基因重组到有N-myc扩增,且NGF受体表达很低的神经母细胞瘤系(IMR-32)中,经克隆化培养、筛选,建立了稳定的细胞系—IMR-32/NGFR和对照细胞系IMR-32/NEO。经用抗NGFR的单克隆抗体检测用Flow cytometry技术证实IMR-32/NGFR系中有明显的NGF受体表达,而其母系IMR-32和空病毒对照系IMR-32/NEO则无表达迹象,说明NGF受体表达在IMR-32/NGFR系中是特异的,并能同抗NGFR单克隆抗体特异结合。用Northern B10ting技术亦测得IMR-32/NGFR中NGFR的mRN A明显表达。而其母系IMR-32和对照系IMR-32/NEO则无明显表达。这说明IMR-32/NGFR系中NGFR在mRNA水平上亦是特异的。N-myc和K-ras癌基因在IMR-32、IMR-32/...

神经母细胞瘤是儿童期的常见恶性肿瘤之一。临床上,半数以上神经母细胞瘤有明显的N-myc癌基因扩增。神经生长因子(NGF)可使某些神经母细胞瘤细胞分化成神经元样的细胞。但对有N-myc扩增的神经母细胞瘤则可能因NGF受体缺乏而无明显促分化反应。本研究运用重组DNA技术将人NGF受体基因重组到有N-myc扩增,且NGF受体表达很低的神经母细胞瘤系(IMR-32)中,经克隆化培养、筛选,建立了稳定的细胞系—IMR-32/NGFR和对照细胞系IMR-32/NEO。经用抗NGFR的单克隆抗体检测用Flow cytometry技术证实IMR-32/NGFR系中有明显的NGF受体表达,而其母系IMR-32和空病毒对照系IMR-32/NEO则无表达迹象,说明NGF受体表达在IMR-32/NGFR系中是特异的,并能同抗NGFR单克隆抗体特异结合。用Northern B10ting技术亦测得IMR-32/NGFR中NGFR的mRN A明显表达。而其母系IMR-32和对照系IMR-32/NEO则无明显表达。这说明IMR-32/NGFR系中NGFR在mRNA水平上亦是特异的。N-myc和K-ras癌基因在IMR-32、IMR-32/NEO、IMR-32/NGFR三系中无明显变化。在NGF处理后,形态上三系均无明显的分化迹象。但IMR-32/NGFR在神经原纤维轻链的表达上轻度增高。c-fos癌基因的表达见于所有三个细胞系,IMR-32/NGFR略强些。这些说明,在恢复了NGFR基因和表达之后,对N-myc和K-ra

The changes of several oncogenes and suppressor genes in the specimens of cancerous and juxtacancerous tissues of 42 cases of gastric cancer were studied with Southern blot hybridization and PCR-RELP method.The probes used were c-Ha-ras,K-ras,N-ras,N-myc,c-myc,hst,EGFR,c-erbB-2,p53 and Rb.Amplification,rearrangement,and deletion of c-Ha-ras were detected in 8/33 (25.8%) cases of gastric cancer (amplification or rearrangement of hst and c-erbB-2 in 11/42 (26.6%) and 12/42 (29.2%) cases...

The changes of several oncogenes and suppressor genes in the specimens of cancerous and juxtacancerous tissues of 42 cases of gastric cancer were studied with Southern blot hybridization and PCR-RELP method.The probes used were c-Ha-ras,K-ras,N-ras,N-myc,c-myc,hst,EGFR,c-erbB-2,p53 and Rb.Amplification,rearrangement,and deletion of c-Ha-ras were detected in 8/33 (25.8%) cases of gastric cancer (amplification or rearrangement of hst and c-erbB-2 in 11/42 (26.6%) and 12/42 (29.2%) cases respectively (amplification of EGFR in 21.4% of cas-esideletion or rearrangement of p53 and Rb in S/30 (30%) and 2/15 (13%) cases respectively) and amplification or rearrangement of N-ras (0/33),K-ras (1/26),N-myc (1/26),and c-myc (1/ 35) was only rarely encounted.The point mutation in codon 248 and 249 of p53 in gastric cancer was analyzed.2 cases of the 42 harbored point mutation in codon 248 of p53.These findings suggest that e-Ha-ras,hst,c-erbB-2,EGFR and p53 may be the hot point genes in the occurrence and development of gastric cancer.

本文采用Southern杂交技术分析了42例胃癌及癌旁组织中癌基因c-Ha-ras、K-ras、N-ras、c-myc、N-myc、hst、EGFR、c-erbB-2和抑癌基因p53和Rb的变化;使用PCR-RFLP方法分析了p53基因第248和249位密码子的点突变。结果显示,胃癌组织中有多种癌基因激活和抑癌基因失活,但多集中在c-Ha-ras、c-erbB-2、hst、EGFR和p53基因。这些结果表明,多种癌基因和抑癌基因可能参与了胃癌的发生和发展。

The c-myc, L-myc, N-myc, erbB, c-fos, sis and Ha-ras oncogenes were used as probes to investigate the amplification and rearrangement of DNA isolated from 52 case of human primary brain tumors and 5 case of normal human brain by dot blot and Southern blot hybridization analysis.The results showed that the amplification of c-myc, L-myc, erbB and c-fos genes was usual in human brain glioma, and the alteration of myc gene family EcoRI fragments was in a few brain tumors.It...

The c-myc, L-myc, N-myc, erbB, c-fos, sis and Ha-ras oncogenes were used as probes to investigate the amplification and rearrangement of DNA isolated from 52 case of human primary brain tumors and 5 case of normal human brain by dot blot and Southern blot hybridization analysis.The results showed that the amplification of c-myc, L-myc, erbB and c-fos genes was usual in human brain glioma, and the alteration of myc gene family EcoRI fragments was in a few brain tumors.It slao showed that the amplification and rearrangement of two or two more oncogenes simultaneously in human primary brain tumor.The possible relationship between oncogenes and human brain tumor was discussed.

作者对52例人脑原发性肿瘤和5例正常人脑DNA中c-myc、L-myc、Nmyc、erbB、c-fos、sis及Ha-ras等七种癌基因的扩增和重排进行了研究,发现多数胶质瘤中有c-myc、L-myc、erbB及c-fos等癌基因的扩增,少数胶质瘤和脑膜瘤中发现myc家族癌基因的限制性酶切区带位置有多态性变化;同时还观察到原发性脑瘤中存在两种或两种以上癌基因的扩增和重排现象。作者对癌基因与人脑原发性肿瘤的关系进行了讨论。

 
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