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molecular expression
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  分子表达
     The Suppressive Effect of FK506 on CD 28 Molecular Expression of T Lymphocytes in Human Peripheral Blood in Vitro
     FK506对人外周血T淋巴细胞CD_(28)分子表达的体外抑制作用
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     CD28 molecular expression and autoimmunity in human peripheral blood T cells activation by SEB
     外周血增殖的T细胞CD28分子表达和自身反应性
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     Influence of Xingnaojing Injection on CD54 molecular expression in patients with acute cerebral
     醒脑静注射液对急性脑梗死患者单核细胞CD_(54)~+分子表达的影响
短句来源
     Progressing of RNA molecular expression technology
     RNA分子表达技术研究进展
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     Results: XFZYD in 40 mg/ml or 80 mg/ml could obviously inhibit the adenosine diphosphate induced glycoprotein Ⅱb/Ⅲa molecular expression, as compared with the control group, the difference was significant (P<0 05,P<0 01), but it did not influence the TM level significantly.
     结果:血府逐瘀液(40mg/ml,80mg/ml)明显抑制二磷酸腺苷诱导的GPⅡb/Ⅲa复合物分子表达,与对照组比较有显著性差异(P<005,P<001),而血府逐瘀液对TM无明显影响。
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  分子的表达
     CD23 MOLECULAR EXPRESSION ON ACTIVATED HUMAN TONSIL LYMPHOCYTES
     活化的扁桃体淋巴细胞上CD~(23)分子的表达
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     Objective To explore the relationship between CD8 + T cell CD28 molecular expression in peripheral blood and TCM type in patients with chronic aplastic anemia (CAA).
     目的探讨慢性再生障碍性贫血 (chronicaplasticanemia ,CAA)患者外周血CD8+T细胞CD2 8分子的表达与中医辨证分型的关系。
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     Study on the Correlation Between Molecular Expression and Biological Behavior in Breast Carcinoma Cells
     乳腺肿瘤细胞分子的表达及其与肿瘤细胞生物行为相关性的研究
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     Results:High dose of triptolide induced all cells death on day 7.However,the DC treated with low dose of triptolide(0 3,1 0,and 3 0 μg/L)showed no significant changes on the cell shape,cell number,co stimulation molecular expression,antigen endocytosis activity and allogeneic T cells stimulating activity.
     低剂量 (0 3、1 0、3 0 μg/L)雷公藤内酯醇处理对生成的DC的形态及数量、共刺激分子的表达、内吞蛋白质抗原OVA FITC的能力、同种T细胞的免疫刺激活性均无显著影响 ;
短句来源
     Results and Conclusions The results show that the CD28 molecular expression in CD3 +T cells was enhanced after irradiated by 10cGy.
     结果 用低剂量γ射线诱导辐射后 ,正常人CD3+ T细胞CD2 8受体分子的表达有所增加 ;
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  “molecular expression”译为未确定词的双语例句
     (3) The correlation of cell molecular expression of ER and C-erbB-2; PCNA and CD138; C-erbB-2 and gelsolin in breast carcinoma was evidenced.
     (3)ER与C-erbB-2、PCNA与CD138、C-erbB-2与gelsolin等指标间存在密切的关系(均P<0.05)。
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     1% F022 stimulated mice's liver,kidney,spleen molecular expression of moesin mRNA stimulated by LPS was 93.5%,88.6% and 87.8%,restrain rate was 90.1% for average;
     1%F0 2 2 液对脂多糖刺激鼠肝、肾、脾组织moesimRNA分子表达的抑制率分别为 93 5 %、88 6 %和 87 8% ,平均抑制率为 90 1% ;
短句来源
     Study on CD40 molecular expression in breast carcinoma
     CD40分子在乳腺癌组织中表达的研究
短句来源
     Results:the ratio of inversion in the volunteers and normal human was 64% Enhancing CD8 + T cells were related to CD16 molecular expression ( P < 0.05).
     20~29岁的男性献血员CD4:CD8的倒置与CD16分子高表达相关(P<0.05)。
短句来源
     CONCLUSIONS: The special siRNA targeting to CⅡTA inhibits CⅡTA mRNA and further inhibits its regulation of MHC Ⅱ molecular expression.
     结论:在大鼠角膜基质细胞中,靶向CⅡTAsiRNA抑制了自身mRNA表达,并阻止其调控的MHCⅡ类分子的相应表达。
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  molecular expression
Matching neural morphology to molecular expression: Single cell injection following immunostaining
      
The identification of the nucleotide sequences of VEGF isoforms in the dog heart should prove useful in investigating the molecular expression of VEGF in canine tissues.
      
Frequencies of circulating CD4+CD25highTr cells among CD4+ T cells were also similar and their surface or intracellular molecular expression did not vary in MS patients, irrespective of treatment, compared to HC.
      
The molecular expression of the abnormal gene is in the completely defective activity of the enzyme hypoxanthine guanine phosphoribosyl transferase.
      
