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combined anti-tumor effect
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     Objective To observe the combined anti-tumor effect of electroporation and bleomycin (BLM) in human colon cancer xenografts in nude mice, and to establish the experimental basis for clinical application of electrochemotherapy(ECT).
     目的:观察电穿孔技术结合博莱霉素化疗对结肠癌裸鼠移植瘤的抗肿瘤效果,为本疗法的临床应用提供实验依据。
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Objective To observe the combined anti-tumor effect of electroporation and bleomycin (BLM) in human colon cancer xenografts in nude mice, and to establish the experimental basis for clinical application of electrochemotherapy(ECT). Methods Forty nude mice,inoculated subcutaneously with human colon cancer cell line LoVo for three weeks, were allocated randomly into 4 groups: B+E+(electrochemotherapy), B+E-(intratumoral bleomycin injection only), B-E+(electrotherapy only), and B-E-(no treatment). Tumor volumes...

Objective To observe the combined anti-tumor effect of electroporation and bleomycin (BLM) in human colon cancer xenografts in nude mice, and to establish the experimental basis for clinical application of electrochemotherapy(ECT). Methods Forty nude mice,inoculated subcutaneously with human colon cancer cell line LoVo for three weeks, were allocated randomly into 4 groups: B+E+(electrochemotherapy), B+E-(intratumoral bleomycin injection only), B-E+(electrotherapy only), and B-E-(no treatment). Tumor volumes were measured daily. The animals were sacrificed on the seventh day after the treatments, the xenografts were weighed, and studied histologically. Results The mean tumor volume of Group B+E+ animals was statistically lower than the other 3 groups ( P<0.01). There were 1 animal of complete response(CR) and 7 animals of partial response(PR) in Group B+E+; 1 animal of PR in Group B+E- and Group B-E+ respectively, and no response was observed in group B-E-. The difference in response observed between Group B+E+ and the other three groups was statistically significant (P<0.01). Histologically, extensive necrosis of the tumor cells with considerable vascular damage and inflammatory cells infiltration were observed in Group B+E+. Conclusions Electrochemotherapy could significantly enhance the chemosensitivit of human colon cancer xenografts in nude mice, and could serve as new mode treatment for human colon cancer.

目的:观察电穿孔技术结合博莱霉素化疗对结肠癌裸鼠移植瘤的抗肿瘤效果,为本疗法的临床应用提供实验依据。方法:于裸鼠左前肢皮下接种人结肠癌LoVo单细胞悬液,3周后成功建立结肠癌裸鼠皮下移植瘤模型40只,随机将其分为电穿孔化疗(B+E+)组、单纯化疗(B+E-)组、单纯电穿孔(B-E+)组和阴性对照(B-E-)组,每组10只。动态观察肿瘤大小,治疗第7天处死小鼠并取出皮下肿瘤称重,。并观察其组织学改变。结果:B+E+组裸鼠移植瘤体积较其他各组明显缩小(P<0.01),该组1只裸鼠的移植瘤呈完全缓解,部分缓解7只;B-E+和B+E-组内各有1只部分缓解,而B-E-组中无一有效。B+E+组有效率与其余各组的差别有统计学意义(P<0.01)。组织学观察也显示B+E+组的移植瘤内大片肿瘤细胞坏死、血管损伤和炎细胞浸润。结论:电穿孔化疗可显著增强结肠癌裸鼠皮下移植瘤对化疗的敏感性,疗效明显,有可能成为结直肠癌治疗的一种新方法。

Objective:To investigate the combined anti-tumor effects of apoptin gene,hemagglutinin-neuramidinase gene(HN)of newcastle disease virus(NDV),and human IL18 gene(hIL-18)on colon carcinoma cells HCT-116 in vitro.Methods:The recombinant plasmid pIRApoptinHNIL18 was introduced into human colon carcinoma cells HCT-116 by liposome-mediated transfection.The expression of the exogenous genes was detected by Western blotting and RT-PCR.The anti-tumor effects of pIRApoptinHNIL18 on HCT-116 cells were...

