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severe acute exacerbation
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  “severe acute exacerbation”译为未确定词的双语例句
     Clinic value of bronchial lavage combining non-invasive positive pressure ventilation in treating severe acute exacerbation of asthma with respiratory failure.
     无创正压通气和支气管灌洗术在哮喘重度急性发作伴有呼吸衰竭治疗中的价值
短句来源
     Methods Full length genomes of two HBV strains before lamivudine treatment and after occurring severe acute exacerbation during lamivudine treatment were cloned and sequenced in a patient with chronic hepatitis B. Nucleotide sequence and predicted amino acid sequences of 4 open reading frames in two HBV strains were analyzed.
     方法 对治疗前及出现病情急性恶化后的慢性乙型肝炎患者的两株HBV全基因进行克隆、测序 ,分析各读码框架核苷酸和氨基酸的变化。
短句来源
     Conclusions In a patient with severe acute exacerbation during lamivudine therapy, together with 29 additional amino acid substitutions were detected outside the YMDD motif in the lamivudine resistant HBV strain.
     结论 对拉米夫定耐药并致病情急性恶化的HBV株在YMDD基序之处共有 2 9个氨基酸变异。
短句来源
     Methods Twenty patients with moderate to severe acute exacerbation and 15 patients with remission of asthma were included in this study. Ten normal volunteers were also enrolled as control group.
     方法 选择初治未经皮质激素治疗的中重度急性加重期哮喘患者 2 0例 ,缓解期患者 15例 ,正常对照组 10名。
短句来源
     Objective To investigate the clinic effect of bronchial lavage (BL) combining non-invasive positive pressure ventilation (NIPPV) in treating severe acute exacerbation of asthma and respiratory failure.
     目的探讨无创正压通气结合支气管灌洗术在哮喘重度急性发作伴有呼吸衰竭治疗中的价值。
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  相似匹配句对
     SEVERE ACUTE PANCREATITIS IN CHILDREN
     儿童重症胰腺炎治疗的商榷
短句来源
     Therapy of severe acute pancreatitis
     重症急性胰腺炎的治疗
短句来源
     COPD Exacerbation and Eosinophilia in Airway
     气道嗜酸性粒细胞增高与COPD加重
短句来源
     The variations in ABGPs of asthma exacerbation were observed.
     观察 5 1例支气管哮喘患者动脉血气指标在血气图上的变化。
短句来源
     RESEARCHES ON THE CAUSES OF ACUTE EXACERBATION IN CHRONIC HEPATITIS B
     慢性乙型肝炎肝病急性加重的原因探讨
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Objective To compare the structural genome variations of lamivudine resistant HBV strain from a patient with acute exacerbation after lamivudine therapy with pretretment HBV strain. Methods Full length genomes of two HBV strains before lamivudine treatment and after occurring severe acute exacerbation during lamivudine treatment were cloned and sequenced in a patient with chronic hepatitis B. Nucleotide sequence and predicted amino acid sequences of 4 open reading frames in two HBV strains were analyzed....

Objective To compare the structural genome variations of lamivudine resistant HBV strain from a patient with acute exacerbation after lamivudine therapy with pretretment HBV strain. Methods Full length genomes of two HBV strains before lamivudine treatment and after occurring severe acute exacerbation during lamivudine treatment were cloned and sequenced in a patient with chronic hepatitis B. Nucleotide sequence and predicted amino acid sequences of 4 open reading frames in two HBV strains were analyzed. Results Compared with pretreatment full length HBV genome, there were 30 amino acid substitutions in four ORFs of lamivudine resistant HBV strain, including substitution of valine for methionine at residue 550(M550V)accompanied by substitution of methionine for leucine at residue 526(L526M). The numbers of amino acid substitutions in ORF P, X, S, Precore/Core were 10(1.19%), 4(2.60%), 8( 2.00%) and 8 (3.77%) respectively. The total variation rate along the whole HBV genome was 1.86%. A G→A change at nucleotide position 1898 resulted in a precore stop codon and led to lack of HBeAg expression; At the preS2 initiation codon ATG was changed to ATA which caused the loss of preS2 protein expression. Some amino acid changes occurred within the known CTL, B or T cells epitopes.Conclusions In a patient with severe acute exacerbation during lamivudine therapy, together with 29 additional amino acid substitutions were detected outside the YMDD motif in the lamivudine resistant HBV strain.

