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saw bone
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Objective To evaluate the effect of reconstruction and to reduce the surgical trauma by restoring cleft alveolar with osteoconductive porous block β-tricalcium phosphote. We also discussed the application of porous block β-tricalcium phosphote in cleft alveolar reconstruction. Methods In the process of reconstructive operation, first, we formed a bag with mucosa-periosteum flap to accept implant. Meanwhile, we closed parenchyma cleft of nasal cavity, lip, and palate and resumed anatomic shape. We rubbed out...

Objective To evaluate the effect of reconstruction and to reduce the surgical trauma by restoring cleft alveolar with osteoconductive porous block β-tricalcium phosphote. We also discussed the application of porous block β-tricalcium phosphote in cleft alveolar reconstruction. Methods In the process of reconstructive operation, first, we formed a bag with mucosa-periosteum flap to accept implant. Meanwhile, we closed parenchyma cleft of nasal cavity, lip, and palate and resumed anatomic shape. We rubbed out cortical bone of cleft alveolar and then shaped the block β-TCP based on the normal anatomic shape of the other side of alveolar, and put the shaped implant into the cleft and closed the wound. Results The surgeries were successful and the shape reconstructions were perfect as no implant was rejected. Three months after surgery, we could see bone concrescence on the X-ray, and we also saw the artificial bone was absorbed and replaced by the patient's own bone one year and a half after surgery. Conclusions We could find some advantages in reconstructing the maxillary cleft alveolar with porous block β-TCP. We could reconstruct the maxillary shape at once and reduce the surgical trauma. The implant had very good biocompatibility, osteoconductibility and degradability.

目的评价多孔块状β-磷酸三钙在齿槽裂修复中的应用价值。方法齿槽裂的修复手术运用局部黏骨膜瓣形成袋状受植囊,同时关闭鼻、唇、腭间的软组织裂隙,恢复解剖形态;去除裂隙两侧上颌突的骨皮质;采用多孔块状β-磷酸三钙,根据裂隙大小、形状及与健侧的对称性,修整人工骨,植入裂隙。结果手术切口一期愈合,无植入物排出,外形恢复理想,局部饱满。术后3个月X线片可见局部骨性愈合,术后1.5年X线片可见植入人工骨基本被自体骨取代。结论用多孔块状β-磷酸三钙修复齿槽裂,具有恢复形态准确;修复创伤小的优点;植入物组织相容性好,具有骨引导性,可降解,能被自体骨完全取代,且无不良反应。

Objective:To evaluate the effective and toxicity of Vinorelbine(NVB) plus Cispiatin(DDP) in the treatment of elderly patients with non-small-cell lung cancer(NSCLC).Methods: 32 elderly patients with NSCLC were treated with NVB 25mg/m~2 iv drip for day 1?day 8 and DDP 80 mg/m~2 IVD for day 1~3.The second treatment cycle was given on day 22.And compared with 30 cases of young peoples with NSCLC.The objective effect was estimated according to the standard of WHO and the clinical benefit response was evaluated at...

Objective:To evaluate the effective and toxicity of Vinorelbine(NVB) plus Cispiatin(DDP) in the treatment of elderly patients with non-small-cell lung cancer(NSCLC).Methods: 32 elderly patients with NSCLC were treated with NVB 25mg/m~2 iv drip for day 1?day 8 and DDP 80 mg/m~2 IVD for day 1~3.The second treatment cycle was given on day 22.And compared with 30 cases of young peoples with NSCLC.The objective effect was estimated according to the standard of WHO and the clinical benefit response was evaluated at the same time.Results: One patient had a complete response(CR),14 patients had a partial responses(PR),for overall response rate of 46.9% for the elderly patients and 46.6% for the young patients.There was no significance for overall response rate(P>0.05).The median survival time(MST) of elderly patients and young patients was 8.5 months and 9.1months;the diseases median response time(DRT) was 4.5 months and 4.0 month of it.MTS and DRT were similar in two groups(P>0.05).The main toxicities were seen bone marrow depression?gastro enteric tract reaction and phlebitis.Conclusion: NVB combined with DDP is effective and well tolerable for elderly patients with NSCLC.

目的:观察诺维本(NVB)与顺铂(DDP)联合治疗老年非小细胞肺癌(NSCLC)的疗效和毒副反应。方法:老年组NSCLC 32例,予以NVB 25mg/m2于第1、8天静脉泵入,DDP 80mg/m2d13静滴,21天为一周期,至少化疗两周期,并与30例青年组NSCLC患者进行对比;按WHO疗效及毒副反应标准进行评价。结果:老年组中完全缓解(CR)1例(3.2%),部分缓解(PR)14例(43.7%),总有效率RR(CR+PR)达46.9%,青年组中CR1例(3.3%),PR13例(43.3%),RR达46.6%,两组间差异无显著性(P>0.05);中位生存期(MST)老年组和青年组分别为8.5个月和9.1个月,中位缓解时间(DRT)两组分别为4.5个月及4.0个月,两组间差异无显著性(P>0.05);主要毒副作用为骨髓抑制、胃肠道反应和静脉炎。结论:NVB联合DDP对老年NSCLC的治疗有一定的客观缓解率,毒副反应低,耐受性好,值得临床推广。

 
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