Quantitative immunohistochemical detection of the molecular expression patterns in proliferative inflammatory atrophy
      
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Objective:To identify the feasibility of liposome mediated IL-2 gene tansfer in vivo and determine its effects on activation of systemic immune effectors and induction of cytokine production. Metbods:IL-2 DNA, plasmid DNA or PBS was encapsulated into liposome,and was injected into B16-F10 tumor mass directly. Ten days later , the splenocytes from the treated mice were used to detect the cytotoxicity of CTL and LAK activity and the levels of cytokines. The MHC class- I molecular expression on the peritoneal...

Objective:To identify the feasibility of liposome mediated IL-2 gene tansfer in vivo and determine its effects on activation of systemic immune effectors and induction of cytokine production. Metbods:IL-2 DNA, plasmid DNA or PBS was encapsulated into liposome,and was injected into B16-F10 tumor mass directly. Ten days later , the splenocytes from the treated mice were used to detect the cytotoxicity of CTL and LAK activity and the levels of cytokines. The MHC class- I molecular expression on the peritoneal macrophage was determined by monoantibody with FACS. Results: After intratumoral injection of IL-2 DNA , the potent CTL activity of the splenocytes from the treated mice could be induced. The splenic NK and LAK activity was increased markedly. High levels of IL-2 and IFN-γ secreted by splenocytes were also detected. Peritoneal macrophages expressed much more MHC Ia molecules. Conclusion : These results demonstrate that direct intratumoral injection of IL-2 DNA-liposome can transfect IL-2 gene into tumor cells in situ , alter the immunogenicity of the tumor cells , induce tumor-specific and non-specific antitumor response and then exhibit potent antitumor effect. The results offer a practical method for gene therapy of malignant tumor.

目的:为了探讨脂质体介导的IL-2基因体内基因转移的可行性及对荷瘤小鼠全身免疫功能的激活作用及诱导细胞因子产生的效果。方法:将脂质体分别包裹IL-2基因、空白质粒及PBS后,直接注射至黑瘤体内,10d后无菌取出小鼠脾细胞,诱导并检测肿瘤特异性杀伤细胞(CTL)活性、LAK活性及细胞因子的含量,用抗MHCIa单抗检测腹腔巨噬细胞的MHCI类分子的表达。结果:瘤体内注射脂质体包裹的IL-2基因后,小鼠脾CTL细胞活性明显高于瘤体内注射脂质体包裹空白质粒及PBS的对照组,其脾淋巴细胞LAK活性、诱导IFN-γ等细胞因子的含量及表达MHCIa分子的水平均有相应的提高。结论:瘤体内注射脂质体包裹的IL-2基因后,通过在原位转染肿瘤细胞,增强了肿瘤细胞的免疫原性,诱导机体产生肿瘤特异性的CTL以及提高机体非特异性的抗肿瘤免疫反应,发挥抗肿瘤作用。本研究为肿瘤的基因治疗的研究和应用提供了较实用的方法。

The Purpose of this study was to address the mechanism of medicine S which has anti rejection effects of renal allografts in rats. Kidney transplantations were performed from SD to Wistar strain (allogeneic) and from Wistar to Wistar (Isograft) using the same modified technigue described by Fabre and kamada. Experimental rats were divided into five groups. Group Ⅰ (Isograft group) and group Ⅱ (allograft group)as controls were not treated with medicine. The others were allograft groups which received medicine...

The Purpose of this study was to address the mechanism of medicine S which has anti rejection effects of renal allografts in rats. Kidney transplantations were performed from SD to Wistar strain (allogeneic) and from Wistar to Wistar (Isograft) using the same modified technigue described by Fabre and kamada. Experimental rats were divided into five groups. Group Ⅰ (Isograft group) and group Ⅱ (allograft group)as controls were not treated with medicine. The others were allograft groups which received medicine S, Cyclosporine A, and low dose Cyclosporine combined with medicine S, respectively. Renal function and resultant morphology changes were assessed 2, 4 weeks after transplantation. All sections of kidney grafts were stained with monoclonal antibody class Ⅱ MHC (OX6), and then the surface densities of positive staining were quantified by computer image analysis. The level of molecular expression in group Ⅱ was significantly increased (7.61±0.57 vs 0.51±0.2 of group Ⅰ, P<0.01) . In groups Ⅰ and Ⅳ, the molecule of expression was reduced, compared with the groups Ⅱ, Ⅲ and Ⅴ ( P<0.05 ). The results suggest that medicine S decreases the level of class Ⅱ MHC expression and medicines combined with lowe dose cyclosporine is more effective than cyclosporine alone.