目的 对比研究同一慢性乙型肝炎患者拉米夫定治疗前及病情急性恶化后乙型肝炎病毒 (HBV)株的结构基因组。方法 对治疗前及出现病情急性恶化后的慢性乙型肝炎患者的两株HBV全基因进行克隆、测序 ,分析各读码框架核苷酸和氨基酸的变化。结果 出现病情急性恶化后的HBV株与治疗前毒株比较 ,共有 30个氨基酸发生替代 (包括YMDD基序的M 5 5 0V变异和上游的L5 2 6M变异 ) ,P、X、S和PreC/Core 4个开放读码框架的替代氨基酸数 (变异率 )分别为 10 (1.2 % )、4(2 .6 % )、8(2 .0 % )和 8(3.8% ) ,氨基酸总变异率为 1.9%。其中 ,HBVPreC区的第 1898位核苷酸发生G→A变异 ,产生一个终止密码子 ,导致HBeAg缺失 ;PreS2的起始密码子出现ATG→ATA变异 ,可致PreS2表达缺陷 ;另有变异位点分布于已知CTL、B和T细胞的细胞表位。结论 对拉米夫定耐药并致病情急性恶化的HBV株在YMDD基序之处共有 2 9个氨基酸变异。

Objective To evaluate the results in treatment of 1 020 chronic hepatitis B patients with lamivudine(LAM) alone and lamivudine combined with alpha interferon at the end of treatment Methods 1 020 hepatitis B patients were treatment with lamivudine alone and lamivudine combined with alpha interferon at the end of treatment Follow-up was made six months after treatment and the results were statistically analyzed Results 1) The complete response rate was 44 9% in lamivudine group and 50 78% in lamivudine...

Objective To evaluate the results in treatment of 1 020 chronic hepatitis B patients with lamivudine(LAM) alone and lamivudine combined with alpha interferon at the end of treatment Methods 1 020 hepatitis B patients were treatment with lamivudine alone and lamivudine combined with alpha interferon at the end of treatment Follow-up was made six months after treatment and the results were statistically analyzed Results 1) The complete response rate was 44 9% in lamivudine group and 50 78% in lamivudine plus alpha interferon group Significant differences were observed between the two groups (P<0 01) 2) The Lamivudine alone is apparently effective on patients with high serum HBV DNA level; while the combined therapy of lamivudine plus alpha interferon is more effective on patients with low serum HBV DNA level; 3) the therapeutic effect on patients with short course is better than that with long course; 4) those who's health condition aggravated after treatment are male patients with long course, high HBV DNA level and treated with lamivudine alone, including 5 severe acute exacerbation (SAE) patients accounted for 0 49% of the total number of patients Conclusion 1) The therapeutic effect of lamivudine in combination with alpha interferon is better than that using lamivudine alone There few aggravated patients were observed in both groups of the study and it depends on patients' individual conditions in selecting combined therapy or monotherapy; 2) To avoid the occurrence of SAE patients, ALT and HBV DNA level in the patients be carefully followed up after stopping administration of lamivudine, especially within two months after stopped use of lamivudine The drugs for protecting liver and antiviral therapy be used in case there is SAE patients

目的 评价拉米夫定或联用α 干扰素治疗慢性乙型肝炎终点后的效果。 方法 对 10 2 0例接受拉米夫定或联用α 干扰素治疗病人终点后 6个月进行随访 ,并作统计分析。 结果  (1)拉米夫定治疗组完全应答率为44 94% ,拉米夫定加α 干扰素治疗组为 5 0 78% ,P <0 0 1;(2 )拉米夫定治疗HBVDNA高含量效果明显 ,拉米夫定加α 干扰素治疗HBVDNA低含量效果好 ;(3 )短病程治疗效果优于长病程 ;(4 )治疗后加重病例多为长病程、HBVDNA高含量及单用拉米夫定的男性病人 ,发生严重急性恶化病例 5例 ,仅占总病例 0 49%。 结论  (1)抗病毒药物拉米夫定与α 干扰素联合应用较单一拉米夫定治疗效果好 ,发生治疗后加重反应和较少 ,但需个体化 ;(2 )为避免发生严重急性恶化病例 ,停用拉米夫定后应严密随访ALT及HBVDNA ,特别是停药后 2个月内。一旦发生严重急性恶化 ,除积极护肝治疗外 ,改用其他抗病毒药可望收效

Objective To observe the production of IFN-γ and IL-4 released in peripheral T lymphocytes in asthmatic patients and rat models and to clarify the dynamic changes of proliferation and differentiation of T lymphocytes during the progress of airway inflammation.Methods Twenty patients with moderate to severe acute exacerbation and 15 patients with remission of asthma were included in this study. Ten normal volunteers were also enrolled as control group. T lymphocytes were obtained from their peripheral...