Objective:To investigate the combined anti-tumor effects of apoptin gene,hemagglutinin-neuramidinase gene(HN)of newcastle disease virus(NDV),and human IL18 gene(hIL-18)on colon carcinoma cells HCT-116 in vitro.Methods:The recombinant plasmid pIRApoptinHNIL18 was introduced into human colon carcinoma cells HCT-116 by liposome-mediated transfection.The expression of the exogenous genes was detected by Western blotting and RT-PCR.The anti-tumor effects of pIRApoptinHNIL18 on HCT-116 cells were determined by AO/EB staining.The influence of pIRApoptinHNIL18 on mitochondrial transmembrane potential(△Ψ)and reactive oxygen species(ROS)were detected by flow cytometry(FCM).Sialic acid content was determined by using 3,5-dihydroxytoluene.Results:pIRApoptinHNIL18 transfection resulted in expression of the exogenous genes,repression of HCT-116 cells,down-regulation of △Ψ [(94.41±8.17)% vs(30.70±8.01)%,P<0.05] and Sialic acid content [(0.33±0.06)mmol/L vs(0.09±0.03)mmol/L,P<0.01],and up-regulation of ROS [(52.48±6.09)% vs(68.98±7.26)% P<0.05].Conclusion:pIRApoptinHNIL18 may inhibit the growth of HCT-116 cells via mitochondrial pathway-induced apoptosis.

目的:探讨联合应用凋亡素(apoptin)基因、新城疫病毒(newcastle disease virus,NDV)血凝素-神经氨酸酶(he-magglutinin-neuramidinase,HN)基因及人白介素18(hIL-18)基因体外对人结肠癌细胞HCT-116的抑制效应。方法:重组质粒pIRApoptinHNIL18通过脂质体介导法体外转染人结肠癌细胞HCT-116,通过Western blotting和RT-PCR检测外源基因表达;采用AO/EB染色法检测pIRApoptinHNIL18对人结肠癌细胞HCT-116抑制作用;利用流式细胞术分析pIRApoptinHNIL18对人结肠癌细胞HCT-116线粒体膜电位(mitochondrial transmembrane potential,△Ψ)和活性氧(reactive oxygen species,ROS)水平;采用3,5-二羟基甲苯法测定唾液酸含量。结果:pIRApoptinHNIL18转染人结肠癌细胞HCT-116后,外源基因能够有效表达;肿瘤细胞生长受到抑制;线粒体△Ψ由(94.41±8.17)%下降到(30.70±8.01)%(P<0....

目的:探讨联合应用凋亡素(apoptin)基因、新城疫病毒(newcastle disease virus,NDV)血凝素-神经氨酸酶(he-magglutinin-neuramidinase,HN)基因及人白介素18(hIL-18)基因体外对人结肠癌细胞HCT-116的抑制效应。方法:重组质粒pIRApoptinHNIL18通过脂质体介导法体外转染人结肠癌细胞HCT-116,通过Western blotting和RT-PCR检测外源基因表达;采用AO/EB染色法检测pIRApoptinHNIL18对人结肠癌细胞HCT-116抑制作用;利用流式细胞术分析pIRApoptinHNIL18对人结肠癌细胞HCT-116线粒体膜电位(mitochondrial transmembrane potential,△Ψ)和活性氧(reactive oxygen species,ROS)水平;采用3,5-二羟基甲苯法测定唾液酸含量。结果:pIRApoptinHNIL18转染人结肠癌细胞HCT-116后,外源基因能够有效表达;肿瘤细胞生长受到抑制;线粒体△Ψ由(94.41±8.17)%下降到(30.70±8.01)%(P<0.05);唾液酸含量由(0.33±0.06)mmol/L下降到(0.09±0.03)mmol/L(P<0.01);ROS水平由(52.48±6.09)%升高到(68.98±7.26)%(P<0.05)。结论:pIRApoptinHNIL18可通过线粒体途径诱导细胞凋亡,从而抑制人结肠癌细胞HCT-116的生长。

 
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