为探索草药S抗大鼠同种异体肾移植急性排斥的作用机理,采用改进的Fabre和Ka-mada大鼠原位肾移植模型,将SD大鼠肾移植给Wistar大鼠为同种异体移植,Wistar移植给Wistar大鼠为同品系移植(空白对照),共设五个实验组,观察移植后受体鼠存活、检测移植肾功能及定量测定移植肾内MHCClasⅡ抗原分子的表达。结果表明,草药S能延长受体鼠存活时间,并抑制MHCClasⅡ在移植肾内的表达(与不用药物组比较P<0.01),S药加小剂量环孢素A(cyclosporineA,CsA)治疗组与同系组相比差异无显著性(P>0.05)。这些结果提示,移植肾内MHCClassⅡ表达水平的高低与其排斥的强弱有相关性。

Expressions of tumor-associated markers and S-100+ dendritic cell infiltration in resected gallbladder specimens of 70 patients with various lesions including adenocarcinoma 30, cholecystolithiasis 20, and chronic cholecystitis 20 were studied immunohistochemically. The expressions of p53 protein, CEA and PCNA were found in 46. 7 % (14/30), 30% (9/30), 86. 7 % (26/30) in carcinomatous lesions; and were 0, 15 % (3/20), and 35% (7/20) in cholecystolithiasis; and 0%, 0 %, 25 % (5/20)in inflalmmatory lesions respectively....

Expressions of tumor-associated markers and S-100+ dendritic cell infiltration in resected gallbladder specimens of 70 patients with various lesions including adenocarcinoma 30, cholecystolithiasis 20, and chronic cholecystitis 20 were studied immunohistochemically. The expressions of p53 protein, CEA and PCNA were found in 46. 7 % (14/30), 30% (9/30), 86. 7 % (26/30) in carcinomatous lesions; and were 0, 15 % (3/20), and 35% (7/20) in cholecystolithiasis; and 0%, 0 %, 25 % (5/20)in inflalmmatory lesions respectively. It was revealed that there was a significant difference between carcinomatous and non-neoplastic lesions (P< 0. 05). The frequency of positive finding of S-100+ DC in carcinoma, cholecystolithiasis and chronic cholecystitis were as much as 40 % (12/30 ), 50% (10/20 ), 85 % (17/20)respectively (P<0. 05 ). The present data suggest that: 1 )inflammatory lesion has no tumor-related molecular expression but a higher immunoconlpetency in eplthelial tissues; 2 )malignant change of epithelial cells may occur in some gall stone patients in whom immunoactivity declines; 3 ) in carcinomatous lesions there are overexpression of mutant p53 genes,CEA,PCNA and impaired imrnunocompetency which might predispose to neoplastic transformation.

70例不同胆囊病变标本包括胆囊腺癌30例]、胆结石20例、慢性胆囊炎20例,应用免疫组化观察P53蛋白、癌胚抗原(CEA)、增殖细胞核抗原(PCNA)表达状态及病变组织内S-100蛋白阳性树突状细胞(S-100+DC)浸润情况。p53蛋白、CEA及PCNA表达的阳性检出率,胆囊癌组分别为46.7%(14/30)、30%(9/30)及86.7%(26/30);胆囊结石组分别为0、15%(3/20)及35%(7/20);胆囊炎组分别为0、0及25%(5/20)。癌与非癌病变之间有明显差异(P<0.05)。S-100+DC浸润阳性检出率,癌组织为40%(12/30)、胆囊结石组织为50%(10/20)、胆囊炎为85%(17/20)。S-100+DC的阳性检出率与组织内浸润细胞的密度,胆囊炎组与癌、胆囊结石组之间均存在明显统计学差异(P<0.05)。研究结果提示:1)胆囊炎组织无肿瘤相关分子表达,但存在较高的免疫活性;2)胆结石标本内存在某些上皮细胞恶性转化,且其免疫活性有所降低。这种病变可能有较高肿瘤发生的危险;3)胆囊癌组织不仅有突变型P53基因、CEA及PCNA的过度表达,同时伴有免疫能力的损害,丧失了对肿瘤细...

70例不同胆囊病变标本包括胆囊腺癌30例]、胆结石20例、慢性胆囊炎20例,应用免疫组化观察P53蛋白、癌胚抗原(CEA)、增殖细胞核抗原(PCNA)表达状态及病变组织内S-100蛋白阳性树突状细胞(S-100+DC)浸润情况。p53蛋白、CEA及PCNA表达的阳性检出率,胆囊癌组分别为46.7%(14/30)、30%(9/30)及86.7%(26/30);胆囊结石组分别为0、15%(3/20)及35%(7/20);胆囊炎组分别为0、0及25%(5/20)。癌与非癌病变之间有明显差异(P<0.05)。S-100+DC浸润阳性检出率,癌组织为40%(12/30)、胆囊结石组织为50%(10/20)、胆囊炎为85%(17/20)。S-100+DC的阳性检出率与组织内浸润细胞的密度,胆囊炎组与癌、胆囊结石组之间均存在明显统计学差异(P<0.05)。研究结果提示:1)胆囊炎组织无肿瘤相关分子表达,但存在较高的免疫活性;2)胆结石标本内存在某些上皮细胞恶性转化,且其免疫活性有所降低。这种病变可能有较高肿瘤发生的危险;3)胆囊癌组织不仅有突变型P53基因、CEA及PCNA的过度表达,同时伴有免疫能力的损害,丧失了对肿瘤细胞的免疫监视作用,从而有利于癌的发展。

 
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