Objective To observe the production of IFN-γ and IL-4 released in peripheral T lymphocytes in asthmatic patients and rat models and to clarify the dynamic changes of proliferation and differentiation of T lymphocytes during the progress of airway inflammation.Methods Twenty patients with moderate to severe acute exacerbation and 15 patients with remission of asthma were included in this study. Ten normal volunteers were also enrolled as control group. T lymphocytes were obtained from their peripheral blood and the percentage of IFN-γ+CD4 ++, IFN-γ+CD8 ++ and IL-4+CD4 ++ cells were determined by flow cytometric method. Asthmatic rat models were established by sensitizing and challenging by ovalbumin(OVA), and the blood samples were taken and the percentage of IFN-γ+CD4+, IFN-γ+CD8+ and IL-4+CD4+ cells were assessed 2, 4, 6, 8, 10,12, 24, 48, and 72 h after OVA challenge. Results (1)The percentages of IFN-γ+CD4+, IFN-γ+CD8+ and IL-4+CD4+cells in the peripheral blood were signifcantly higher in the patients with acute exacerbation [(30%±10%), (42%±15%),and (4.2%±1.6%) respectively] than those in the patients with remission asthma [(20%±8%), (30%±10%), and (2.0%±0.8%) respectively, and P<0.001; ] and those in the normal subjects [(18%±8%), and (24%±9%),P<0.01, and (1.9%±0.9%), P<0.001; respectively]. But all the parameters were not different significantly between the patients with remission asthma and the normal subjects.(2)In the asthmatic rat models, the IFN-γ+CD4+cells in peripheral blood increased 2 h after OVA challenge (5.7%±1.6%), and peaked 10 h after (9.9%±4.4%), and decreased afterwards. The IFN-γ+CD8+cells in peripheral blood increased 2 h after (11.5%±5.1%) OVA challenge, and peaked 10 h after (38.7%±6.3%), and then decreased afterwards. The IL-4+CD4+cells increased 2 h(1.7%±1.0%) after OVA challenge, and peaked 36 h after (4.0%±1.6%), and then decreased. Conclusion Both Th1 (IFN-γ) and Th2 (IL-4) cytokines generated by peripheral blood mononuclear cells in asthma subjects and asthmatic rat models play a role in the development of airway inflammation in bronchial asthma dynamically. Th1 cytokines dominate at the early stage of airway inflammation, whereas Th2 cytokines achieves the major effects at later stage of the inflammation. It suggests that using different strategy in treatment of asthmatics in early stage and late stage may be necessary to control asthma.

目的 探讨T淋巴细胞的增殖和分化在哮喘气道炎症过程中的变化。方法 选择初治未经皮质激素治疗的中重度急性加重期哮喘患者 2 0例 ,缓解期患者 15例 ,正常对照组 10名。SD大鼠 16只 ,按随机表法分为实验组和对照组 ,每组 8只 ,实验组给予卵清蛋白致敏激发。采用流式细胞分析技术检测哮喘患者及大鼠外周血分泌干扰素γ(IFN γ)的CD4 + 、CD8+ 细胞及分泌白细胞介素 4(IL 4 )的CD4 + 细胞的百分数。结果  (1)哮喘急性加重期患者外周血分泌IFN γ的CD4 + 细胞(30 %± 10 % )和CD8+ 细胞 (4 2 %± 15 % )均高于缓解期患者 (分别为 2 0 %± 8% ,P <0 0 1;30 %±10 % ,P <0 0 1)和正常人 (分别为 18%± 8% ,P <0 0 1;2 4 %± 9% ,P <0 0 1) ;分泌IL 4的CD4 + 细胞 (4 2 %± 1 6 % )也显著高于缓解期患者 (2 0 %± 0 8% ,P <0 0 1)及正常人 (1 9%± 0 9% ,P <0 0 0 1)。缓解期患者与正常人之间上述各参数差异...

目的 探讨T淋巴细胞的增殖和分化在哮喘气道炎症过程中的变化。方法 选择初治未经皮质激素治疗的中重度急性加重期哮喘患者 2 0例 ,缓解期患者 15例 ,正常对照组 10名。SD大鼠 16只 ,按随机表法分为实验组和对照组 ,每组 8只 ,实验组给予卵清蛋白致敏激发。采用流式细胞分析技术检测哮喘患者及大鼠外周血分泌干扰素γ(IFN γ)的CD4 + 、CD8+ 细胞及分泌白细胞介素 4(IL 4 )的CD4 + 细胞的百分数。结果  (1)哮喘急性加重期患者外周血分泌IFN γ的CD4 + 细胞(30 %± 10 % )和CD8+ 细胞 (4 2 %± 15 % )均高于缓解期患者 (分别为 2 0 %± 8% ,P <0 0 1;30 %±10 % ,P <0 0 1)和正常人 (分别为 18%± 8% ,P <0 0 1;2 4 %± 9% ,P <0 0 1) ;分泌IL 4的CD4 + 细胞 (4 2 %± 1 6 % )也显著高于缓解期患者 (2 0 %± 0 8% ,P <0 0 1)及正常人 (1 9%± 0 9% ,P <0 0 0 1)。缓解期患者与正常人之间上述各参数差异无显著意义。 (2 )哮喘模型大鼠外周血分泌IFN γ的CD4 + 细胞在激发 2h后开始升高 (5 7%± 1 6 % ) ,并在 10h时达到高峰 (9 9%± 4 4 % ) ,以后逐渐下降 ;分泌IFN γ的CD8+ 细胞在激发后 2h开始增高 (11 5 %± 5 1% ) ,并于 10h达到高峰 (38 7%± 6 3% ) ,以后逐渐下降 ;分泌IL 4的CD4

 
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